Click here to switch to the map view.

The map label for this gene is rnc

Identifier: 167623017

GI number: 167623017

Start: 1321923

End: 1322600

Strand: Direct

Name: rnc

Synonym: Shal_1083

Alternate gene names: 167623017

Gene position: 1321923-1322600 (Clockwise)

Preceding gene: 167623016

Following gene: 167623018

Centisome position: 25.29

GC content: 44.1

Gene sequence:

>678_bases
ATGGAACCGATTAAAAATATTCCTCGCCTGTGTCGTACATTAGGCTATGAATTTACCGAACAAGCCTTTTTAGACCAAGC
GTTAACACATCGTAGCGCGTCTAATAAGCATAACGAGAGACTAGAGTTCTTAGGTGATTCGATTCTTTCAATCGTCATTT
CTGATGCTTTATACCATCAGTTTCCTACTGCAACAGAGGGCGACTTAAGCCGTATGCGCGCCACACTGGTTTGCGGTAAG
ATGCTGGCCGAAATTGCGATAGAGTTTAAGCTTGGCGACTACCTCAAGCTTGGACCTGGTGAGCTTAAAAGTGGCGGGTT
TAGACGTGAGTCGATTCTTGCCGATGCCGTCGAGGCCATTATTGGTGCGATTTATCTTGATTCAGAAATCGAGAAATGTC
GCTCATTAGTGCTGAAGTGGTATGAATCGCGTTTAAAGGTCATTGAGCCTATAAACCAAAAAGATCCAAAAACTTTGCTG
CAAGAGCATTTGCAGAAGTTTAGAAAACCACTGCCAGTGTACAAAGTGGTCCATACTGAAGGTGATGCTCATGAGCAGAC
TTTCACCGTTGAATGTATTGTTGAAGACTTGAGCCAAGCCGTTGTTGGAGTAGCCAGTTCACGCAGAAAAGCCGAACAAA
GTGCTGCAGCTCAAGTGTTGGAGTTAATGAAGAAATGA

Upstream 100 bases:

>100_bases
ATTTGGATTAGCTTCGAATTTGACAGAACACCAGCAGACTTTTTGCCGACTTGGATCCCAACAGGGGTTCGCTTTAACCG
TGTAGGCGGAATTGAGTAAT

Downstream 100 bases:

>100_bases
GTGACAACAAAGATTTACCTGAAAGCCACGAGCCAAGCTTAGACGAATTACTGGCTAATATGAACAATCCGTCATCAGCG
GTTAAGTACGCTGTGACTTA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MEPIKNIPRLCRTLGYEFTEQAFLDQALTHRSASNKHNERLEFLGDSILSIVISDALYHQFPTATEGDLSRMRATLVCGK
MLAEIAIEFKLGDYLKLGPGELKSGGFRRESILADAVEAIIGAIYLDSEIEKCRSLVLKWYESRLKVIEPINQKDPKTLL
QEHLQKFRKPLPVYKVVHTEGDAHEQTFTVECIVEDLSQAVVGVASSRRKAEQSAAAQVLELMKK

Sequences:

>Translated_225_residues
MEPIKNIPRLCRTLGYEFTEQAFLDQALTHRSASNKHNERLEFLGDSILSIVISDALYHQFPTATEGDLSRMRATLVCGK
MLAEIAIEFKLGDYLKLGPGELKSGGFRRESILADAVEAIIGAIYLDSEIEKCRSLVLKWYESRLKVIEPINQKDPKTLL
QEHLQKFRKPLPVYKVVHTEGDAHEQTFTVECIVEDLSQAVVGVASSRRKAEQSAAAQVLELMKK
>Mature_225_residues
MEPIKNIPRLCRTLGYEFTEQAFLDQALTHRSASNKHNERLEFLGDSILSIVISDALYHQFPTATEGDLSRMRATLVCGK
MLAEIAIEFKLGDYLKLGPGELKSGGFRRESILADAVEAIIGAIYLDSEIEKCRSLVLKWYESRLKVIEPINQKDPKTLL
QEHLQKFRKPLPVYKVVHTEGDAHEQTFTVECIVEDLSQAVVGVASSRRKAEQSAAAQVLELMKK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030236, Length=219, Percent_Identity=31.5068493150685, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI155030234, Length=219, Percent_Identity=31.5068493150685, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1788920, Length=211, Percent_Identity=64.9289099526066, Blast_Score=273, Evalue=7e-75,
Organism=Caenorhabditis elegans, GI17506883, Length=189, Percent_Identity=33.3333333333333, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI193202651, Length=189, Percent_Identity=33.3333333333333, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323895, Length=99, Percent_Identity=36.3636363636364, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137682, Length=233, Percent_Identity=30.0429184549356, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_SHEHH (B0TIV7)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001673311.1
- ProteinModelPortal:   B0TIV7
- SMR:   B0TIV7
- GeneID:   5903534
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_1083
- HOGENOM:   HBG744556
- OMA:   VECRIDD
- ProtClustDB:   PRK00102
- BioCyc:   SHAL458817:SHAL_1083-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 25330; Mature: 25330

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEPIKNIPRLCRTLGYEFTEQAFLDQALTHRSASNKHNERLEFLGDSILSIVISDALYHQ
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FPTATEGDLSRMRATLVCGKMLAEIAIEFKLGDYLKLGPGELKSGGFRRESILADAVEAI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
IGAIYLDSEIEKCRSLVLKWYESRLKVIEPINQKDPKTLLQEHLQKFRKPLPVYKVVHTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHEEEECC
GDAHEQTFTVECIVEDLSQAVVGVASSRRKAEQSAAAQVLELMKK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MEPIKNIPRLCRTLGYEFTEQAFLDQALTHRSASNKHNERLEFLGDSILSIVISDALYHQ
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FPTATEGDLSRMRATLVCGKMLAEIAIEFKLGDYLKLGPGELKSGGFRRESILADAVEAI
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
IGAIYLDSEIEKCRSLVLKWYESRLKVIEPINQKDPKTLLQEHLQKFRKPLPVYKVVHTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHEEEECC
GDAHEQTFTVECIVEDLSQAVVGVASSRRKAEQSAAAQVLELMKK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA