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The map label for this gene is caiT [H]

Identifier: 16763464

GI number: 16763464

Start: 86686

End: 88203

Strand: Reverse

Name: caiT [H]

Synonym: STM0074

Alternate gene names: 16763464

Gene position: 88203-86686 (Counterclockwise)

Preceding gene: 16763472

Following gene: 16763463

Centisome position: 1.82

GC content: 54.08

Gene sequence:

>1518_bases
ATGAAAAATGAAAAGAAAAAATCGGGAATTGAACCGAAGGTTTTTTTTCCGCCATTAATAATTGTCGGGATACTTTGCTG
GCTAACAGTCAGAGATCTTGATGCCGCTAACGTCGTTATTAATGCGGTATTCAGTTATGTCACCAACGTCTGGGGTTGGG
CATTTGAATGGTATATGGTCGTCATGCTCTTCGGCTGGTTCTGGCTGGTTTTTGGCCCCTATGCCAAAAAGAGATTAGGT
GACGAAAAACCGGAGTTTAGCACCGCCAGCTGGATTTTCATGATGTTCGCCTCCTGTACATCCGCTGCGGTTCTGTTCTG
GGGCTCTATTGAGATCTACTACTATATCTCCACCCCGCCGTTCGGCCTGGAACCAAATTCCACGGGCGCGAAAGAGATAG
GCCTGGCGTACAGCCTGTTCCACTGGGGGCCGCTGCCGTGGGCAACCTATAGCTTCCTTTCCGTGGCCTTCGCCTACTTC
TTCTTTGTACGCAAGATGGATGTCATCCGCCCCAGCTCCACGCTGGTACCGCTCGTCGGTGAAAAGCATGCGAAAGGGTT
GTTCGGTACCATCGTCGATAACTTCTACCTGGTGGCGCTGATCTTCGCGATGGGCACCAGCCTCGGTCTGGCTACCCCGC
TGGTCACCGAGTGTATGCAATGGCTGTTCGGTATTCCGCATACGCTGCAACTCGACGCCATCATCATTACCTGCTGGATC
ATTCTGAACGCGATTTGCGTGGCCTGCGGCCTGCAAAAAGGGGTCAGAATCGCCAGCGATGTGCGTAGCTACCTGAGCTT
CCTGATGCTCGGCTGGGTGTTTATCGTCAGCGGCGCCAGCTTCATCATGAACTACTTCACCGACTCCGTCGGGATGCTGT
TAATGCACCTGCCACGGATGCTGTTCTATACCGACGCCATCGGTAAAGGCGGCTTCCCGCAGGGCTGGACCGTTTTCTAC
TGGGCGTGGTGGGTTATTTACGCCATCCAGATGAGTATCTTCCTGGCCCGTATTTCCCGTGGTCGTACCGTACGTGAGCT
GTGCTTCGGGATGGTGATGGGTCTGACCGCGTCTACCTGGATCCTGTGGACAGTGCTGGGCAGTAACACGCTGCTGCTGA
TGGATAAAAACATCCTCAACATTCCGCAACTGATTGAGCAACACGGCGTGGCGCGCGCCATTATCGAAACCTGGGCCGCC
TTGCCGCTCAGCACCGCCACCATGTGGGGCTTCTTCATCCTCTGCTTTATTGCCACCGTCACGCTGATTAACGCCTGCTC
TTACACCCTGGCGATGTCGACCTGTCGCGAAGTTCGCGATGGTGAAGAGCCGCCTCTGTTAGTGCGTATCGGCTGGTCAG
TGCTGGTCGGCATCATCGGTATCGTTCTGCTGGCGCTGGGTGGGTTGAAGCCGATTCAGACCGCGATTATCGCCGGAGGA
TGTCCGCTGTTCTTCGTCAACATTATGGTGACGCTGTCCTTTATTAAAGACGCCAAAGTGCACTGGAAAGACAAGTAA

Upstream 100 bases:

>100_bases
CAGAGGTTAAAAACTTATCAACAAATCATTAATAATAAATAAACAAACGTTCATGGACTGGCACGCTAAATAAATTTCGT
TTTCACACTGGAATTCACTT

Downstream 100 bases:

>100_bases
TTCTTATTAACCCAATTGATCAAGAGGCTGAAAGATGGATTTCAACTTAAATGACGAACAGGAGCTGTTTGTCGCCGGTA
TTCGCGAACTGATGGCCAGT

Product: L-carnitine/gamma-butyrobetaine antiporter

Products: Proton [Cytoplasm]; L-carnitine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MKNEKKKSGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMVVMLFGWFWLVFGPYAKKRLG
DEKPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPPFGLEPNSTGAKEIGLAYSLFHWGPLPWATYSFLSVAFAYF
FFVRKMDVIRPSSTLVPLVGEKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWI
ILNAICVACGLQKGVRIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMHLPRMLFYTDAIGKGGFPQGWTVFY
WAWWVIYAIQMSIFLARISRGRTVRELCFGMVMGLTASTWILWTVLGSNTLLLMDKNILNIPQLIEQHGVARAIIETWAA
LPLSTATMWGFFILCFIATVTLINACSYTLAMSTCREVRDGEEPPLLVRIGWSVLVGIIGIVLLALGGLKPIQTAIIAGG
CPLFFVNIMVTLSFIKDAKVHWKDK

Sequences:

>Translated_505_residues
MKNEKKKSGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMVVMLFGWFWLVFGPYAKKRLG
DEKPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPPFGLEPNSTGAKEIGLAYSLFHWGPLPWATYSFLSVAFAYF
FFVRKMDVIRPSSTLVPLVGEKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWI
ILNAICVACGLQKGVRIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMHLPRMLFYTDAIGKGGFPQGWTVFY
WAWWVIYAIQMSIFLARISRGRTVRELCFGMVMGLTASTWILWTVLGSNTLLLMDKNILNIPQLIEQHGVARAIIETWAA
LPLSTATMWGFFILCFIATVTLINACSYTLAMSTCREVRDGEEPPLLVRIGWSVLVGIIGIVLLALGGLKPIQTAIIAGG
CPLFFVNIMVTLSFIKDAKVHWKDK
>Mature_505_residues
MKNEKKKSGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMVVMLFGWFWLVFGPYAKKRLG
DEKPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPPFGLEPNSTGAKEIGLAYSLFHWGPLPWATYSFLSVAFAYF
FFVRKMDVIRPSSTLVPLVGEKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWI
ILNAICVACGLQKGVRIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMHLPRMLFYTDAIGKGGFPQGWTVFY
WAWWVIYAIQMSIFLARISRGRTVRELCFGMVMGLTASTWILWTVLGSNTLLLMDKNILNIPQLIEQHGVARAIIETWAA
LPLSTATMWGFFILCFIATVTLINACSYTLAMSTCREVRDGEEPPLLVRIGWSVLVGIIGIVLLALGGLKPIQTAIIAGG
CPLFFVNIMVTLSFIKDAKVHWKDK

Specific function: Catalyzes the exchange of L-carnitine for gamma- butyrobetaine and related betaines [H]

COG id: COG1292

COG function: function code M; Choline-glycine betaine transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BCCT transporter (TC 2.A.15) family. CaiT subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786224, Length=504, Percent_Identity=96.4285714285714, Blast_Score=989, Evalue=0.0,
Organism=Escherichia coli, GI1788102, Length=438, Percent_Identity=29.4520547945205, Blast_Score=232, Evalue=4e-62,
Organism=Escherichia coli, GI1786506, Length=511, Percent_Identity=25.8317025440313, Blast_Score=158, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000060
- InterPro:   IPR018093 [H]

Pfam domain/function: PF02028 BCCT [H]

EC number: NA

Molecular weight: Translated: 56644; Mature: 56644

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS01303 BCCT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNEKKKSGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMV
CCCCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VMLFGWFWLVFGPYAKKRLGDEKPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPP
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCC
FGLEPNSTGAKEIGLAYSLFHWGPLPWATYSFLSVAFAYFFFVRKMDVIRPSSTLVPLVG
CCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
EKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWI
CHHHCHHHHHHHHHHHHHHHHHHHHCHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ILNAICVACGLQKGVRIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMHLPRM
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFYTDAIGKGGFPQGWTVFYWAWWVIYAIQMSIFLARISRGRTVRELCFGMVMGLTASTW
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ILWTVLGSNTLLLMDKNILNIPQLIEQHGVARAIIETWAALPLSTATMWGFFILCFIATV
HHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
TLINACSYTLAMSTCREVRDGEEPPLLVRIGWSVLVGIIGIVLLALGGLKPIQTAIIAGG
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHCCC
CPLFFVNIMVTLSFIKDAKVHWKDK
HHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKNEKKKSGIEPKVFFPPLIIVGILCWLTVRDLDAANVVINAVFSYVTNVWGWAFEWYMV
CCCCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VMLFGWFWLVFGPYAKKRLGDEKPEFSTASWIFMMFASCTSAAVLFWGSIEIYYYISTPP
HHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCC
FGLEPNSTGAKEIGLAYSLFHWGPLPWATYSFLSVAFAYFFFVRKMDVIRPSSTLVPLVG
CCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCC
EKHAKGLFGTIVDNFYLVALIFAMGTSLGLATPLVTECMQWLFGIPHTLQLDAIIITCWI
CHHHCHHHHHHHHHHHHHHHHHHHHCHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
ILNAICVACGLQKGVRIASDVRSYLSFLMLGWVFIVSGASFIMNYFTDSVGMLLMHLPRM
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFYTDAIGKGGFPQGWTVFYWAWWVIYAIQMSIFLARISRGRTVRELCFGMVMGLTASTW
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
ILWTVLGSNTLLLMDKNILNIPQLIEQHGVARAIIETWAALPLSTATMWGFFILCFIATV
HHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
TLINACSYTLAMSTCREVRDGEEPPLLVRIGWSVLVGIIGIVLLALGGLKPIQTAIIAGG
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHCCC
CPLFFVNIMVTLSFIKDAKVHWKDK
HHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-carnitine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-carnitine [Periplasm] = Proton [Cytoplasm] + L-carnitine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA