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The map label for this gene is czcC [H]

Identifier: 167625811

GI number: 167625811

Start: 4742685

End: 4744025

Strand: Reverse

Name: czcC [H]

Synonym: Shal_3906

Alternate gene names: 167625811

Gene position: 4744025-4742685 (Counterclockwise)

Preceding gene: 167625812

Following gene: 167625810

Centisome position: 90.76

GC content: 48.84

Gene sequence:

>1341_bases
ATGTTTTACAATACTTATGTCGCCAGAATAGGCATTGCTTGCCTATGGCGAGGGCTTTATAGCACGTTCGTTATCGTCGC
TCTGCTATTGGCAGGTTCGTTTGTTGCCGAGGCTGCAACACAAAATAATACTCTTTCTTTGACCACGGTTATCCAGCGGG
TACAGCAACAGCATCCTGCTCTTAAGGTCTTTGAATTTAGACGGCAGGCACTGGACGGTGCGGCGCATACTCAAGCTCTG
ACCCCAGGTTATGATCTCGGTTTTGATCTCGATAACGTCGCAGGCTCAGGTGAGTACCAAGGGATTGATAGTGCGGAGTT
CAGTATCTCACTGTCGTCAGTAATTGAAATGGGAGATAAGCTCGACGCTCGCTCAGGTGTGGTGAGTGAGCAGCGTGCCT
ACCTTGAAGCTGAGCACAAAATTGCCGCCCTTAATCTACTTGCCGAAGCCACTCGACGTTATATCGATGTATTGGCTGCG
CAATCACAGTTGCAGCTTGCATCAGACTCTTTAAAACTTGCGGAGCAAACGCTTGAGGTGGTGAGTGAGCGAGCCAAGGC
TGGAGTCACGCCCGATGCCGAAGTTAAGCGCGCCCGCGCTGCGGTGTTTAGCGCTAGATTGGTAGCAGAAACTCAGCTGC
ACCAGCTCGATTATGCCAAGCTTGCGCTCAGCATGATGTGGGGCGAGTCACAGGTGAGCTTTGACACGCTTGCTGGCAGT
CTATTTGCGTTTTCTGACGATGTGGCATTGGCACCACTATTTGAAAAGGTGAAATACAGTCCTGCCATCGCGGCTTACTT
AACCCAAGCACAACTGAAAGAAGCTGAGCTGCGCTTTGCTAAAACCCAATCGACTACCGATATCAAATGGTCTGTAGGGG
TAAAGCAGTTACAGCAAACCAATGATATGGCACTGACAGCAGGTTTTAATGTGCCGCTGTTTAACGGTGAACGTAATACC
GGTGCTGTTATGTCAGCTCAAGCGGCTAAACAAGAAGTGCTAGCCAACAGAGAGGTTGCGCTACTAGAGCTTTACGGTCA
GTTATACCGTGCGTATACCAGTCGTAAACAAGCCATTGTGACCGTAAATCGTTTACAAGCCAGTGTGATTCCTACCTTAA
CCTTAGCCCTAGAAGATACCAAAATCGCTTATGAGCAAGGGTTATACAGTTACCTCGATTATTTAACCGCTAGAGAAGAG
CTGCTTTTTGCACGCCGAGCGTTAATTGATGCGGCGGCCTCTGCGCTGCGTTATGGCGTCGATATCGAGCAACTGATTGC
TGAACCTTTGCCTGCTTCTCAACACTCCTTCTTTAATGATTTTCAAGGACAGCCAAAATGA

Upstream 100 bases:

>100_bases
GTTCTGCTGTCAGAGCTTGCTTAAGATCTGTTGAGTTTATTTAAAACTATAACTTTTATCAGGTCTTGTATTTTTGTATT
AAATCGAGGCTTACACTCAG

Downstream 100 bases:

>100_bases
ACACTAACGTATTAAACAAACTTTCTCTGGTTCATATTGCTGTTGCTGCAGCATTGATATTTAGCAGCGCTGTTAACGCC
TCACCAGAGCACAGCCATGA

Product: outer membrane efflux protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MFYNTYVARIGIACLWRGLYSTFVIVALLLAGSFVAEAATQNNTLSLTTVIQRVQQQHPALKVFEFRRQALDGAAHTQAL
TPGYDLGFDLDNVAGSGEYQGIDSAEFSISLSSVIEMGDKLDARSGVVSEQRAYLEAEHKIAALNLLAEATRRYIDVLAA
QSQLQLASDSLKLAEQTLEVVSERAKAGVTPDAEVKRARAAVFSARLVAETQLHQLDYAKLALSMMWGESQVSFDTLAGS
LFAFSDDVALAPLFEKVKYSPAIAAYLTQAQLKEAELRFAKTQSTTDIKWSVGVKQLQQTNDMALTAGFNVPLFNGERNT
GAVMSAQAAKQEVLANREVALLELYGQLYRAYTSRKQAIVTVNRLQASVIPTLTLALEDTKIAYEQGLYSYLDYLTAREE
LLFARRALIDAAASALRYGVDIEQLIAEPLPASQHSFFNDFQGQPK

Sequences:

>Translated_446_residues
MFYNTYVARIGIACLWRGLYSTFVIVALLLAGSFVAEAATQNNTLSLTTVIQRVQQQHPALKVFEFRRQALDGAAHTQAL
TPGYDLGFDLDNVAGSGEYQGIDSAEFSISLSSVIEMGDKLDARSGVVSEQRAYLEAEHKIAALNLLAEATRRYIDVLAA
QSQLQLASDSLKLAEQTLEVVSERAKAGVTPDAEVKRARAAVFSARLVAETQLHQLDYAKLALSMMWGESQVSFDTLAGS
LFAFSDDVALAPLFEKVKYSPAIAAYLTQAQLKEAELRFAKTQSTTDIKWSVGVKQLQQTNDMALTAGFNVPLFNGERNT
GAVMSAQAAKQEVLANREVALLELYGQLYRAYTSRKQAIVTVNRLQASVIPTLTLALEDTKIAYEQGLYSYLDYLTAREE
LLFARRALIDAAASALRYGVDIEQLIAEPLPASQHSFFNDFQGQPK
>Mature_446_residues
MFYNTYVARIGIACLWRGLYSTFVIVALLLAGSFVAEAATQNNTLSLTTVIQRVQQQHPALKVFEFRRQALDGAAHTQAL
TPGYDLGFDLDNVAGSGEYQGIDSAEFSISLSSVIEMGDKLDARSGVVSEQRAYLEAEHKIAALNLLAEATRRYIDVLAA
QSQLQLASDSLKLAEQTLEVVSERAKAGVTPDAEVKRARAAVFSARLVAETQLHQLDYAKLALSMMWGESQVSFDTLAGS
LFAFSDDVALAPLFEKVKYSPAIAAYLTQAQLKEAELRFAKTQSTTDIKWSVGVKQLQQTNDMALTAGFNVPLFNGERNT
GAVMSAQAAKQEVLANREVALLELYGQLYRAYTSRKQAIVTVNRLQASVIPTLTLALEDTKIAYEQGLYSYLDYLTAREE
LLFARRALIDAAASALRYGVDIEQLIAEPLPASQHSFFNDFQGQPK

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 48923; Mature: 48923

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CHHHHHCCCCCCCHHHHHHCCCCCCC
>Mature Secondary Structure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CHHHHHCCCCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]