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The map label for this gene is uvrB [H]

Identifier: 167623929

GI number: 167623929

Start: 2415867

End: 2417861

Strand: Direct

Name: uvrB [H]

Synonym: Shal_2003

Alternate gene names: 167623929

Gene position: 2415867-2417861 (Clockwise)

Preceding gene: 167623927

Following gene: 167623930

Centisome position: 46.22

GC content: 46.07

Gene sequence:

>1995_bases
ATGTCCAACTCTCTACTTTCTCAAAACAAGTTTATCCTACACTCAAGTTATCTCCCGTCAGGTGATCAACCTGAAGCCAT
TGCCCGCTTAATTGATGGGATAGAAAGCGGAGCCTCTCACCAGACATTAAAAGGCGTGACGGGATCCGGTAAAACATTCA
CGGTTGCCAACATAATCCATAGGTTAAAACGTCCTACGATTATTTTGGCGCATAACAAGACATTAGCCGCTCAGCTCTAT
AGTGAAATGAGACATTTTTTCCCCGAAAATGCCGTCGAGTTCTTTGTTTCTTATTATGATTATTATCAGCCCGAAGTGTA
CCTTCCAGGTAGTGATCGTTTTATTCGTAAAGATTCTGCCATTAACGCACATTTAGAGCGTTTACGTTTATCAACGACCA
AAGCATTAATAGAACGCAGAGACGTTATTGTTGTGGCGTCGGTATCATCGGTATATGGCCTTGGCGATCCTGATGCATAC
CGCTCCTTACAGGTTAAGCTCAGCCTAGGGCAGGCGATTGAAACTGAAGAGTTAATCGAGCGATTAGAACGGCTGCAGTA
TGGCCGTTGTAATCGCACCATCAAGCGGGCGACATTTTTAGTGCGCGATGGAGCGGTTGATATATTTCCTGCAGACTCTG
AGCATAAGGCACTGACCCTTGAACTCGATGATGGCCATCTAAATAAGCTCTATTGGATCGATGCCGTCAGCGGTGAAAAA
CTAGCAGATGTGGACGAATATTATGTGTCGCCAAAAACGTTGTACTCGGTGTCTGTCGAGCAGGTGGATTTGGCTTGTGA
GCAGATCATGAAAGATATGGAGCTGCAGGTTGCTTCACTCTCCGCTGAAAATAGGTTGACCGAGGCGGCGAGATTGTATG
AGCGGACGGTATCGGATCTCGAGCTACTTCGCCTACAAGGTTATTGTCCCGGCATAGAAAATTATGCATCCTATCTAAAT
CAGCGCGATCCTAAGCTGCCGCCAACCACACTGTTCGATTACCTACCTAAAGATGGCTTACTGTTTATCGACGAATCCCA
TGTGATGGTGCCGCAAATATCGGCGATGTATAAGAGCGATCAAAGCAGGAAAAATACCTTAATCGATTTTGGTTTCCGTC
TTCCCTCCGCCCGAAATAATCGACCGCTGAGCTTTGATGAGTTTGAGAGCATCAAACCACAAACCATTTTTGTTTCCGCT
ACGCCGGGCCGTTATGAACTGTCAAAATCCAACTCACATATTTTTAAGCAGATCATCCGCCCGACAGGGCTACTGGATCC
TGAAATTGAAATACGTCCCTCAGAGAATAACCTTAAGGATTTAGTAAAGGAGATAGAGCTAAGAGTGGCGCGTAACGAGC
GGACACTAGTAACCACCTTAACCAAGAAAAGTGCAGAGGCATTAAACGACTTTATCGCCGCAAGAGGGATAAAGGTCAGT
TACTTGCACTCAGACGTTAAAACCAATGACAGAGTCGAGATCATTAATGCGCTTCGTGCCGGTGAGCTTGATGTGCTAAT
CGGAATTAACCTATTACGAGAAGGCTTGGATATTCCGGAAGCATCGCTGGTGGCAGTGCTCGATGCCGATCATGCAGGCT
TTTTACGCTCCGAGCAGGCACTTATCCAGATTATCGGGCGAGCCGCCCGTAATGAAAATGGTAAGGCTATCTTATATGCC
GACAAAATGACTTTTGCAATGCAAAAAGCCATAGATGAGTCTTCCGAGCGCCGAGGCCATCAGATGCTGTATAACATGGC
TAACGGCATAGTGCCTAGTTCATCTAAGCGAAAACTCGATTCAGGCGACCAAGCTCATGTAGTTGTCGGCTCGGTAGACA
GAGCTAAATTTTGTGAAAGTCTATCTGAGCTGTGCCGACAGATCACCGCAAAAGAGAAGGAGTTACTGCAGTTGGTGGAT
GAAGAGGGCGCCGAGCAAGCCAAGCTTATTAGAGAGCAGCTGATTGTGCTATATCGCCAGTTTATCTATATGTAA

Upstream 100 bases:

>100_bases
GTCAATAAATCGACTAAGCTTGATACTTAATCGTTATACTAAGCAGTTGCTTAGCGGGTTTTAATATCAGGCACTCAGAC
TTTATTAAAGGCTCACTCTT

Downstream 100 bases:

>100_bases
GGGATAGAGTTTACTCCGGTGCTTATGTATATACCAAATTAATGTGATTTTCAGAATAATTAAGAGGTGGAATAAGCGAT
TAACGCTATAAAAACAAAAA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 664; Mature: 663

Protein sequence:

>664_residues
MSNSLLSQNKFILHSSYLPSGDQPEAIARLIDGIESGASHQTLKGVTGSGKTFTVANIIHRLKRPTIILAHNKTLAAQLY
SEMRHFFPENAVEFFVSYYDYYQPEVYLPGSDRFIRKDSAINAHLERLRLSTTKALIERRDVIVVASVSSVYGLGDPDAY
RSLQVKLSLGQAIETEELIERLERLQYGRCNRTIKRATFLVRDGAVDIFPADSEHKALTLELDDGHLNKLYWIDAVSGEK
LADVDEYYVSPKTLYSVSVEQVDLACEQIMKDMELQVASLSAENRLTEAARLYERTVSDLELLRLQGYCPGIENYASYLN
QRDPKLPPTTLFDYLPKDGLLFIDESHVMVPQISAMYKSDQSRKNTLIDFGFRLPSARNNRPLSFDEFESIKPQTIFVSA
TPGRYELSKSNSHIFKQIIRPTGLLDPEIEIRPSENNLKDLVKEIELRVARNERTLVTTLTKKSAEALNDFIAARGIKVS
YLHSDVKTNDRVEIINALRAGELDVLIGINLLREGLDIPEASLVAVLDADHAGFLRSEQALIQIIGRAARNENGKAILYA
DKMTFAMQKAIDESSERRGHQMLYNMANGIVPSSSKRKLDSGDQAHVVVGSVDRAKFCESLSELCRQITAKEKELLQLVD
EEGAEQAKLIREQLIVLYRQFIYM

Sequences:

>Translated_664_residues
MSNSLLSQNKFILHSSYLPSGDQPEAIARLIDGIESGASHQTLKGVTGSGKTFTVANIIHRLKRPTIILAHNKTLAAQLY
SEMRHFFPENAVEFFVSYYDYYQPEVYLPGSDRFIRKDSAINAHLERLRLSTTKALIERRDVIVVASVSSVYGLGDPDAY
RSLQVKLSLGQAIETEELIERLERLQYGRCNRTIKRATFLVRDGAVDIFPADSEHKALTLELDDGHLNKLYWIDAVSGEK
LADVDEYYVSPKTLYSVSVEQVDLACEQIMKDMELQVASLSAENRLTEAARLYERTVSDLELLRLQGYCPGIENYASYLN
QRDPKLPPTTLFDYLPKDGLLFIDESHVMVPQISAMYKSDQSRKNTLIDFGFRLPSARNNRPLSFDEFESIKPQTIFVSA
TPGRYELSKSNSHIFKQIIRPTGLLDPEIEIRPSENNLKDLVKEIELRVARNERTLVTTLTKKSAEALNDFIAARGIKVS
YLHSDVKTNDRVEIINALRAGELDVLIGINLLREGLDIPEASLVAVLDADHAGFLRSEQALIQIIGRAARNENGKAILYA
DKMTFAMQKAIDESSERRGHQMLYNMANGIVPSSSKRKLDSGDQAHVVVGSVDRAKFCESLSELCRQITAKEKELLQLVD
EEGAEQAKLIREQLIVLYRQFIYM
>Mature_663_residues
SNSLLSQNKFILHSSYLPSGDQPEAIARLIDGIESGASHQTLKGVTGSGKTFTVANIIHRLKRPTIILAHNKTLAAQLYS
EMRHFFPENAVEFFVSYYDYYQPEVYLPGSDRFIRKDSAINAHLERLRLSTTKALIERRDVIVVASVSSVYGLGDPDAYR
SLQVKLSLGQAIETEELIERLERLQYGRCNRTIKRATFLVRDGAVDIFPADSEHKALTLELDDGHLNKLYWIDAVSGEKL
ADVDEYYVSPKTLYSVSVEQVDLACEQIMKDMELQVASLSAENRLTEAARLYERTVSDLELLRLQGYCPGIENYASYLNQ
RDPKLPPTTLFDYLPKDGLLFIDESHVMVPQISAMYKSDQSRKNTLIDFGFRLPSARNNRPLSFDEFESIKPQTIFVSAT
PGRYELSKSNSHIFKQIIRPTGLLDPEIEIRPSENNLKDLVKEIELRVARNERTLVTTLTKKSAEALNDFIAARGIKVSY
LHSDVKTNDRVEIINALRAGELDVLIGINLLREGLDIPEASLVAVLDADHAGFLRSEQALIQIIGRAARNENGKAILYAD
KMTFAMQKAIDESSERRGHQMLYNMANGIVPSSSKRKLDSGDQAHVVVGSVDRAKFCESLSELCRQITAKEKELLQLVDE
EGAEQAKLIREQLIVLYRQFIYM

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=589, Percent_Identity=56.5365025466893, Blast_Score=681, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 74902; Mature: 74771

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSLLSQNKFILHSSYLPSGDQPEAIARLIDGIESGASHQTLKGVTGSGKTFTVANIIH
CCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHH
RLKRPTIILAHNKTLAAQLYSEMRHFFPENAVEFFVSYYDYYQPEVYLPGSDRFIRKDSA
HHCCCEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECCCCCEEECCHH
INAHLERLRLSTTKALIERRDVIVVASVSSVYGLGDPDAYRSLQVKLSLGQAIETEELIE
HHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCHHHCEEEEEEECCCCCCHHHHHH
RLERLQYGRCNRTIKRATFLVRDGAVDIFPADSEHKALTLELDDGHLNKLYWIDAVSGEK
HHHHHHCCHHHHHHHHHEEEEECCCEEEECCCCCCCEEEEEECCCCCCEEEEEECCCCCC
LADVDEYYVSPKTLYSVSVEQVDLACEQIMKDMELQVASLSAENRLTEAARLYERTVSDL
HHCCHHHHCCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
ELLRLQGYCPGIENYASYLNQRDPKLPPTTLFDYLPKDGLLFIDESHVMVPQISAMYKSD
HHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEECCCEECHHHHHHHHCC
QSRKNTLIDFGFRLPSARNNRPLSFDEFESIKPQTIFVSATPGRYELSKSNSHIFKQIIR
CCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCCEEECCCCHHHHHHHHC
PTGLLDPEIEIRPSENNLKDLVKEIELRVARNERTLVTTLTKKSAEALNDFIAARGIKVS
CCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCEEE
YLHSDVKTNDRVEIINALRAGELDVLIGINLLREGLDIPEASLVAVLDADHAGFLRSEQA
EEECCCCCCCHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHH
LIQIIGRAARNENGKAILYADKMTFAMQKAIDESSERRGHQMLYNMANGIVPSSSKRKLD
HHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SGDQAHVVVGSVDRAKFCESLSELCRQITAKEKELLQLVDEEGAEQAKLIREQLIVLYRQ
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
FIYM
HHCC
>Mature Secondary Structure 
SNSLLSQNKFILHSSYLPSGDQPEAIARLIDGIESGASHQTLKGVTGSGKTFTVANIIH
CCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHH
RLKRPTIILAHNKTLAAQLYSEMRHFFPENAVEFFVSYYDYYQPEVYLPGSDRFIRKDSA
HHCCCEEEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEECCCCCEEECCHH
INAHLERLRLSTTKALIERRDVIVVASVSSVYGLGDPDAYRSLQVKLSLGQAIETEELIE
HHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCHHHCEEEEEEECCCCCCHHHHHH
RLERLQYGRCNRTIKRATFLVRDGAVDIFPADSEHKALTLELDDGHLNKLYWIDAVSGEK
HHHHHHCCHHHHHHHHHEEEEECCCEEEECCCCCCCEEEEEECCCCCCEEEEEECCCCCC
LADVDEYYVSPKTLYSVSVEQVDLACEQIMKDMELQVASLSAENRLTEAARLYERTVSDL
HHCCHHHHCCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
ELLRLQGYCPGIENYASYLNQRDPKLPPTTLFDYLPKDGLLFIDESHVMVPQISAMYKSD
HHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEECCCEECHHHHHHHHCC
QSRKNTLIDFGFRLPSARNNRPLSFDEFESIKPQTIFVSATPGRYELSKSNSHIFKQIIR
CCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCCCEEECCCCHHHHHHHHC
PTGLLDPEIEIRPSENNLKDLVKEIELRVARNERTLVTTLTKKSAEALNDFIAARGIKVS
CCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCEEE
YLHSDVKTNDRVEIINALRAGELDVLIGINLLREGLDIPEASLVAVLDADHAGFLRSEQA
EEECCCCCCCHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCCCEEEEEECCCCCHHHHHHH
LIQIIGRAARNENGKAILYADKMTFAMQKAIDESSERRGHQMLYNMANGIVPSSSKRKLD
HHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SGDQAHVVVGSVDRAKFCESLSELCRQITAKEKELLQLVDEEGAEQAKLIREQLIVLYRQ
CCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
FIYM
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14528314 [H]