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The map label for this gene is groEL [H]

Identifier: 167625681

GI number: 167625681

Start: 4585136

End: 4586779

Strand: Reverse

Name: groEL [H]

Synonym: Shal_3776

Alternate gene names: 167625681

Gene position: 4586779-4585136 (Counterclockwise)

Preceding gene: 167625682

Following gene: 167625680

Centisome position: 87.75

GC content: 47.26

Gene sequence:

>1644_bases
ATGGCAGCTAAAGAAGTATTATTTGGTAATGACGCACGCGTAAAAATGCTTGCAGGCGTAAACGTTCTAGCTAACGCAGT
TAAAGTTACCTTGGGCCCCAAAGGTCGTAACGTAGTACTAGACAAGAGCTTCGGTGCTCCGCTTATCACTAAAGATGGCG
TGTCAGTAGCTAAAGAGATCGAGCTAGAAGACAAGTTCGAAAACATGGGCGCACAAATGGTTAAAGAAGTTGCTTCTAAA
GCCAATGATGCAGCCGGTGACGGTACTACTACTGCTACAGTACTTGCGCAAGCAATCGTTACTGAAGGCCTAAAAGCTGT
TGCAGCTGGTATGAACCCAATGGATCTTAAGCGCGGTATCGACAAAGCGGTAATCGCTGCAGTTGCCGAGCTTAAAAACC
TGTCTCAAGAGTGTTCTGATACTAAAGCTATCGCTCAAGTAGGTACTATCTCTGCTAACTCTGACGAGTCAATTGGTGAA
ATCATCGCAACGGCGATGGAGCGCGTGGGTAAAGAAGGCGTTATCACCGTTGAAGAAGGTCAAGCACTAGAAAATGAGCT
AGACGTAGTTGAAGGTATGCAGTTCGACCGCGGTTACCTATCTCCATACTTCATTAACAAGCCAGAAACTGGCAGCGTTG
AACTAGAAAGCCCATTCATCCTTCTAGTAGACAAGAAAGTATCAAACATCCGTGAATTGCTACCAATCCTTGAAGGTCTA
GCTAAAACAGGTAAGCCACTGCTTATCGTTGCAGAAGACGTTGAAGGTGAAGCACTAGCAACCCTAGTAGTAAACAACAT
GCGCGGCATCGTTAAAGTTGCAGCTGTTAAGGCGCCAGGCTTTGGTGACCGTCGTAAGGCAATGCTACAAGACATCGCTA
TCCTAACTGGCGGAACTGTTATTGCTGAAGAGATTGGCCTAGAGCTAGAAAAAGCGACCCTAGAAGATCTAGGTACGGCT
AAGCGCGTTATTATCACTAAAGATGACACGACTATCATCGACGGTAACGGCGAAGAGACTCAGATCAAAGCGCGTGTTGC
ACAGATCAAGATCCAAGCTGAAGAATCAACATCAGACTACGACAAAGAAAAGCTTCAAGAGCGTATGGCTAAACTTGCTG
GTGGCGTAGCCGTAATCAAGGTTGGCGCAGCAACTGAAGTTGAAATGAAAGAAAAGAAAGCACGCGTAGAAGACGCACTA
CACGCAACTCGCGCAGCGGTTGAAGAAGGTGTCGTTGCTGGTGGTGGTGTTGCACTAGTACGCGTTGCAAGCAAAATCGG
CGAAGTTGAAGTACTTAACGAAGACCAGAAGCACGGTGTGATCATTGCACTACGTGCTATGGAAGCGCCACTACGTCAAA
TCGCTACCAACGCGGGTGAAGAAGGTTCAGTTGTTGCTAACAACGTTAAGAACGGCACCGGTAACTACGGTTACAACGCG
GGTAACGATACATACGGCGACATGCTAGAGATGGGTATCCTAGACCCAACTAAAGTAACCCGTAGCGCGCTACAGTTCGC
TTCTTCAATTGCTGGTCTAATGATCACAACTGAATGTATGGTAGCTGACGTTAAAGAAGATGCTGCTGATATGGGCGGCA
TGGGCGGTATGGGTGGAATGGGCGGTATGGGCGGCATGATGTAA

Upstream 100 bases:

>100_bases
TAGTAGGTTAATCCCTTACTCTTGTAACATACAAATCATTAATGCCGTTGTTGGCGCAACTGTGTAACCACGGCTAAAAA
GAATTGAAAGGATATTAAAG

Downstream 100 bases:

>100_bases
TTATTGCCCATGACTTAACAGTCATATAAAACAATAAGTTAAGGCTACCGTGTTGACACCAATGTTGACCCCAACGGTAG
CCTTTTTGTTTATAGGTAGC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAAKEVLFGNDARVKMLAGVNVLANAVKVTLGPKGRNVVLDKSFGAPLITKDGVSVAKEIELEDKFENMGAQMVKEVASK
ANDAAGDGTTTATVLAQAIVTEGLKAVAAGMNPMDLKRGIDKAVIAAVAELKNLSQECSDTKAIAQVGTISANSDESIGE
IIATAMERVGKEGVITVEEGQALENELDVVEGMQFDRGYLSPYFINKPETGSVELESPFILLVDKKVSNIRELLPILEGL
AKTGKPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAILTGGTVIAEEIGLELEKATLEDLGTA
KRVIITKDDTTIIDGNGEETQIKARVAQIKIQAEESTSDYDKEKLQERMAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGVVAGGGVALVRVASKIGEVEVLNEDQKHGVIIALRAMEAPLRQIATNAGEEGSVVANNVKNGTGNYGYNA
GNDTYGDMLEMGILDPTKVTRSALQFASSIAGLMITTECMVADVKEDAADMGGMGGMGGMGGMGGMM

Sequences:

>Translated_547_residues
MAAKEVLFGNDARVKMLAGVNVLANAVKVTLGPKGRNVVLDKSFGAPLITKDGVSVAKEIELEDKFENMGAQMVKEVASK
ANDAAGDGTTTATVLAQAIVTEGLKAVAAGMNPMDLKRGIDKAVIAAVAELKNLSQECSDTKAIAQVGTISANSDESIGE
IIATAMERVGKEGVITVEEGQALENELDVVEGMQFDRGYLSPYFINKPETGSVELESPFILLVDKKVSNIRELLPILEGL
AKTGKPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAILTGGTVIAEEIGLELEKATLEDLGTA
KRVIITKDDTTIIDGNGEETQIKARVAQIKIQAEESTSDYDKEKLQERMAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGVVAGGGVALVRVASKIGEVEVLNEDQKHGVIIALRAMEAPLRQIATNAGEEGSVVANNVKNGTGNYGYNA
GNDTYGDMLEMGILDPTKVTRSALQFASSIAGLMITTECMVADVKEDAADMGGMGGMGGMGGMGGMM
>Mature_546_residues
AAKEVLFGNDARVKMLAGVNVLANAVKVTLGPKGRNVVLDKSFGAPLITKDGVSVAKEIELEDKFENMGAQMVKEVASKA
NDAAGDGTTTATVLAQAIVTEGLKAVAAGMNPMDLKRGIDKAVIAAVAELKNLSQECSDTKAIAQVGTISANSDESIGEI
IATAMERVGKEGVITVEEGQALENELDVVEGMQFDRGYLSPYFINKPETGSVELESPFILLVDKKVSNIRELLPILEGLA
KTGKPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAILTGGTVIAEEIGLELEKATLEDLGTAK
RVIITKDDTTIIDGNGEETQIKARVAQIKIQAEESTSDYDKEKLQERMAKLAGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVEEGVVAGGGVALVRVASKIGEVEVLNEDQKHGVIIALRAMEAPLRQIATNAGEEGSVVANNVKNGTGNYGYNAG
NDTYGDMLEMGILDPTKVTRSALQFASSIAGLMITTECMVADVKEDAADMGGMGGMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=529, Percent_Identity=50.2835538752363, Blast_Score=520, Evalue=1e-147,
Organism=Homo sapiens, GI31542947, Length=529, Percent_Identity=50.2835538752363, Blast_Score=520, Evalue=1e-147,
Organism=Escherichia coli, GI1790586, Length=532, Percent_Identity=83.4586466165414, Blast_Score=880, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=51.2287334593573, Blast_Score=531, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=51.6587677725119, Blast_Score=207, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=54.9429657794677, Blast_Score=558, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6322524, Length=583, Percent_Identity=20.926243567753, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=52.9411764705882, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=52.9411764705882, Blast_Score=547, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45550936, Length=523, Percent_Identity=48.565965583174, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI45550132, Length=523, Percent_Identity=48.565965583174, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI45550935, Length=523, Percent_Identity=48.565965583174, Blast_Score=506, Evalue=1e-143,
Organism=Drosophila melanogaster, GI17864606, Length=540, Percent_Identity=41.4814814814815, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24584129, Length=522, Percent_Identity=36.3984674329502, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI19921262, Length=522, Percent_Identity=36.3984674329502, Blast_Score=320, Evalue=2e-87,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57304; Mature: 57172

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKEVLFGNDARVKMLAGVNVLANAVKVTLGPKGRNVVLDKSFGAPLITKDGVSVAKEI
CCCCCEEECCCCCEEEEHHHHHHHHHEEEEECCCCCEEEEECCCCCCEEECCCCHHHHHC
ELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIVTEGLKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DKAVIAAVAELKNLSQECSDTKAIAQVGTISANSDESIGEIIATAMERVGKEGVITVEEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCC
QALENELDVVEGMQFDRGYLSPYFINKPETGSVELESPFILLVDKKVSNIRELLPILEGL
CHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCEEECCCEEEEECCHHHHHHHHHHHHHHH
AKTGKPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAILTGGTV
HHCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCH
IAEEIGLELEKATLEDLGTAKRVIITKDDTTIIDGNGEETQIKARVAQIKIQAEESTSDY
HHHHHCCHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCHHHEEEEEEEEEEECCCCCCC
DKEKLQERMAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVALV
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
RVASKIGEVEVLNEDQKHGVIIALRAMEAPLRQIATNAGEEGSVVANNVKNGTGNYGYNA
HHHHHCCCEEEECCCCCCCEEEEEEHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCC
GNDTYGDMLEMGILDPTKVTRSALQFASSIAGLMITTECMVADVKEDAADMGGMGGMGGM
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GGMGGMM
CCCCCCC
>Mature Secondary Structure 
AAKEVLFGNDARVKMLAGVNVLANAVKVTLGPKGRNVVLDKSFGAPLITKDGVSVAKEI
CCCCEEECCCCCEEEEHHHHHHHHHEEEEECCCCCEEEEECCCCCCEEECCCCHHHHHC
ELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIVTEGLKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DKAVIAAVAELKNLSQECSDTKAIAQVGTISANSDESIGEIIATAMERVGKEGVITVEEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCC
QALENELDVVEGMQFDRGYLSPYFINKPETGSVELESPFILLVDKKVSNIRELLPILEGL
CHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCEEECCCEEEEECCHHHHHHHHHHHHHHH
AKTGKPLLIVAEDVEGEALATLVVNNMRGIVKVAAVKAPGFGDRRKAMLQDIAILTGGTV
HHCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCH
IAEEIGLELEKATLEDLGTAKRVIITKDDTTIIDGNGEETQIKARVAQIKIQAEESTSDY
HHHHHCCHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCHHHEEEEEEEEEEECCCCCCC
DKEKLQERMAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVALV
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
RVASKIGEVEVLNEDQKHGVIIALRAMEAPLRQIATNAGEEGSVVANNVKNGTGNYGYNA
HHHHHCCCEEEECCCCCCCEEEEEEHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCC
GNDTYGDMLEMGILDPTKVTRSALQFASSIAGLMITTECMVADVKEDAADMGGMGGMGGM
CCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GGMGGMM
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA