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The map label for this gene is tyrA [H]

Identifier: 167623036

GI number: 167623036

Start: 1339900

End: 1341054

Strand: Direct

Name: tyrA [H]

Synonym: Shal_1102

Alternate gene names: 167623036

Gene position: 1339900-1341054 (Clockwise)

Preceding gene: 167623035

Following gene: 167623037

Centisome position: 25.63

GC content: 48.74

Gene sequence:

>1155_bases
ATGGAAGAAAGATTGATGAATGAGAAGACCACTGCAGAGCTTGAGAACCTGAGAGGTTTGATTGACGGTGTCGATCAGCA
GTTGCTGCATTTACTGAGAAAACGTTTAGATCTTGTGGCGCAAGTTGGTGCGGTAAAACATGGTGCGGGCCTACCAATCT
ATGCTCCCCAGCGCGAGGCCAATATGCTGGCTAAGCGGCGAGAAGAAGCTAAGGCAATGAATGTGGCGCCGCAGCTCATT
GAAGATATCCTGCGTCGCTTGATGCGAGAGTCTTACCTTAATGAGAAGGATGTCGGCTTTAAGCAGGTGAAAGCCGACTT
AGGCCATGTCGTTATCGTGGGCGGTGAGGGTAAGCTTGGTGGCTTGTTTTCACAGATGTTGACGCTTTCAGGTTATGAGG
TCAGATCGCTTGATAAAGATGATTGGCTTAATAGTGAGGCTATCTTCGCTGGCGCAGGACTAGTGATCGTAACTGTACCC
ATCAATATCACTTGTGATCTGATAGCACAAAAACTGACGAACTTACCTGCAAACTGTATTTTGGCGGACCTGACGTCGAT
TAAGACTGCGCCTGTCGAGGCAATGCTGGCGGCACACAGTGGTCCTGTGCTGGGACTACACCCGATGTTTGGCCCCGATG
TAGGCAGCCTTGCAAAGCAAGTCGTGGTCGTGTGTCATGGCCGCGATAGCGAGGCCTATCAATGGCTGATTGAACAGATC
CAGATCTGGGGCGCACGTATTGTAGAAACTGAGTCCACTAAGCATGATAAAGCGATGCAGCTGGTACAGGCGATGCGACA
CTTCTCTTCTTTTGTTTATGGCTTAAACCTTTACAAAGAGGAAGCGGATATTGAGTCTCTGTTGCAGTTTAGCTCGCCAA
TCTACCGTTTAGAACTGGCGATGGTTGGCCGTTTGTTTGCACAAAGTCCTGAGCTTTATGCCGATATTATTTTTGCCCAA
GAAGAGAGTTTAGTCGCCATTAGTGATTATTTGGATAACTACTCTCAAGCACTGTCGCTCCTCAAGTCGGGAGATCGCGA
TGGCTTTGTCGCTCAGTTTGAAGAGGTGTCTCGCTGGTTTGGTGACTTTGCGCCACAGTTCCAAAGAGAGAGCCGTGCGA
TGTTGCAATCCGTTAATGATATGAAAACCGGCTAG

Upstream 100 bases:

>100_bases
TTGATTGGGCAACAACGGAATCATTATTACGTACCGGTGCCAGCGACTTAGCGTCGGTACTACCAACAAGGTTTGATATG
CTGAAAGTAGCAAACGGCTG

Downstream 100 bases:

>100_bases
TGTGTTGAACCGCCGAAACGATATCGACAAAAAGGGAGCTTAGGCTCCTTTTTAGTACCCAAAACCGAGTGGTTTAGTGT
GTTTTAGTCGGGGTGAATGT

Product: bifunctional chorismate mutase/prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MEERLMNEKTTAELENLRGLIDGVDQQLLHLLRKRLDLVAQVGAVKHGAGLPIYAPQREANMLAKRREEAKAMNVAPQLI
EDILRRLMRESYLNEKDVGFKQVKADLGHVVIVGGEGKLGGLFSQMLTLSGYEVRSLDKDDWLNSEAIFAGAGLVIVTVP
INITCDLIAQKLTNLPANCILADLTSIKTAPVEAMLAAHSGPVLGLHPMFGPDVGSLAKQVVVVCHGRDSEAYQWLIEQI
QIWGARIVETESTKHDKAMQLVQAMRHFSSFVYGLNLYKEEADIESLLQFSSPIYRLELAMVGRLFAQSPELYADIIFAQ
EESLVAISDYLDNYSQALSLLKSGDRDGFVAQFEEVSRWFGDFAPQFQRESRAMLQSVNDMKTG

Sequences:

>Translated_384_residues
MEERLMNEKTTAELENLRGLIDGVDQQLLHLLRKRLDLVAQVGAVKHGAGLPIYAPQREANMLAKRREEAKAMNVAPQLI
EDILRRLMRESYLNEKDVGFKQVKADLGHVVIVGGEGKLGGLFSQMLTLSGYEVRSLDKDDWLNSEAIFAGAGLVIVTVP
INITCDLIAQKLTNLPANCILADLTSIKTAPVEAMLAAHSGPVLGLHPMFGPDVGSLAKQVVVVCHGRDSEAYQWLIEQI
QIWGARIVETESTKHDKAMQLVQAMRHFSSFVYGLNLYKEEADIESLLQFSSPIYRLELAMVGRLFAQSPELYADIIFAQ
EESLVAISDYLDNYSQALSLLKSGDRDGFVAQFEEVSRWFGDFAPQFQRESRAMLQSVNDMKTG
>Mature_384_residues
MEERLMNEKTTAELENLRGLIDGVDQQLLHLLRKRLDLVAQVGAVKHGAGLPIYAPQREANMLAKRREEAKAMNVAPQLI
EDILRRLMRESYLNEKDVGFKQVKADLGHVVIVGGEGKLGGLFSQMLTLSGYEVRSLDKDDWLNSEAIFAGAGLVIVTVP
INITCDLIAQKLTNLPANCILADLTSIKTAPVEAMLAAHSGPVLGLHPMFGPDVGSLAKQVVVVCHGRDSEAYQWLIEQI
QIWGARIVETESTKHDKAMQLVQAMRHFSSFVYGLNLYKEEADIESLLQFSSPIYRLELAMVGRLFAQSPELYADIIFAQ
EESLVAISDYLDNYSQALSLLKSGDRDGFVAQFEEVSRWFGDFAPQFQRESRAMLQSVNDMKTG

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=372, Percent_Identity=58.0645161290323, Blast_Score=444, Evalue=1e-126,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 42726; Mature: 42726

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEERLMNEKTTAELENLRGLIDGVDQQLLHLLRKRLDLVAQVGAVKHGAGLPIYAPQREA
CCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
NMLAKRREEAKAMNVAPQLIEDILRRLMRESYLNEKDVGFKQVKADLGHVVIVGGEGKLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEECCCCCHH
GLFSQMLTLSGYEVRSLDKDDWLNSEAIFAGAGLVIVTVPINITCDLIAQKLTNLPANCI
HHHHHHHHHCCCHHHCCCCCCCCCCCCEEECCCEEEEEECCCCHHHHHHHHHHCCCHHHH
LADLTSIKTAPVEAMLAAHSGPVLGLHPMFGPDVGSLAKQVVVVCHGRDSEAYQWLIEQI
HHHHHHCCCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHEEEEECCCHHHHHHHHHHH
QIWGARIVETESTKHDKAMQLVQAMRHFSSFVYGLNLYKEEADIESLLQFSSPIYRLELA
HHHCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
MVGRLFAQSPELYADIIFAQEESLVAISDYLDNYSQALSLLKSGDRDGFVAQFEEVSRWF
HHHHHHHCCCHHHHHHHEECCCCEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GDFAPQFQRESRAMLQSVNDMKTG
HHHCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEERLMNEKTTAELENLRGLIDGVDQQLLHLLRKRLDLVAQVGAVKHGAGLPIYAPQREA
CCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
NMLAKRREEAKAMNVAPQLIEDILRRLMRESYLNEKDVGFKQVKADLGHVVIVGGEGKLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEECCCCCHH
GLFSQMLTLSGYEVRSLDKDDWLNSEAIFAGAGLVIVTVPINITCDLIAQKLTNLPANCI
HHHHHHHHHCCCHHHCCCCCCCCCCCCEEECCCEEEEEECCCCHHHHHHHHHHCCCHHHH
LADLTSIKTAPVEAMLAAHSGPVLGLHPMFGPDVGSLAKQVVVVCHGRDSEAYQWLIEQI
HHHHHHCCCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHEEEEECCCHHHHHHHHHHH
QIWGARIVETESTKHDKAMQLVQAMRHFSSFVYGLNLYKEEADIESLLQFSSPIYRLELA
HHHCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
MVGRLFAQSPELYADIIFAQEESLVAISDYLDNYSQALSLLKSGDRDGFVAQFEEVSRWF
HHHHHHHCCCHHHHHHHEECCCCEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
GDFAPQFQRESRAMLQSVNDMKTG
HHHCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]