Click here to switch to the map view.

The map label for this gene is csrD [H]

Identifier: 167623862

GI number: 167623862

Start: 2320813

End: 2322729

Strand: Reverse

Name: csrD [H]

Synonym: Shal_1932

Alternate gene names: 167623862

Gene position: 2322729-2320813 (Counterclockwise)

Preceding gene: 167623864

Following gene: 167623861

Centisome position: 44.44

GC content: 40.85

Gene sequence:

>1917_bases
ATGACAACCTCTAAACTTTTCCAGTTGTTTTTATTTTTACTTTTTTCAGGGCTTACTTTTTTAAGTTACCAACATGAAAG
ACAAAGTTTAATAGCCCAGGCTGACATAACGCTCAATCAATACGCCAGTCACATTAAGCAACACAAACAATGGCAAGGCA
GTGGTGAAGCTCTCTATAACACGCTCAAACAAGATTATAACTTTCAATTCTTCCAATACATCGATAAATCGGATAGCAGT
AATAATTTCACCAAGGGGCTACTCGTCCCTAAAGATAAAGCTGACCTAACTGAACTATTCACCCTAGAATCTCCTCACAC
TCAAGCTTTAGATGCCGGGCGACTACAAGTCAAACTGTCTAACGTACTCGCTATAGATCACACTGTCGCTCAATTTAAAA
ATCACCTAATGATTATTTGGACTACTTTTCTCTTAATTAGTCTCACTCACTTACTGTTATCCATGAGACAACGCAAAAGC
ATTCATTATATTTCAGTGTACATTGAAAACTTAGCCAACCTCTCTTTCGACGCAATTGAACAGTCCCGCATTAAAGGCGA
ATATAAAGGCATAGGATTGATGCTTGAGAAAAGTAAACAGCGTTTAAAAGCTAAGATAGATGAGTTTGACGCTGCCCATG
AAAAACTGAGCAAAACTGCGTTTCAAGATCCGATAACAGGTTTTGCTACTCGAGCTCTGTTTACAGAAAAGCTCGATGAA
ATTGGTAAAATCGAACGAAAAGAGCAAGGCATTTTAGTGGTCATTAGAGCCACAGAGCTAACCACGATTAATCAGATGCA
CGGAAGAAAGGCCGGTGATGATTACCTTGCACGTATTGCTCACGAGATTAGACGCGCATTTAATGATAAGCCTCATGCCC
TGTGTTATAGGATCTCTACAGCCGATTTCGCCATCGTTATTGCCGAGCTAAGTATCAAACAAGCCGTAACAATTGCCGAA
GGGATCAAGACGGCATTTATCGTGTATCAACAACAAGTTGGCACTGCATCGATTGCTCATATTGGCCTAGTGCCCTACCT
TCAAGATAGTGATCCTGTCTCTTTAATGACCCTATCGGATACCGCAGTCAGTATCGCACAAACCCTAGGGCCCAACAGTT
ATCATGTTCAGGAAAAACTAACGGGAGGAGAACTTTTTGGAGAGAGTCGTTGGAAAGTCGCAATTAACGACCTGTTACGA
CGTAAAGCGATAAAATTTTATGTACAAGCTATACGTCCTTGCCGAAACGATGTTGAATCCTACCGAGAGTTGCTGTCTCG
CTTTTATAATAGCCAAGGCAAATTATTACCAACGACCACAGTTATTGCCATGGCAGAGCGTCATGGCATGAGCGAAGAAA
TAGACAAACTCGTCGTGCTTAACACGATGCGTATACTGCTTGATTACCCTAACCTAAGCGGACTTATCGGGATCAATATT
AGCCCTGCATCTGCCACCAATAAAGCTTTTGTCGCTTGGCTGAAAAATATCTTAACTAGACAGAGGCAAATTGCTGCACG
ATTAGTTTTTGAGGTCAATGAATCAGGAATGCAAACAAATCTGAGTGCGACTTATCACTTTATAAATGAACTACATAGTG
TTGGCTCACGTATATCGATTGAGCGTTTTGGATTGGGGTTTACCTCGTTTAAATTTTTTAAAGAGGTTCGACCTGACTTT
ATCAAACTAGATCATAGTTATACCCAAGGGATCAGCCAAGACCCACATAATAAATTCTTTGTAAAAATGATTATCGATAT
CGCCAGAAAGCTCAGCATTCGAGTGATAGCAACTGGTGTAGAGAAACAAGAAGACCAACTGATTATGGAGCAACTGCTTG
TCGATGGGTTACAGGGCTACTATATCGCGCAACCAACCCCCTTTATGCAAGAAGATAAATTGAAAAGTCTGGCCTGA

Upstream 100 bases:

>100_bases
AAATCCACTGCAATTCAAGAATAAACCTGTTTATAATACATCCAATTAAACCAGCGTAACTCAATATTACGAGTTATTGA
CCGCGTCGAACGGACTCTTT

Downstream 100 bases:

>100_bases
AATTGCTCACTTATAAGGCAAACTTTTTATCCATGCTTTCTATGTGTTGTTAATACCTAAGGAAAAGCTGATAATAGCCT
TAATTCTGTCTAAAAAAATT

Product: diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: Regulator of CsrB and CsrC decay CsrD [H]

Number of amino acids: Translated: 638; Mature: 637

Protein sequence:

>638_residues
MTTSKLFQLFLFLLFSGLTFLSYQHERQSLIAQADITLNQYASHIKQHKQWQGSGEALYNTLKQDYNFQFFQYIDKSDSS
NNFTKGLLVPKDKADLTELFTLESPHTQALDAGRLQVKLSNVLAIDHTVAQFKNHLMIIWTTFLLISLTHLLLSMRQRKS
IHYISVYIENLANLSFDAIEQSRIKGEYKGIGLMLEKSKQRLKAKIDEFDAAHEKLSKTAFQDPITGFATRALFTEKLDE
IGKIERKEQGILVVIRATELTTINQMHGRKAGDDYLARIAHEIRRAFNDKPHALCYRISTADFAIVIAELSIKQAVTIAE
GIKTAFIVYQQQVGTASIAHIGLVPYLQDSDPVSLMTLSDTAVSIAQTLGPNSYHVQEKLTGGELFGESRWKVAINDLLR
RKAIKFYVQAIRPCRNDVESYRELLSRFYNSQGKLLPTTTVIAMAERHGMSEEIDKLVVLNTMRILLDYPNLSGLIGINI
SPASATNKAFVAWLKNILTRQRQIAARLVFEVNESGMQTNLSATYHFINELHSVGSRISIERFGLGFTSFKFFKEVRPDF
IKLDHSYTQGISQDPHNKFFVKMIIDIARKLSIRVIATGVEKQEDQLIMEQLLVDGLQGYYIAQPTPFMQEDKLKSLA

Sequences:

>Translated_638_residues
MTTSKLFQLFLFLLFSGLTFLSYQHERQSLIAQADITLNQYASHIKQHKQWQGSGEALYNTLKQDYNFQFFQYIDKSDSS
NNFTKGLLVPKDKADLTELFTLESPHTQALDAGRLQVKLSNVLAIDHTVAQFKNHLMIIWTTFLLISLTHLLLSMRQRKS
IHYISVYIENLANLSFDAIEQSRIKGEYKGIGLMLEKSKQRLKAKIDEFDAAHEKLSKTAFQDPITGFATRALFTEKLDE
IGKIERKEQGILVVIRATELTTINQMHGRKAGDDYLARIAHEIRRAFNDKPHALCYRISTADFAIVIAELSIKQAVTIAE
GIKTAFIVYQQQVGTASIAHIGLVPYLQDSDPVSLMTLSDTAVSIAQTLGPNSYHVQEKLTGGELFGESRWKVAINDLLR
RKAIKFYVQAIRPCRNDVESYRELLSRFYNSQGKLLPTTTVIAMAERHGMSEEIDKLVVLNTMRILLDYPNLSGLIGINI
SPASATNKAFVAWLKNILTRQRQIAARLVFEVNESGMQTNLSATYHFINELHSVGSRISIERFGLGFTSFKFFKEVRPDF
IKLDHSYTQGISQDPHNKFFVKMIIDIARKLSIRVIATGVEKQEDQLIMEQLLVDGLQGYYIAQPTPFMQEDKLKSLA
>Mature_637_residues
TTSKLFQLFLFLLFSGLTFLSYQHERQSLIAQADITLNQYASHIKQHKQWQGSGEALYNTLKQDYNFQFFQYIDKSDSSN
NFTKGLLVPKDKADLTELFTLESPHTQALDAGRLQVKLSNVLAIDHTVAQFKNHLMIIWTTFLLISLTHLLLSMRQRKSI
HYISVYIENLANLSFDAIEQSRIKGEYKGIGLMLEKSKQRLKAKIDEFDAAHEKLSKTAFQDPITGFATRALFTEKLDEI
GKIERKEQGILVVIRATELTTINQMHGRKAGDDYLARIAHEIRRAFNDKPHALCYRISTADFAIVIAELSIKQAVTIAEG
IKTAFIVYQQQVGTASIAHIGLVPYLQDSDPVSLMTLSDTAVSIAQTLGPNSYHVQEKLTGGELFGESRWKVAINDLLRR
KAIKFYVQAIRPCRNDVESYRELLSRFYNSQGKLLPTTTVIAMAERHGMSEEIDKLVVLNTMRILLDYPNLSGLIGINIS
PASATNKAFVAWLKNILTRQRQIAARLVFEVNESGMQTNLSATYHFINELHSVGSRISIERFGLGFTSFKFFKEVRPDFI
KLDHSYTQGISQDPHNKFFVKMIIDIARKLSIRVIATGVEKQEDQLIMEQLLVDGLQGYYIAQPTPFMQEDKLKSLA

Specific function: Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility ge

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1789650, Length=414, Percent_Identity=22.7053140096618, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1788849, Length=225, Percent_Identity=29.3333333333333, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI87081980, Length=235, Percent_Identity=28.5106382978723, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1787541, Length=430, Percent_Identity=23.0232558139535, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87082096, Length=223, Percent_Identity=26.9058295964126, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786507, Length=249, Percent_Identity=26.5060240963855, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI87081845, Length=248, Percent_Identity=27.0161290322581, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1790496, Length=240, Percent_Identity=26.25, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1787055, Length=216, Percent_Identity=28.7037037037037, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1788502, Length=152, Percent_Identity=28.9473684210526, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI226510982, Length=431, Percent_Identity=20.6496519721578, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI87081921, Length=434, Percent_Identity=21.4285714285714, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI87081743, Length=243, Percent_Identity=20.9876543209877, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF [H]

EC number: NA

Molecular weight: Translated: 72463; Mature: 72331

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSKLFQLFLFLLFSGLTFLSYQHERQSLIAQADITLNQYASHIKQHKQWQGSGEALYN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHH
TLKQDYNFQFFQYIDKSDSSNNFTKGLLVPKDKADLTELFTLESPHTQALDAGRLQVKLS
HHHHCCCCHHHHHHCCCCCCCCCCCCEECCCCCHHHHHHHCCCCCCCHHCCCCEEEEEEH
NVLAIDHTVAQFKNHLMIIWTTFLLISLTHLLLSMRQRKSIHYISVYIENLANLSFDAIE
HEEEHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHH
QSRIKGEYKGIGLMLEKSKQRLKAKIDEFDAAHEKLSKTAFQDPITGFATRALFTEKLDE
HHHHCCHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
IGKIERKEQGILVVIRATELTTINQMHGRKAGDDYLARIAHEIRRAFNDKPHALCYRIST
HHHHHHCCCCEEEEEEECCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECC
ADFAIVIAELSIKQAVTIAEGIKTAFIVYQQQVGTASIAHIGLVPYLQDSDPVSLMTLSD
CCEEEEEEHHHHHHHHHHHHHHHHHHHEEHHHCCCHHHHHHCCCCCCCCCCCEEEEEECH
TAVSIAQTLGPNSYHVQEKLTGGELFGESRWKVAINDLLRRKAIKFYVQAIRPCRNDVES
HHHHHHHHCCCCCEEHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRELLSRFYNSQGKLLPTTTVIAMAERHGMSEEIDKLVVLNTMRILLDYPNLSGLIGINI
HHHHHHHHHCCCCCEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCCEEEEEE
SPASATNKAFVAWLKNILTRQRQIAARLVFEVNESGMQTNLSATYHFINELHSVGSRISI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEH
ERFGLGFTSFKFFKEVRPDFIKLDHSYTQGISQDPHNKFFVKMIIDIARKLSIRVIATGV
HHHCCCHHHHHHHHHCCCHHEEECCHHHCCCCCCCCHHHHHHHHHHHHHHHEEEEEEECC
EKQEDQLIMEQLLVDGLQGYYIAQPTPFMQEDKLKSLA
CCHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHCC
>Mature Secondary Structure 
TTSKLFQLFLFLLFSGLTFLSYQHERQSLIAQADITLNQYASHIKQHKQWQGSGEALYN
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHH
TLKQDYNFQFFQYIDKSDSSNNFTKGLLVPKDKADLTELFTLESPHTQALDAGRLQVKLS
HHHHCCCCHHHHHHCCCCCCCCCCCCEECCCCCHHHHHHHCCCCCCCHHCCCCEEEEEEH
NVLAIDHTVAQFKNHLMIIWTTFLLISLTHLLLSMRQRKSIHYISVYIENLANLSFDAIE
HEEEHHHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHH
QSRIKGEYKGIGLMLEKSKQRLKAKIDEFDAAHEKLSKTAFQDPITGFATRALFTEKLDE
HHHHCCHHCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
IGKIERKEQGILVVIRATELTTINQMHGRKAGDDYLARIAHEIRRAFNDKPHALCYRIST
HHHHHHCCCCEEEEEEECCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECC
ADFAIVIAELSIKQAVTIAEGIKTAFIVYQQQVGTASIAHIGLVPYLQDSDPVSLMTLSD
CCEEEEEEHHHHHHHHHHHHHHHHHHHEEHHHCCCHHHHHHCCCCCCCCCCCEEEEEECH
TAVSIAQTLGPNSYHVQEKLTGGELFGESRWKVAINDLLRRKAIKFYVQAIRPCRNDVES
HHHHHHHHCCCCCEEHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRELLSRFYNSQGKLLPTTTVIAMAERHGMSEEIDKLVVLNTMRILLDYPNLSGLIGINI
HHHHHHHHHCCCCCEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCCEEEEEE
SPASATNKAFVAWLKNILTRQRQIAARLVFEVNESGMQTNLSATYHFINELHSVGSRISI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEH
ERFGLGFTSFKFFKEVRPDFIKLDHSYTQGISQDPHNKFFVKMIIDIARKLSIRVIATGV
HHHCCCHHHHHHHHHCCCHHEEECCHHHCCCCCCCCHHHHHHHHHHHHHHHEEEEEEECC
EKQEDQLIMEQLLVDGLQGYYIAQPTPFMQEDKLKSLA
CCHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 3049542 [H]