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The map label for this gene is fadH [C]

Identifier: 167624041

GI number: 167624041

Start: 2550163

End: 2552283

Strand: Reverse

Name: fadH [C]

Synonym: Shal_2117

Alternate gene names: 167624041

Gene position: 2552283-2550163 (Counterclockwise)

Preceding gene: 167624042

Following gene: 167624032

Centisome position: 48.83

GC content: 45.59

Gene sequence:

>2121_bases
ATGGCACACTTCGAACATTTACTCAAACCCGGAAAAATAGGCAATTTATCTCTAAAAAACCGTATGGTAATGGCTCCTAT
GGGATCCAATTTTGCCGAGTCTAACGGTCATTGCGGTGAACGCATTCAAGCTTTTTATGAAGAAAGAGCAAAAGGTGGCG
CAGCGCTATTAACCATGGGGGTGGGTGCGATTGCTTATCCCTCAGGTACCGCAGAGCCTTACCAAGTTGGCATTTCAACA
GATGAGTTTATTCCCGGTCTAAAACAGTTAACCGACCGTGTCCATAAGCATGGTGCAAAAATCGCTATCCAGTTACAGCA
TGCAGGTAAGACTGCGGTTAGAGATTTAGCCGAAGGCCGTGACTTATGGGTACCATCCATGCCTCCAGCGACCAATAGCG
ATATGATGAAAACGCTGACCCATAACGAACTGGCTAGTTTTATTCGGCCTAAAGCCGGTGGCCAGATCAAGATTCGGGTT
ATGGACGAGGATGACATCAAGCAAATGGTGGCTTGGTTTGCATCAGCCGCACTTAGGGCTAAACAAGCAGGCTTTGACGG
CGTAGAAATCCACGCAGCTCATAGTTACATTATTGCCGGTTTTTTATCTTCTTATTACAACAAACGTGACGACCAGTATG
GTGGCAACCTCGAAAATCGAGCGCGACTTTTACTCGAAGTCATTGCAGCTGTACGTGAACAAGTTGGTAACGATTATCCC
GTTTGGCTAAGGCTCGATGCTGCAGAGTTACGTACACCAGGTGGGATAACCATTGAAGACTGTATTGAAGTGGCAAAACT
AGTTGAGGCTGCTGGACTTAATGCTATCAGTATTTCTGCCTACGCCACTATCAACCGTGGTGATGCATTCACCGAAGCCC
CATTAGTACAAAAGCCCGCTGGCTTTCTTGATTGGGCTGCAATGGTTAGTAAGCATGTTTCAATACCGGTTACCGCTGTG
GGTCGCTTAGAACCCGATGTAGCCAATAAAGCCATTGGGAGCGGCCAAATTGCCTTTGTCGCAATGGCGAGGAAACTGCT
TGCCGACCCACAGTTACCAAACAAAATTATTAATAACCGTGCTCAGGATATCCGCCCCTGCATATATTGTTATGCCTGTG
TCAGCCAAATTTTTATTAATCAAAGGGTGAAGTGTGCGGTAAACCCAAGAACTGGACATGAATCAACCCTCAATATCATT
GCTACTGACAAAGCCAAACATGTCGTTATAGTAGGCGCGGGTCCTAGCGGGATGGAAGCAGCCAAAGTCGCGAGTGACCG
AGGCCATAGAGTGACCCTAATTGAGCGTGCTTCACGCCTGGGTGGCACGCTGTTTTTCGCCTCTATGACCTACCCTGAAA
ATGGCAAATTGCTCGAATACCAAATTAATCAGCTTAAGCAATCAAACGTTGATATTCAGCTTAATACTGAGGTATCTGTT
GAATTGCTCAGCCAACTTCAACCCGATGAAGTATTTCTTGCTGTAGGGGCATTGCGCACTTCACCAAATATAGAAGGGTC
ACAGTTGCAACACGTTTGGTCTGGTGATGAATTACGCAAACTAATGACTGGTGAAGGTAAAGATATTGCTAAGCAGAAGC
TTTCTTTATCACAACGCGCTATGTTCAATGCCGGTTCAGTCAGTGGCGTAACATCAAGTTTAGATGCTTGCCGTCAACTT
TCTAAATTATGGATGCCGCTGGGTAAAAATATCGCCGTTATTGGGGGCGGGCTTGTTGGGCTGGAACTGGCAGAGTTCTT
GGCACTTCGAGGGCGTAATGTCACCATTCTTGAAGCAACAAGAGACTTAGGAAGTGAACTTTCTATTGTACGTCGTTGGC
GGATCCTCCAAGAACACAATGAACTAGGCGTAACAATCATTAACAATGCATCCGTGAATAAAATTGACGCCAAAACTGTA
ACTTTCACTGATAAAGAAGGCAAATTGCAACTGTTAGACAGTGATAGTGTCATCATGGCCCAAGGTGCGACCCCAAACAG
CACTTTTGAGCAAATATTAGTTGATGAGGGCTTCAAAGTGAGTTCTATCGGAGATAGCAGTGCTGTCAATTATATTGAAG
GCGCTATTGCTTCTGGGATGAATGCCGCGATAAAACTATAA

Upstream 100 bases:

>100_bases
TTTTTCTGTAATTCGGACAGCCTTCTACCTATTAACTACTGATCGAAAACTAACCGAAAACTAATAACGATTATAAAGAC
AATAATTTGAGAGACTACCA

Downstream 100 bases:

>100_bases
CGTTATGCCTTCAGCCTAAGCGATTACACTTGGGCATCAATACTACAAGTGGGTGGTAAAATATAAAAGATGGATTATTA
ACTTAATAATCCATCTTTTT

Product: NADH:flavin oxidoreductase/NADH oxidase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 706; Mature: 705

Protein sequence:

>706_residues
MAHFEHLLKPGKIGNLSLKNRMVMAPMGSNFAESNGHCGERIQAFYEERAKGGAALLTMGVGAIAYPSGTAEPYQVGIST
DEFIPGLKQLTDRVHKHGAKIAIQLQHAGKTAVRDLAEGRDLWVPSMPPATNSDMMKTLTHNELASFIRPKAGGQIKIRV
MDEDDIKQMVAWFASAALRAKQAGFDGVEIHAAHSYIIAGFLSSYYNKRDDQYGGNLENRARLLLEVIAAVREQVGNDYP
VWLRLDAAELRTPGGITIEDCIEVAKLVEAAGLNAISISAYATINRGDAFTEAPLVQKPAGFLDWAAMVSKHVSIPVTAV
GRLEPDVANKAIGSGQIAFVAMARKLLADPQLPNKIINNRAQDIRPCIYCYACVSQIFINQRVKCAVNPRTGHESTLNII
ATDKAKHVVIVGAGPSGMEAAKVASDRGHRVTLIERASRLGGTLFFASMTYPENGKLLEYQINQLKQSNVDIQLNTEVSV
ELLSQLQPDEVFLAVGALRTSPNIEGSQLQHVWSGDELRKLMTGEGKDIAKQKLSLSQRAMFNAGSVSGVTSSLDACRQL
SKLWMPLGKNIAVIGGGLVGLELAEFLALRGRNVTILEATRDLGSELSIVRRWRILQEHNELGVTIINNASVNKIDAKTV
TFTDKEGKLQLLDSDSVIMAQGATPNSTFEQILVDEGFKVSSIGDSSAVNYIEGAIASGMNAAIKL

Sequences:

>Translated_706_residues
MAHFEHLLKPGKIGNLSLKNRMVMAPMGSNFAESNGHCGERIQAFYEERAKGGAALLTMGVGAIAYPSGTAEPYQVGIST
DEFIPGLKQLTDRVHKHGAKIAIQLQHAGKTAVRDLAEGRDLWVPSMPPATNSDMMKTLTHNELASFIRPKAGGQIKIRV
MDEDDIKQMVAWFASAALRAKQAGFDGVEIHAAHSYIIAGFLSSYYNKRDDQYGGNLENRARLLLEVIAAVREQVGNDYP
VWLRLDAAELRTPGGITIEDCIEVAKLVEAAGLNAISISAYATINRGDAFTEAPLVQKPAGFLDWAAMVSKHVSIPVTAV
GRLEPDVANKAIGSGQIAFVAMARKLLADPQLPNKIINNRAQDIRPCIYCYACVSQIFINQRVKCAVNPRTGHESTLNII
ATDKAKHVVIVGAGPSGMEAAKVASDRGHRVTLIERASRLGGTLFFASMTYPENGKLLEYQINQLKQSNVDIQLNTEVSV
ELLSQLQPDEVFLAVGALRTSPNIEGSQLQHVWSGDELRKLMTGEGKDIAKQKLSLSQRAMFNAGSVSGVTSSLDACRQL
SKLWMPLGKNIAVIGGGLVGLELAEFLALRGRNVTILEATRDLGSELSIVRRWRILQEHNELGVTIINNASVNKIDAKTV
TFTDKEGKLQLLDSDSVIMAQGATPNSTFEQILVDEGFKVSSIGDSSAVNYIEGAIASGMNAAIKL
>Mature_705_residues
AHFEHLLKPGKIGNLSLKNRMVMAPMGSNFAESNGHCGERIQAFYEERAKGGAALLTMGVGAIAYPSGTAEPYQVGISTD
EFIPGLKQLTDRVHKHGAKIAIQLQHAGKTAVRDLAEGRDLWVPSMPPATNSDMMKTLTHNELASFIRPKAGGQIKIRVM
DEDDIKQMVAWFASAALRAKQAGFDGVEIHAAHSYIIAGFLSSYYNKRDDQYGGNLENRARLLLEVIAAVREQVGNDYPV
WLRLDAAELRTPGGITIEDCIEVAKLVEAAGLNAISISAYATINRGDAFTEAPLVQKPAGFLDWAAMVSKHVSIPVTAVG
RLEPDVANKAIGSGQIAFVAMARKLLADPQLPNKIINNRAQDIRPCIYCYACVSQIFINQRVKCAVNPRTGHESTLNIIA
TDKAKHVVIVGAGPSGMEAAKVASDRGHRVTLIERASRLGGTLFFASMTYPENGKLLEYQINQLKQSNVDIQLNTEVSVE
LLSQLQPDEVFLAVGALRTSPNIEGSQLQHVWSGDELRKLMTGEGKDIAKQKLSLSQRAMFNAGSVSGVTSSLDACRQLS
KLWMPLGKNIAVIGGGLVGLELAEFLALRGRNVTILEATRDLGSELSIVRRWRILQEHNELGVTIINNASVNKIDAKTVT
FTDKEGKLQLLDSDSVIMAQGATPNSTFEQILVDEGFKVSSIGDSSAVNYIEGAIASGMNAAIKL

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=728, Percent_Identity=29.8076923076923, Blast_Score=266, Evalue=4e-72,
Organism=Escherichia coli, GI1787939, Length=354, Percent_Identity=29.0960451977401, Blast_Score=109, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17565138, Length=199, Percent_Identity=30.1507537688442, Blast_Score=100, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17559802, Length=278, Percent_Identity=27.3381294964029, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17559804, Length=275, Percent_Identity=27.2727272727273, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17566914, Length=385, Percent_Identity=26.2337662337662, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17564188, Length=276, Percent_Identity=25.3623188405797, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI72001454, Length=276, Percent_Identity=27.8985507246377, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17540738, Length=281, Percent_Identity=25.6227758007117, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321973, Length=245, Percent_Identity=32.2448979591837, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6325086, Length=234, Percent_Identity=30.7692307692308, Blast_Score=91, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 76347; Mature: 76215

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHFEHLLKPGKIGNLSLKNRMVMAPMGSNFAESNGHCGERIQAFYEERAKGGAALLTMG
CCCHHHHCCCCCCCCEEECCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEC
VGAIAYPSGTAEPYQVGISTDEFIPGLKQLTDRVHKHGAKIAIQLQHAGKTAVRDLAEGR
CCEEECCCCCCCCEEECCCCHHHCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCC
DLWVPSMPPATNSDMMKTLTHNELASFIRPKAGGQIKIRVMDEDDIKQMVAWFASAALRA
CEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHH
KQAGFDGVEIHAAHSYIIAGFLSSYYNKRDDQYGGNLENRARLLLEVIAAVREQVGNDYP
HHCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
VWLRLDAAELRTPGGITIEDCIEVAKLVEAAGLNAISISAYATINRGDAFTEAPLVQKPA
EEEEEEHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCCC
GFLDWAAMVSKHVSIPVTAVGRLEPDVANKAIGSGQIAFVAMARKLLADPQLPNKIINNR
CHHHHHHHHHCCCCCCEEEECCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHCCC
AQDIRPCIYCYACVSQIFINQRVKCAVNPRTGHESTLNIIATDKAKHVVIVGAGPSGMEA
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEECCCCEEEEEECCCCCCHH
AKVASDRGHRVTLIERASRLGGTLFFASMTYPENGKLLEYQINQLKQSNVDIQLNTEVSV
HHHHCCCCCEEHHHHHHHHCCCEEEEEEEECCCCCCEEHHHHHHHHHCCCCEEECCCHHH
ELLSQLQPDEVFLAVGALRTSPNIEGSQLQHVWSGDELRKLMTGEGKDIAKQKLSLSQRA
HHHHCCCCCCEEEEEEHHCCCCCCCHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHH
MFNAGSVSGVTSSLDACRQLSKLWMPLGKNIAVIGGGLVGLELAEFLALRGRNVTILEAT
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECC
RDLGSELSIVRRWRILQEHNELGVTIINNASVNKIDAKTVTFTDKEGKLQLLDSDSVIMA
HHCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCEECCEEEEEECCCCCEEEECCCCEEEE
QGATPNSTFEQILVDEGFKVSSIGDSSAVNYIEGAIASGMNAAIKL
ECCCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEC
>Mature Secondary Structure 
AHFEHLLKPGKIGNLSLKNRMVMAPMGSNFAESNGHCGERIQAFYEERAKGGAALLTMG
CCHHHHCCCCCCCCEEECCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEC
VGAIAYPSGTAEPYQVGISTDEFIPGLKQLTDRVHKHGAKIAIQLQHAGKTAVRDLAEGR
CCEEECCCCCCCCEEECCCCHHHCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCC
DLWVPSMPPATNSDMMKTLTHNELASFIRPKAGGQIKIRVMDEDDIKQMVAWFASAALRA
CEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHH
KQAGFDGVEIHAAHSYIIAGFLSSYYNKRDDQYGGNLENRARLLLEVIAAVREQVGNDYP
HHCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
VWLRLDAAELRTPGGITIEDCIEVAKLVEAAGLNAISISAYATINRGDAFTEAPLVQKPA
EEEEEEHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCCC
GFLDWAAMVSKHVSIPVTAVGRLEPDVANKAIGSGQIAFVAMARKLLADPQLPNKIINNR
CHHHHHHHHHCCCCCCEEEECCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHHHCCC
AQDIRPCIYCYACVSQIFINQRVKCAVNPRTGHESTLNIIATDKAKHVVIVGAGPSGMEA
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEEEEEECCCCEEEEEECCCCCCHH
AKVASDRGHRVTLIERASRLGGTLFFASMTYPENGKLLEYQINQLKQSNVDIQLNTEVSV
HHHHCCCCCEEHHHHHHHHCCCEEEEEEEECCCCCCEEHHHHHHHHHCCCCEEECCCHHH
ELLSQLQPDEVFLAVGALRTSPNIEGSQLQHVWSGDELRKLMTGEGKDIAKQKLSLSQRA
HHHHCCCCCCEEEEEEHHCCCCCCCHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHH
MFNAGSVSGVTSSLDACRQLSKLWMPLGKNIAVIGGGLVGLELAEFLALRGRNVTILEAT
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCCEEEEECC
RDLGSELSIVRRWRILQEHNELGVTIINNASVNKIDAKTVTFTDKEGKLQLLDSDSVIMA
HHCCHHHHHHHHHHHHHHCCCCCEEEECCCCCCEECCEEEEEECCCCCEEEECCCCEEEE
QGATPNSTFEQILVDEGFKVSSIGDSSAVNYIEGAIASGMNAAIKL
ECCCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]