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The map label for this gene is guaB [H]

Identifier: 167623308

GI number: 167623308

Start: 1655008

End: 1656480

Strand: Direct

Name: guaB [H]

Synonym: Shal_1376

Alternate gene names: 167623308

Gene position: 1655008-1656480 (Clockwise)

Preceding gene: 167623305

Following gene: 167623309

Centisome position: 31.66

GC content: 45.96

Gene sequence:

>1473_bases
ATGTTAAGATTGAAAAAAGAAGCGTTAACTTTTGATGATGTGTTGCTGGTTCCGGCACACTCTACCGTCCTCCCAAATAC
AGCTGTTTTAAAAACACGCCTGACGAATAAGATTGAGTTGAATACTCCGATCGTTTCTGCTGCTATGGATACTGTTACTG
AAGCTCGCTTGGCAATTGCTATTGCGCAAGAAGGTGGCTTAGGTTTTATCCATAAAAACATGACGATTGAGCAACAAGCT
GAAGAAGTTCGCAAAGTAAAAATTTACGAAGCGGGCATCGTTCAGCAGCCAGTGACCGTGACTCCTACTACTACACTAGC
CGATCTTAAGTTATTGACTGAGAAAAATGGTTTCGCAGGTTACCCTGTAGTAAACGAAGCTAACGAATTAGTGGGTATCA
TTACTGGTCGTGACGTACGCTTTATCACTGACTGGTCTCGTACGGTTGACCAAGTGATGACACCTAAAGAGCGCCTAGTG
ACAGTTCTAGAAGGGACTAAACTGGATGAAGTTCAAAAGCTGATGCATTCTCACCGTGTTGAGAAAGTTTTGGTTGTTGA
TGATAACTTCAAGCTTAAAGGCCTTATCACAGTAAAAGATTTCCAAAAAGCTGAGCGTAAGCCAAACGCATGTAAAGACG
AGTTAGGTCGTTTACGTGTTGGCGCTGCTGTTGGTGCGGGCCCGGGTAACGAAGCGCGTGTTGACGCACTGGTACTCGCT
GGTGTTGATATCTTGCTTATTGACTCATCACACGGACATTCAGAAGGCGTTTTACAACGTATTCGTGATACGCGTGCTAA
ATATCCTGACTTACAGATTGTGGGCGGTAACGTCGCGACGGCTGAAGGTGCAATCGCACTGGTTGAAGCGGGCGTAAACG
CAGTTAAAGTGGGTATTGGTCCTGGCTCTATCTGTACGACTCGTATCGTAACAGGTGTGGGTGTACCACAAATTACAGCA
GTATCTGATGCTGCTGCTGCGGTTAAACACCTTGATATCCCAGTGATTGCCGATGGCGGTATTCGTTTCTCTGGTGACCT
AGCTAAAGCATTAGCAGCGGGTGCATCATGCATCATGGCGGGTTCTATGTTTGCTGGTACTGAAGAAGCTCCGGGTGAAA
CTGAGCTATATAACGGCCGCGCTTATAAGTCATACCGTGGTATGGGTTCACTAGGTGCAATGACACAGACTCAAGGTTCG
TCTGACCGTTATTTCCAAAGTGATAACGCTGCAGACAAGCTAGTACCTGAAGGTATTGAAGGTCGTGTTGCTTACAAAGG
TAAGCTAAAAGAGATCATTCACCAGCACATGGGCGGTTTACGTTCATGCATGGGCCTAACGGGTTGTGCAACCATTAAAG
AGCTAAACGAGAAAGCGGAATTTGTTAAAATCACTGCAGCGGGTATGGGCGAGTCTCATGTTCACGACGTGACTATCAGC
AAAGAAGCGCCTAACTATAGCCCTCGTTCTTAA

Upstream 100 bases:

>100_bases
CGAATTAATGTCTATTTTCCATTTACCAACCCATATATGCAAGGTATAATCTCGCCGCAATATTTCACCTCTAATTCCTA
ATCTCTTGGGGAGATGTTGC

Downstream 100 bases:

>100_bases
TTAGAGTTTTTAGATATTAAAGGCGACAGATAAAGTCGCCTTTAAATTAAGCCAAGTAGAAGGTTCGCAGAGTACTCACT
GCTTGGTTAGTTAACAATGA

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MLRLKKEALTFDDVLLVPAHSTVLPNTAVLKTRLTNKIELNTPIVSAAMDTVTEARLAIAIAQEGGLGFIHKNMTIEQQA
EEVRKVKIYEAGIVQQPVTVTPTTTLADLKLLTEKNGFAGYPVVNEANELVGIITGRDVRFITDWSRTVDQVMTPKERLV
TVLEGTKLDEVQKLMHSHRVEKVLVVDDNFKLKGLITVKDFQKAERKPNACKDELGRLRVGAAVGAGPGNEARVDALVLA
GVDILLIDSSHGHSEGVLQRIRDTRAKYPDLQIVGGNVATAEGAIALVEAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAAAAVKHLDIPVIADGGIRFSGDLAKALAAGASCIMAGSMFAGTEEAPGETELYNGRAYKSYRGMGSLGAMTQTQGS
SDRYFQSDNAADKLVPEGIEGRVAYKGKLKEIIHQHMGGLRSCMGLTGCATIKELNEKAEFVKITAAGMGESHVHDVTIS
KEAPNYSPRS

Sequences:

>Translated_490_residues
MLRLKKEALTFDDVLLVPAHSTVLPNTAVLKTRLTNKIELNTPIVSAAMDTVTEARLAIAIAQEGGLGFIHKNMTIEQQA
EEVRKVKIYEAGIVQQPVTVTPTTTLADLKLLTEKNGFAGYPVVNEANELVGIITGRDVRFITDWSRTVDQVMTPKERLV
TVLEGTKLDEVQKLMHSHRVEKVLVVDDNFKLKGLITVKDFQKAERKPNACKDELGRLRVGAAVGAGPGNEARVDALVLA
GVDILLIDSSHGHSEGVLQRIRDTRAKYPDLQIVGGNVATAEGAIALVEAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAAAAVKHLDIPVIADGGIRFSGDLAKALAAGASCIMAGSMFAGTEEAPGETELYNGRAYKSYRGMGSLGAMTQTQGS
SDRYFQSDNAADKLVPEGIEGRVAYKGKLKEIIHQHMGGLRSCMGLTGCATIKELNEKAEFVKITAAGMGESHVHDVTIS
KEAPNYSPRS
>Mature_490_residues
MLRLKKEALTFDDVLLVPAHSTVLPNTAVLKTRLTNKIELNTPIVSAAMDTVTEARLAIAIAQEGGLGFIHKNMTIEQQA
EEVRKVKIYEAGIVQQPVTVTPTTTLADLKLLTEKNGFAGYPVVNEANELVGIITGRDVRFITDWSRTVDQVMTPKERLV
TVLEGTKLDEVQKLMHSHRVEKVLVVDDNFKLKGLITVKDFQKAERKPNACKDELGRLRVGAAVGAGPGNEARVDALVLA
GVDILLIDSSHGHSEGVLQRIRDTRAKYPDLQIVGGNVATAEGAIALVEAGVNAVKVGIGPGSICTTRIVTGVGVPQITA
VSDAAAAVKHLDIPVIADGGIRFSGDLAKALAAGASCIMAGSMFAGTEEAPGETELYNGRAYKSYRGMGSLGAMTQTQGS
SDRYFQSDNAADKLVPEGIEGRVAYKGKLKEIIHQHMGGLRSCMGLTGCATIKELNEKAEFVKITAAGMGESHVHDVTIS
KEAPNYSPRS

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=39.8340248962656, Blast_Score=329, Evalue=4e-90,
Organism=Homo sapiens, GI34328930, Length=480, Percent_Identity=39.1666666666667, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI217035146, Length=480, Percent_Identity=39.1666666666667, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI34328928, Length=480, Percent_Identity=39.1666666666667, Blast_Score=326, Evalue=4e-89,
Organism=Homo sapiens, GI156616279, Length=480, Percent_Identity=39.1666666666667, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI217035152, Length=486, Percent_Identity=38.8888888888889, Blast_Score=320, Evalue=1e-87,
Organism=Homo sapiens, GI217035148, Length=480, Percent_Identity=38.125, Blast_Score=311, Evalue=9e-85,
Organism=Homo sapiens, GI217035150, Length=480, Percent_Identity=35.625, Blast_Score=283, Evalue=3e-76,
Organism=Homo sapiens, GI156104880, Length=248, Percent_Identity=37.9032258064516, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI50541956, Length=249, Percent_Identity=36.144578313253, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI50541954, Length=249, Percent_Identity=36.5461847389558, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI50541952, Length=249, Percent_Identity=36.5461847389558, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI50541948, Length=249, Percent_Identity=36.5461847389558, Blast_Score=156, Evalue=3e-38,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=79.0123456790123, Blast_Score=723, Evalue=0.0,
Organism=Escherichia coli, GI1786293, Length=223, Percent_Identity=35.8744394618834, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=477, Percent_Identity=36.0587002096436, Blast_Score=269, Evalue=3e-72,
Organism=Caenorhabditis elegans, GI71994389, Length=422, Percent_Identity=38.3886255924171, Blast_Score=259, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17560440, Length=276, Percent_Identity=33.695652173913, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323585, Length=483, Percent_Identity=39.7515527950311, Blast_Score=340, Evalue=3e-94,
Organism=Saccharomyces cerevisiae, GI6323464, Length=482, Percent_Identity=39.8340248962656, Blast_Score=322, Evalue=8e-89,
Organism=Saccharomyces cerevisiae, GI6322012, Length=482, Percent_Identity=37.9668049792531, Blast_Score=321, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=38.7573964497041, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6319353, Length=122, Percent_Identity=38.5245901639344, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=38.9233954451346, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=38.9233954451346, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=39.6825396825397, Blast_Score=283, Evalue=1e-76,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52211; Mature: 52211

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRLKKEALTFDDVLLVPAHSTVLPNTAVLKTRLTNKIELNTPIVSAAMDTVTEARLAIA
CCEECCHHCCCCCEEEEECCCCCCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHCEEEEE
IAQEGGLGFIHKNMTIEQQAEEVRKVKIYEAGIVQQPVTVTPTTTLADLKLLTEKNGFAG
EECCCCEEEEECCCCHHHHHHHHHEEEEEECCCCCCCEEECCCCHHHHEEEEECCCCCCC
YPVVNEANELVGIITGRDVRFITDWSRTVDQVMTPKERLVTVLEGTKLDEVQKLMHSHRV
CCCCCCCCCEEEEEECCCEEEEECHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCC
EKVLVVDDNFKLKGLITVKDFQKAERKPNACKDELGRLRVGAAVGAGPGNEARVDALVLA
CEEEEECCCEEEEEEEEEHHHHHHHCCCCHHHHHHCCEEECEEECCCCCCCHHEEEEEEE
GVDILLIDSSHGHSEGVLQRIRDTRAKYPDLQIVGGNVATAEGAIALVEAGVNAVKVGIG
CCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCEEECCCCEEEEECCCCEEEEECC
PGSICTTRIVTGVGVPQITAVSDAAAAVKHLDIPVIADGGIRFSGDLAKALAAGASCIMA
CCCHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCEEEECCCEEECHHHHHHHHCCCHHEEE
GSMFAGTEEAPGETELYNGRAYKSYRGMGSLGAMTQTQGSSDRYFQSDNAADKLVPEGIE
CCCCCCCCCCCCCCEEECCCCCHHHCCCCCCCCCCCCCCCCCCEECCCCCHHHCCCCCCC
GRVAYKGKLKEIIHQHMGGLRSCMGLTGCATIKELNEKAEFVKITAAGMGESHVHDVTIS
CEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEEE
KEAPNYSPRS
CCCCCCCCCC
>Mature Secondary Structure
MLRLKKEALTFDDVLLVPAHSTVLPNTAVLKTRLTNKIELNTPIVSAAMDTVTEARLAIA
CCEECCHHCCCCCEEEEECCCCCCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHCEEEEE
IAQEGGLGFIHKNMTIEQQAEEVRKVKIYEAGIVQQPVTVTPTTTLADLKLLTEKNGFAG
EECCCCEEEEECCCCHHHHHHHHHEEEEEECCCCCCCEEECCCCHHHHEEEEECCCCCCC
YPVVNEANELVGIITGRDVRFITDWSRTVDQVMTPKERLVTVLEGTKLDEVQKLMHSHRV
CCCCCCCCCEEEEEECCCEEEEECHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHCCC
EKVLVVDDNFKLKGLITVKDFQKAERKPNACKDELGRLRVGAAVGAGPGNEARVDALVLA
CEEEEECCCEEEEEEEEEHHHHHHHCCCCHHHHHHCCEEECEEECCCCCCCHHEEEEEEE
GVDILLIDSSHGHSEGVLQRIRDTRAKYPDLQIVGGNVATAEGAIALVEAGVNAVKVGIG
CCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEECCCEEECCCCEEEEECCCCEEEEECC
PGSICTTRIVTGVGVPQITAVSDAAAAVKHLDIPVIADGGIRFSGDLAKALAAGASCIMA
CCCHHHHHHHHCCCCCCEEEHHHHHHHHHHCCCEEEECCCEEECHHHHHHHHCCCHHEEE
GSMFAGTEEAPGETELYNGRAYKSYRGMGSLGAMTQTQGSSDRYFQSDNAADKLVPEGIE
CCCCCCCCCCCCCCEEECCCCCHHHCCCCCCCCCCCCCCCCCCEECCCCCHHHCCCCCCC
GRVAYKGKLKEIIHQHMGGLRSCMGLTGCATIKELNEKAEFVKITAAGMGESHVHDVTIS
CEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEEE
KEAPNYSPRS
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]