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The map label for this gene is strD [H]

Identifier: 167622860

GI number: 167622860

Start: 1140669

End: 1141337

Strand: Direct

Name: strD [H]

Synonym: Shal_0920

Alternate gene names: 167622860

Gene position: 1140669-1141337 (Clockwise)

Preceding gene: 167622859

Following gene: 167622861

Centisome position: 21.82

GC content: 47.38

Gene sequence:

>669_bases
ATGAAAGCGATGATTTTAGCGGCTGGACGTGGAGAACGCTTACGGCCATTAACAGATACTGTTCCTAAGCCTCTAATTGA
GGTGGCAGGTAAACCCTTGATTGTCTATCACATAGAAAAGCTAGCAGCTGCAGGCTTCTCTGAAATAGTCATTAATCATG
CTTGGCTTGGTCATAAGTTGGTTGAGCGACTCGGTGATGGCAGTCAATGGCAGGTCAGTATCCAATACAGCGAGGAAACA
TCGGCCTTAGAGACTGGCGGCGGCATTAGGCAGGCGCTGAATTTGTTAGGCAATGCCCCATTTTTAGTGATCAATGGCGA
TATATTTATCGACGAATTGCCAACGATTAATACACTGGAGCCGGGGAAACTGGCTCACCTCTGGTTAGTGGATAACCCAC
AGCATCACCTTAAGGGAGATTTTACACTGCAGGGGGGCGATGTGAGTGATGTTGGGGAGTCTAGATTGACCTTCTCGGGC
ATGGGGATTTATCATCCTGCTCTATTTCAAGATACGCCAGAAGGCGCGTTCGCACTGGCACCTTTGCTGCGCGAAGCCAT
GGGAAGTAGACAGGTCAGTGGTGGCCATTTTAATCAGTATTGGTGTGATGTAGGCACGATTGAGCGACTCGCACAAATTG
AAAAACGTGAAATAAAAAAGGTTAGATAA

Upstream 100 bases:

>100_bases
TCGGGATATTGCCGGACGTTATAACGAGCTTCAGGTACTGGGTGGTTGGATAGGTGAGGTGATCATTCCTGCGGTTAAGG
CTAAGAGTAAAGGGCGGTAA

Downstream 100 bases:

>100_bases
TGCGTATTTGGGGTAAAGTTTTTGGCTTCATTATTGGGTATATGGCTGGTCGTTTAGGCGGCGCTATTTTTGGCCTTTGG
TTAGGGCATATGTATGACCG

Product: nucleotidyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MKAMILAAGRGERLRPLTDTVPKPLIEVAGKPLIVYHIEKLAAAGFSEIVINHAWLGHKLVERLGDGSQWQVSIQYSEET
SALETGGGIRQALNLLGNAPFLVINGDIFIDELPTINTLEPGKLAHLWLVDNPQHHLKGDFTLQGGDVSDVGESRLTFSG
MGIYHPALFQDTPEGAFALAPLLREAMGSRQVSGGHFNQYWCDVGTIERLAQIEKREIKKVR

Sequences:

>Translated_222_residues
MKAMILAAGRGERLRPLTDTVPKPLIEVAGKPLIVYHIEKLAAAGFSEIVINHAWLGHKLVERLGDGSQWQVSIQYSEET
SALETGGGIRQALNLLGNAPFLVINGDIFIDELPTINTLEPGKLAHLWLVDNPQHHLKGDFTLQGGDVSDVGESRLTFSG
MGIYHPALFQDTPEGAFALAPLLREAMGSRQVSGGHFNQYWCDVGTIERLAQIEKREIKKVR
>Mature_222_residues
MKAMILAAGRGERLRPLTDTVPKPLIEVAGKPLIVYHIEKLAAAGFSEIVINHAWLGHKLVERLGDGSQWQVSIQYSEET
SALETGGGIRQALNLLGNAPFLVINGDIFIDELPTINTLEPGKLAHLWLVDNPQHHLKGDFTLQGGDVSDVGESRLTFSG
MGIYHPALFQDTPEGAFALAPLLREAMGSRQVSGGHFNQYWCDVGTIERLAQIEKREIKKVR

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=114, Percent_Identity=36.8421052631579, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI11761619, Length=114, Percent_Identity=36.8421052631579, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1788351, Length=253, Percent_Identity=27.2727272727273, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=113, Percent_Identity=38.9380530973451, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=114, Percent_Identity=42.1052631578947, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355443, Length=113, Percent_Identity=34.5132743362832, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24644084, Length=113, Percent_Identity=34.5132743362832, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 24368; Mature: 24368

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAMILAAGRGERLRPLTDTVPKPLIEVAGKPLIVYHIEKLAAAGFSEIVINHAWLGHKL
CCEEEEECCCCCCCCCCHHHCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHHHHH
VERLGDGSQWQVSIQYSEETSALETGGGIRQALNLLGNAPFLVINGDIFIDELPTINTLE
HHHHCCCCEEEEEEEECCCCCHHHCCCHHHHHHHHHCCCCEEEEECCEEEECCCCCCCCC
PGKLAHLWLVDNPQHHLKGDFTLQGGDVSDVGESRLTFSGMGIYHPALFQDTPEGAFALA
CCCEEEEEEECCCHHHCCCCEEECCCCCCCCCCCCEEECCCCCCCCHHHCCCCCCHHHHH
PLLREAMGSRQVSGGHFNQYWCDVGTIERLAQIEKREIKKVR
HHHHHHHCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKAMILAAGRGERLRPLTDTVPKPLIEVAGKPLIVYHIEKLAAAGFSEIVINHAWLGHKL
CCEEEEECCCCCCCCCCHHHCHHHHHHHCCCCEEEEEHHHHHHCCHHHHHHHHHHHHHHH
VERLGDGSQWQVSIQYSEETSALETGGGIRQALNLLGNAPFLVINGDIFIDELPTINTLE
HHHHCCCCEEEEEEEECCCCCHHHCCCHHHHHHHHHCCCCEEEEECCEEEECCCCCCCCC
PGKLAHLWLVDNPQHHLKGDFTLQGGDVSDVGESRLTFSGMGIYHPALFQDTPEGAFALA
CCCEEEEEEECCCHHHCCCCEEECCCCCCCCCCCCEEECCCCCCCCHHHCCCCCCHHHHH
PLLREAMGSRQVSGGHFNQYWCDVGTIERLAQIEKREIKKVR
HHHHHHHCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]