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The map label for this gene is cysG1 [H]

Identifier: 167625442

GI number: 167625442

Start: 4310235

End: 4311056

Strand: Reverse

Name: cysG1 [H]

Synonym: Shal_3534

Alternate gene names: 167625442

Gene position: 4311056-4310235 (Counterclockwise)

Preceding gene: 167625446

Following gene: 167625441

Centisome position: 82.48

GC content: 51.22

Gene sequence:

>822_bases
ATGGAGATTGTAGCTTTACCCGGTCAAGCCGCTGTAGGGAAAGTATGGCTAGTGGGCGCAGGCCCTGGTGATGTCGATCT
ACTGACGGTAAAAGCCTATCGCGTACTGCAAAGTGCCGATGCCGTGCTCTACGATGCGCTGGTCAGTGATGAAATCCTCG
CGCTTATCCCAAAGCATGCCGAGAAGATCGTTGTGGGTAAGCGTGCGGGTAAGCATAGCGCCGCGCAAAGCGAGATTAAT
CAGCTATTGGTCACTAAGGCCTACACCCGTAAAAACGTGGTGCGCTTAAAAGGGGGGGACCCCTTTATTTTCGGTCGCGG
CGGTGAAGAGCTAGAAACCATCGTGGACGCTGGCGTCGAGTTTGAAGTGGTCCCAGGGATCACGGCGGCAAGTGGCACCG
CTGCTTATGCCGGTATTCCGTTAACTCATAGAGATTATGCCCAAGGGGTGAGCTTTATTACTGGCCACTGCAAGCTTGAG
AGCCGCCCAATGGATTGGCAAGGTTATGCAAACCCGAACAATACGTTAGTGATCTACATGGGTATTTTAAATGCAGGGCT
CATAAAACAAGGTCTGCTCAATGCGGGCCGAAAGCCACAAACACCCGTTGCTATCGTATCGAAAGCTACGACTGTCGAGC
AGCAAACCTTTATCGGTAACCTAGATAACCTTGATGAGCTTGCCAGCCACCCAGATTTGATGATGCCCGCCTTAATGGTC
ATTGGCGAGGTCGTCGAGCTCGCCGATAGCCTTAATTGGTTTACGCCTAAAACACAGAACAGCCAGCTCAATGATCCTGA
GTTAGCCGAAATAACAAAATAA

Upstream 100 bases:

>100_bases
CTTAAATAACTAAAAGTTATAAAAGGTAATAAATATCTATTTATTATGGAATAAGCAGGCGGCTATATTTCACTGTAACG
AATTAGAGTGAGGTAGCGTG

Downstream 100 bases:

>100_bases
TTGATTGAAGAATACGGAGAATTAGCATGGCCGCGAAAGAGTTAAGCCATTTGCAACAACTGGAAGCTGAGAGCATTCAA
ATCATTCGTGAAGTGGCGGC

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MEIVALPGQAAVGKVWLVGAGPGDVDLLTVKAYRVLQSADAVLYDALVSDEILALIPKHAEKIVVGKRAGKHSAAQSEIN
QLLVTKAYTRKNVVRLKGGDPFIFGRGGEELETIVDAGVEFEVVPGITAASGTAAYAGIPLTHRDYAQGVSFITGHCKLE
SRPMDWQGYANPNNTLVIYMGILNAGLIKQGLLNAGRKPQTPVAIVSKATTVEQQTFIGNLDNLDELASHPDLMMPALMV
IGEVVELADSLNWFTPKTQNSQLNDPELAEITK

Sequences:

>Translated_273_residues
MEIVALPGQAAVGKVWLVGAGPGDVDLLTVKAYRVLQSADAVLYDALVSDEILALIPKHAEKIVVGKRAGKHSAAQSEIN
QLLVTKAYTRKNVVRLKGGDPFIFGRGGEELETIVDAGVEFEVVPGITAASGTAAYAGIPLTHRDYAQGVSFITGHCKLE
SRPMDWQGYANPNNTLVIYMGILNAGLIKQGLLNAGRKPQTPVAIVSKATTVEQQTFIGNLDNLDELASHPDLMMPALMV
IGEVVELADSLNWFTPKTQNSQLNDPELAEITK
>Mature_273_residues
MEIVALPGQAAVGKVWLVGAGPGDVDLLTVKAYRVLQSADAVLYDALVSDEILALIPKHAEKIVVGKRAGKHSAAQSEIN
QLLVTKAYTRKNVVRLKGGDPFIFGRGGEELETIVDAGVEFEVVPGITAASGTAAYAGIPLTHRDYAQGVSFITGHCKLE
SRPMDWQGYANPNNTLVIYMGILNAGLIKQGLLNAGRKPQTPVAIVSKATTVEQQTFIGNLDNLDELASHPDLMMPALMV
IGEVVELADSLNWFTPKTQNSQLNDPELAEITK

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=243, Percent_Identity=55.5555555555556, Blast_Score=264, Evalue=4e-72,
Organism=Saccharomyces cerevisiae, GI6322922, Length=248, Percent_Identity=34.6774193548387, Blast_Score=124, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 29211; Mature: 29211

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIVALPGQAAVGKVWLVGAGPGDVDLLTVKAYRVLQSADAVLYDALVSDEILALIPKHA
CEEEECCCCCCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKIVVGKRAGKHSAAQSEINQLLVTKAYTRKNVVRLKGGDPFIFGRGGEELETIVDAGVE
HEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCHHHHHHHHCCCE
FEVVPGITAASGTAAYAGIPLTHRDYAQGVSFITGHCKLESRPMDWQGYANPNNTLVIYM
EEEECCEEECCCCCEEECCCCCCHHHHCCHHEEEEEEEECCCCCCCCCCCCCCCEEEEEE
GILNAGLIKQGLLNAGRKPQTPVAIVSKATTVEQQTFIGNLDNLDELASHPDLMMPALMV
HHHCHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHH
IGEVVELADSLNWFTPKTQNSQLNDPELAEITK
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCC
>Mature Secondary Structure
MEIVALPGQAAVGKVWLVGAGPGDVDLLTVKAYRVLQSADAVLYDALVSDEILALIPKHA
CEEEECCCCCCCCEEEEEECCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKIVVGKRAGKHSAAQSEINQLLVTKAYTRKNVVRLKGGDPFIFGRGGEELETIVDAGVE
HEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECCCCHHHHHHHHCCCE
FEVVPGITAASGTAAYAGIPLTHRDYAQGVSFITGHCKLESRPMDWQGYANPNNTLVIYM
EEEECCEEECCCCCEEECCCCCCHHHHCCHHEEEEEEEECCCCCCCCCCCCCCCEEEEEE
GILNAGLIKQGLLNAGRKPQTPVAIVSKATTVEQQTFIGNLDNLDELASHPDLMMPALMV
HHHCHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHH
IGEVVELADSLNWFTPKTQNSQLNDPELAEITK
HHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA