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The map label for this gene is lpxK

Identifier: 167624427

GI number: 167624427

Start: 3021232

End: 3022224

Strand: Reverse

Name: lpxK

Synonym: Shal_2505

Alternate gene names: 167624427

Gene position: 3022224-3021232 (Counterclockwise)

Preceding gene: 167624428

Following gene: 167624426

Centisome position: 57.82

GC content: 47.83

Gene sequence:

>993_bases
ATGCAATCTTGGGTTAATAAATTATGGTATCAAGGCCATCCGCTTAGGTTTGCGTTATGGCCTCTGTCTCTACTATTTGG
CTTTGTCACTTGGCTAAGACGTGTACTTTTTAGTTTAGGGCTCAAAAAAGCGGCTAAATTGCCAGTTCCCGTGATTATTG
TGGGAAACATTACCGTTGGCGGCAGCGGTAAAACACCAACGGTTATCTACCTGATTGAGTTATTAAGAAAGCACGGTTTA
AAGCCAGGAGTCATTAGTCGTGGCTATGGTGTCGAGATTGATGGCGTCAGAGCCGTTTTGTCTGGAGATCGCGCCGATAG
CGTTGGCGATGAGCCTGCGATGATCGTGGCACGAACTCAAGTGCCTATGCTCGTGGGGGCGAAACGTATCGATGCTGCTA
ATCTGCTGCTATCTGAGTTTGATGTCGATATTATTATTAGTGATGATGGACTGCAGCATTACCAACTCGCCCGAGATATC
GAGCTGGTCATACTCGATGGTGAGCGCCGTTTAGGTAATGGTATGTTGTTGCCTGCGGGGCCACTGCGCGAAGGACCTTG
GCGTTTACAAAACGTTGACCATGTCATCGTTAATGGTGGTAAGGCGTTGCAAGGAGAAGTGCAGATGACATTGCAGCCAT
CAGCATGGCTACCCGTGTCGACTAAACATAATGCTGGAGAGCCTCCAAGTAAAGATTCGCCGCTGGTGGCGATGGCGGGG
ATTGGCAATCCACAGCGTTTCTTCGATACATTAGCGCAGCAGGGGTATCAAGTGGAGCATACTCAAACATTTGACGATCA
TAGTGCATACAGTGAGTCAGTGCTCAATGAACTGGCAAGCGGTCGCATGTTGGTCATGACTGAAAAAGATGCGGTGAAAT
GTCGCGATTTCGCAAAAGATAACTGGTGGTATCTCGCAGTAGATGCGAAGCTATCCGCCTCGTTTGATCAACAACTACTC
GCTAAAATCGATCGGTTAGTAGCAGATAAGTAA

Upstream 100 bases:

>100_bases
GGTTGATCAGGGACAGATTGTAGAGCGTGGCACTCATGTATCCTTGCTTGCTAAGGGTGGCGTTTACGCCAACCTGTATC
AGATGCAGTTTGGTAGCTAG

Downstream 100 bases:

>100_bases
AGGTATTCTAAATGGCATTTGATAAAAAATTACTCGAAATTGTTGCGTGTCCAGTGTGCAAAGGCAAGCTTGAATACAAT
AAAGAAGCGCAACAGTTGAT

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MQSWVNKLWYQGHPLRFALWPLSLLFGFVTWLRRVLFSLGLKKAAKLPVPVIIVGNITVGGSGKTPTVIYLIELLRKHGL
KPGVISRGYGVEIDGVRAVLSGDRADSVGDEPAMIVARTQVPMLVGAKRIDAANLLLSEFDVDIIISDDGLQHYQLARDI
ELVILDGERRLGNGMLLPAGPLREGPWRLQNVDHVIVNGGKALQGEVQMTLQPSAWLPVSTKHNAGEPPSKDSPLVAMAG
IGNPQRFFDTLAQQGYQVEHTQTFDDHSAYSESVLNELASGRMLVMTEKDAVKCRDFAKDNWWYLAVDAKLSASFDQQLL
AKIDRLVADK

Sequences:

>Translated_330_residues
MQSWVNKLWYQGHPLRFALWPLSLLFGFVTWLRRVLFSLGLKKAAKLPVPVIIVGNITVGGSGKTPTVIYLIELLRKHGL
KPGVISRGYGVEIDGVRAVLSGDRADSVGDEPAMIVARTQVPMLVGAKRIDAANLLLSEFDVDIIISDDGLQHYQLARDI
ELVILDGERRLGNGMLLPAGPLREGPWRLQNVDHVIVNGGKALQGEVQMTLQPSAWLPVSTKHNAGEPPSKDSPLVAMAG
IGNPQRFFDTLAQQGYQVEHTQTFDDHSAYSESVLNELASGRMLVMTEKDAVKCRDFAKDNWWYLAVDAKLSASFDQQLL
AKIDRLVADK
>Mature_330_residues
MQSWVNKLWYQGHPLRFALWPLSLLFGFVTWLRRVLFSLGLKKAAKLPVPVIIVGNITVGGSGKTPTVIYLIELLRKHGL
KPGVISRGYGVEIDGVRAVLSGDRADSVGDEPAMIVARTQVPMLVGAKRIDAANLLLSEFDVDIIISDDGLQHYQLARDI
ELVILDGERRLGNGMLLPAGPLREGPWRLQNVDHVIVNGGKALQGEVQMTLQPSAWLPVSTKHNAGEPPSKDSPLVAMAG
IGNPQRFFDTLAQQGYQVEHTQTFDDHSAYSESVLNELASGRMLVMTEKDAVKCRDFAKDNWWYLAVDAKLSASFDQQLL
AKIDRLVADK

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=327, Percent_Identity=46.7889908256881, Blast_Score=283, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_SHEHH (B0TK43)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001674721.1
- GeneID:   5904456
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_2505
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- ProtClustDB:   PRK00652
- BioCyc:   SHAL458817:SHAL_2505-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 36384; Mature: 36384

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSWVNKLWYQGHPLRFALWPLSLLFGFVTWLRRVLFSLGLKKAAKLPVPVIIVGNITVG
CCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCEEEEEEEEEC
GSGKTPTVIYLIELLRKHGLKPGVISRGYGVEIDGVRAVLSGDRADSVGDEPAMIVARTQ
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEECCCHHEECCCCCCCCCCCCEEEEEECC
VPMLVGAKRIDAANLLLSEFDVDIIISDDGLQHYQLARDIELVILDGERRLGNGMLLPAG
CCHHHCCCCCCHHHHHHHHCCEEEEECCCCCHHHHHHCCEEEEEECCCCCCCCCEEECCC
PLREGPWRLQNVDHVIVNGGKALQGEVQMTLQPSAWLPVSTKHNAGEPPSKDSPLVAMAG
CCCCCCCCCCCCCEEEEECCCEEECEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEC
IGNPQRFFDTLAQQGYQVEHTQTFDDHSAYSESVLNELASGRMLVMTEKDAVKCRDFAKD
CCCHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCC
NWWYLAVDAKLSASFDQQLLAKIDRLVADK
CCEEEEEECCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQSWVNKLWYQGHPLRFALWPLSLLFGFVTWLRRVLFSLGLKKAAKLPVPVIIVGNITVG
CCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCEEEEEEEEEC
GSGKTPTVIYLIELLRKHGLKPGVISRGYGVEIDGVRAVLSGDRADSVGDEPAMIVARTQ
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEECCCHHEECCCCCCCCCCCCEEEEEECC
VPMLVGAKRIDAANLLLSEFDVDIIISDDGLQHYQLARDIELVILDGERRLGNGMLLPAG
CCHHHCCCCCCHHHHHHHHCCEEEEECCCCCHHHHHHCCEEEEEECCCCCCCCCEEECCC
PLREGPWRLQNVDHVIVNGGKALQGEVQMTLQPSAWLPVSTKHNAGEPPSKDSPLVAMAG
CCCCCCCCCCCCCEEEEECCCEEECEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEC
IGNPQRFFDTLAQQGYQVEHTQTFDDHSAYSESVLNELASGRMLVMTEKDAVKCRDFAKD
CCCHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHCCCC
NWWYLAVDAKLSASFDQQLLAKIDRLVADK
CCEEEEEECCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA