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The map label for this gene is mutL

Identifier: 167625542

GI number: 167625542

Start: 4432401

End: 4434314

Strand: Reverse

Name: mutL

Synonym: Shal_3636

Alternate gene names: 167625542

Gene position: 4434314-4432401 (Counterclockwise)

Preceding gene: 167625543

Following gene: 167625541

Centisome position: 84.84

GC content: 45.77

Gene sequence:

>1914_bases
ATGGCTATAGAAAAGTTACCGCCTCAATTAGCAAACCAGATCGCTGCGGGCGAAGTGGTTGAGCGTCCTGCATCTGTCAT
CAAAGAGTTAGTTGAAAATAGTCTTGATGCAGGCGCAACACGAGTCGACATTGAGATAGAAAAAGGCGGTAGTAAGCTTA
TTCGGATCCGCGATAATGGATCCGGGATCCCGAAGGCGGATCTCTGTTTAGCACTTTCTCGGCACGCAACCTCTAAGCTT
AAATCCCTCGACGATTTAGAGGCCATTTTAAGCTTTGGTTTTCGCGGTGAAGCCTTAGCGAGTATTAGCTCTGTTTCTCG
TCTTATCTTAACCTCACGCACGGCAGAGCAAGCTGAAGCATGGCAAGCCCATGCAGAGGGAACAGAGATGGCGGTTAAAG
TCCTGCCAGCTGCCCATCCGGTTGGCTCAACGGTAGAAGCGGTCGATCTTTTTTTTAATACGCCAGCTAGACGCCGCTTC
TTAAAAAGTGACAAGACAGAGTTTACTCATATCGATGAGTGGCTAAAGCGTATTGCTTTGGCGAGACGAGATATCCATTT
TACCCTTAAACACAACGGTAAAACGGTTCGAAATTATCGGCCAGCCAATACTGAGAGCCAGTATATCCAGCGTTTAGCTC
TAGTTTGTGGTAAAGCATTTGCCGAGACTTGCCTGCGGATTGAATGCCAGCATAATGACTTAAGTTTGAGTGGTTATCTG
CAATCACCCAGCTCCGCTAATGGGTACAGTGAAACTCAGTATTTTTATGTCAATGGTCGTTTAGTAAAAGACAGGCTAGT
CAACCATGCGGTTCGTCAAGCCTTCGCACAGTATGCAGAAGGTGTCTCACCCGGTTATGTGCTAATGCTGGATCTTGATC
CACACCAGGTCGATGTTAACGTGCATCCAGCTAAGCATGAAGTACGTTTCCATCAGAGCCGTTATGTGCATGATTTTATT
CTGCAAGCGCTGCAATCTGCGATCTCTCAATCTATGGAACTAGCGCTCAATAATGAGCCAGAAATACAACAATCGCCTGA
TAGACAAGTGAGTCCGACTCGAGGAGCGGTAACTGCGCCCCTGTATTCTGAAAGTATTGAGCGTAAACCATCGGTTTCTT
ATGACGTGCGTGATAGTCACTCTGTTACTAATCAAAGGGATTATTCGAGCGGGAGTTCAAGCTACCGAAGTCCGCTGAAA
CCCTCTGCTCGAAATGGTGATGTTAGTTTACCCTCTCAAAGCAGTATTCGAGCTTATGGTGAACTGCTGAGCACACAAAG
CAGTAGCACGCACAGTGATCGTGTTCTAAGTACTCAGCAAAATAATTATGCAGTCCGCTCTCCTGCAGGGAACCAAAATG
GATTGGCAGCTTCTAACTCGCATGCGGCGAGTATGCCAGCGGTTATAGCGGGTGAATTTTGGGTGTTGGTTAGGGACGAC
AAAATATCGCTTTTAAGTATCTCTATGGTGGCAAGGGCAGTGCTAAAAGCTGAGATAGCAGCTAAGTTTTCACAAGGGCT
AGTTGGTCAGCCATTATTGATGCCTGTCGCCGTTGCAGTTGATGATGATTGGTTAGCGATTATAGAAAATCGAGAACAGT
TACTGCGAAAATTAGGAATTGAACTATCTATTCGTTTGGGGCAGTTGATTATTAAGAAAGTGCCCCCATATCTAAGAAAC
AGTCAATTAGCTGTTTTGATCCCTGAGTTATTGCAGTGGATTCAATTAGAATTACCAAGTGACGCTGCGGTTGTTAAGTG
GCTTGCTGAACAAGGTGCGAACCGGTTTACCTCTGCAGGTGAAGCGTGGTTTGGCCTAAATGCCTTGCCTGATGATGTGC
AACGCGAGCTTTATAATTTATCCCAAGATTTACCTTGGGAACAATGGATGAAAGAAAATCAGAGTGACCGATAA

