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The map label for this gene is panF [H]

Identifier: 167624508

GI number: 167624508

Start: 3136778

End: 3138220

Strand: Reverse

Name: panF [H]

Synonym: Shal_2587

Alternate gene names: 167624508

Gene position: 3138220-3136778 (Counterclockwise)

Preceding gene: 167624509

Following gene: 167624507

Centisome position: 60.04

GC content: 47.96

Gene sequence:

>1443_bases
ATGACTAGTTTATTGCCGGTATTAATTTACCTTGGGTTAAGTTTGGTGATCACTCGGGTCTGGAGTGCGCGTCAGGCTAA
ACAGTCTCAGCAATTCAGTGATGATAAAGCTAAGCGCTTTTTTATCGGTGGGGCGTTCCTTAGCGGCCCATTGTTAGCGT
TAACTTTGGTGGCTACCTATACCAGTGCGGGCTCATTTATTGGCGGGCCCGGTGCTGCTTATAAGTTCGGACTAGGCTGG
GTATGGCTGGCTGTGATCCAGGTTCCTGTGGTTATTCTTACCTTAGGGGTTTTAGGGCCTAAATTTCTCGCGCAAAAAAA
GCAGTACAGCACCATTATTGAATGGCTTGACGAACGATATAGCAATAACTGGTTGAGCACGATTGCTATGCTGAGTTTGG
TTGTTGGCTTTGTCGCTATGATCTCGGTGCAATTTATTGGCGGTGCCCGATTACTTTCTGGAGTAACCGGAGTCAGTTAC
GAGCTGGGTTTGGCGGTATTTGTGCTGACAGTGCTTGCCTACACCTTAACGGGTGGTTTCAGAGCGGTTGTACTCACAGA
CGCTCTGCAAGGCATAGTGATGCTACTCGGATTAATCATCTTGTTACTTGTGATCTTAACTCGCCCCGAGCTCAGTTCAC
AGTTAGCGGTGGAAACCGCCAAAATGCCCCAGCTACTCAGCCCTCATGGGGTGGATGACTTTTTAAGCTGGCCTATGATG
TTGTCGTTTTGGGTATTGATCTGTTTTGGCACCATGGGCTTACCTCATACTATTGTAAGGCTATTAGCAGTTAAAGACCC
GTTGTCACTAAAGCGAGGCATGTTGTGGGGAACGATAATTTGCTTCTTGATGACACTGATCCCACATCTATGCGGCTTTC
TTGGTCGCGCGCTATTTCCAAATCTTAGCGTGCCCGATCAAATTATGCCGACCTTAATCGCGCAGTTAATGAGTCCATTC
TGGGCGGGTATTTTGCTCGCCGCGCCGATTGCTGCGGTGATGTCATCGGTAGACTCTATGTTGCTGCAGTCGGCTGTCAG
TATCGTTCGTGATGGCGTGGTTAAAACAAGGCCAGCAATGAGCGCGACGGCTCAGGTGCGCATGACGCAAGTGCTGATGG
TCGTTATTACGGCGCTAGCCTGTTTTTGGGCTGTGAAGCCGCCAGATATGATCGTTTGGATTAACCTTGCGGCTTTTGGC
GCTTTGCAGGCAGTATTTCTATGGCCCATTATCGCCGGGATGTTTTGCCCAACGGTGAATGGTCAAACGGCCTTGATAGC
CATGTGCAGTGGTATGCTAAGTTATATTGTGCTGCAATGGCAGTCGCCGTTGATTTTCCATATTCATCCTATTGTGCCAG
CATTGCTATTTTCGTTGCTTATGTTGGTTATAAGTCACTTTATTAGCAAAGTCTTTGTTAAGAGCTCTATCGCAAGTGGT
TAA

Upstream 100 bases:

>100_bases
CCGCTATGGTTTTGGTTTTCCTGTATCGGTGCACCGCTTTTGCTGATAGTCAGTCTTAGATTTTTACTTACTAAGGTTGT
GAGTAAGGTTGAGGAACGTA

Downstream 100 bases:

>100_bases
GGTAGATGGTTAACTTGGCTAGCTAATAGTCAGTCATTGGTTTATATTGCCGCCATATAATAATAAAATGGTGGCAAAAT
GGACCCTGTTAGCGCTTCTA

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MTSLLPVLIYLGLSLVITRVWSARQAKQSQQFSDDKAKRFFIGGAFLSGPLLALTLVATYTSAGSFIGGPGAAYKFGLGW
VWLAVIQVPVVILTLGVLGPKFLAQKKQYSTIIEWLDERYSNNWLSTIAMLSLVVGFVAMISVQFIGGARLLSGVTGVSY
ELGLAVFVLTVLAYTLTGGFRAVVLTDALQGIVMLLGLIILLLVILTRPELSSQLAVETAKMPQLLSPHGVDDFLSWPMM
LSFWVLICFGTMGLPHTIVRLLAVKDPLSLKRGMLWGTIICFLMTLIPHLCGFLGRALFPNLSVPDQIMPTLIAQLMSPF
WAGILLAAPIAAVMSSVDSMLLQSAVSIVRDGVVKTRPAMSATAQVRMTQVLMVVITALACFWAVKPPDMIVWINLAAFG
ALQAVFLWPIIAGMFCPTVNGQTALIAMCSGMLSYIVLQWQSPLIFHIHPIVPALLFSLLMLVISHFISKVFVKSSIASG

Sequences:

>Translated_480_residues
MTSLLPVLIYLGLSLVITRVWSARQAKQSQQFSDDKAKRFFIGGAFLSGPLLALTLVATYTSAGSFIGGPGAAYKFGLGW
VWLAVIQVPVVILTLGVLGPKFLAQKKQYSTIIEWLDERYSNNWLSTIAMLSLVVGFVAMISVQFIGGARLLSGVTGVSY
ELGLAVFVLTVLAYTLTGGFRAVVLTDALQGIVMLLGLIILLLVILTRPELSSQLAVETAKMPQLLSPHGVDDFLSWPMM
LSFWVLICFGTMGLPHTIVRLLAVKDPLSLKRGMLWGTIICFLMTLIPHLCGFLGRALFPNLSVPDQIMPTLIAQLMSPF
WAGILLAAPIAAVMSSVDSMLLQSAVSIVRDGVVKTRPAMSATAQVRMTQVLMVVITALACFWAVKPPDMIVWINLAAFG
ALQAVFLWPIIAGMFCPTVNGQTALIAMCSGMLSYIVLQWQSPLIFHIHPIVPALLFSLLMLVISHFISKVFVKSSIASG
>Mature_479_residues
TSLLPVLIYLGLSLVITRVWSARQAKQSQQFSDDKAKRFFIGGAFLSGPLLALTLVATYTSAGSFIGGPGAAYKFGLGWV
WLAVIQVPVVILTLGVLGPKFLAQKKQYSTIIEWLDERYSNNWLSTIAMLSLVVGFVAMISVQFIGGARLLSGVTGVSYE
LGLAVFVLTVLAYTLTGGFRAVVLTDALQGIVMLLGLIILLLVILTRPELSSQLAVETAKMPQLLSPHGVDDFLSWPMML
SFWVLICFGTMGLPHTIVRLLAVKDPLSLKRGMLWGTIICFLMTLIPHLCGFLGRALFPNLSVPDQIMPTLIAQLMSPFW
AGILLAAPIAAVMSSVDSMLLQSAVSIVRDGVVKTRPAMSATAQVRMTQVLMVVITALACFWAVKPPDMIVWINLAAFGA
LQAVFLWPIIAGMFCPTVNGQTALIAMCSGMLSYIVLQWQSPLIFHIHPIVPALLFSLLMLVISHFISKVFVKSSIASG

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=452, Percent_Identity=25.8849557522124, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI4507035, Length=420, Percent_Identity=24.047619047619, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI157671931, Length=425, Percent_Identity=22.8235294117647, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI14140236, Length=463, Percent_Identity=24.4060475161987, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI87082237, Length=455, Percent_Identity=45.9340659340659, Blast_Score=367, Evalue=1e-103,
Organism=Escherichia coli, GI1790113, Length=473, Percent_Identity=24.9471458773784, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787251, Length=476, Percent_Identity=24.3697478991597, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 51975; Mature: 51843

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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>Mature Secondary Structure 
TSLLPVLIYLGLSLVITRVWSARQAKQSQQFSDDKAKRFFIGGAFLSGPLLALTLVATY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHEEEECHHHHHHHHHHHHHHHHH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PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]