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The map label for this gene is ffh [H]

Identifier: 167623030

GI number: 167623030

Start: 1334904

End: 1336277

Strand: Direct

Name: ffh [H]

Synonym: Shal_1096

Alternate gene names: 167623030

Gene position: 1334904-1336277 (Clockwise)

Preceding gene: 167623027

Following gene: 167623031

Centisome position: 25.54

GC content: 47.16

Gene sequence:

>1374_bases
ATGTTTGAGAACTTAACTGACAGATTGTCACGGACTCTGAAAAATATCAGTGGCCGTGGTCGCTTAACGGAAGAAAACGT
TAAGGAAACCTTACGCGAAGTACGCATGGCACTTCTTGAGGCCGATGTTGCCTTGCCTGTGGTTCGTGAATTCGTAAATA
GCGTTAAAGAACGCGCTGTTGGACAAGAGGTTTCTAAGAGTCTAAGTCCAGGCCAAGCCTTTATTAAGATCGTTCAAAGC
GAACTTGAAAATGCGATGGGCGAAGCGAACGAAGCTTTAGACCTATCGGCTCAGCCGCCAGCTGTTATCATGATGGCAGG
TCTGCAAGGTGCGGGTAAAACCACCAGTGTTGCAAAGCTTGCTAAATTCTTGCGTGAACGTGAGAAGAAGTCTGTTCTGG
TTGTGTCTGCTGACGTTTATCGTCCTGCGGCGATTAAGCAGCTAGAAACCTTAGCGGCGGAAGTTGAAGTTCAGTTCTTC
CCGTCAGACGTGAGCCAAAAGCCAGTTGATATCGCCAAAGCGGCAATTGCTCATGCTAAGCTAAAATTCATTGATGTGGT
TATTGTCGATACTGCAGGTCGTCTGCACGTCGATGAAGCCATGATGGATGAAATTAAAGAGCTTCATGCCGTGATTAACC
CGGTTGAGACATTGTTTGTGGTTGATGCCATGACAGGTCAAGATGCGGCAAACACAGCAAAGGCCTTTAACGAAGCCTTA
CCGTTAACGGGTGTGGTACTGACAAAAGTCGATGGTGACGCACGAGGCGGTGCTGCGCTTTCTATCCGCCACATTACCGG
TAAGCCAATTAAATTCTTAGGTGTCGGTGAAAAGACTGATGCGTTAGAAGCATTCCACCCAGATCGTGTCGCGTCACGCA
TCCTTGGTATGGGCGACGTTCTTTCTCTTATTGAAGAGGTTGAGCGTGGTGTAGACCAAGAAAAGGCGATGAAGCTTGCT
GCTAAAGTGAAAAAAGGTGGAAACTTTGATTTAGAAGATTTCCGCGAACAGCTGCAGCAGATGAAGAACATGGGCGGCAT
GATGAACATGATTGAGAAGCTACCAGGTGTGGGTCAATTACCACCTGAAGCACTTGCTCAAGTTCAAGACGGCAAGATGA
CAGGGCAGATGGAAGCGATTATCAATTCTATGACGGCAGGTGAACGTCAACGCCCTGACATTATTAAAGGTTCGCGTAAG
CGCAGAATCGCCATGGGTTCAGGAACACAAATTCAAGATGTGAACCGTTTGCTTAAACAGTTCACTCAAATGCAGAAAAT
GATGAAGAAAATGTCATCTAAAGGTGGCATGAAAAAGATGATGCGTGGCATGAGTGGTATGTTGCCACCGGGCATGAAAA
TGCCGGGCCGCTAG

Upstream 100 bases:

>100_bases
CAGTTGTAAAAGTAACTTGCTTCATTCTGTAGCATAATAGCTGGGCATCGCTATAATACAGCCCCATCAATATTAATTTT
AAACGGTAAAGAGCTGGATA

Downstream 100 bases:

>100_bases
GCTATCTTTTAATTCTGCAAAGCTAAATTTACAGACCAGAGTGAAACTCACGCTGGTCTGTAAATCGTTTTAGGCGTAAA
AAACGTCGATTACGGTTGCA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MFENLTDRLSRTLKNISGRGRLTEENVKETLREVRMALLEADVALPVVREFVNSVKERAVGQEVSKSLSPGQAFIKIVQS
ELENAMGEANEALDLSAQPPAVIMMAGLQGAGKTTSVAKLAKFLREREKKSVLVVSADVYRPAAIKQLETLAAEVEVQFF
PSDVSQKPVDIAKAAIAHAKLKFIDVVIVDTAGRLHVDEAMMDEIKELHAVINPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTDALEAFHPDRVASRILGMGDVLSLIEEVERGVDQEKAMKLA
AKVKKGGNFDLEDFREQLQQMKNMGGMMNMIEKLPGVGQLPPEALAQVQDGKMTGQMEAIINSMTAGERQRPDIIKGSRK
RRIAMGSGTQIQDVNRLLKQFTQMQKMMKKMSSKGGMKKMMRGMSGMLPPGMKMPGR

Sequences:

>Translated_457_residues
MFENLTDRLSRTLKNISGRGRLTEENVKETLREVRMALLEADVALPVVREFVNSVKERAVGQEVSKSLSPGQAFIKIVQS
ELENAMGEANEALDLSAQPPAVIMMAGLQGAGKTTSVAKLAKFLREREKKSVLVVSADVYRPAAIKQLETLAAEVEVQFF
PSDVSQKPVDIAKAAIAHAKLKFIDVVIVDTAGRLHVDEAMMDEIKELHAVINPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTDALEAFHPDRVASRILGMGDVLSLIEEVERGVDQEKAMKLA
AKVKKGGNFDLEDFREQLQQMKNMGGMMNMIEKLPGVGQLPPEALAQVQDGKMTGQMEAIINSMTAGERQRPDIIKGSRK
RRIAMGSGTQIQDVNRLLKQFTQMQKMMKKMSSKGGMKKMMRGMSGMLPPGMKMPGR
>Mature_457_residues
MFENLTDRLSRTLKNISGRGRLTEENVKETLREVRMALLEADVALPVVREFVNSVKERAVGQEVSKSLSPGQAFIKIVQS
ELENAMGEANEALDLSAQPPAVIMMAGLQGAGKTTSVAKLAKFLREREKKSVLVVSADVYRPAAIKQLETLAAEVEVQFF
PSDVSQKPVDIAKAAIAHAKLKFIDVVIVDTAGRLHVDEAMMDEIKELHAVINPVETLFVVDAMTGQDAANTAKAFNEAL
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTDALEAFHPDRVASRILGMGDVLSLIEEVERGVDQEKAMKLA
AKVKKGGNFDLEDFREQLQQMKNMGGMMNMIEKLPGVGQLPPEALAQVQDGKMTGQMEAIINSMTAGERQRPDIIKGSRK
RRIAMGSGTQIQDVNRLLKQFTQMQKMMKKMSSKGGMKKMMRGMSGMLPPGMKMPGR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=449, Percent_Identity=32.0712694877506, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI226371618, Length=351, Percent_Identity=34.1880341880342, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI23308697, Length=316, Percent_Identity=29.4303797468354, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI295424842, Length=316, Percent_Identity=29.4303797468354, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=37.5, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1788963, Length=457, Percent_Identity=77.2428884026258, Blast_Score=682, Evalue=0.0,
Organism=Escherichia coli, GI1789874, Length=265, Percent_Identity=33.5849056603774, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=459, Percent_Identity=29.4117647058824, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI193206261, Length=215, Percent_Identity=35.8139534883721, Blast_Score=108, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6325345, Length=445, Percent_Identity=33.7078651685393, Blast_Score=220, Evalue=5e-58,
Organism=Saccharomyces cerevisiae, GI6320498, Length=211, Percent_Identity=31.7535545023697, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17647949, Length=446, Percent_Identity=30.9417040358744, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=32.7272727272727, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49822; Mature: 49822

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.6 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.6 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFENLTDRLSRTLKNISGRGRLTEENVKETLREVRMALLEADVALPVVREFVNSVKERAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVSKSLSPGQAFIKIVQSELENAMGEANEALDLSAQPPAVIMMAGLQGAGKTTSVAKL
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHH
AKFLREREKKSVLVVSADVYRPAAIKQLETLAAEVEVQFFPSDVSQKPVDIAKAAIAHAK
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHH
LKFIDVVIVDTAGRLHVDEAMMDEIKELHAVINPVETLFVVDAMTGQDAANTAKAFNEAL
HHHEEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTDALEAFHPDRVASRILGMGDV
CCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCHHHHHHCCHHHHHHHHHCHHHH
LSLIEEVERGVDQEKAMKLAAKVKKGGNFDLEDFREQLQQMKNMGGMMNMIEKLPGVGQL
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
PPEALAQVQDGKMTGQMEAIINSMTAGERQRPDIIKGSRKRRIAMGSGTQIQDVNRLLKQ
CHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCEEECCCCCCHHHHHHHHHH
FTQMQKMMKKMSSKGGMKKMMRGMSGMLPPGMKMPGR
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MFENLTDRLSRTLKNISGRGRLTEENVKETLREVRMALLEADVALPVVREFVNSVKERAV
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVSKSLSPGQAFIKIVQSELENAMGEANEALDLSAQPPAVIMMAGLQGAGKTTSVAKL
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHH
AKFLREREKKSVLVVSADVYRPAAIKQLETLAAEVEVQFFPSDVSQKPVDIAKAAIAHAK
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHHH
LKFIDVVIVDTAGRLHVDEAMMDEIKELHAVINPVETLFVVDAMTGQDAANTAKAFNEAL
HHHEEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHC
PLTGVVLTKVDGDARGGAALSIRHITGKPIKFLGVGEKTDALEAFHPDRVASRILGMGDV
CCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCCHHHHHHCCHHHHHHHHHCHHHH
LSLIEEVERGVDQEKAMKLAAKVKKGGNFDLEDFREQLQQMKNMGGMMNMIEKLPGVGQL
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
PPEALAQVQDGKMTGQMEAIINSMTAGERQRPDIIKGSRKRRIAMGSGTQIQDVNRLLKQ
CHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHCCCCCCEEECCCCCCHHHHHHHHHH
FTQMQKMMKKMSSKGGMKKMMRGMSGMLPPGMKMPGR
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]