Upstream 100 bases:

>100_bases
CAATAAACAGTTTGAAGAAGGCAAATAACCTTAAATCAAATAGCATTCGAATCGGTCAGAGACTGATTATCCCCAGAGCT
TAGGCTGTTAAGAGTAAACC

Downstream 100 bases:

>100_bases
TAAATCACAAAAAGTTATTACCTTAATGGGCCCTACTGCCTCTGGTAAAACCGCATTAGCGATTGAGCTTGTTAAGCAGT
ATAACTGTGAAATTATCTCT

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 636

Protein sequence:

>637_residues
MAIEKLPPQLANQIAAGEVVERPASVIKELVENSLDAGATRVDIEIEKGGSKLIRIRDNGSGIPKADLCLALSRHATSKL
KSLDDLEAILSFGFRGEALASISSVSRLILTSRTAEQAEAWQAHAEGTEMAVKVLPAAHPVGSTVEAVDLFFNTPARRRF
LKSDKTEFTHIDEWLKRIALARRDIHFTLKHNGKTVRNYRPANTESQYIQRLALVCGKAFAETCLRIECQHNDLSLSGYL
QSPSSANGYSETQYFYVNGRLVKDRLVNHAVRQAFAQYAEGVSPGYVLMLDLDPHQVDVNVHPAKHEVRFHQSRYVHDFI
LQALQSAISQSMELALNNEPEIQQSPDRQVSPTRGAVTAPLYSESIERKPSVSYDVRDSHSVTNQRDYSSGSSSYRSPLK
PSARNGDVSLPSQSSIRAYGELLSTQSSSTHSDRVLSTQQNNYAVRSPAGNQNGLAASNSHAASMPAVIAGEFWVLVRDD
KISLLSISMVARAVLKAEIAAKFSQGLVGQPLLMPVAVAVDDDWLAIIENREQLLRKLGIELSIRLGQLIIKKVPPYLRN
SQLAVLIPELLQWIQLELPSDAAVVKWLAEQGANRFTSAGEAWFGLNALPDDVQRELYNLSQDLPWEQWMKENQSDR

Sequences:

>Translated_637_residues
MAIEKLPPQLANQIAAGEVVERPASVIKELVENSLDAGATRVDIEIEKGGSKLIRIRDNGSGIPKADLCLALSRHATSKL
KSLDDLEAILSFGFRGEALASISSVSRLILTSRTAEQAEAWQAHAEGTEMAVKVLPAAHPVGSTVEAVDLFFNTPARRRF
LKSDKTEFTHIDEWLKRIALARRDIHFTLKHNGKTVRNYRPANTESQYIQRLALVCGKAFAETCLRIECQHNDLSLSGYL
QSPSSANGYSETQYFYVNGRLVKDRLVNHAVRQAFAQYAEGVSPGYVLMLDLDPHQVDVNVHPAKHEVRFHQSRYVHDFI
LQALQSAISQSMELALNNEPEIQQSPDRQVSPTRGAVTAPLYSESIERKPSVSYDVRDSHSVTNQRDYSSGSSSYRSPLK
PSARNGDVSLPSQSSIRAYGELLSTQSSSTHSDRVLSTQQNNYAVRSPAGNQNGLAASNSHAASMPAVIAGEFWVLVRDD
KISLLSISMVARAVLKAEIAAKFSQGLVGQPLLMPVAVAVDDDWLAIIENREQLLRKLGIELSIRLGQLIIKKVPPYLRN
SQLAVLIPELLQWIQLELPSDAAVVKWLAEQGANRFTSAGEAWFGLNALPDDVQRELYNLSQDLPWEQWMKENQSDR
>Mature_636_residues
AIEKLPPQLANQIAAGEVVERPASVIKELVENSLDAGATRVDIEIEKGGSKLIRIRDNGSGIPKADLCLALSRHATSKLK
SLDDLEAILSFGFRGEALASISSVSRLILTSRTAEQAEAWQAHAEGTEMAVKVLPAAHPVGSTVEAVDLFFNTPARRRFL
KSDKTEFTHIDEWLKRIALARRDIHFTLKHNGKTVRNYRPANTESQYIQRLALVCGKAFAETCLRIECQHNDLSLSGYLQ
SPSSANGYSETQYFYVNGRLVKDRLVNHAVRQAFAQYAEGVSPGYVLMLDLDPHQVDVNVHPAKHEVRFHQSRYVHDFIL
QALQSAISQSMELALNNEPEIQQSPDRQVSPTRGAVTAPLYSESIERKPSVSYDVRDSHSVTNQRDYSSGSSSYRSPLKP
SARNGDVSLPSQSSIRAYGELLSTQSSSTHSDRVLSTQQNNYAVRSPAGNQNGLAASNSHAASMPAVIAGEFWVLVRDDK
ISLLSISMVARAVLKAEIAAKFSQGLVGQPLLMPVAVAVDDDWLAIIENREQLLRKLGIELSIRLGQLIIKKVPPYLRNS
QLAVLIPELLQWIQLELPSDAAVVKWLAEQGANRFTSAGEAWFGLNALPDDVQRELYNLSQDLPWEQWMKENQSDR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=331, Percent_Identity=36.2537764350453, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI4505911, Length=320, Percent_Identity=30, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI189458898, Length=320, Percent_Identity=30, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI189458896, Length=313, Percent_Identity=29.7124600638978, Blast_Score=140, Evalue=5e-33,
Organism=Homo sapiens, GI4505913, Length=348, Percent_Identity=25.8620689655172, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI310128478, Length=348, Percent_Identity=25.8620689655172, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI263191589, Length=237, Percent_Identity=30.379746835443, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI310128480, Length=298, Percent_Identity=23.1543624161074, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI91992162, Length=338, Percent_Identity=23.3727810650888, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI91992160, Length=340, Percent_Identity=23.8235294117647, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1790612, Length=576, Percent_Identity=48.4375, Blast_Score=504, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI71991825, Length=325, Percent_Identity=34.7692307692308, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17562796, Length=345, Percent_Identity=26.3768115942029, Blast_Score=122, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=336, Percent_Identity=37.797619047619, Blast_Score=206, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6324247, Length=362, Percent_Identity=26.5193370165746, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325093, Length=371, Percent_Identity=26.4150943396226, Blast_Score=97, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6323063, Length=386, Percent_Identity=24.0932642487047, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17136968, Length=332, Percent_Identity=35.8433734939759, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17136970, Length=184, Percent_Identity=34.2391304347826, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_SHEHH (B0TU66)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001675836.1
- ProteinModelPortal:   B0TU66
- GeneID:   5904709
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_3636
- HOGENOM:   HBG520262
- OMA:   FTHIDEW
- ProtClustDB:   PRK00095
- BioCyc:   SHAL458817:SHAL_3636-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 70500; Mature: 70369

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIEKLPPQLANQIAAGEVVERPASVIKELVENSLDAGATRVDIEIEKGGSKLIRIRDNG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCC
SGIPKADLCLALSRHATSKLKSLDDLEAILSFGFRGEALASISSVSRLILTSRTAEQAEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
WQAHAEGTEMAVKVLPAAHPVGSTVEAVDLFFNTPARRRFLKSDKTEFTHIDEWLKRIAL
HHHHCCCHHEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
ARRDIHFTLKHNGKTVRNYRPANTESQYIQRLALVCGKAFAETCLRIECQHNDLSLSGYL
HHCCEEEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEEE
QSPSSANGYSETQYFYVNGRLVKDRLVNHAVRQAFAQYAEGVSPGYVLMLDLDPHQVDVN
CCCCCCCCCCCCEEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEE
VHPAKHEVRFHQSRYVHDFILQALQSAISQSMELALNNEPEIQQSPDRQVSPTRGAVTAP
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECC
LYSESIERKPSVSYDVRDSHSVTNQRDYSSGSSSYRSPLKPSARNGDVSLPSQSSIRAYG
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
ELLSTQSSSTHSDRVLSTQQNNYAVRSPAGNQNGLAASNSHAASMPAVIAGEFWVLVRDD
HHHHCCCCCCCCCHHEEECCCCEEEECCCCCCCCCCCCCCCCCCCCEEEECCEEEEEECC
KISLLSISMVARAVLKAEIAAKFSQGLVGQPLLMPVAVAVDDDWLAIIENREQLLRKLGI
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHCC
ELSIRLGQLIIKKVPPYLRNSQLAVLIPELLQWIQLELPSDAAVVKWLAEQGANRFTSAG
EEEEHHHHHHHHHCCHHHCCCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHCCCC
EAWFGLNALPDDVQRELYNLSQDLPWEQWMKENQSDR
CCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCC
>Mature Secondary Structure 
AIEKLPPQLANQIAAGEVVERPASVIKELVENSLDAGATRVDIEIEKGGSKLIRIRDNG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCEEEEEECCC
SGIPKADLCLALSRHATSKLKSLDDLEAILSFGFRGEALASISSVSRLILTSRTAEQAEA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
WQAHAEGTEMAVKVLPAAHPVGSTVEAVDLFFNTPARRRFLKSDKTEFTHIDEWLKRIAL
HHHHCCCHHEEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHH
ARRDIHFTLKHNGKTVRNYRPANTESQYIQRLALVCGKAFAETCLRIECQHNDLSLSGYL
HHCCEEEEEECCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEEE
QSPSSANGYSETQYFYVNGRLVKDRLVNHAVRQAFAQYAEGVSPGYVLMLDLDPHQVDVN
CCCCCCCCCCCCEEEEECCEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEE
VHPAKHEVRFHQSRYVHDFILQALQSAISQSMELALNNEPEIQQSPDRQVSPTRGAVTAP
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECC
LYSESIERKPSVSYDVRDSHSVTNQRDYSSGSSSYRSPLKPSARNGDVSLPSQSSIRAYG
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
ELLSTQSSSTHSDRVLSTQQNNYAVRSPAGNQNGLAASNSHAASMPAVIAGEFWVLVRDD
HHHHCCCCCCCCCHHEEECCCCEEEECCCCCCCCCCCCCCCCCCCCEEEECCEEEEEECC
KISLLSISMVARAVLKAEIAAKFSQGLVGQPLLMPVAVAVDDDWLAIIENREQLLRKLGI
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHEEEEEECCCHHHHHHHHHHHHHHHCC
ELSIRLGQLIIKKVPPYLRNSQLAVLIPELLQWIQLELPSDAAVVKWLAEQGANRFTSAG
EEEEHHHHHHHHHCCHHHCCCCCEEHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHCCCC
EAWFGLNALPDDVQRELYNLSQDLPWEQWMKENQSDR
CCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA