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The map label for this gene is nagB

Identifier: 167622753

GI number: 167622753

Start: 1016292

End: 1017083

Strand: Direct

Name: nagB

Synonym: Shal_0813

Alternate gene names: 167622753

Gene position: 1016292-1017083 (Clockwise)

Preceding gene: 167622751

Following gene: 167622754

Centisome position: 19.44

GC content: 45.83

Gene sequence:

>792_bases
ATGCAAATCGTAATATTAAAAGACAGTGCGTCGGTTGCTGAATATGGCGCAAATATTTTTATTAAGCAGCTGCAGAAAAA
GGCTGATTCGGTATTGGGATTAGCCACAGGCTCGACACCGCTGTCGCTTTACCAAGGTTTAATAGCCGCCAACAAAGATA
AGCAGATCTCTTTTAAAGCTGTCACCACGTTTAATCTAGATGAATACCTAGGGCTTGAGGGGACGCACCCACAAAGTTAC
CGCTACTTTATGAATGAGCAGCTGTTCGATCACATTGATATCGACAAGAGCAAGACCTTTGTTCCTCCTGGTGACGCCGA
AAATCCGATTGCAGCTTGTCAGGGTTATGAAGATAAGATTAAGTCTGCAGGCGGAATCGATATTCAACTACTCGGTATTG
GTCGTAACGGTCATATCGGCTTTAATGAACCCTCATCGGGCTTGATGTCGCGCACACGAGTGAAGACCTTAACTAAAGCG
ACGATTGATGACAATGCTCGTTTCTTCAAAGAAGGTGAGTATCAGCCGCACCTATCGATCACCATGGGTATTGGCACTAT
CTTAGATGCCAAGAAAGTCGTGCTATTAGCAACGGGCGAGAATAAGGCTGAGGCTATTTTAGCAACGGTTGAAGGTGCAT
TAACCGCCGCTTGCCCTGCATCAGCCTTGCAACTACACCAAGATGCAGTGCTAGTGATCGACGAAGCCGCAGCTTCTAAG
CTGACAGACCGAGATTTCTATAAACACATCGAAGTCGAGAATCAAAAGCTGATGGCGAGATTGGGTTTGTAG

Upstream 100 bases:

>100_bases
GGTTTAAACAATAGCTAATGACAGCGTTGTCATTCGGCTCGTATAAGGTTATAGTAATGTTACATAGTTAACTGCCGCTA
ACAGATATTGGATCAAGTTT

Downstream 100 bases:

>100_bases
ACTAGATTGGTAAACGCCCGTTTAGGTGCCAATTCACTATAAAAAGACAAGCTGAGCTTGTCTTTTTACGTATAGATTAG
GCTTACGTTTAGGCTTAGCC

Product: glucosamine-6-phosphate isomerase

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MQIVILKDSASVAEYGANIFIKQLQKKADSVLGLATGSTPLSLYQGLIAANKDKQISFKAVTTFNLDEYLGLEGTHPQSY
RYFMNEQLFDHIDIDKSKTFVPPGDAENPIAACQGYEDKIKSAGGIDIQLLGIGRNGHIGFNEPSSGLMSRTRVKTLTKA
TIDDNARFFKEGEYQPHLSITMGIGTILDAKKVVLLATGENKAEAILATVEGALTAACPASALQLHQDAVLVIDEAAASK
LTDRDFYKHIEVENQKLMARLGL

Sequences:

>Translated_263_residues
MQIVILKDSASVAEYGANIFIKQLQKKADSVLGLATGSTPLSLYQGLIAANKDKQISFKAVTTFNLDEYLGLEGTHPQSY
RYFMNEQLFDHIDIDKSKTFVPPGDAENPIAACQGYEDKIKSAGGIDIQLLGIGRNGHIGFNEPSSGLMSRTRVKTLTKA
TIDDNARFFKEGEYQPHLSITMGIGTILDAKKVVLLATGENKAEAILATVEGALTAACPASALQLHQDAVLVIDEAAASK
LTDRDFYKHIEVENQKLMARLGL
>Mature_263_residues
MQIVILKDSASVAEYGANIFIKQLQKKADSVLGLATGSTPLSLYQGLIAANKDKQISFKAVTTFNLDEYLGLEGTHPQSY
RYFMNEQLFDHIDIDKSKTFVPPGDAENPIAACQGYEDKIKSAGGIDIQLLGIGRNGHIGFNEPSSGLMSRTRVKTLTKA
TIDDNARFFKEGEYQPHLSITMGIGTILDAKKVVLLATGENKAEAILATVEGALTAACPASALQLHQDAVLVIDEAAASK
LTDRDFYKHIEVENQKLMARLGL

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily

Homologues:

Organism=Homo sapiens, GI13027378, Length=270, Percent_Identity=42.2222222222222, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI19923881, Length=248, Percent_Identity=43.1451612903226, Blast_Score=198, Evalue=3e-51,
Organism=Escherichia coli, GI1786893, Length=264, Percent_Identity=41.2878787878788, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1789530, Length=229, Percent_Identity=27.5109170305677, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI48994958, Length=240, Percent_Identity=25, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17554876, Length=247, Percent_Identity=41.2955465587045, Blast_Score=194, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24581960, Length=247, Percent_Identity=43.3198380566802, Blast_Score=211, Evalue=5e-55,
Organism=Drosophila melanogaster, GI19920764, Length=247, Percent_Identity=43.3198380566802, Blast_Score=211, Evalue=5e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NAGB_SHEHH (B0TTP5)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001673047.1
- ProteinModelPortal:   B0TTP5
- SMR:   B0TTP5
- GeneID:   5903265
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_0813
- HOGENOM:   HBG725991
- OMA:   HLSITMG
- ProtClustDB:   CLSK938082
- BioCyc:   SHAL458817:SHAL_0813-MONOMER
- HAMAP:   MF_01241
- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321
- PANTHER:   PTHR11280
- TIGRFAMs:   TIGR00502

Pfam domain/function: PF01182 Glucosamine_iso

EC number: =3.5.99.6

Molecular weight: Translated: 28532; Mature: 28532

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: ACT_SITE 67-67 ACT_SITE 136-136 ACT_SITE 138-138 ACT_SITE 143-143

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIVILKDSASVAEYGANIFIKQLQKKADSVLGLATGSTPLSLYQGLIAANKDKQISFKA
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHCCCCCEEEEEE
VTTFNLDEYLGLEGTHPQSYRYFMNEQLFDHIDIDKSKTFVPPGDAENPIAACQGYEDKI
EEEECHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHCCCHHHH
KSAGGIDIQLLGIGRNGHIGFNEPSSGLMSRTRVKTLTKATIDDNARFFKEGEYQPHLSI
HCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCEEE
TMGIGTILDAKKVVLLATGENKAEAILATVEGALTAACPASALQLHQDAVLVIDEAAASK
EECCCCCCCCCEEEEEEECCCCHHEEEEEHHCHHHHCCCHHHHHHCCCEEEEEECHHHHH
LTDRDFYKHIEVENQKLMARLGL
CCHHHHHHHHCCCCHHHHHHCCC
>Mature Secondary Structure
MQIVILKDSASVAEYGANIFIKQLQKKADSVLGLATGSTPLSLYQGLIAANKDKQISFKA
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHCCCCCEEEEEE
VTTFNLDEYLGLEGTHPQSYRYFMNEQLFDHIDIDKSKTFVPPGDAENPIAACQGYEDKI
EEEECHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHCCCHHHH
KSAGGIDIQLLGIGRNGHIGFNEPSSGLMSRTRVKTLTKATIDDNARFFKEGEYQPHLSI
HCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCEEE
TMGIGTILDAKKVVLLATGENKAEAILATVEGALTAACPASALQLHQDAVLVIDEAAASK
EECCCCCCCCCEEEEEEECCCCHHEEEEEHHCHHHHCCCHHHHHHCCCEEEEEECHHHHH
LTDRDFYKHIEVENQKLMARLGL
CCHHHHHHHHCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA