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The map label for this gene is ttcA

Identifier: 167624131

GI number: 167624131

Start: 2670499

End: 2671434

Strand: Direct

Name: ttcA

Synonym: Shal_2207

Alternate gene names: 167624131

Gene position: 2670499-2671434 (Clockwise)

Preceding gene: 167624130

Following gene: 167624134

Centisome position: 51.09

GC content: 44.23

Gene sequence:

>936_bases
ATGTCCGAAGAATTAACTCCACAACAAGTCACTCGTATGGCAAAACTACAGAAGCGTTTACGCACTGAAGTTGGTCGTGC
CATCGGTGATTACAACATGATTGAAGAAGGTGACCGTGTCATGTGTTGCCTATCTGGTGGCAAAGACAGTTATGCCATGC
TCGATATCTTGTTGAACCTTCAGCAACGCGCTCCTATTAAATTCGAAATCGTTGCGGTTAACTTAGATCAAAAGCAGCCA
GGTTTCCCTGAAGACATTTTGCCTGCGTATCTCGATACCCTAGGTGTTGCTTACCACATTTTGGAAAAAGACACTTATTC
TATCGTTAAAGATAAAATTCCTGAAGGCAAAACAACTTGTTCTCTTTGTTCTCGCCTGCGCCGCGGAACTCTTTACGGTT
TCGCACAAAAAATAGGGGCTACCAAGATTGCCCTTGGTCATCACAGAGACGACATCATTGAAACCATGTTCCTGAACATG
TTTTTTGCCGGCAAGATGAAAGCCATGCCGCCAAAACTATTGTCTGATGATGGCGCCAATATGGTGATCCGTCCGTTAGC
TTACAGTCGTGAAAAAGATATTGCTGAATACGCTGGTCTGAAAGGCTTCCCAATTATTCCTTGTAACCTTTGTGGCTCAC
AAGAAAACTTAAAGCGCGCTGCAGTTAAAGAGATGTTGGTGCAGTGGGATCGTGATTACCCTGGCCGTATCGAAACTATT
TTTACGGCAATGCAAAATACCGCGCCATCTCAAGGTGTCGATAGAGAACAGTTTGATTTCTTAAGCTTGACTCGAGATCC
AGATGCGCCAATGCGAGGCGATGTTGCAGAGTCAGATCTACCCGCCTTTGACTTTGTTGATGTCGCCAACAATGGTCATA
TTAATTTAGATAAAGCGGTCCGTATTGACGTGGTAAATACCTATACGCCCGATTAA

Upstream 100 bases:

>100_bases
CACCATTAGAAGAGGTATAACCGCTTTCTAAGCTTTACCAAAAGCTTTTAAGCTGGAATAATACGCGCCCTGAACATTTG
TGTACTAGGCGCGTTTTTTT

Downstream 100 bases:

>100_bases
CCGTTATCAGCGTAAAAGTAGAATCAAAAGCCCTGCATTGCAGGGCTTTTGATTAAAGAAGAATTACTTAGATGTCCAAG
GGCTAATAACCTTAGGCGCA

Product: PP-loop domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MSEELTPQQVTRMAKLQKRLRTEVGRAIGDYNMIEEGDRVMCCLSGGKDSYAMLDILLNLQQRAPIKFEIVAVNLDQKQP
GFPEDILPAYLDTLGVAYHILEKDTYSIVKDKIPEGKTTCSLCSRLRRGTLYGFAQKIGATKIALGHHRDDIIETMFLNM
FFAGKMKAMPPKLLSDDGANMVIRPLAYSREKDIAEYAGLKGFPIIPCNLCGSQENLKRAAVKEMLVQWDRDYPGRIETI
FTAMQNTAPSQGVDREQFDFLSLTRDPDAPMRGDVAESDLPAFDFVDVANNGHINLDKAVRIDVVNTYTPD

Sequences:

>Translated_311_residues
MSEELTPQQVTRMAKLQKRLRTEVGRAIGDYNMIEEGDRVMCCLSGGKDSYAMLDILLNLQQRAPIKFEIVAVNLDQKQP
GFPEDILPAYLDTLGVAYHILEKDTYSIVKDKIPEGKTTCSLCSRLRRGTLYGFAQKIGATKIALGHHRDDIIETMFLNM
FFAGKMKAMPPKLLSDDGANMVIRPLAYSREKDIAEYAGLKGFPIIPCNLCGSQENLKRAAVKEMLVQWDRDYPGRIETI
FTAMQNTAPSQGVDREQFDFLSLTRDPDAPMRGDVAESDLPAFDFVDVANNGHINLDKAVRIDVVNTYTPD
>Mature_310_residues
SEELTPQQVTRMAKLQKRLRTEVGRAIGDYNMIEEGDRVMCCLSGGKDSYAMLDILLNLQQRAPIKFEIVAVNLDQKQPG
FPEDILPAYLDTLGVAYHILEKDTYSIVKDKIPEGKTTCSLCSRLRRGTLYGFAQKIGATKIALGHHRDDIIETMFLNMF
FAGKMKAMPPKLLSDDGANMVIRPLAYSREKDIAEYAGLKGFPIIPCNLCGSQENLKRAAVKEMLVQWDRDYPGRIETIF
TAMQNTAPSQGVDREQFDFLSLTRDPDAPMRGDVAESDLPAFDFVDVANNGHINLDKAVRIDVVNTYTPD

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32)

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family

Homologues:

Organism=Escherichia coli, GI1787606, Length=275, Percent_Identity=65.8181818181818, Blast_Score=390, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI193211090, Length=224, Percent_Identity=33.9285714285714, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17540090, Length=192, Percent_Identity=28.6458333333333, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24651972, Length=189, Percent_Identity=29.6296296296296, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TTCA_SHEHH (B0TUN8)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001674425.1
- ProteinModelPortal:   B0TUN8
- GeneID:   5906381
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_2207
- HOGENOM:   HBG347038
- OMA:   EHILPEY
- ProtClustDB:   PRK10696
- BioCyc:   SHAL458817:SHAL_2207-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01850
- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063
- Gene3D:   G3DSA:3.40.50.620
- PIRSF:   PIRSF004976

Pfam domain/function: PF01171 ATP_bind_3

EC number: NA

Molecular weight: Translated: 34848; Mature: 34716

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEELTPQQVTRMAKLQKRLRTEVGRAIGDYNMIEEGDRVMCCLSGGKDSYAMLDILLNL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHH
QQRAPIKFEIVAVNLDQKQPGFPEDILPAYLDTLGVAYHILEKDTYSIVKDKIPEGKTTC
HHCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
SLCSRLRRGTLYGFAQKIGATKIALGHHRDDIIETMFLNMFFAGKMKAMPPKLLSDDGAN
HHHHHHHHCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCC
MVIRPLAYSREKDIAEYAGLKGFPIIPCNLCGSQENLKRAAVKEMLVQWDRDYPGRIETI
EEEECCHHCCHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
FTAMQNTAPSQGVDREQFDFLSLTRDPDAPMRGDVAESDLPAFDFVDVANNGHINLDKAV
HHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEECCEE
RIDVVNTYTPD
EEEEECCCCCC
>Mature Secondary Structure 
SEELTPQQVTRMAKLQKRLRTEVGRAIGDYNMIEEGDRVMCCLSGGKDSYAMLDILLNL
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHH
QQRAPIKFEIVAVNLDQKQPGFPEDILPAYLDTLGVAYHILEKDTYSIVKDKIPEGKTTC
HHCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
SLCSRLRRGTLYGFAQKIGATKIALGHHRDDIIETMFLNMFFAGKMKAMPPKLLSDDGAN
HHHHHHHHCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCC
MVIRPLAYSREKDIAEYAGLKGFPIIPCNLCGSQENLKRAAVKEMLVQWDRDYPGRIETI
EEEECCHHCCHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
FTAMQNTAPSQGVDREQFDFLSLTRDPDAPMRGDVAESDLPAFDFVDVANNGHINLDKAV
HHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEECCEE
RIDVVNTYTPD
EEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA