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The map label for this gene is ppiB [H]

Identifier: 167625639

GI number: 167625639

Start: 4529435

End: 4529929

Strand: Reverse

Name: ppiB [H]

Synonym: Shal_3734

Alternate gene names: 167625639

Gene position: 4529929-4529435 (Counterclockwise)

Preceding gene: 167625641

Following gene: 167625636

Centisome position: 86.67

GC content: 47.68

Gene sequence:

>495_bases
ATGATTATTTTTACCACCAACTTAGGTGATATCGAGATAGAGCTGGATCTGGAAAAGGCGCCAGTGAGTGCCAAGAATTT
TATCAAGTACTGCCAAGATGGCTTCTTTGAGGGCACGATTTTCCATCGCGTCATTAAGGGCTTTATGATCCAAGGCGGTG
GTTTTACTGCCGAAATGGAGGAAAAGCCAACTCGAGCGGCGATAGTCAATGAGGCTAACCGTGGCCTCAAGAACGTTCGT
GGAAGCATTGCCATGGCGCGCACCGATGCCCCCCATTCGGCGACCGGACAGTTTTTTATTAATCTAGCCGATAATAGCTT
TTTAGATCATAGTGCAACTACCAATGCTGGCTGGGGCTATGCGGTGTTTGGTCAAGTGACGGCGGGTATGGATGTGGTGA
CAAAGATAGGCCGCGCTAAAACAGCCTCTAAAGGCGACCATGATGATGTACCAAGAGAGGCTATCATCATTGAGAAGGTG
ACTATCAATCAATAA

Upstream 100 bases:

>100_bases
TTGAGGCCGGGCGTTGATGGGGGAATAATATATTTTTAGTCTCAACTAGGAGTAAAATGTCTTATAGACCGCATAAGCGC
ATGATGAGAGTGTGAGTACC

Downstream 100 bases:

>100_bases
TCGATTGTGTACTCTAGGATAATAAAAAAGCGCTTAAAAGCGCTTTTTTATTATCTGTTACCTTAGTATTTCACTGCGGT
CCGGATCTTATAGATACGGT

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MIIFTTNLGDIEIELDLEKAPVSAKNFIKYCQDGFFEGTIFHRVIKGFMIQGGGFTAEMEEKPTRAAIVNEANRGLKNVR
GSIAMARTDAPHSATGQFFINLADNSFLDHSATTNAGWGYAVFGQVTAGMDVVTKIGRAKTASKGDHDDVPREAIIIEKV
TINQ

Sequences:

>Translated_164_residues
MIIFTTNLGDIEIELDLEKAPVSAKNFIKYCQDGFFEGTIFHRVIKGFMIQGGGFTAEMEEKPTRAAIVNEANRGLKNVR
GSIAMARTDAPHSATGQFFINLADNSFLDHSATTNAGWGYAVFGQVTAGMDVVTKIGRAKTASKGDHDDVPREAIIIEKV
TINQ
>Mature_164_residues
MIIFTTNLGDIEIELDLEKAPVSAKNFIKYCQDGFFEGTIFHRVIKGFMIQGGGFTAEMEEKPTRAAIVNEANRGLKNVR
GSIAMARTDAPHSATGQFFINLADNSFLDHSATTNAGWGYAVFGQVTAGMDVVTKIGRAKTASKGDHDDVPREAIIIEKV
TINQ

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=33.5365853658537, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=33.5365853658537, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=33.5365853658537, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI19557636, Length=165, Percent_Identity=30.9090909090909, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI24308049, Length=170, Percent_Identity=31.1764705882353, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI7706339, Length=145, Percent_Identity=31.7241379310345, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI64276486, Length=129, Percent_Identity=35.6589147286822, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI310110104, Length=134, Percent_Identity=33.5820895522388, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1786736, Length=164, Percent_Identity=57.9268292682927, Blast_Score=199, Evalue=6e-53,
Organism=Escherichia coli, GI1789763, Length=156, Percent_Identity=53.8461538461538, Blast_Score=177, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17539496, Length=175, Percent_Identity=33.7142857142857, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17532641, Length=167, Percent_Identity=28.7425149700599, Blast_Score=76, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=34.2465753424658, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=34.2465753424658, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17506311, Length=163, Percent_Identity=31.2883435582822, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71997782, Length=135, Percent_Identity=34.8148148148148, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323562, Length=159, Percent_Identity=32.7044025157233, Blast_Score=64, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17986117, Length=165, Percent_Identity=29.6969696969697, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922376, Length=164, Percent_Identity=30.4878048780488, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI19922912, Length=153, Percent_Identity=32.0261437908497, Blast_Score=74, Evalue=6e-14,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17840; Mature: 17840

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIFTTNLGDIEIELDLEKAPVSAKNFIKYCQDGFFEGTIFHRVIKGFMIQGGGFTAEME
CEEEEECCCCEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCEECCC
EKPTRAAIVNEANRGLKNVRGSIAMARTDAPHSATGQFFINLADNSFLDHSATTNAGWGY
CCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCE
AVFGQVTAGMDVVTKIGRAKTASKGDHDDVPREAIIIEKVTINQ
EEECCHHCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCC
>Mature Secondary Structure
MIIFTTNLGDIEIELDLEKAPVSAKNFIKYCQDGFFEGTIFHRVIKGFMIQGGGFTAEME
CEEEEECCCCEEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHEECCCCCEECCC
EKPTRAAIVNEANRGLKNVRGSIAMARTDAPHSATGQFFINLADNSFLDHSATTNAGWGY
CCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCE
AVFGQVTAGMDVVTKIGRAKTASKGDHDDVPREAIIIEKVTINQ
EEECCHHCCHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]