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The map label for this gene is sdhA [H]

Identifier: 167624413

GI number: 167624413

Start: 2995509

End: 2997275

Strand: Reverse

Name: sdhA [H]

Synonym: Shal_2491

Alternate gene names: 167624413

Gene position: 2997275-2995509 (Counterclockwise)

Preceding gene: 167624414

Following gene: 167624412

Centisome position: 57.34

GC content: 48.78

Gene sequence:

>1767_bases
GTGAGTATTCCTGTTCGCGAATTTGACGCGGTTGTAATCGGTGCTGGTGGCGCTGGTATGCGTGCCGCTCTACAGATCTC
TAAAGAAGGTAAGAGCTGTGCGCTGTTATCTAAAGTATTCCCAACCCGTTCTCATACCGTATCTGCCCAGGGGGGTATTA
CTGTAGCCCTTGGTAATGCCCACGAAGATCATTGGGAACAGCATATGTACGACACCGTGAAAGGCTCCGATTTTATCGGT
GACCAAGAAGCGATTGAGTTTATGTGTAAGACGGGCCCCGAGGCGGTGATTGAACTTGAGCATATGGGATTACCCTTCTC
TCGTTTTGAAAACGGTACTATTTATCAGCGCCCATTTGGTGGCCAATCTAGAAATTTTGGTGGCGAGCAGGCTGCTCGTA
CTGCAGCAGCGGCTGACCGTACCGGTCACGCACTGCTTCACTGCCTGTACCAGCAAAACGTTAAGCATAAAACGGAAGTC
TTTTCTGAGTGGTATGCACTCGATTTAGTTAAAAATGAAGACGGCGTGATTGTGGGTTGTACCGCTATCGAAATTGAAAC
CGGCGAAATTGTCTATTTCAAAGCCAAAGCAACGATTTTAGCGACCGGTGGAGCAGGGCGTATTTACGCATCAACCACTA
ACGCTCATATCAACACTGGTGACGGTGTCGGCATGGCGATGCGCGCTGGCGTTCAGATGCAAGACATGGAAATGTGGCAG
TTCCACCCAACGGGTATTGCTGGCGCAGGTGTTTTGGTGACTGAAGGTTGTCGTGGTGAAGGTGGATATCTGCTAAACAA
AGACGGCGAGCGCTTTATGGAGCGTTATGCGCCAAACGCGAAAGATTTGGCATCACGAGACGTGGTAGCACGCTCTATGA
TGACTGAAATTCGCGAAGGTCGAGGTCTCGATGGCCCATTAGGCCCGCATTGCTTACTTAAGCTTGATCACTTAGGTAAA
GAAACCCTTGAAGCTCGTCTTCCTGGTGTTTGTGAACTGTCTCGCACCTTCGCACATATCGATCCAGCCGATGGCCCAAT
CCCCGTTTTGCCGACTTGCCACTATATGATGGGTGGTCTACCTGCTAAAGTCAGTGGCCAGGTCGTACGCCAAAATTCAG
ATGGCAGTGAAGAAGAAGTAACCGGTCTATTTGCGGTTGGCGAAATTGCGTGCGTATCGGTACACGGAGCGAACAGATTG
GGTGGTAACTCATTGTTAGATCTTGTAGTATTTGGTCGAGCAGCGGGTCAACATTTAGGTAAAGCGCTGGACGAAACTCC
AATTGCTAAAGATGCAACTGAGGCCGATATTGATGCTTCTCTAGCACGCTTGAACCGCTGGGAAAGCAACAAGAATGGCG
AAGATCCTGCGGTGATCCGTAAAGACCTACAGCTTTGTATGCAACTTAACTTCTCGGTATTTAGAAGTGGTGATGCGATG
GCTGAAGGCCTTAAAGAGCTTAAGGCGATTAGAGAGCGTTTGGCGAATGCCAAGCTTTCTGATAACTCAACAGAATTTAA
TACTCAGCGTATCGAATGCTTAGAATTAGATAACTTGATGGCAACGGCAATTGCTACGGCGACAGCGGCGAACTTCCGTA
CTGAAAGTCGTGGTGCTCACTCTCGTGAAGACTATCTGGACCGAGATGATGAAAACTGGCTATGTCACAGTATTTATGAC
CCAGTCACCGAGCTTATGACTAAGCGCGATGTGAACATGCAGCCAAAGCTTCGTGATGCATTCCCGCCAATCAAGCGTAC
TTACTAA

Upstream 100 bases:

>100_bases
CGTTAAGTGTATTTCTCTACGTGGTGTACTTCAGTTTGTTTTTGTCATTGCAGCCTTCTGTTATTTGGTCGCTGGCATTT
TGATTGTGTGGGGTGTTTAA

Downstream 100 bases:

>100_bases
GGAGAAGTCGAGATGAAATTGGAATTTGCAGTTTATCGCTACAATCCTGATGTAGATACTAAGCCGTATATGAAGGATTA
CAGCTTAGAAGTGGAAGAAG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 588; Mature: 587

Protein sequence:

>588_residues
MSIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNAHEDHWEQHMYDTVKGSDFIG
DQEAIEFMCKTGPEAVIELEHMGLPFSRFENGTIYQRPFGGQSRNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTEV
FSEWYALDLVKNEDGVIVGCTAIEIETGEIVYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQ
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREGRGLDGPLGPHCLLKLDHLGK
ETLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGLPAKVSGQVVRQNSDGSEEEVTGLFAVGEIACVSVHGANRL
GGNSLLDLVVFGRAAGQHLGKALDETPIAKDATEADIDASLARLNRWESNKNGEDPAVIRKDLQLCMQLNFSVFRSGDAM
AEGLKELKAIRERLANAKLSDNSTEFNTQRIECLELDNLMATAIATATAANFRTESRGAHSREDYLDRDDENWLCHSIYD
PVTELMTKRDVNMQPKLRDAFPPIKRTY

Sequences:

>Translated_588_residues
MSIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNAHEDHWEQHMYDTVKGSDFIG
DQEAIEFMCKTGPEAVIELEHMGLPFSRFENGTIYQRPFGGQSRNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTEV
FSEWYALDLVKNEDGVIVGCTAIEIETGEIVYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQ
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREGRGLDGPLGPHCLLKLDHLGK
ETLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGLPAKVSGQVVRQNSDGSEEEVTGLFAVGEIACVSVHGANRL
GGNSLLDLVVFGRAAGQHLGKALDETPIAKDATEADIDASLARLNRWESNKNGEDPAVIRKDLQLCMQLNFSVFRSGDAM
AEGLKELKAIRERLANAKLSDNSTEFNTQRIECLELDNLMATAIATATAANFRTESRGAHSREDYLDRDDENWLCHSIYD
PVTELMTKRDVNMQPKLRDAFPPIKRTY
>Mature_587_residues
SIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNAHEDHWEQHMYDTVKGSDFIGD
QEAIEFMCKTGPEAVIELEHMGLPFSRFENGTIYQRPFGGQSRNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTEVF
SEWYALDLVKNEDGVIVGCTAIEIETGEIVYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQF
HPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREGRGLDGPLGPHCLLKLDHLGKE
TLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGLPAKVSGQVVRQNSDGSEEEVTGLFAVGEIACVSVHGANRLG
GNSLLDLVVFGRAAGQHLGKALDETPIAKDATEADIDASLARLNRWESNKNGEDPAVIRKDLQLCMQLNFSVFRSGDAMA
EGLKELKAIRERLANAKLSDNSTEFNTQRIECLELDNLMATAIATATAANFRTESRGAHSREDYLDRDDENWLCHSIYDP
VTELMTKRDVNMQPKLRDAFPPIKRTY

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=550, Percent_Identity=53.4545454545455, Blast_Score=521, Evalue=1e-148,
Organism=Escherichia coli, GI1786942, Length=588, Percent_Identity=79.421768707483, Blast_Score=927, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=577, Percent_Identity=38.9948006932409, Blast_Score=381, Evalue=1e-107,
Organism=Escherichia coli, GI1788928, Length=567, Percent_Identity=30.1587301587302, Blast_Score=211, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI17550100, Length=600, Percent_Identity=48.5, Blast_Score=529, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17505833, Length=595, Percent_Identity=47.3949579831933, Blast_Score=525, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI71986328, Length=78, Percent_Identity=44.8717948717949, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322701, Length=596, Percent_Identity=50.6711409395973, Blast_Score=562, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6322416, Length=554, Percent_Identity=52.8880866425993, Blast_Score=557, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6320788, Length=489, Percent_Identity=27.19836400818, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322511, Length=487, Percent_Identity=23.6139630390144, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17137288, Length=545, Percent_Identity=52.8440366972477, Blast_Score=537, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24655642, Length=545, Percent_Identity=52.8440366972477, Blast_Score=537, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24655647, Length=545, Percent_Identity=52.8440366972477, Blast_Score=537, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24663005, Length=617, Percent_Identity=45.8670988654781, Blast_Score=503, Evalue=1e-142,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 63961; Mature: 63830

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNA
CCCCCCCCCEEEEECCCCCCEEEEEECCCCCCHHHHHHHCCCCCCEEECCCCEEEEECCC
HEDHWEQHMYDTVKGSDFIGDQEAIEFMCKTGPEAVIELEHMGLPFSRFENGTIYQRPFG
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHEEEEHHCCCCHHHCCCCEEEECCCC
GQSRNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTEVFSEWYALDLVKNEDGVIVGC
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHEEEEEECCCCEEEEE
TAIEIETGEIVYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQ
EEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCHHHHCCCCEECCHHEE
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
RGLDGPLGPHCLLKLDHLGKETLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGL
CCCCCCCCCHHEEEEHHCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCC
PAKVSGQVVRQNSDGSEEEVTGLFAVGEIACVSVHGANRLGGNSLLDLVVFGRAAGQHLG
CCCCCCEEEECCCCCCHHHHHEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KALDETPIAKDATEADIDASLARLNRWESNKNGEDPAVIRKDLQLCMQLNFSVFRSGDAM
HHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHCCCHHH
AEGLKELKAIRERLANAKLSDNSTEFNTQRIECLELDNLMATAIATATAANFRTESRGAH
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCC
SREDYLDRDDENWLCHSIYDPVTELMTKRDVNMQPKLRDAFPPIKRTY
CHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHCCC
>Mature Secondary Structure 
SIPVREFDAVVIGAGGAGMRAALQISKEGKSCALLSKVFPTRSHTVSAQGGITVALGNA
CCCCCCCCEEEEECCCCCCEEEEEECCCCCCHHHHHHHCCCCCCEEECCCCEEEEECCC
HEDHWEQHMYDTVKGSDFIGDQEAIEFMCKTGPEAVIELEHMGLPFSRFENGTIYQRPFG
CHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHEEEEHHCCCCHHHCCCCEEEECCCC
GQSRNFGGEQAARTAAAADRTGHALLHCLYQQNVKHKTEVFSEWYALDLVKNEDGVIVGC
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHEEEEEECCCCEEEEE
TAIEIETGEIVYFKAKATILATGGAGRIYASTTNAHINTGDGVGMAMRAGVQMQDMEMWQ
EEEEEECCCEEEEEEEEEEEEECCCCEEEEECCCCEEECCCCCCHHHHCCCCEECCHHEE
FHPTGIAGAGVLVTEGCRGEGGYLLNKDGERFMERYAPNAKDLASRDVVARSMMTEIREG
ECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
RGLDGPLGPHCLLKLDHLGKETLEARLPGVCELSRTFAHIDPADGPIPVLPTCHYMMGGL
CCCCCCCCCHHEEEEHHCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCC
PAKVSGQVVRQNSDGSEEEVTGLFAVGEIACVSVHGANRLGGNSLLDLVVFGRAAGQHLG
CCCCCCEEEECCCCCCHHHHHEEEEECCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KALDETPIAKDATEADIDASLARLNRWESNKNGEDPAVIRKDLQLCMQLNFSVFRSGDAM
HHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHCCCHHH
AEGLKELKAIRERLANAKLSDNSTEFNTQRIECLELDNLMATAIATATAANFRTESRGAH
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCC
SREDYLDRDDENWLCHSIYDPVTELMTKRDVNMQPKLRDAFPPIKRTY
CHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]