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The map label for this gene is uvrC

Identifier: 167624269

GI number: 167624269

Start: 2832833

End: 2834662

Strand: Reverse

Name: uvrC

Synonym: Shal_2345

Alternate gene names: 167624269

Gene position: 2834662-2832833 (Counterclockwise)

Preceding gene: 167624270

Following gene: 167624268

Centisome position: 54.23

GC content: 43.61

Gene sequence:

>1830_bases
ATGTCTGACGTGTTTAATGCCAATCAGTTTTTAAAGACAGTGACATCGTCACCCGGTGTTTATCGGATGTATGATGCAAA
GGCTGTAGTGATTTATGTGGGGAAGGCTAAAGATCTAAAAAAGCGGCTTTCCTCCTATTTCCGCAAAAATCTTACCAACG
TTAAAACTCAAGCCTTGGTGTCACATATTGCTAATATTGATGTGACTGTGACACACAGCGAAACCGATGCGTTAATTTTA
GAAAATGATTATATCAAGCAGTACATGCCTAAATACAATGTATTGCTACGTGATGACAAGTCTTATCCCTACATTTTACT
CAGTAACCATAAGCATCCTCGCTTAGCCTATCACCGTGGTCCGAAACGCGATAAAGGCTTGTACTTTGGACCTTATCCCA
ACGGTGGAGCGGTGCGAGAAAGTCTACATTTGCTGCAGAAAATCTTCCCGATAAGACAGTGTGACGATCTATACTATAAA
TCTCGTTCACGTCCCTGTTTGCAATATCAAATAGGTCGTTGTAGCGCACCTTGTGTAGGTAAGGTGTCTTTAGAGGATTA
TCAAGAGCAGGTTAGGCTCGCGACCTTGTTTTTAAAAGGTAAAGATCATCAAGTCATGTCAGTCTTGGTTGGCAAAATGG
AACAAGCCGCCAGTGATATGCGCTATGAACAGGCAGCACTCTATCGAGATCAAATAACCGCATTAAGACGAGTATCAGAG
CAGCAGGAGGTATCTAATGCATCGGGCGATATGGATGTGATAGGTGCTTACTATGCATCTGGCGTTGCTTGTTTTCACCT
GCTATTTATCCGAGAGGGTAAGATTTTTGGTAGCCGCAGTTATTACCCTAAGGTTCCGGTTAATACCGAAGTGTCAGAAG
TTTTACGCTCGTTTATGCTGCAGTTTTATCTTAATTCGGATAGCCAGCGATTAACGCCGAAAGAGATTTTAATCAGTGAG
CCATTCGAGGAGCAGGATGAACTCGCTAAAGCTATTCAGGCGGCACAGAATAAGAAAGTAGAGATAAAGACTCAGGTTCG
TGGCGAAAGAGCGAGTTTTTTACGCCTAGCACTCACTAATGCTACCAATGCGGTCAATACTCGTTTGTCTCACAAGAACA
CCATAGAGCAACGTTTCTTACTCTTAGAAGAGGCTATCGAGTCGACCAACAAAATCCAGCGCATGGAATGTTTCGATATT
AGCCACACTATGGGCGAGAGCACAGTTGCATCTTGTGTAGTGTTTAATCGAGAGGGGCCAAGTAAGGCTGACTATCGGCG
CTATAATATTACAGGGATCACTCCAGGCGATGATTATGCAGCAATGAAGCAAGCTATCACTCGTCGCTTTGATAAAATCA
GTAGTAGCGGGAAAATTCCCGATATCCTGTTTATTGACGGGGGTATTGGCCAGTTGCGTATTGCTCAAAAAGTGGTAGAT
GAGAAATTTGTTGCGCTAGATAATGCTCCGACATTAATTGGTGTTGCGAAAGGAGAGGGGCGAAAACCTGGCTTAGAAAC
GTTAATCTACGGTGAGAATGAAGAATCATTCACCTTACCTGCAGATTCGGGCGCACTGCATCTAATCCAACATATTCGTG
ATGAGTCTCATCGTTTTGCGATTACCGGCCATAGAAATAAACGCCAGAAAACCCGCAACACCTCAACCTTAGAGTCAATT
GCTGGAGTTGGGCCTAAGCGACGTAAAGCATTACTGCAATACTTAGGTGGTTTGCAAGAAGTGAAGGGCGCAAGTGTATC
TGAATTGGTAAAAGTACCCGGTATTAGCCTAGAAATGGCACAAACGATACATGATGCATTGCGAGGGTAG

Upstream 100 bases:

>100_bases
TTGCAAAGTTAGGCATAGGCGGAGACGTTGAGCTGACTCGCTTAGCAATTCGATACAAAATGCTGGATACTGGACAATTC
TAAACAATTAGCCAAAATTT

Downstream 100 bases:

>100_bases
CAAAATTAAGGCAAGATTGGCGCTGCTTTTGAATATTAGGTTCTAAAATGCCGTTTAACATTCCTATTGCGTTAACACTT
TTCAGGTTAGCTCTGTTACC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 609; Mature: 608

Protein sequence:

>609_residues
MSDVFNANQFLKTVTSSPGVYRMYDAKAVVIYVGKAKDLKKRLSSYFRKNLTNVKTQALVSHIANIDVTVTHSETDALIL
ENDYIKQYMPKYNVLLRDDKSYPYILLSNHKHPRLAYHRGPKRDKGLYFGPYPNGGAVRESLHLLQKIFPIRQCDDLYYK
SRSRPCLQYQIGRCSAPCVGKVSLEDYQEQVRLATLFLKGKDHQVMSVLVGKMEQAASDMRYEQAALYRDQITALRRVSE
QQEVSNASGDMDVIGAYYASGVACFHLLFIREGKIFGSRSYYPKVPVNTEVSEVLRSFMLQFYLNSDSQRLTPKEILISE
PFEEQDELAKAIQAAQNKKVEIKTQVRGERASFLRLALTNATNAVNTRLSHKNTIEQRFLLLEEAIESTNKIQRMECFDI
SHTMGESTVASCVVFNREGPSKADYRRYNITGITPGDDYAAMKQAITRRFDKISSSGKIPDILFIDGGIGQLRIAQKVVD
EKFVALDNAPTLIGVAKGEGRKPGLETLIYGENEESFTLPADSGALHLIQHIRDESHRFAITGHRNKRQKTRNTSTLESI
AGVGPKRRKALLQYLGGLQEVKGASVSELVKVPGISLEMAQTIHDALRG

Sequences:

>Translated_609_residues
MSDVFNANQFLKTVTSSPGVYRMYDAKAVVIYVGKAKDLKKRLSSYFRKNLTNVKTQALVSHIANIDVTVTHSETDALIL
ENDYIKQYMPKYNVLLRDDKSYPYILLSNHKHPRLAYHRGPKRDKGLYFGPYPNGGAVRESLHLLQKIFPIRQCDDLYYK
SRSRPCLQYQIGRCSAPCVGKVSLEDYQEQVRLATLFLKGKDHQVMSVLVGKMEQAASDMRYEQAALYRDQITALRRVSE
QQEVSNASGDMDVIGAYYASGVACFHLLFIREGKIFGSRSYYPKVPVNTEVSEVLRSFMLQFYLNSDSQRLTPKEILISE
PFEEQDELAKAIQAAQNKKVEIKTQVRGERASFLRLALTNATNAVNTRLSHKNTIEQRFLLLEEAIESTNKIQRMECFDI
SHTMGESTVASCVVFNREGPSKADYRRYNITGITPGDDYAAMKQAITRRFDKISSSGKIPDILFIDGGIGQLRIAQKVVD
EKFVALDNAPTLIGVAKGEGRKPGLETLIYGENEESFTLPADSGALHLIQHIRDESHRFAITGHRNKRQKTRNTSTLESI
AGVGPKRRKALLQYLGGLQEVKGASVSELVKVPGISLEMAQTIHDALRG
>Mature_608_residues
SDVFNANQFLKTVTSSPGVYRMYDAKAVVIYVGKAKDLKKRLSSYFRKNLTNVKTQALVSHIANIDVTVTHSETDALILE
NDYIKQYMPKYNVLLRDDKSYPYILLSNHKHPRLAYHRGPKRDKGLYFGPYPNGGAVRESLHLLQKIFPIRQCDDLYYKS
RSRPCLQYQIGRCSAPCVGKVSLEDYQEQVRLATLFLKGKDHQVMSVLVGKMEQAASDMRYEQAALYRDQITALRRVSEQ
QEVSNASGDMDVIGAYYASGVACFHLLFIREGKIFGSRSYYPKVPVNTEVSEVLRSFMLQFYLNSDSQRLTPKEILISEP
FEEQDELAKAIQAAQNKKVEIKTQVRGERASFLRLALTNATNAVNTRLSHKNTIEQRFLLLEEAIESTNKIQRMECFDIS
HTMGESTVASCVVFNREGPSKADYRRYNITGITPGDDYAAMKQAITRRFDKISSSGKIPDILFIDGGIGQLRIAQKVVDE
KFVALDNAPTLIGVAKGEGRKPGLETLIYGENEESFTLPADSGALHLIQHIRDESHRFAITGHRNKRQKTRNTSTLESIA
GVGPKRRKALLQYLGGLQEVKGASVSELVKVPGISLEMAQTIHDALRG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=610, Percent_Identity=59.5081967213115, Blast_Score=748, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_SHEHH (B0TIW9)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001674563.1
- ProteinModelPortal:   B0TIW9
- GeneID:   5904241
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_2345
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   SHAL458817:SHAL_2345-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 68556; Mature: 68425

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVFNANQFLKTVTSSPGVYRMYDAKAVVIYVGKAKDLKKRLSSYFRKNLTNVKTQALV
CCCCCCHHHHHHHHHCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
SHIANIDVTVTHSETDALILENDYIKQYMPKYNVLLRDDKSYPYILLSNHKHPRLAYHRG
HHHCCCEEEEEECCCCEEEEECHHHHHHCCCCCEEEECCCCCCEEEECCCCCCCCCCCCC
PKRDKGLYFGPYPNGGAVRESLHLLQKIFPIRQCDDLYYKSRSRPCLQYQIGRCSAPCVG
CCCCCCEEECCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEEECCCCCCCCCC
KVSLEDYQEQVRLATLFLKGKDHQVMSVLVGKMEQAASDMRYEQAALYRDQITALRRVSE
CCCHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQEVSNASGDMDVIGAYYASGVACFHLLFIREGKIFGSRSYYPKVPVNTEVSEVLRSFML
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCHHHHHHHHHHH
QFYLNSDSQRLTPKEILISEPFEEQDELAKAIQAAQNKKVEIKTQVRGERASFLRLALTN
HHHCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHEEEHHC
ATNAVNTRLSHKNTIEQRFLLLEEAIESTNKIQRMECFDISHTMGESTVASCVVFNREGP
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHEEEEEECCCCC
SKADYRRYNITGITPGDDYAAMKQAITRRFDKISSSGKIPDILFIDGGIGQLRIAQKVVD
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHH
EKFVALDNAPTLIGVAKGEGRKPGLETLIYGENEESFTLPADSGALHLIQHIRDESHRFA
HHHEEECCCCCEEEEECCCCCCCCCCEEEECCCCCCEECCCCCCHHHHHHHHHCCCCEEE
ITGHRNKRQKTRNTSTLESIAGVGPKRRKALLQYLGGLQEVKGASVSELVKVPGISLEMA
EECCCCHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCHHHHHHCCCCCHHHH
QTIHDALRG
HHHHHHHCC
>Mature Secondary Structure 
SDVFNANQFLKTVTSSPGVYRMYDAKAVVIYVGKAKDLKKRLSSYFRKNLTNVKTQALV
CCCCCHHHHHHHHHCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
SHIANIDVTVTHSETDALILENDYIKQYMPKYNVLLRDDKSYPYILLSNHKHPRLAYHRG
HHHCCCEEEEEECCCCEEEEECHHHHHHCCCCCEEEECCCCCCEEEECCCCCCCCCCCCC
PKRDKGLYFGPYPNGGAVRESLHLLQKIFPIRQCDDLYYKSRSRPCLQYQIGRCSAPCVG
CCCCCCEEECCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEEECCCCCCCCCC
KVSLEDYQEQVRLATLFLKGKDHQVMSVLVGKMEQAASDMRYEQAALYRDQITALRRVSE
CCCHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQEVSNASGDMDVIGAYYASGVACFHLLFIREGKIFGSRSYYPKVPVNTEVSEVLRSFML
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCHHHHHHHHHHH
QFYLNSDSQRLTPKEILISEPFEEQDELAKAIQAAQNKKVEIKTQVRGERASFLRLALTN
HHHCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHEEEHHC
ATNAVNTRLSHKNTIEQRFLLLEEAIESTNKIQRMECFDISHTMGESTVASCVVFNREGP
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCHHHEEEEEECCCCC
SKADYRRYNITGITPGDDYAAMKQAITRRFDKISSSGKIPDILFIDGGIGQLRIAQKVVD
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHH
EKFVALDNAPTLIGVAKGEGRKPGLETLIYGENEESFTLPADSGALHLIQHIRDESHRFA
HHHEEECCCCCEEEEECCCCCCCCCCEEEECCCCCCEECCCCCCHHHHHHHHHCCCCEEE
ITGHRNKRQKTRNTSTLESIAGVGPKRRKALLQYLGGLQEVKGASVSELVKVPGISLEMA
EECCCCHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCHHHHHHCCCCCHHHH
QTIHDALRG
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA