Click here to switch to the map view.

The map label for this gene is pgi

Identifier: 167623055

GI number: 167623055

Start: 1360100

End: 1361737

Strand: Reverse

Name: pgi

Synonym: Shal_1121

Alternate gene names: 167623055

Gene position: 1361737-1360100 (Counterclockwise)

Preceding gene: 167623056

Following gene: 167623054

Centisome position: 26.05

GC content: 44.14

Gene sequence:

>1638_bases
ATGACTGAACTCACTCAACAAGCCACTTGGCAAGCATTAGAAAAGCACAGTAAAACGCTTTCCCATATGCGCGAGCTATT
TAGCACAGAACCTCAGCGTTTTAATGACATGTCGACTCAGGCCTGTGGATTGTTTCTAGATTACTCTAAAAACCGCGCCT
CACAAGAGACGATGTCTCTTTTATTTAAGCTGGCGAAAGACACTCAGCTTGAATCAAAAATTAAGGCGATGTTTGCTGGA
GAAGCAATCAACAACACAGAACAAAGAGCGGTACTACACACGGCTCTTCGTGCACCAGCAGACAAAGTTATTATTGTCGA
TGGCAATAATATTGTCGCCGAGGTTCAGCAAACACTGGCAAAAATGAGTGAGTTCGTCGAGTCGCTTACATCCGGAAGCT
GGAAAGGCTACACAGGTAAAGCCATTACTGACGTCGTCAGTATCGGTATTGGCGGCTCTTTCTTAGGGCCTAAAATCGTT
TCTCAAGCATTGCGTCCATATTGGACGGGTGAGCTAAATTGCCATTTTGTGGCAAATGTTGATGGAACCTCTATCACTGA
AAAACTAAAAGGCCTAGACCCGCAAACCACCTTGTTTGTGATGTCTTCTAAATCTTTTGGTACTCAAGAAACGTTAACCA
ATACGCTTACCGCTAAAGCGTGGTTTTTAGGACAAGGTGCATCACAATCTGATGTTGCTAAGCACTTTGTCGCTGTGAGC
TCAAATGTCGCTAAGGCAACGGAGTTTGGTATCGATGCCGATAACATCTTCCCTATGTGGGACTGGGTCGGTGGTCGCTA
TTCACTTTGGTCTGCAATTGGATTACCTATCGCTCTGCTAATCGGTATGGATAACTTTCGCGAGTTATTAGCCGGTGCTC
ATGAGATGGATGAACACTTTGCCAATACTCCATTAGAAGACAATATGCCCGTTATTATGGGCTTATTCTCACTATGGTAT
GGTAATTTTTTCAATGCTCAGTCTCATGTAGTGTTAACTTATGATCATTACCTAAGAGGCCTGCCAGCTTACTTTCAGCA
GCTAGATATGGAGAGTAACGGTAAGTCTGTCACCCTAAATGGTACCGATGTTGATTACAGCACTGGACCTGTAATTTGGG
GCGGCGAAGGAACTAACGGTCAACACGCATACCACCAGCTATTGCATCAAGGAACGGCACTCATTCCAGCCGACTTCATT
ATGCCACTCAACAGCCACAACCCGGTGGGTGAGCATCATGTTCAACTTGCTTCAAACTGCTTTGGTCAAACCCAAGCATT
GATGCAAGGTAGAACCTATGAAGAAGCATTAGCAGAGTTAAGCTCTAGTAGCCTTAACGATGAGCAGAAGCAACTTATCG
CTAAACATAAGGTGATGCCGGGTAATAAGCCGAGCAATACCATCTTAATGGATAAGCTTACTCCTTCAACGTTAGGTGCA
TTAATTGCTCTATATGAACACAGAACATTTGTTCAAGGTGCTATTTGGCAGATTAACTCATTTGATCAGTGGGGAGTCGA
GCTTGGTAAGCAACTAGGCAACGATGTTCTCGATCGCCTCACGGCAAGTAAAGATGCCGATGAGCTCGACACTTCTAGTA
ATGGTTTGATTAACCTGTTTAGGCAAGGAAATATCTAA

Upstream 100 bases:

>100_bases
GAAAAGCTTGCTGAAGGTATTCGCAACTTCGCTATCGACCAAGGTAAGCTTGAAGTTATGCTAAAAAACAAACTTTCGTC
TTAATCAATAGGACAAAAAA

Downstream 100 bases:

>100_bases
GCTCGTACTCAAGCTATAAAAAAGCCAGTTTCTACTGGCTTTTTTGTTTTTTACAGCCAAGCATTCCATATAGCTTAAAA
AAAAGACCATATTTATCTCA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MTELTQQATWQALEKHSKTLSHMRELFSTEPQRFNDMSTQACGLFLDYSKNRASQETMSLLFKLAKDTQLESKIKAMFAG
EAINNTEQRAVLHTALRAPADKVIIVDGNNIVAEVQQTLAKMSEFVESLTSGSWKGYTGKAITDVVSIGIGGSFLGPKIV
SQALRPYWTGELNCHFVANVDGTSITEKLKGLDPQTTLFVMSSKSFGTQETLTNTLTAKAWFLGQGASQSDVAKHFVAVS
SNVAKATEFGIDADNIFPMWDWVGGRYSLWSAIGLPIALLIGMDNFRELLAGAHEMDEHFANTPLEDNMPVIMGLFSLWY
GNFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSVTLNGTDVDYSTGPVIWGGEGTNGQHAYHQLLHQGTALIPADFI
MPLNSHNPVGEHHVQLASNCFGQTQALMQGRTYEEALAELSSSSLNDEQKQLIAKHKVMPGNKPSNTILMDKLTPSTLGA
LIALYEHRTFVQGAIWQINSFDQWGVELGKQLGNDVLDRLTASKDADELDTSSNGLINLFRQGNI

Sequences:

>Translated_545_residues
MTELTQQATWQALEKHSKTLSHMRELFSTEPQRFNDMSTQACGLFLDYSKNRASQETMSLLFKLAKDTQLESKIKAMFAG
EAINNTEQRAVLHTALRAPADKVIIVDGNNIVAEVQQTLAKMSEFVESLTSGSWKGYTGKAITDVVSIGIGGSFLGPKIV
SQALRPYWTGELNCHFVANVDGTSITEKLKGLDPQTTLFVMSSKSFGTQETLTNTLTAKAWFLGQGASQSDVAKHFVAVS
SNVAKATEFGIDADNIFPMWDWVGGRYSLWSAIGLPIALLIGMDNFRELLAGAHEMDEHFANTPLEDNMPVIMGLFSLWY
GNFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSVTLNGTDVDYSTGPVIWGGEGTNGQHAYHQLLHQGTALIPADFI
MPLNSHNPVGEHHVQLASNCFGQTQALMQGRTYEEALAELSSSSLNDEQKQLIAKHKVMPGNKPSNTILMDKLTPSTLGA
LIALYEHRTFVQGAIWQINSFDQWGVELGKQLGNDVLDRLTASKDADELDTSSNGLINLFRQGNI
>Mature_544_residues
TELTQQATWQALEKHSKTLSHMRELFSTEPQRFNDMSTQACGLFLDYSKNRASQETMSLLFKLAKDTQLESKIKAMFAGE
AINNTEQRAVLHTALRAPADKVIIVDGNNIVAEVQQTLAKMSEFVESLTSGSWKGYTGKAITDVVSIGIGGSFLGPKIVS
QALRPYWTGELNCHFVANVDGTSITEKLKGLDPQTTLFVMSSKSFGTQETLTNTLTAKAWFLGQGASQSDVAKHFVAVSS
NVAKATEFGIDADNIFPMWDWVGGRYSLWSAIGLPIALLIGMDNFRELLAGAHEMDEHFANTPLEDNMPVIMGLFSLWYG
NFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSVTLNGTDVDYSTGPVIWGGEGTNGQHAYHQLLHQGTALIPADFIM
PLNSHNPVGEHHVQLASNCFGQTQALMQGRTYEEALAELSSSSLNDEQKQLIAKHKVMPGNKPSNTILMDKLTPSTLGAL
IALYEHRTFVQGAIWQINSFDQWGVELGKQLGNDVLDRLTASKDADELDTSSNGLINLFRQGNI

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=551, Percent_Identity=50.9981851179673, Blast_Score=583, Evalue=1e-166,
Organism=Homo sapiens, GI296080693, Length=551, Percent_Identity=47.3684210526316, Blast_Score=528, Evalue=1e-150,
Organism=Escherichia coli, GI1790457, Length=540, Percent_Identity=53.5185185185185, Blast_Score=597, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI71996708, Length=547, Percent_Identity=52.8336380255942, Blast_Score=585, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI71996703, Length=547, Percent_Identity=52.8336380255942, Blast_Score=584, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6319673, Length=550, Percent_Identity=50.9090909090909, Blast_Score=543, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24651916, Length=551, Percent_Identity=52.4500907441016, Blast_Score=579, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24651914, Length=551, Percent_Identity=52.4500907441016, Blast_Score=579, Evalue=1e-165,
Organism=Drosophila melanogaster, GI17737445, Length=551, Percent_Identity=52.4500907441016, Blast_Score=579, Evalue=1e-165,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_SHEHH (B0TJ99)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001673349.1
- ProteinModelPortal:   B0TJ99
- SMR:   B0TJ99
- GeneID:   5905720
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_1121
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- ProtClustDB:   PRK00179
- BioCyc:   SHAL458817:SHAL_1121-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 59983; Mature: 59852

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 351-351 ACT_SITE 382-382 ACT_SITE 510-510

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELTQQATWQALEKHSKTLSHMRELFSTEPQRFNDMSTQACGLFLDYSKNRASQETMSL
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHEEEECCCCCCHHHHHHH
LFKLAKDTQLESKIKAMFAGEAINNTEQRAVLHTALRAPADKVIIVDGNNIVAEVQQTLA
HHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHH
KMSEFVESLTSGSWKGYTGKAITDVVSIGIGGSFLGPKIVSQALRPYWTGELNCHFVANV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEEECC
DGTSITEKLKGLDPQTTLFVMSSKSFGTQETLTNTLTAKAWFLGQGASQSDVAKHFVAVS
CCCHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHH
SNVAKATEFGIDADNIFPMWDWVGGRYSLWSAIGLPIALLIGMDNFRELLAGAHEMDEHF
CCHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ANTPLEDNMPVIMGLFSLWYGNFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSVTLN
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHCCHHHHHHHHCCCCCCCEEEEC
GTDVDYSTGPVIWGGEGTNGQHAYHQLLHQGTALIPADFIMPLNSHNPVGEHHVQLASNC
CCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHEEECCCCCCCCHHHHHHHHHH
FGQTQALMQGRTYEEALAELSSSSLNDEQKQLIAKHKVMPGNKPSNTILMDKLTPSTLGA
HHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHH
LIALYEHRTFVQGAIWQINSFDQWGVELGKQLGNDVLDRLTASKDADELDTSSNGLINLF
HHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCEEEE
RQGNI
ECCCC
>Mature Secondary Structure 
TELTQQATWQALEKHSKTLSHMRELFSTEPQRFNDMSTQACGLFLDYSKNRASQETMSL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHEEEECCCCCCHHHHHHH
LFKLAKDTQLESKIKAMFAGEAINNTEQRAVLHTALRAPADKVIIVDGNNIVAEVQQTLA
HHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHH
KMSEFVESLTSGSWKGYTGKAITDVVSIGIGGSFLGPKIVSQALRPYWTGELNCHFVANV
HHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEEECC
DGTSITEKLKGLDPQTTLFVMSSKSFGTQETLTNTLTAKAWFLGQGASQSDVAKHFVAVS
CCCHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHH
SNVAKATEFGIDADNIFPMWDWVGGRYSLWSAIGLPIALLIGMDNFRELLAGAHEMDEHF
CCHHHHHHCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ANTPLEDNMPVIMGLFSLWYGNFFNAQSHVVLTYDHYLRGLPAYFQQLDMESNGKSVTLN
CCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEHHHHHCCHHHHHHHHCCCCCCCEEEEC
GTDVDYSTGPVIWGGEGTNGQHAYHQLLHQGTALIPADFIMPLNSHNPVGEHHVQLASNC
CCCCCCCCCCEEECCCCCCCHHHHHHHHHCCCCCCCHHHEEECCCCCCCCHHHHHHHHHH
FGQTQALMQGRTYEEALAELSSSSLNDEQKQLIAKHKVMPGNKPSNTILMDKLTPSTLGA
HHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHHH
LIALYEHRTFVQGAIWQINSFDQWGVELGKQLGNDVLDRLTASKDADELDTSSNGLINLF
HHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCEEEE
RQGNI
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA