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The map label for this gene is pepQ [H]

Identifier: 167622912

GI number: 167622912

Start: 1195595

End: 1197382

Strand: Reverse

Name: pepQ [H]

Synonym: Shal_0972

Alternate gene names: 167622912

Gene position: 1197382-1195595 (Counterclockwise)

Preceding gene: 167622914

Following gene: 167622911

Centisome position: 22.91

GC content: 47.43

Gene sequence:

>1788_bases
ATGTCAAATACAATTGCAGCACGTCTCAATGCCATCCGCACAGAAATGGCTAAATCAAATCTCGATGCTTTTATTATTCC
TCGTGCCGATGAATACTTGGGCGAGTATGTCCCCGAGCATAATGAGCGCATGTTATGGGCCAGTGGATTTACCGGTTCTG
CGGGAACAATTATCGTATTGAAGGACAGTGCCGCAATTTTTGTCGATGGCCGTTATACCGTGCAAGTGCGTCAACAAGTC
GATCCGAGTCTATTTGAATACTTAAGCTTACACGATACCCCTCAAGCTCCGTGGTTAATTGAACAACTTGGCGCAAATGC
AAAAGTCGGCTTCGATGCTCGCCTGCATACATTAGCTTGGTTTAACCAAACCGAAGCTGAACTTAATAAAGCGCAAATAG
AGTTAACTCAAGTCGAGCAAAACCCCATTGACGTGCACTGGACTGACAGGCCTTCTCCAGCAAGTAGCCCGATTATGCTG
TTTAGCGAGCAAAGCGCGGGGAGAACTAGCCTTGAGAAACGCAAAACTATTGGCTTAGAGATCAAAAAACAGGGCGCCGA
CATTGCGATTATCTCGGCCTTAGATTCTTTCTGCTGGTTACTCAATATTCGCGGCAAAGATATTCCATGCCTGCCCATAG
TATTAGGCACTGCGCTACTGCGCACCAATGGCGATATGCTGTTATTTACTGACACTAAAAAGTTACCGGAAAACATCCTC
GAGCATGTAGGTGAAGGCGTCAGCTTTAAAGCGGAATCTGAGCTCGCCGCAGAACTCGTCAGCTTAAACGGCTGTAAAGT
GTTAGCAAGCCCAGAGAGCTGCAACGCTTGGCTGCAACTAACCGCTCAAGATGCTGGTGCACAGCTTATTGCAGGTAGCG
ATCCGGTCGCCTTACCTAAGGCGCAGAAGAATGAAGCTGAACTTACAGGCATGAAAGCCTGCCATATTCGTGACGGCGTG
GCAGTAAGCCGCTTTCTTGCTTGGTTAGACCGCGAAGTTGCCGCTAACCGCCTATATGATGAAGCCGTACTTGCAGATAA
ACTAGAAAGCTTCCGCTTAGCCGATCCACGGTATCAAGAACCAAGCTTCGACACCATTTCAGCAACTGGCGCAAATGCCG
CCATGTGTCACTATAACCACAATAACGGCACACCTGCACAGATGACGATGAACAGCATCTACCTTGTCGACTCTGGCGCA
CAATATCTAGATGGCACCACAGATGTGACCCGTACTGTTGCCATTGGTGACGTTACCGATGAGCAGAGAAAGATGGTGAC
CTTAGTACTAAAAGGCCATATAGCAATCGATCAAGCCAAGTTCCCCAAAGGCACTAGCGGTATGCAGCTAGACTCCTTTG
CCCGCCAATATTTATGGCAGCATGGTTTCGACTTTGACCACGGTACAGGCCATGGCGTGGGCCACTATTTAAGTGTGCAT
GAAGGTCCACAGGGTATCGCAAAAGGCCGTTCAAACGTGGCTCTTCTCGAAGGTATGGTGCTGTCAAATGAGCCCGGTTA
CTACCGCGCCAATGAGTTCGGTATTCGATTAGAGAACTTAATCGCCGTACGTCCTTGTAAAGCCTTAGCTAATAGCGAAC
GGGAAATGTTGGAATTTGAGGCATTAACCTTTATTCCAATGGATGCTCGCTTGATCGATAAAAGCTATTTAACTGATGCA
GAAGTTAGCTGGTTTAACCAATATCATCAGCAGGTTAGAGAAAAACTCTCACCATTTATGCGGGGCGATGATTTAACTTG
GCTAAATAAAGTGACCGCAGCGATTTAA

Upstream 100 bases:

>100_bases
CAAGCAAATGCGCTTTATGGTAATCTCCGCGCTAAATTCGTACAAAAATAAACTGCCTCTAGTGAGTACAACAAGCTTTT
GCGCAGATAACGGAGTTTGA

Downstream 100 bases:

>100_bases
CTCTGCCATAAACCGCTTCAATAACAGCAGCGCCCCGGCGCTGCTTTTTAATGGAAATTACCCAGAGTCTCCAACAAAAA
GTGCAGGTTTTAAGCTAAAA

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 595; Mature: 594

Protein sequence:

>595_residues
MSNTIAARLNAIRTEMAKSNLDAFIIPRADEYLGEYVPEHNERMLWASGFTGSAGTIIVLKDSAAIFVDGRYTVQVRQQV
DPSLFEYLSLHDTPQAPWLIEQLGANAKVGFDARLHTLAWFNQTEAELNKAQIELTQVEQNPIDVHWTDRPSPASSPIML
FSEQSAGRTSLEKRKTIGLEIKKQGADIAIISALDSFCWLLNIRGKDIPCLPIVLGTALLRTNGDMLLFTDTKKLPENIL
EHVGEGVSFKAESELAAELVSLNGCKVLASPESCNAWLQLTAQDAGAQLIAGSDPVALPKAQKNEAELTGMKACHIRDGV
AVSRFLAWLDREVAANRLYDEAVLADKLESFRLADPRYQEPSFDTISATGANAAMCHYNHNNGTPAQMTMNSIYLVDSGA
QYLDGTTDVTRTVAIGDVTDEQRKMVTLVLKGHIAIDQAKFPKGTSGMQLDSFARQYLWQHGFDFDHGTGHGVGHYLSVH
EGPQGIAKGRSNVALLEGMVLSNEPGYYRANEFGIRLENLIAVRPCKALANSEREMLEFEALTFIPMDARLIDKSYLTDA
EVSWFNQYHQQVREKLSPFMRGDDLTWLNKVTAAI

Sequences:

>Translated_595_residues
MSNTIAARLNAIRTEMAKSNLDAFIIPRADEYLGEYVPEHNERMLWASGFTGSAGTIIVLKDSAAIFVDGRYTVQVRQQV
DPSLFEYLSLHDTPQAPWLIEQLGANAKVGFDARLHTLAWFNQTEAELNKAQIELTQVEQNPIDVHWTDRPSPASSPIML
FSEQSAGRTSLEKRKTIGLEIKKQGADIAIISALDSFCWLLNIRGKDIPCLPIVLGTALLRTNGDMLLFTDTKKLPENIL
EHVGEGVSFKAESELAAELVSLNGCKVLASPESCNAWLQLTAQDAGAQLIAGSDPVALPKAQKNEAELTGMKACHIRDGV
AVSRFLAWLDREVAANRLYDEAVLADKLESFRLADPRYQEPSFDTISATGANAAMCHYNHNNGTPAQMTMNSIYLVDSGA
QYLDGTTDVTRTVAIGDVTDEQRKMVTLVLKGHIAIDQAKFPKGTSGMQLDSFARQYLWQHGFDFDHGTGHGVGHYLSVH
EGPQGIAKGRSNVALLEGMVLSNEPGYYRANEFGIRLENLIAVRPCKALANSEREMLEFEALTFIPMDARLIDKSYLTDA
EVSWFNQYHQQVREKLSPFMRGDDLTWLNKVTAAI
>Mature_594_residues
SNTIAARLNAIRTEMAKSNLDAFIIPRADEYLGEYVPEHNERMLWASGFTGSAGTIIVLKDSAAIFVDGRYTVQVRQQVD
PSLFEYLSLHDTPQAPWLIEQLGANAKVGFDARLHTLAWFNQTEAELNKAQIELTQVEQNPIDVHWTDRPSPASSPIMLF
SEQSAGRTSLEKRKTIGLEIKKQGADIAIISALDSFCWLLNIRGKDIPCLPIVLGTALLRTNGDMLLFTDTKKLPENILE
HVGEGVSFKAESELAAELVSLNGCKVLASPESCNAWLQLTAQDAGAQLIAGSDPVALPKAQKNEAELTGMKACHIRDGVA
VSRFLAWLDREVAANRLYDEAVLADKLESFRLADPRYQEPSFDTISATGANAAMCHYNHNNGTPAQMTMNSIYLVDSGAQ
YLDGTTDVTRTVAIGDVTDEQRKMVTLVLKGHIAIDQAKFPKGTSGMQLDSFARQYLWQHGFDFDHGTGHGVGHYLSVHE
GPQGIAKGRSNVALLEGMVLSNEPGYYRANEFGIRLENLIAVRPCKALANSEREMLEFEALTFIPMDARLIDKSYLTDAE
VSWFNQYHQQVREKLSPFMRGDDLTWLNKVTAAI

