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The map label for this gene is clcA [H]

Identifier: 167622968

GI number: 167622968

Start: 1262624

End: 1264345

Strand: Reverse

Name: clcA [H]

Synonym: Shal_1034

Alternate gene names: 167622968

Gene position: 1264345-1262624 (Counterclockwise)

Preceding gene: 167622971

Following gene: 167622967

Centisome position: 24.19

GC content: 46.63

Gene sequence:

>1722_bases
TTGGAAATTTCTGTGCATCAAACAATTGTTAAGAAGCGAGAGCAATTTCAAAAATACCTACATACCGACCTTAAAGATAC
GCTTTCGCAAGCCAAGATCAGTGTACAGCTATGTTTGCTCGCATTACTGTTTGCACTATTTGCGTCTGGCATCATTGTTC
TTTTTAGGTTATTACTGCTCTGGTGCGACACCTTCACCAAAGCCCAAGAGTTGAATTTTACGGATATCATCGATGACTGG
CGAGTATTATTACCGCTTTTCGGCTCATTTTTAATCTGGGGTGTCGCAAAAATGGGATCTCAGCGTTATAAACGTATGGG
CATCGCCTATGTAATCCACAGAGTTAAGCTGCATTACGGTAAAATTCCACTGCAGTCTGCACCGGGACAGTTTTTCCAAG
CCCTATTTGCCCTTGCTACCAACTTCTCTGTAGGCCGAGAAGGCCCAGCGATTCATTTAGGTGCGGTCAGCGCCAGTGTA
TTAGCCGAAAAATTTAAGCTACCCGACAACAGCGTAAGAGTTATGTGTGCCAGTGGTATTGCCGCCGGTATTGCGGCGAT
TTTTAACGCACCATTAGCCGCAGTGATATTTGTATTTGAAGTGGTGCTCAGAGAATACAAGATCCATTACTTTTTTCCGA
TTATGCTGTCTGCGATTTGCGGTGCTGTTAGCAGCCAGCTGGTGTTTGGTGACGTTCATGAGTTAGATCAAATTGGTGTG
GCTGCAATCCCACTCACTCAATATCCACTACTGGCAATATTCGGTGTGATCCTTGGCTGCATCGCCGCCTTCTTTAATGC
CAGCCTGCTTAAAGTTACCGCTATCGGACAAAACTGGCCACTGATTAATCGCCTATTACTCGCCGGTGCAGTTACTACTT
TAGTGGGCCTAGTTTTACCGCAAGCAATTGGTAGCGGTGAGCTCGCCATAGCTGAAACCATTAACCAGCACCCGAGCATT
TTATTCTTATGCGCCATTTTAGCCGGTAAGATCATCGCCACCATTGCCGCCATAGGCCTTGGCATACCAGGCGGACTTAT
TGGTCCACTCTACGGTATTGGCGCGTTATTCGGCACGATTTTAGCGTTAGTTAGCGCGCTCATGTTTCCAAGTATCGCTC
CCTATATTGGCCTTTATACCATTATCGGTATGACGGGCATGATGGGCGTGTGTTTAAGCGCCCCACTAGCCGCACTAGTG
GCGTTAATTGAGCTAACCAATAACGCTTCCATCATCTTACCCTCTATGTTTGTGGTTATCCCCGCTTTTTTGATTGCCCA
CCAAGGTTTCAAGACCAAGTCTATCTTCTTCGAGCAGCTAGAGATCATGGGGCTGGGCTATAAAGTTGCCCCAGTAAACC
TTGGGCTACAAAAAGTCGGTGTGCGCCAACTCATGGATAAGCGCTTTGTGATTGTGGCTGACAATGACGAACTCTTGCTG
GAGGTGCTAAAGCGTGCAGAGGGGCGCTCTGTGCTAATTAGAAATACCCAAGGAAAAGTTGATATGCTGCAGCTTGAGCT
GCAAGTTAGAGATGAGGATACAACCTTGACTCGCCACCCTATTCAAGGTCTTCCGGATACTTCAACCCTCAATGAGGTAT
ACGCCATTTTGGCCAAAGAGCGCCGAGGGGAGGTCTATATCTACCAAGATACAAAAGAACAGATTGTTGGTGTGATTAAC
TGGATTTCCCTACGAAAAGAGATCCGTTCGGGGCAAGTGTAA

Upstream 100 bases:

>100_bases
CACTTGCAAGCGATCGATCCAACGATGATAATTTGGCATTAAGTAACAGCCCCTTAATAAAAAATCTCACATTTTGATAT
CAATGTGACAAACATACATT

Downstream 100 bases:

>100_bases
ACAGTCATTGTTATAACCTAATTTGATAACCACAAGTTAATAACAACCACTATCCAGGCTCAGCCCCCTCCTAGACAATC
GCTTCATCAGCTGCTAGGAA

Product: chloride channel core

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 573; Mature: 573

Protein sequence:

>573_residues
MEISVHQTIVKKREQFQKYLHTDLKDTLSQAKISVQLCLLALLFALFASGIIVLFRLLLLWCDTFTKAQELNFTDIIDDW
RVLLPLFGSFLIWGVAKMGSQRYKRMGIAYVIHRVKLHYGKIPLQSAPGQFFQALFALATNFSVGREGPAIHLGAVSASV
LAEKFKLPDNSVRVMCASGIAAGIAAIFNAPLAAVIFVFEVVLREYKIHYFFPIMLSAICGAVSSQLVFGDVHELDQIGV
AAIPLTQYPLLAIFGVILGCIAAFFNASLLKVTAIGQNWPLINRLLLAGAVTTLVGLVLPQAIGSGELAIAETINQHPSI
LFLCAILAGKIIATIAAIGLGIPGGLIGPLYGIGALFGTILALVSALMFPSIAPYIGLYTIIGMTGMMGVCLSAPLAALV
ALIELTNNASIILPSMFVVIPAFLIAHQGFKTKSIFFEQLEIMGLGYKVAPVNLGLQKVGVRQLMDKRFVIVADNDELLL
EVLKRAEGRSVLIRNTQGKVDMLQLELQVRDEDTTLTRHPIQGLPDTSTLNEVYAILAKERRGEVYIYQDTKEQIVGVIN
WISLRKEIRSGQV

Sequences:

>Translated_573_residues
MEISVHQTIVKKREQFQKYLHTDLKDTLSQAKISVQLCLLALLFALFASGIIVLFRLLLLWCDTFTKAQELNFTDIIDDW
RVLLPLFGSFLIWGVAKMGSQRYKRMGIAYVIHRVKLHYGKIPLQSAPGQFFQALFALATNFSVGREGPAIHLGAVSASV
LAEKFKLPDNSVRVMCASGIAAGIAAIFNAPLAAVIFVFEVVLREYKIHYFFPIMLSAICGAVSSQLVFGDVHELDQIGV
AAIPLTQYPLLAIFGVILGCIAAFFNASLLKVTAIGQNWPLINRLLLAGAVTTLVGLVLPQAIGSGELAIAETINQHPSI
LFLCAILAGKIIATIAAIGLGIPGGLIGPLYGIGALFGTILALVSALMFPSIAPYIGLYTIIGMTGMMGVCLSAPLAALV
ALIELTNNASIILPSMFVVIPAFLIAHQGFKTKSIFFEQLEIMGLGYKVAPVNLGLQKVGVRQLMDKRFVIVADNDELLL
EVLKRAEGRSVLIRNTQGKVDMLQLELQVRDEDTTLTRHPIQGLPDTSTLNEVYAILAKERRGEVYIYQDTKEQIVGVIN
WISLRKEIRSGQV
>Mature_573_residues
MEISVHQTIVKKREQFQKYLHTDLKDTLSQAKISVQLCLLALLFALFASGIIVLFRLLLLWCDTFTKAQELNFTDIIDDW
RVLLPLFGSFLIWGVAKMGSQRYKRMGIAYVIHRVKLHYGKIPLQSAPGQFFQALFALATNFSVGREGPAIHLGAVSASV
LAEKFKLPDNSVRVMCASGIAAGIAAIFNAPLAAVIFVFEVVLREYKIHYFFPIMLSAICGAVSSQLVFGDVHELDQIGV
AAIPLTQYPLLAIFGVILGCIAAFFNASLLKVTAIGQNWPLINRLLLAGAVTTLVGLVLPQAIGSGELAIAETINQHPSI
LFLCAILAGKIIATIAAIGLGIPGGLIGPLYGIGALFGTILALVSALMFPSIAPYIGLYTIIGMTGMMGVCLSAPLAALV
ALIELTNNASIILPSMFVVIPAFLIAHQGFKTKSIFFEQLEIMGLGYKVAPVNLGLQKVGVRQLMDKRFVIVADNDELLL
EVLKRAEGRSVLIRNTQGKVDMLQLELQVRDEDTTLTRHPIQGLPDTSTLNEVYAILAKERRGEVYIYQDTKEQIVGVIN
WISLRKEIRSGQV

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=313, Percent_Identity=29.073482428115, Blast_Score=96, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 62429; Mature: 62429

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure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CCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA