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The map label for this gene is gltT [H]

Identifier: 167623173

GI number: 167623173

Start: 1508834

End: 1510084

Strand: Reverse

Name: gltT [H]

Synonym: Shal_1239

Alternate gene names: 167623173

Gene position: 1510084-1508834 (Counterclockwise)

Preceding gene: 167623178

Following gene: 167623172

Centisome position: 28.89

GC content: 46.76

Gene sequence:

>1251_bases
ATGTGGCAAACAATTAAAAATATCCCATTTTGGCAAAAAGTATTAGCTGCCTTTATCTTAGGTGCTGGCGTCGGTGTCAT
TTTCGGCGAATCAGCAACAGTACTAAAACCGCTGGGCGATCTATTTATTAGTGCGATTAAGATGTTAGTCGCGCCGCTAA
TTTTCTGCGCCATCGTTGTCAGTATCACTTCTTTAGGCTCTGAAGTCAGTTTAAAGAGACTGAGCTTTAAAACCTTAGCC
ATGTTCATGTTTACTGGCACCATCGCTTCACTGATTGGCTTAACTATCGGCTCAGTTATCGACATGGGCGGCTCGATGGA
ACTTGTTGCTACTGAAGTTCGTGAGCGAAATGTACCAGGCTTTGCTCAGGTGCTTCTAGATATGATCCCTGTGAATCCAT
TTGCCTCTCTTGCTGAGGGTAAGGTACTGCAGATCATCATATTTGCCGCTTTGATTGGTGTTGCGATTAATAAAGTTGGC
GAAAAAGCTGAGCCCTTAAAACGCACTATAGAAGCCGGTGCAGAAGTCATGTTCCAGTTAACCCGTATGGTGCTACAACT
TACTCCAATTGGTGTATTTGGTTTAATGGCTTGGGTTGTAGGTGAATACGGCTTATCGACTCTACTGCCACTGGGTAAAT
TTATCGGTGCTATTTATCTTGCTGCATTTATCCACATTATCTTCGTTTACGGTGGCTTGATTAAGTTTGCCGCTAAGCTA
AGTCCTGTTCAATTTTTCCGTAAGGCAATACCAGCACAAATAGTGGCATTTACCACAGCGTCAAGTTTTGGCACCCTGCC
GGCAAGTACTCGTTGCACCGAGTCTATGGGCGTTTCTAAGCGTTATGGCTCTTTTGTTTTGCCCTTAGGCGCCACCATGA
ACATGGATGGCTGTGGTGGTATTTACCCTGCAATTGCCGCGATTTTCATTGCGCAGATCTACGGTATCCCACTGGATATG
ACCGACTATATGCTTATCGCCGTGACGGCAACAGTGGCTTCAGTCGGTACCGCAGGCGTGCCGGGGAGTGCCATGGTGAT
GCTAACGGTAACCTTAGGTGTTGTAGGCTTGCCGCTCGAAGGTATCGCCTTTATCGCAGCAGTTGACCGTATCATCGATA
TGATCCGCACCGCCACTAACGTCACAGGCGACATGATGACAGCCGTTGTTATTGGTAAGTCAGAAGGGCAGCTCGATGAG
GCGCAGTTTTATGCACAAGAAAACGCTCCGCTAGAGCAGGCCAGTAACTAA

Upstream 100 bases:

>100_bases
ATGTAAATATTGATAGCGATTGCCTAAAACTAACACTGGAGTGAACAAAGATTCACCCGTAAAGTAACTTTAGAAAACTA
AAATAGTTGGAATTTCGATA

Downstream 100 bases:

>100_bases
ACAGCGTTTTTCATCGAATAAAAAGGCCGCAATCGCGGCCTTTTTAATTTATACTTTTCAATATTCTACAAAAATAACAC
CTTATTGGGGCGCTTAGATA

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MWQTIKNIPFWQKVLAAFILGAGVGVIFGESATVLKPLGDLFISAIKMLVAPLIFCAIVVSITSLGSEVSLKRLSFKTLA
MFMFTGTIASLIGLTIGSVIDMGGSMELVATEVRERNVPGFAQVLLDMIPVNPFASLAEGKVLQIIIFAALIGVAINKVG
EKAEPLKRTIEAGAEVMFQLTRMVLQLTPIGVFGLMAWVVGEYGLSTLLPLGKFIGAIYLAAFIHIIFVYGGLIKFAAKL
SPVQFFRKAIPAQIVAFTTASSFGTLPASTRCTESMGVSKRYGSFVLPLGATMNMDGCGGIYPAIAAIFIAQIYGIPLDM
TDYMLIAVTATVASVGTAGVPGSAMVMLTVTLGVVGLPLEGIAFIAAVDRIIDMIRTATNVTGDMMTAVVIGKSEGQLDE
AQFYAQENAPLEQASN

Sequences:

>Translated_416_residues
MWQTIKNIPFWQKVLAAFILGAGVGVIFGESATVLKPLGDLFISAIKMLVAPLIFCAIVVSITSLGSEVSLKRLSFKTLA
MFMFTGTIASLIGLTIGSVIDMGGSMELVATEVRERNVPGFAQVLLDMIPVNPFASLAEGKVLQIIIFAALIGVAINKVG
EKAEPLKRTIEAGAEVMFQLTRMVLQLTPIGVFGLMAWVVGEYGLSTLLPLGKFIGAIYLAAFIHIIFVYGGLIKFAAKL
SPVQFFRKAIPAQIVAFTTASSFGTLPASTRCTESMGVSKRYGSFVLPLGATMNMDGCGGIYPAIAAIFIAQIYGIPLDM
TDYMLIAVTATVASVGTAGVPGSAMVMLTVTLGVVGLPLEGIAFIAAVDRIIDMIRTATNVTGDMMTAVVIGKSEGQLDE
AQFYAQENAPLEQASN
>Mature_416_residues
MWQTIKNIPFWQKVLAAFILGAGVGVIFGESATVLKPLGDLFISAIKMLVAPLIFCAIVVSITSLGSEVSLKRLSFKTLA
MFMFTGTIASLIGLTIGSVIDMGGSMELVATEVRERNVPGFAQVLLDMIPVNPFASLAEGKVLQIIIFAALIGVAINKVG
EKAEPLKRTIEAGAEVMFQLTRMVLQLTPIGVFGLMAWVVGEYGLSTLLPLGKFIGAIYLAAFIHIIFVYGGLIKFAAKL
SPVQFFRKAIPAQIVAFTTASSFGTLPASTRCTESMGVSKRYGSFVLPLGATMNMDGCGGIYPAIAAIFIAQIYGIPLDM
TDYMLIAVTATVASVGTAGVPGSAMVMLTVTLGVVGLPLEGIAFIAAVDRIIDMIRTATNVTGDMMTAVVIGKSEGQLDE
AQFYAQENAPLEQASN

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=436, Percent_Identity=29.3577981651376, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4827012, Length=291, Percent_Identity=34.7079037800687, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI40254478, Length=277, Percent_Identity=35.7400722021661, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI194239697, Length=287, Percent_Identity=33.1010452961672, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI66773030, Length=271, Percent_Identity=33.5793357933579, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI169790839, Length=412, Percent_Identity=30.3398058252427, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI223468566, Length=304, Percent_Identity=32.8947368421053, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI223468564, Length=270, Percent_Identity=34.0740740740741, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI5032093, Length=283, Percent_Identity=34.2756183745583, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI301601644, Length=183, Percent_Identity=36.0655737704918, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI262359914, Length=340, Percent_Identity=27.9411764705882, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1790514, Length=431, Percent_Identity=36.1948955916473, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1789947, Length=404, Percent_Identity=32.6732673267327, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1788024, Length=422, Percent_Identity=30.8056872037915, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1789473, Length=373, Percent_Identity=23.0563002680965, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71983106, Length=412, Percent_Identity=31.0679611650485, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI71983099, Length=412, Percent_Identity=31.0679611650485, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71996953, Length=427, Percent_Identity=29.03981264637, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17537407, Length=385, Percent_Identity=30.9090909090909, Blast_Score=147, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI193206505, Length=419, Percent_Identity=26.7303102625298, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI193206654, Length=422, Percent_Identity=28.436018957346, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17541374, Length=392, Percent_Identity=26.7857142857143, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24583025, Length=425, Percent_Identity=25.8823529411765, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17137668, Length=425, Percent_Identity=25.8823529411765, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24583023, Length=425, Percent_Identity=25.8823529411765, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI281360483, Length=447, Percent_Identity=26.6219239373602, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI17137666, Length=447, Percent_Identity=26.6219239373602, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI281360481, Length=447, Percent_Identity=26.6219239373602, Blast_Score=101, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43945; Mature: 43945

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEECCCCCCHHHHHHHHCCCCHHCCCC
>Mature Secondary Structure
MWQTIKNIPFWQKVLAAFILGAGVGVIFGESATVLKPLGDLFISAIKMLVAPLIFCAIVV
CCCCCCCCCHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SITSLGSEVSLKRLSFKTLAMFMFTGTIASLIGLTIGSVIDMGGSMELVATEVRERNVPG
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCH
FAQVLLDMIPVNPFASLAEGKVLQIIIFAALIGVAINKVGEKAEPLKRTIEAGAEVMFQL
HHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
TRMVLQLTPIGVFGLMAWVVGEYGLSTLLPLGKFIGAIYLAAFIHIIFVYGGLIKFAAKL
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SPVQFFRKAIPAQIVAFTTASSFGTLPASTRCTESMGVSKRYGSFVLPLGATMNMDGCGG
CHHHHHHHHCCHHHHHEEECCCCCCCCCCCHHHHHCCCHHHCCCEEEECCCEECCCCCCC
IYPAIAAIFIAQIYGIPLDMTDYMLIAVTATVASVGTAGVPGSAMVMLTVTLGVVGLPLE
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHH
GIAFIAAVDRIIDMIRTATNVTGDMMTAVVIGKSEGQLDEAQFYAQENAPLEQASN
HHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEECCCCCCHHHHHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]