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The map label for this gene is metC [H]

Identifier: 167623663

GI number: 167623663

Start: 2075634

End: 2076854

Strand: Reverse

Name: metC [H]

Synonym: Shal_1732

Alternate gene names: 167623663

Gene position: 2076854-2075634 (Counterclockwise)

Preceding gene: 167623664

Following gene: 167623662

Centisome position: 39.73

GC content: 46.85

Gene sequence:

>1221_bases
ATGTTAAGATGGCTAAAAATACAAACTAATGGAATTCGACCGATGAAAAAAGAAACGCAGATAATCAGTCTAGGCCGAGA
TAAGAAATGGACCCAAGGGGTGATTAACCCGCCAGTTTACCGAGCCTCGACGATGGTGTTCGATACCATGGAAGATCTCC
GTTTTGCGGCTAAAAACAAAGCCAACGGCGAACTGTTTTATGGTCGTCGCGGCGGACCCACTCATTTTGCGTTTCAAGCA
GCCATAGCCGAACTCGAAGGCGGCGTAGGTACGGCGCTGTATCCGTCAGGAAGTGCTGCCATCAGTAATAGTCTACTGTC
ATTTTTAAAAGCGGGTGATCATCTGCTTATGGTCGATAGCGTCTATGAGCCCACTCGCGATCTGTGTCATAAATTACTTG
CGGGTTACGGCATCGAAACCACCTATTACGATCCTATGATTGGTGATGGCATCGAAGCGTTAATCCAGCCTAACACCAAG
GTGCTGTTCCTAGAGTCTCCAGGTTCAATCACCATGGAAGTGCAAGATGTGCCAACACTGAGCCGTATAGCCCACCAACA
CGATATCGTGGTGATGCTCGATAATACCTGGGCATCGCCAATAAACTCGCGTCCATTTGAGATGGGCGTCGATATCTCAA
TTCAAGCGGCGACAAAGTACATTGTTGGTCATTCAGATGTGATGATGGGCACCGCCACCGCGAACGAAAAACATTGGGAA
CAACTACGAGAAAATAGTTACCTGCTTGGTCAATGCACCTCACCAGATGATGTATACCTTGCTAGCCGAGGGCTGAGGAC
CTTGGGTATTCGTTTAGCCCAGCATGAACAAAATGCATTAAAAGTGGCTAACTGGCTTGCTAGTCGCCCTGAAGTGGATC
ATCTGCGTCACCCCGCTTTTGAGTCATGCCCTGGCCATGAGTTTTTTAAACGCGATTTTAGCGCGTCAAACGGACTGTTT
TCGTTTGTCTTAAAACAAGGCGATGTTCACTCGGTCACTGCATTCGTTGAAAATATGCAGCATTTTAAAATGGGCTTTTC
TTGGGGCGGATTTGAAAGCTTAATTTTAGGGGTATTTGGCATCGACAAACTACGTACAGCAACACAATGGGACAGTAGTA
AGCCACTTATCCGTTTGCATATTGGTCTTGAAAATGTCGATGACCTGATTGCCGATCTTGAGGCTGCCTTTGAGCGCTAC
AATCGAGTATTGAACGCTTAA

Upstream 100 bases:

>100_bases
GTCTTTAAAAGTGTTAGGCCTGTTTCAAACAATGGCAAAATTGAAAACTGCTCCTGAAAGCGAATGTTGAAGATAATGAC
ACTTTATTTTGGCCGTTTAG

Downstream 100 bases:

>100_bases
AGCTCTGGTTAAGTTCACTCCTAGCTCAGACTAAGTTAAGGCAAAGCTCACTCTTAGTTCAGACAAAGCTCTCCCGCCAC
AAGCCGACCTCTAACGTCGG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MLRWLKIQTNGIRPMKKETQIISLGRDKKWTQGVINPPVYRASTMVFDTMEDLRFAAKNKANGELFYGRRGGPTHFAFQA
AIAELEGGVGTALYPSGSAAISNSLLSFLKAGDHLLMVDSVYEPTRDLCHKLLAGYGIETTYYDPMIGDGIEALIQPNTK
VLFLESPGSITMEVQDVPTLSRIAHQHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMMGTATANEKHWE
QLRENSYLLGQCTSPDDVYLASRGLRTLGIRLAQHEQNALKVANWLASRPEVDHLRHPAFESCPGHEFFKRDFSASNGLF
SFVLKQGDVHSVTAFVENMQHFKMGFSWGGFESLILGVFGIDKLRTATQWDSSKPLIRLHIGLENVDDLIADLEAAFERY
NRVLNA

Sequences:

>Translated_406_residues
MLRWLKIQTNGIRPMKKETQIISLGRDKKWTQGVINPPVYRASTMVFDTMEDLRFAAKNKANGELFYGRRGGPTHFAFQA
AIAELEGGVGTALYPSGSAAISNSLLSFLKAGDHLLMVDSVYEPTRDLCHKLLAGYGIETTYYDPMIGDGIEALIQPNTK
VLFLESPGSITMEVQDVPTLSRIAHQHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMMGTATANEKHWE
QLRENSYLLGQCTSPDDVYLASRGLRTLGIRLAQHEQNALKVANWLASRPEVDHLRHPAFESCPGHEFFKRDFSASNGLF
SFVLKQGDVHSVTAFVENMQHFKMGFSWGGFESLILGVFGIDKLRTATQWDSSKPLIRLHIGLENVDDLIADLEAAFERY
NRVLNA
>Mature_406_residues
MLRWLKIQTNGIRPMKKETQIISLGRDKKWTQGVINPPVYRASTMVFDTMEDLRFAAKNKANGELFYGRRGGPTHFAFQA
AIAELEGGVGTALYPSGSAAISNSLLSFLKAGDHLLMVDSVYEPTRDLCHKLLAGYGIETTYYDPMIGDGIEALIQPNTK
VLFLESPGSITMEVQDVPTLSRIAHQHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMMGTATANEKHWE
QLRENSYLLGQCTSPDDVYLASRGLRTLGIRLAQHEQNALKVANWLASRPEVDHLRHPAFESCPGHEFFKRDFSASNGLF
SFVLKQGDVHSVTAFVENMQHFKMGFSWGGFESLILGVFGIDKLRTATQWDSSKPLIRLHIGLENVDDLIADLEAAFERY
NRVLNA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=339, Percent_Identity=35.3982300884956, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI299473759, Length=339, Percent_Identity=32.4483775811209, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI25453487, Length=338, Percent_Identity=31.0650887573964, Blast_Score=156, Evalue=4e-38,
Organism=Escherichia coli, GI1789383, Length=389, Percent_Identity=52.9562982005141, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI1790375, Length=392, Percent_Identity=30.3571428571429, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71980708, Length=371, Percent_Identity=33.6927223719677, Blast_Score=217, Evalue=9e-57,
Organism=Caenorhabditis elegans, GI17538055, Length=341, Percent_Identity=33.4310850439883, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17560056, Length=376, Percent_Identity=31.6489361702128, Blast_Score=179, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6321170, Length=333, Percent_Identity=48.6486486486487, Blast_Score=324, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6319307, Length=362, Percent_Identity=31.4917127071823, Blast_Score=166, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6321904, Length=386, Percent_Identity=25.9067357512953, Blast_Score=109, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6323333, Length=420, Percent_Identity=25.7142857142857, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6321254, Length=420, Percent_Identity=26.1904761904762, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19922554, Length=402, Percent_Identity=33.5820895522388, Blast_Score=213, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 45280; Mature: 45280

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRWLKIQTNGIRPMKKETQIISLGRDKKWTQGVINPPVYRASTMVFDTMEDLRFAAKNK
CCEEEEEECCCCCCCCCCCCEEECCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
ANGELFYGRRGGPTHFAFQAAIAELEGGVGTALYPSGSAAISNSLLSFLKAGDHLLMVDS
CCCCEEECCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEECC
VYEPTRDLCHKLLAGYGIETTYYDPMIGDGIEALIQPNTKVLFLESPGSITMEVQDVPTL
CCCHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHCCCCCEEEEEECCCCEEEEEECCCHH
SRIAHQHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMMGTATANEKHWE
HHHHCCCCEEEEECCCCCCCCCCCCCEECCCEEEEEHHEEEECCCCEEEEECCCCHHHHH
QLRENSYLLGQCTSPDDVYLASRGLRTLGIRLAQHEQNALKVANWLASRPEVDHLRHPAF
HHHHCCEEEEECCCCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCC
ESCPGHEFFKRDFSASNGLFSFVLKQGDVHSVTAFVENMQHFKMGFSWGGFESLILGVFG
CCCCCHHHHHHHCCCCCCHHEEHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
IDKLRTATQWDSSKPLIRLHIGLENVDDLIADLEAAFERYNRVLNA
HHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLRWLKIQTNGIRPMKKETQIISLGRDKKWTQGVINPPVYRASTMVFDTMEDLRFAAKNK
CCEEEEEECCCCCCCCCCCCEEECCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
ANGELFYGRRGGPTHFAFQAAIAELEGGVGTALYPSGSAAISNSLLSFLKAGDHLLMVDS
CCCCEEECCCCCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEECC
VYEPTRDLCHKLLAGYGIETTYYDPMIGDGIEALIQPNTKVLFLESPGSITMEVQDVPTL
CCCHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHCCCCCEEEEEECCCCEEEEEECCCHH
SRIAHQHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMMGTATANEKHWE
HHHHCCCCEEEEECCCCCCCCCCCCCEECCCEEEEEHHEEEECCCCEEEEECCCCHHHHH
QLRENSYLLGQCTSPDDVYLASRGLRTLGIRLAQHEQNALKVANWLASRPEVDHLRHPAF
HHHHCCEEEEECCCCCCEEHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCC
ESCPGHEFFKRDFSASNGLFSFVLKQGDVHSVTAFVENMQHFKMGFSWGGFESLILGVFG
CCCCCHHHHHHHCCCCCCHHEEHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
IDKLRTATQWDSSKPLIRLHIGLENVDDLIADLEAAFERYNRVLNA
HHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3513164; 9278503; 3307782; 8831789 [H]