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The map label for this gene is gcvR [H]

Identifier: 167624246

GI number: 167624246

Start: 2808547

End: 2809083

Strand: Direct

Name: gcvR [H]

Synonym: Shal_2322

Alternate gene names: 167624246

Gene position: 2808547-2809083 (Clockwise)

Preceding gene: 167624241

Following gene: 167624247

Centisome position: 53.73

GC content: 42.27

Gene sequence:

>537_bases
ATGTCCAATCACTTGGTCGTTACTGCAATGGGAGCCGATCGCTCAGGTATTGTGAGTAAGTTTGCACGACTCGCTAGTGA
GTGTGACTGCGATATCGTTGATAGTCGCATGGCACTGTTTGGTAATGAATTTACCTTAATTATGATGCTTTCAGGTTCGT
GGGCGTCGATTACTAAGATGGAAACCACATTACCGAGCTTAAGTGTTGAACTTGAGTTATTAACGGTAATGAAGCGTACT
TCAAAACATACTCCACAAAACTATATCTCCCGTTTAGAAGTTAACTTCAGCGGTCATGACCAACGTGGAACAATGAGAAA
AATAACACAATTTTTAGCGGACAGGTCGCTCGATCTGGCTGCAGTTAAATCTCATGCGGAAGAAGATGCGACTGGCGAGC
CAACACAAAACATTAGTCTAACCATTAATGTGCCAGAAAAAGTCGACTTAGATAAACTCGAAGTCAGCTTAAATGATCTA
GCAGCCGAGCTAACTCTAGAATGTACCATTGAGCGTATGCAAGGCGTTGAAAGTTAA

Upstream 100 bases:

>100_bases
CGCAAACTGATTAACTTGTGATAGCATGACTGACCACAAGGAAAATACGTCATCACATCGTCTATTTTTCAGCCTAAACA
ATAAGAATATGGGGTATGAA

Downstream 100 bases:

>100_bases
ATTTTCAGAATGGATAAAAATATGAAAACCTTAACCGTTGGCGATATTGCGCCGCTTTTTACCCTACAAAACCAAAAAGA
CGAAACCGTTAGCTTAACTG

Product: amino acid-binding ACT domain-containing protein

Products: NA

Alternate protein names: Gcv operon repressor [H]

Number of amino acids: Translated: 178; Mature: 177

Protein sequence:

>178_residues
MSNHLVVTAMGADRSGIVSKFARLASECDCDIVDSRMALFGNEFTLIMMLSGSWASITKMETTLPSLSVELELLTVMKRT
SKHTPQNYISRLEVNFSGHDQRGTMRKITQFLADRSLDLAAVKSHAEEDATGEPTQNISLTINVPEKVDLDKLEVSLNDL
AAELTLECTIERMQGVES

Sequences:

>Translated_178_residues
MSNHLVVTAMGADRSGIVSKFARLASECDCDIVDSRMALFGNEFTLIMMLSGSWASITKMETTLPSLSVELELLTVMKRT
SKHTPQNYISRLEVNFSGHDQRGTMRKITQFLADRSLDLAAVKSHAEEDATGEPTQNISLTINVPEKVDLDKLEVSLNDL
AAELTLECTIERMQGVES
>Mature_177_residues
SNHLVVTAMGADRSGIVSKFARLASECDCDIVDSRMALFGNEFTLIMMLSGSWASITKMETTLPSLSVELELLTVMKRTS
KHTPQNYISRLEVNFSGHDQRGTMRKITQFLADRSLDLAAVKSHAEEDATGEPTQNISLTINVPEKVDLDKLEVSLNDLA
AELTLECTIERMQGVES

Specific function: Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how gcvR acts as a repressor. It does not seem to bind DNA. It could interact with gcvA and suppress its activato

COG id: COG2716

COG function: function code E; Glycine cleavage system regulatory protein

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082113, Length=169, Percent_Identity=36.094674556213, Blast_Score=109, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR016867 [H]

Pfam domain/function: PF01842 ACT [H]

EC number: NA

Molecular weight: Translated: 19653; Mature: 19521

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNHLVVTAMGADRSGIVSKFARLASECDCDIVDSRMALFGNEFTLIMMLSGSWASITKM
CCCCEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHH
ETTLPSLSVELELLTVMKRTSKHTPQNYISRLEVNFSGHDQRGTMRKITQFLADRSLDLA
HHHCCCHHHHHHHHHHHHHHCCCCCHHHHHEEEEEECCCCCCCHHHHHHHHHHCCCCCHH
AVKSHAEEDATGEPTQNISLTINVPEKVDLDKLEVSLNDLAAELTLECTIERMQGVES
HHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHEEHHHHHCCCCC
>Mature Secondary Structure 
SNHLVVTAMGADRSGIVSKFARLASECDCDIVDSRMALFGNEFTLIMMLSGSWASITKM
CCCEEEEEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHH
ETTLPSLSVELELLTVMKRTSKHTPQNYISRLEVNFSGHDQRGTMRKITQFLADRSLDLA
HHHCCCHHHHHHHHHHHHHHCCCCCHHHHHEEEEEECCCCCCCHHHHHHHHHHCCCCCHH
AVKSHAEEDATGEPTQNISLTINVPEKVDLDKLEVSLNDLAAELTLECTIERMQGVES
HHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHEEHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537378; 9205837; 9278503; 2016588 [H]