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=605, Percent_Identity=36.5289256198347, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI93141226, Length=601, Percent_Identity=34.6089850249584, Blast_Score=356, Evalue=3e-98,
Organism=Homo sapiens, GI264681565, Length=605, Percent_Identity=35.0413223140496, Blast_Score=338, Evalue=7e-93,
Organism=Escherichia coli, GI1788728, Length=227, Percent_Identity=30.3964757709251, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17509539, Length=595, Percent_Identity=35.1260504201681, Blast_Score=351, Evalue=6e-97,
Organism=Caenorhabditis elegans, GI25149105, Length=603, Percent_Identity=29.5190713101161, Blast_Score=249, Evalue=3e-66,
Organism=Saccharomyces cerevisiae, GI6322999, Length=652, Percent_Identity=30.3680981595092, Blast_Score=299, Evalue=1e-81,
Organism=Drosophila melanogaster, GI17137632, Length=604, Percent_Identity=38.0794701986755, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI161078230, Length=598, Percent_Identity=28.9297658862876, Blast_Score=266, Evalue=4e-71,
Organism=Drosophila melanogaster, GI21357287, Length=598, Percent_Identity=28.9297658862876, Blast_Score=266, Evalue=4e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 65763; Mature: 65632

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTIAARLNAIRTEMAKSNLDAFIIPRADEYLGEYVPEHNERMLWASGFTGSAGTIIVL
CCCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCEEEEECCCCCCCCEEEEE
KDSAAIFVDGRYTVQVRQQVDPSLFEYLSLHDTPQAPWLIEQLGANAKVGFDARLHTLAW
ECCEEEEECCEEEEEEHHHCCHHHHHHHHHCCCCCCCHHHHHCCCCCEECCCCEEEEEEE
FNQTEAELNKAQIELTQVEQNPIDVHWTDRPSPASSPIMLFSEQSAGRTSLEKRKTIGLE
CCCCHHHHCHHEEEEEEECCCCEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHCCEE
IKKQGADIAIISALDSFCWLLNIRGKDIPCLPIVLGTALLRTNGDMLLFTDTKKLPENIL
EECCCCCEEEHHHHHHHEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHH
EHVGEGVSFKAESELAAELVSLNGCKVLASPESCNAWLQLTAQDAGAQLIAGSDPVALPK
HHCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCCEEEECCCCCCCCC
AQKNEAELTGMKACHIRDGVAVSRFLAWLDREVAANRLYDEAVLADKLESFRLADPRYQE
CCCCCCHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PSFDTISATGANAAMCHYNHNNGTPAQMTMNSIYLVDSGAQYLDGTTDVTRTVAIGDVTD
CCCCEEECCCCCEEEEEEECCCCCCCEEEEEEEEEEECCCHHCCCCCCCEEEEEECCCCC
EQRKMVTLVLKGHIAIDQAKFPKGTSGMQLDSFARQYLWQHGFDFDHGTGHGVGHYLSVH
HHHEEEEEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEC
EGPQGIAKGRSNVALLEGMVLSNEPGYYRANEFGIRLENLIAVRPCKALANSEREMLEFE
CCCHHHHCCCCCEEEEEEEEECCCCCEEECHHHCEEEEHEEEECCHHHHHCCHHHHHEEH
ALTFIPMDARLIDKSYLTDAEVSWFNQYHQQVREKLSPFMRGDDLTWLNKVTAAI
EEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SNTIAARLNAIRTEMAKSNLDAFIIPRADEYLGEYVPEHNERMLWASGFTGSAGTIIVL
CCHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCCCEEEEECCCCCCCCEEEEE
KDSAAIFVDGRYTVQVRQQVDPSLFEYLSLHDTPQAPWLIEQLGANAKVGFDARLHTLAW
ECCEEEEECCEEEEEEHHHCCHHHHHHHHHCCCCCCCHHHHHCCCCCEECCCCEEEEEEE
FNQTEAELNKAQIELTQVEQNPIDVHWTDRPSPASSPIMLFSEQSAGRTSLEKRKTIGLE
CCCCHHHHCHHEEEEEEECCCCEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHCCEE
IKKQGADIAIISALDSFCWLLNIRGKDIPCLPIVLGTALLRTNGDMLLFTDTKKLPENIL
EECCCCCEEEHHHHHHHEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHH
EHVGEGVSFKAESELAAELVSLNGCKVLASPESCNAWLQLTAQDAGAQLIAGSDPVALPK
HHCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCCEEEECCCCCCCCC
AQKNEAELTGMKACHIRDGVAVSRFLAWLDREVAANRLYDEAVLADKLESFRLADPRYQE
CCCCCCHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PSFDTISATGANAAMCHYNHNNGTPAQMTMNSIYLVDSGAQYLDGTTDVTRTVAIGDVTD
CCCCEEECCCCCEEEEEEECCCCCCCEEEEEEEEEEECCCHHCCCCCCCEEEEEECCCCC
EQRKMVTLVLKGHIAIDQAKFPKGTSGMQLDSFARQYLWQHGFDFDHGTGHGVGHYLSVH
HHHEEEEEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEC
EGPQGIAKGRSNVALLEGMVLSNEPGYYRANEFGIRLENLIAVRPCKALANSEREMLEFE
CCCHHHHCCCCCEEEEEEEEECCCCCEEECHHHCEEEEHEEEECCHHHHHCCHHHHHEEH
ALTFIPMDARLIDKSYLTDAEVSWFNQYHQQVREKLSPFMRGDDLTWLNKVTAAI
EEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]