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The map label for this gene is hsaA [H]

Identifier: 167624025

GI number: 167624025

Start: 2532756

End: 2533979

Strand: Direct

Name: hsaA [H]

Synonym: Shal_2101

Alternate gene names: 167624025

Gene position: 2532756-2533979 (Clockwise)

Preceding gene: 167624022

Following gene: 167624026

Centisome position: 48.46

GC content: 43.95

Gene sequence:

>1224_bases
ATGAGTAACCATAGTGAAGTGATAGCGGCCGATTTGGAACAAGAAGACTACATGACCGTAGACGCTCAAGCATTAATCGA
GCTTGCCACTGCTTTAGTGCCAAAACTTGCTGAGCGTGCTAAACAAACAGAGCTTGATGGTAAGGTTTCTGAAGAATCAG
TCAAAGAAATAGCTGCTGCAGGCCTATTTAGAGTATTACAACCAAAAAGATGGGGCGGAGCTGAACTCGATCCTCGTGTG
TTTTACCGAATTCAAATGATTTTGGCTCAGGGTTGTATGTCAACTGCATGGATATATGGGGTTATTAGTGTTCACAATTG
GCAACTGCCTTTGTTTCCTGAGCAAGCTCAACAGGATGTTTGGCAAAAAGACGACTCGACCTTAATCGCGTCAACATATA
TGCCTGTAGGTAAAGCGGTGCCTGTAGAGGGCGGTTATATGTTCTCAGGACGCTGGGGGTTCTCAAGTGGTTGTGAGCAT
TGTGAATGGATTTTCCTCGGGGCGTTATTGCCTAAGGAAGATGGCAGTGAAGGGCTTGAACATACGACTTTTCTGTTACC
TAAGTCAGATTTTACCATTGACAAGAACTGGGATGTCCATGGCCTTAGAGGAACGGGGAGTCATGATATCGTTGTTGATA
ATGTATTTGTTCCCGCTCATCGTACCCAGCGTACTAACAACCATAGTGATGCTGGCTGTCCAGGTAGAGAGCTCAATAAT
GGTTGGTTGTACAAAATCCCGTTTACACAGGTCTTTCAACGTGCGGTTTCAACAGCTTGTATCGGTGCGCTAGACGGCGC
GATTAATGAATTTAAGCAAAGAGCCTCTATGCATGTAGGTAAGCACGGTAGTAAAACTGCAGAGGATCCTAATGCACAAT
TTGCTGTCACAGCAGCAATGATGACAAGCGATCAGCTTAAGTTAGTCATGTTAAGAAATTATCAGCGAATAGTTGACTGC
GTAAAATCCAACCAAGTAATGGATGTTGAAGAACGTTTATTACAACGAGCTCAAGCTGCATCAGTGCCGAAATTGTGTGG
TGAACATGTTGATGATTTACTTAAAGCTTGCGCAGCTTCTGGTTTATATAGATCTAATCCTATCGAACGGATATTTAGAG
ATATTCATCAGGCCCGCGGACATATCGCGAATAATGGTGATGCCTACATGCGTGCACATGGTTCGGTCATGCTTGGACTA
CCAAACCTTGACCCATTTATTTAG

Upstream 100 bases:

>100_bases
TTCAGGCGGGTATGGAACCCTCAACAACAGTGCAGTGTGATGTTTTGTTTGCAAAACACTAAATGAACAAATTTTATCGA
TAATTGGGGAGTGAATATTG

Downstream 100 bases:

>100_bases
TCGCCTTATTAGATAACCCATTTGCTGGAAAGGAGTTGCCATGTCTTCATCTCGTTATCACCATTTGACTGTGAGTCATA
TCATCGAAGAAACTGAAGAT

Product: acyl-CoA dehydrogenase type 2

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MSNHSEVIAADLEQEDYMTVDAQALIELATALVPKLAERAKQTELDGKVSEESVKEIAAAGLFRVLQPKRWGGAELDPRV
FYRIQMILAQGCMSTAWIYGVISVHNWQLPLFPEQAQQDVWQKDDSTLIASTYMPVGKAVPVEGGYMFSGRWGFSSGCEH
CEWIFLGALLPKEDGSEGLEHTTFLLPKSDFTIDKNWDVHGLRGTGSHDIVVDNVFVPAHRTQRTNNHSDAGCPGRELNN
GWLYKIPFTQVFQRAVSTACIGALDGAINEFKQRASMHVGKHGSKTAEDPNAQFAVTAAMMTSDQLKLVMLRNYQRIVDC
VKSNQVMDVEERLLQRAQAASVPKLCGEHVDDLLKACAASGLYRSNPIERIFRDIHQARGHIANNGDAYMRAHGSVMLGL
PNLDPFI

Sequences:

>Translated_407_residues
MSNHSEVIAADLEQEDYMTVDAQALIELATALVPKLAERAKQTELDGKVSEESVKEIAAAGLFRVLQPKRWGGAELDPRV
FYRIQMILAQGCMSTAWIYGVISVHNWQLPLFPEQAQQDVWQKDDSTLIASTYMPVGKAVPVEGGYMFSGRWGFSSGCEH
CEWIFLGALLPKEDGSEGLEHTTFLLPKSDFTIDKNWDVHGLRGTGSHDIVVDNVFVPAHRTQRTNNHSDAGCPGRELNN
GWLYKIPFTQVFQRAVSTACIGALDGAINEFKQRASMHVGKHGSKTAEDPNAQFAVTAAMMTSDQLKLVMLRNYQRIVDC
VKSNQVMDVEERLLQRAQAASVPKLCGEHVDDLLKACAASGLYRSNPIERIFRDIHQARGHIANNGDAYMRAHGSVMLGL
PNLDPFI
>Mature_406_residues
SNHSEVIAADLEQEDYMTVDAQALIELATALVPKLAERAKQTELDGKVSEESVKEIAAAGLFRVLQPKRWGGAELDPRVF
YRIQMILAQGCMSTAWIYGVISVHNWQLPLFPEQAQQDVWQKDDSTLIASTYMPVGKAVPVEGGYMFSGRWGFSSGCEHC
EWIFLGALLPKEDGSEGLEHTTFLLPKSDFTIDKNWDVHGLRGTGSHDIVVDNVFVPAHRTQRTNNHSDAGCPGRELNNG
WLYKIPFTQVFQRAVSTACIGALDGAINEFKQRASMHVGKHGSKTAEDPNAQFAVTAAMMTSDQLKLVMLRNYQRIVDCV
KSNQVMDVEERLLQRAQAASVPKLCGEHVDDLLKACAASGLYRSNPIERIFRDIHQARGHIANNGDAYMRAHGSVMLGLP
NLDPFI

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 45112; Mature: 44981

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNHSEVIAADLEQEDYMTVDAQALIELATALVPKLAERAKQTELDGKVSEESVKEIAAA
CCCCCCEEEECCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
GLFRVLQPKRWGGAELDPRVFYRIQMILAQGCMSTAWIYGVISVHNWQLPLFPEQAQQDV
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHH
WQKDDSTLIASTYMPVGKAVPVEGGYMFSGRWGFSSGCEHCEWIFLGALLPKEDGSEGLE
HCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHEEECCCCCCCCCCCCC
HTTFLLPKSDFTIDKNWDVHGLRGTGSHDIVVDNVFVPAHRTQRTNNHSDAGCPGRELNN
CEEEEEECCCCEECCCCCCCCCCCCCCCCEEEEEEEECCHHHCCCCCCCCCCCCCCCCCC
GWLYKIPFTQVFQRAVSTACIGALDGAINEFKQRASMHVGKHGSKTAEDPNAQFAVTAAM
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEH
MTSDQLKLVMLRNYQRIVDCVKSNQVMDVEERLLQRAQAASVPKLCGEHVDDLLKACAAS
HCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
GLYRSNPIERIFRDIHQARGHIANNGDAYMRAHGSVMLGLPNLDPFI
CCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEECCCCCCCC
>Mature Secondary Structure 
SNHSEVIAADLEQEDYMTVDAQALIELATALVPKLAERAKQTELDGKVSEESVKEIAAA
CCCCCEEEECCCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
GLFRVLQPKRWGGAELDPRVFYRIQMILAQGCMSTAWIYGVISVHNWQLPLFPEQAQQDV
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHH
WQKDDSTLIASTYMPVGKAVPVEGGYMFSGRWGFSSGCEHCEWIFLGALLPKEDGSEGLE
HCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHEEECCCCCCCCCCCCC
HTTFLLPKSDFTIDKNWDVHGLRGTGSHDIVVDNVFVPAHRTQRTNNHSDAGCPGRELNN
CEEEEEECCCCEECCCCCCCCCCCCCCCCEEEEEEEECCHHHCCCCCCCCCCCCCCCCCC
GWLYKIPFTQVFQRAVSTACIGALDGAINEFKQRASMHVGKHGSKTAEDPNAQFAVTAAM
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEH
MTSDQLKLVMLRNYQRIVDCVKSNQVMDVEERLLQRAQAASVPKLCGEHVDDLLKACAAS
HCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHC
GLYRSNPIERIFRDIHQARGHIANNGDAYMRAHGSVMLGLPNLDPFI
CCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA