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The map label for this gene is fadA [H]

Identifier: 167624065

GI number: 167624065

Start: 2579970

End: 2581175

Strand: Direct

Name: fadA [H]

Synonym: Shal_2141

Alternate gene names: 167624065

Gene position: 2579970-2581175 (Clockwise)

Preceding gene: 167624064

Following gene: 167624066

Centisome position: 49.36

GC content: 48.18

Gene sequence:

>1206_bases
ATGACCGAAGCAGTGATCGTCTCCGTCGCACGTACAGCATTAAGCAAATCTTTCCGTGGCGCATTCAATGATACTGAAGC
CCCAGTTCTTGGCGGGCATGTTGTAAAGTCCGTCGTTGAGCGTGCAGGTATTGACCCCGCCTCTATCGATGATGTGATTA
TGGGCGCTGCGGCGCAGCAGGGAACTCAGTCTTACAATATTGGCAGACTTTCGGCTTATACCGCAGGCTTACCGGATACG
GTTTCAGGCATGGCATTAGATCGTATGTGTGCATCAGGTCTTATGAGTATCGGTATTGCAGCAAAATCGATTATGACCGA
TGAGATGAGCACCGTAGTTGCCGGTGGTGTTGAGTCATTATCGTTAACTCAAAATAAGTATAAGAATACTTATCGAGCAC
AATCTCAAGCCGCTATCGCTGCAATGCCAAGTGCCTATATCCAAATGATCGAAACAGCCGAAATTGTCGCCGAGCGGTAT
GGCATTTCTCGTCAGGCACAAGATGAGTATTCTTTGCTAAGCCAACAACGTACTGCTAATGCACAACAAGCAGGCTACTT
TAATGATGAAATAGTGCCGCTTACCGTTCAGCAACTGACCTTTGATGAGAATCGCCAACCCGCCGGTCATAAAGAAACGA
TTGCGTTGCAAGATGACTGTAACAGGCCACAAACAACGCTAGACAGTTTGTCTAATCTTGCTCCTGTTTGGAAAGGTGGC
GAGTGGACTAGCGAAGGCCGCAATGTTACCGCGGGCAATGCATCGCAGTTTGCAGATGGAGCCGCGGCAAGTTTATTAAT
GAGCAAAACCGAAGCGCAAAAGCTTGGCATTGTCCCTTTAGGCACCTACAAAGGTCTTGCCGTTGCGGGGTGTGCCCCTG
AGGAGATGGGTATTGGGCCTGTACTGGCGATCCCAAAACTATTAAAGCGTTTTGGCCTAAGTGTTGATGATATCGGGCTG
TGGGAAATTAATGAAGCTTTTGCTAGCCAAGTTGTCTACTGCCAACAAAAACTAGAAATCCCCGCTGAACGATTAAATGT
CAATGGAGGCGCTATCTCCATTGGTCATCCATTTGGTATGTCAGGCGCACGTATGGTGGGTCATGCACTGATTGAAGGTA
GACGTCGTGGTGTTAAATATGTCGTTGTTGCAATGTGCATTGGCGGCGGTATGGGCGCCGCAGGGCTATTTGAAGTCAAT
CACTAA

Upstream 100 bases:

>100_bases
AATTGAAGGCTCTGAACGACCAGCCTGTGTCGTTGACACCATAAGTTGCTACACCTTTGAAACGCCAAGTTCAAACTCTA
CTAAGTAAAGGAATTTTAAG

Downstream 100 bases:

>100_bases
TTAGGAGACAGTTATGTCAGTTATTTTAGAAAAAGCACAGAAACTGTTTTTATCAGACAACGATGCCAAGGTGCAAACTG
GACATGAGTTTGAAACGGTT

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MTEAVIVSVARTALSKSFRGAFNDTEAPVLGGHVVKSVVERAGIDPASIDDVIMGAAAQQGTQSYNIGRLSAYTAGLPDT
VSGMALDRMCASGLMSIGIAAKSIMTDEMSTVVAGGVESLSLTQNKYKNTYRAQSQAAIAAMPSAYIQMIETAEIVAERY
GISRQAQDEYSLLSQQRTANAQQAGYFNDEIVPLTVQQLTFDENRQPAGHKETIALQDDCNRPQTTLDSLSNLAPVWKGG
EWTSEGRNVTAGNASQFADGAAASLLMSKTEAQKLGIVPLGTYKGLAVAGCAPEEMGIGPVLAIPKLLKRFGLSVDDIGL
WEINEAFASQVVYCQQKLEIPAERLNVNGGAISIGHPFGMSGARMVGHALIEGRRRGVKYVVVAMCIGGGMGAAGLFEVN
H

Sequences:

>Translated_401_residues
MTEAVIVSVARTALSKSFRGAFNDTEAPVLGGHVVKSVVERAGIDPASIDDVIMGAAAQQGTQSYNIGRLSAYTAGLPDT
VSGMALDRMCASGLMSIGIAAKSIMTDEMSTVVAGGVESLSLTQNKYKNTYRAQSQAAIAAMPSAYIQMIETAEIVAERY
GISRQAQDEYSLLSQQRTANAQQAGYFNDEIVPLTVQQLTFDENRQPAGHKETIALQDDCNRPQTTLDSLSNLAPVWKGG
EWTSEGRNVTAGNASQFADGAAASLLMSKTEAQKLGIVPLGTYKGLAVAGCAPEEMGIGPVLAIPKLLKRFGLSVDDIGL
WEINEAFASQVVYCQQKLEIPAERLNVNGGAISIGHPFGMSGARMVGHALIEGRRRGVKYVVVAMCIGGGMGAAGLFEVN
H
>Mature_400_residues
TEAVIVSVARTALSKSFRGAFNDTEAPVLGGHVVKSVVERAGIDPASIDDVIMGAAAQQGTQSYNIGRLSAYTAGLPDTV
SGMALDRMCASGLMSIGIAAKSIMTDEMSTVVAGGVESLSLTQNKYKNTYRAQSQAAIAAMPSAYIQMIETAEIVAERYG
ISRQAQDEYSLLSQQRTANAQQAGYFNDEIVPLTVQQLTFDENRQPAGHKETIALQDDCNRPQTTLDSLSNLAPVWKGGE
WTSEGRNVTAGNASQFADGAAASLLMSKTEAQKLGIVPLGTYKGLAVAGCAPEEMGIGPVLAIPKLLKRFGLSVDDIGLW
EINEAFASQVVYCQQKLEIPAERLNVNGGAISIGHPFGMSGARMVGHALIEGRRRGVKYVVVAMCIGGGMGAAGLFEVNH

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4501853, Length=398, Percent_Identity=40.4522613065327, Blast_Score=269, Evalue=4e-72,
Organism=Homo sapiens, GI167614485, Length=403, Percent_Identity=36.2282878411911, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI148539872, Length=404, Percent_Identity=36.6336633663366, Blast_Score=216, Evalue=4e-56,
Organism=Homo sapiens, GI4557237, Length=406, Percent_Identity=33.743842364532, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI4504327, Length=406, Percent_Identity=27.5862068965517, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI194353979, Length=88, Percent_Identity=56.8181818181818, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1787663, Length=419, Percent_Identity=37.2315035799523, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI48994986, Length=406, Percent_Identity=35.7142857142857, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI1788554, Length=411, Percent_Identity=37.956204379562, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI87082165, Length=413, Percent_Identity=36.0774818401937, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI1788683, Length=416, Percent_Identity=29.0865384615385, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI133906874, Length=403, Percent_Identity=34.4913151364764, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI25147385, Length=403, Percent_Identity=30.5210918114144, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17535921, Length=415, Percent_Identity=31.566265060241, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17551802, Length=442, Percent_Identity=27.8280542986425, Blast_Score=161, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17535917, Length=402, Percent_Identity=28.1094527363184, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322031, Length=404, Percent_Identity=36.1386138613861, Blast_Score=219, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6325229, Length=411, Percent_Identity=30.6569343065693, Blast_Score=155, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24655093, Length=403, Percent_Identity=36.2282878411911, Blast_Score=234, Evalue=7e-62,
Organism=Drosophila melanogaster, GI24640423, Length=406, Percent_Identity=35.4679802955665, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI17648125, Length=404, Percent_Identity=35.1485148514851, Blast_Score=207, Evalue=8e-54,
Organism=Drosophila melanogaster, GI17137578, Length=414, Percent_Identity=31.1594202898551, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 42339; Mature: 42208

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAVIVSVARTALSKSFRGAFNDTEAPVLGGHVVKSVVERAGIDPASIDDVIMGAAAQQ
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
GTQSYNIGRLSAYTAGLPDTVSGMALDRMCASGLMSIGIAAKSIMTDEMSTVVAGGVESL
CCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
SLTQNKYKNTYRAQSQAAIAAMPSAYIQMIETAEIVAERYGISRQAQDEYSLLSQQRTAN
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
AQQAGYFNDEIVPLTVQQLTFDENRQPAGHKETIALQDDCNRPQTTLDSLSNLAPVWKGG
HHHCCCCCCCEEEEEHEEEECCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCC
EWTSEGRNVTAGNASQFADGAAASLLMSKTEAQKLGIVPLGTYKGLAVAGCAPEEMGIGP
CCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECCCHHHCCCCH
VLAIPKLLKRFGLSVDDIGLWEINEAFASQVVYCQQKLEIPAERLNVNGGAISIGHPFGM
HHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEECCCCCC
SGARMVGHALIEGRRRGVKYVVVAMCIGGGMGAAGLFEVNH
CHHHHHHHHHHHHHHCCHHHEEEEHHHCCCCCCCCEEEECC
>Mature Secondary Structure 
TEAVIVSVARTALSKSFRGAFNDTEAPVLGGHVVKSVVERAGIDPASIDDVIMGAAAQQ
CCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
GTQSYNIGRLSAYTAGLPDTVSGMALDRMCASGLMSIGIAAKSIMTDEMSTVVAGGVESL
CCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
SLTQNKYKNTYRAQSQAAIAAMPSAYIQMIETAEIVAERYGISRQAQDEYSLLSQQRTAN
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
AQQAGYFNDEIVPLTVQQLTFDENRQPAGHKETIALQDDCNRPQTTLDSLSNLAPVWKGG
HHHCCCCCCCEEEEEHEEEECCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCC
EWTSEGRNVTAGNASQFADGAAASLLMSKTEAQKLGIVPLGTYKGLAVAGCAPEEMGIGP
CCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEEECCCHHHCCCCH
VLAIPKLLKRFGLSVDDIGLWEINEAFASQVVYCQQKLEIPAERLNVNGGAISIGHPFGM
HHHHHHHHHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEECCCCCC
SGARMVGHALIEGRRRGVKYVVVAMCIGGGMGAAGLFEVNH
CHHHHHHHHHHHHHHCCHHHEEEEHHHCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]