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The map label for this gene is lspA

Identifier: 167623066

GI number: 167623066

Start: 1376891

End: 1377403

Strand: Direct

Name: lspA

Synonym: Shal_1132

Alternate gene names: 167623066

Gene position: 1376891-1377403 (Clockwise)

Preceding gene: 167623065

Following gene: 167623067

Centisome position: 26.34

GC content: 43.47

Gene sequence:

>513_bases
ATGCCAACTAACTGGAAAGACAGTGGTCTGCGTTGGTATTGGGTAGTCGTGTTGGTGTTTGTTGCCGATCAACTATCTAA
GCAGTGGGTGTTGTCGAATTTTGAACTTTACGAGTCGATACAGTTATTGCCCATTTTTAACTTTACCTATGTGCGCAACT
ATGGCGCTGCATTTAGCTTTTTAAGCGATGCTGGTGGCTGGCAACGTTGGTTGTTCACCTTCGTTGCGGTTGGCTTTAGC
GTAGTGTTATCAGTTTGGCTGCGTCAGCAGCCAAGCAAGATGTGGCGCTTAAACTTAGCCTATACCTTAGTGATTGGTGG
TGCGTTAGGTAACTTAATTGATCGTCTGCAGCATGGCTTTGTGGTCGACTTTTTAGATTTTTATTGGAATACCAGTCACT
TCCCAGCATTTAATATCGCCGATTCGGCAATTTGTGTGGGCGCAGCACTTATCATCTTAGACTCATTTGTTACGGGTAAA
GATGATAAAAAAACTGATGGTATAAAGGAGTAG

Upstream 100 bases:

>100_bases
TAGGAGCCGTTGTTTTTTTTGTGTTCTAATTTTACATTTTTAAGAGAGACATCTCTTAAAGCTATGGCAAAACAATATTC
AGATTGAGAAGGAATGATAG

Downstream 100 bases:

>100_bases
CTCAAGTGTCAGAGATGCATTCAATTTTATGTCATATGAATATCGTGCTTGAAGACGGCTCCACCGCTGAAAGCACACGC
TCAAGTGGCAAGCCTGCAAG

Product: lipoprotein signal peptidase

Products: NA

Alternate protein names: Prolipoprotein signal peptidase; Signal peptidase II; SPase II

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MPTNWKDSGLRWYWVVVLVFVADQLSKQWVLSNFELYESIQLLPIFNFTYVRNYGAAFSFLSDAGGWQRWLFTFVAVGFS
VVLSVWLRQQPSKMWRLNLAYTLVIGGALGNLIDRLQHGFVVDFLDFYWNTSHFPAFNIADSAICVGAALIILDSFVTGK
DDKKTDGIKE

Sequences:

>Translated_170_residues
MPTNWKDSGLRWYWVVVLVFVADQLSKQWVLSNFELYESIQLLPIFNFTYVRNYGAAFSFLSDAGGWQRWLFTFVAVGFS
VVLSVWLRQQPSKMWRLNLAYTLVIGGALGNLIDRLQHGFVVDFLDFYWNTSHFPAFNIADSAICVGAALIILDSFVTGK
DDKKTDGIKE
>Mature_169_residues
PTNWKDSGLRWYWVVVLVFVADQLSKQWVLSNFELYESIQLLPIFNFTYVRNYGAAFSFLSDAGGWQRWLFTFVAVGFSV
VLSVWLRQQPSKMWRLNLAYTLVIGGALGNLIDRLQHGFVVDFLDFYWNTSHFPAFNIADSAICVGAALIILDSFVTGKD
DKKTDGIKE

Specific function: This protein specifically catalyzes the removal of signal peptides from prolipoproteins

COG id: COG0597

COG function: function code MU; Lipoprotein signal peptidase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A8 family

Homologues:

Organism=Escherichia coli, GI1786210, Length=164, Percent_Identity=52.4390243902439, Blast_Score=178, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LSPA_SHEHH (B0TJB0)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001673360.1
- MEROPS:   A08.001
- GeneID:   5905897
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_1132
- HOGENOM:   HBG724422
- OMA:   ADSSGWQ
- ProtClustDB:   PRK00376
- BioCyc:   SHAL458817:SHAL_1132-MONOMER
- GO:   GO:0006508
- HAMAP:   MF_00161
- InterPro:   IPR001872
- PRINTS:   PR00781
- TIGRFAMs:   TIGR00077

Pfam domain/function: PF01252 Peptidase_A8

EC number: =3.4.23.36

Molecular weight: Translated: 19464; Mature: 19332

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00855 SPASE_II

Important sites: ACT_SITE 114-114 ACT_SITE 141-141

Signals:

None

Transmembrane regions:

HASH(0x1efd9620)-; HASH(0x1ff277a8)-; HASH(0x206d7398)-; HASH(0x206454c4)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTNWKDSGLRWYWVVVLVFVADQLSKQWVLSNFELYESIQLLPIFNFTYVRNYGAAFSF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHH
LSDAGGWQRWLFTFVAVGFSVVLSVWLRQQPSKMWRLNLAYTLVIGGALGNLIDRLQHGF
HHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
VVDFLDFYWNTSHFPAFNIADSAICVGAALIILDSFVTGKDDKKTDGIKE
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH
>Mature Secondary Structure 
PTNWKDSGLRWYWVVVLVFVADQLSKQWVLSNFELYESIQLLPIFNFTYVRNYGAAFSF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHH
LSDAGGWQRWLFTFVAVGFSVVLSVWLRQQPSKMWRLNLAYTLVIGGALGNLIDRLQHGF
HHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
VVDFLDFYWNTSHFPAFNIADSAICVGAALIILDSFVTGKDDKKTDGIKE
HHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA