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The map label for this gene is lysS

Identifier: 167622750

GI number: 167622750

Start: 1010787

End: 1012292

Strand: Direct

Name: lysS

Synonym: Shal_0810

Alternate gene names: 167622750

Gene position: 1010787-1012292 (Clockwise)

Preceding gene: 167622749

Following gene: 167622751

Centisome position: 19.34

GC content: 47.28

Gene sequence:

>1506_bases
ATGACTGAACAAACACAAGACGAGAACAAGTTAATTGCAGAGCGTCGTGCTAAATTAGAGCACATTCGTACCAACTGCCC
TGCAAACGGTCACCCGAACAACTTCGATCGAAAACACAAAGCGGCAGACATTCAAGCTGAATTTGGTCACAACACCAAAG
AAGAGCTTGAAGGCATGGGCATTGAGCGTTCAATCGCTGGCCGTGTTATGGCTAAGCGTGGTCCATTCTTGGTTATTCAA
GATGTGAGCGGTCGTATCCAAGCTTATGCGGGTAAAGACGTTCAAAAAGATCTTAAAGAGAAATTCCAAGGTCTAGATAT
CGGTGACATCATCGGTGTGACGGGTCAGCTACACCTATCGGGTAAGGGCGACCTATATGTGAACATGGAAGAGTACCAGT
TGCTAACTAAAGCTCTGCGCCCACTTCCTGAAAAGTTCCACGGTCTAACAGACCAAGAGACACGTTACCGTCAGCGTTAT
GTTGACTTGATCGTTAACGAACAGTCACGTGAAGCCTTTATCATGCGTTCTAAAGTCGTTTCGGCTATTCGTAACTTCAT
GGTGAAGAAAGAGTTCATGGAAGTTGAAACACCAATGATGCACAGCATTCCTGGTGGTGCTTCAGCACGTCCATTCGCGA
CGCATCACAATGCGCTAGATATCGCGATGTACCTACGTATTGCACCTGAGCTATACCTTAAGCGTCTAGTGGTTGGTGGT
TTTGAGCGCGTATTCGAAATTAACCGTAACTTCCGTAACGAAGGTCTATCTCCACGTCATAACCCTGAATTCACTATGAT
GGAATTCTATATGGCGTATGCAGATTTCAACGATCTAATGGACTTGACTGAAGAGATGCTAAGCTCTATCGCCACTGAGC
TTTGTGGTTCGCCACAACTGCCATACGGTGAGCACACGGTTGATTTTGGTGGCCCATATGCACGTTTGAGCATGTTGGAT
GCGATCAAGAAGTACAACCCTGACAATGCAACAATCCAGTCGATGACTTACGAAGAAGTTAAAGACGTTGAATTTATGCG
TGATTTGGCTAAGAGCCTAGGCATGACAGTTGAGAAGTTCTGGACTTGTGGTCAGCTACTCGAAGAGATCTTCGGTGAAA
CAGCTGAAACTCAGTTGATGCAACCTACGTTCATCACTGGCTACCCAGCAGACATCTCTCCGCTAGCACGTCGTAACGAC
GACAACCATTTCATCACTGACCGTTTCGAGTTCTTCATCGGCGGCCGTGAAGTGGCTAACGGTTTCTCAGAGCTTAACGA
TGCTGAAGATCAAGACCGCCGTTTCAAGGCGCAGGTTGATGCTAAAGACGCGGGTGATGACGAAGCTATGTTCTACGATG
CAGACTACATCACTGCACTAGAGCACGGTCTACCGCCAACTGCGGGTCAAGGTATCGGTATCGACCGTCTAGTGATGCTA
TTCACTAACACGCACACAATTCGTGACGTGATCCTATTCCCAGCGATGCGCCCACAGGCTAACTAA

Upstream 100 bases:

>100_bases
TACCGGCGTTGAAAACCGAAATACCCAGAGCGTTTTAGATGGCGATCTGGACAAGTTTATTGAAGCTAGCCTGAAATCTG
GCCTTTAACGAGAGAAGAAG

Downstream 100 bases:

>100_bases
TCTCTGGAATATAGGTGCATACCTATAAGACTTTAAAAACCAGCCACTAGGCTGGTTTTTTTATACCACAATTTCGAATT
TTGCATTTCTGTGATCTAGG

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MTEQTQDENKLIAERRAKLEHIRTNCPANGHPNNFDRKHKAADIQAEFGHNTKEELEGMGIERSIAGRVMAKRGPFLVIQ
DVSGRIQAYAGKDVQKDLKEKFQGLDIGDIIGVTGQLHLSGKGDLYVNMEEYQLLTKALRPLPEKFHGLTDQETRYRQRY
VDLIVNEQSREAFIMRSKVVSAIRNFMVKKEFMEVETPMMHSIPGGASARPFATHHNALDIAMYLRIAPELYLKRLVVGG
FERVFEINRNFRNEGLSPRHNPEFTMMEFYMAYADFNDLMDLTEEMLSSIATELCGSPQLPYGEHTVDFGGPYARLSMLD
AIKKYNPDNATIQSMTYEEVKDVEFMRDLAKSLGMTVEKFWTCGQLLEEIFGETAETQLMQPTFITGYPADISPLARRND
DNHFITDRFEFFIGGREVANGFSELNDAEDQDRRFKAQVDAKDAGDDEAMFYDADYITALEHGLPPTAGQGIGIDRLVML
FTNTHTIRDVILFPAMRPQAN

Sequences:

>Translated_501_residues
MTEQTQDENKLIAERRAKLEHIRTNCPANGHPNNFDRKHKAADIQAEFGHNTKEELEGMGIERSIAGRVMAKRGPFLVIQ
DVSGRIQAYAGKDVQKDLKEKFQGLDIGDIIGVTGQLHLSGKGDLYVNMEEYQLLTKALRPLPEKFHGLTDQETRYRQRY
VDLIVNEQSREAFIMRSKVVSAIRNFMVKKEFMEVETPMMHSIPGGASARPFATHHNALDIAMYLRIAPELYLKRLVVGG
FERVFEINRNFRNEGLSPRHNPEFTMMEFYMAYADFNDLMDLTEEMLSSIATELCGSPQLPYGEHTVDFGGPYARLSMLD
AIKKYNPDNATIQSMTYEEVKDVEFMRDLAKSLGMTVEKFWTCGQLLEEIFGETAETQLMQPTFITGYPADISPLARRND
DNHFITDRFEFFIGGREVANGFSELNDAEDQDRRFKAQVDAKDAGDDEAMFYDADYITALEHGLPPTAGQGIGIDRLVML
FTNTHTIRDVILFPAMRPQAN
>Mature_500_residues
TEQTQDENKLIAERRAKLEHIRTNCPANGHPNNFDRKHKAADIQAEFGHNTKEELEGMGIERSIAGRVMAKRGPFLVIQD
VSGRIQAYAGKDVQKDLKEKFQGLDIGDIIGVTGQLHLSGKGDLYVNMEEYQLLTKALRPLPEKFHGLTDQETRYRQRYV
DLIVNEQSREAFIMRSKVVSAIRNFMVKKEFMEVETPMMHSIPGGASARPFATHHNALDIAMYLRIAPELYLKRLVVGGF
ERVFEINRNFRNEGLSPRHNPEFTMMEFYMAYADFNDLMDLTEEMLSSIATELCGSPQLPYGEHTVDFGGPYARLSMLDA
IKKYNPDNATIQSMTYEEVKDVEFMRDLAKSLGMTVEKFWTCGQLLEEIFGETAETQLMQPTFITGYPADISPLARRNDD
NHFITDRFEFFIGGREVANGFSELNDAEDQDRRFKAQVDAKDAGDDEAMFYDADYITALEHGLPPTAGQGIGIDRLVMLF
TNTHTIRDVILFPAMRPQAN

Specific function: Also Can Synthesize A Number Of Adenyl Dinucleotides (In Particular Appppa). These Dinucleotides Have Been Proposed To Act As Modulators Of The Heat-Shock Response And Stress Response. [C]

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI5031815, Length=517, Percent_Identity=41.0058027079304, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI194272210, Length=517, Percent_Identity=41.0058027079304, Blast_Score=379, Evalue=1e-105,
Organism=Homo sapiens, GI45439306, Length=351, Percent_Identity=24.5014245014245, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI40789249, Length=254, Percent_Identity=25.9842519685039, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790571, Length=499, Percent_Identity=60.7214428857716, Blast_Score=622, Evalue=1e-179,
Organism=Escherichia coli, GI1789256, Length=498, Percent_Identity=60.4417670682731, Blast_Score=613, Evalue=1e-177,
Organism=Escherichia coli, GI87082379, Length=330, Percent_Identity=30.6060606060606, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788173, Length=323, Percent_Identity=24.1486068111455, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17535927, Length=509, Percent_Identity=39.8821218074656, Blast_Score=361, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17535925, Length=509, Percent_Identity=39.8821218074656, Blast_Score=361, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71994340, Length=509, Percent_Identity=39.8821218074656, Blast_Score=360, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI32566633, Length=274, Percent_Identity=28.8321167883212, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17551876, Length=356, Percent_Identity=26.4044943820225, Blast_Score=96, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320242, Length=518, Percent_Identity=40.5405405405405, Blast_Score=372, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6324256, Length=398, Percent_Identity=30.4020100502513, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6323011, Length=355, Percent_Identity=25.9154929577465, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325153, Length=305, Percent_Identity=26.2295081967213, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24640849, Length=512, Percent_Identity=40.234375, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI24640851, Length=512, Percent_Identity=40.234375, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI17136276, Length=461, Percent_Identity=22.9934924078091, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24584738, Length=333, Percent_Identity=24.3243243243243, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYK_SHEHH (B0TTP2)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001673044.1
- ProteinModelPortal:   B0TTP2
- SMR:   B0TTP2
- GeneID:   5902617
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_0810
- HOGENOM:   HBG631383
- OMA:   GHPQMMS
- ProtClustDB:   PRK00484
- BioCyc:   SHAL458817:SHAL_0810-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00252
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF4
- PRINTS:   PR00982
- TIGRFAMs:   TIGR00499

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.6

Molecular weight: Translated: 57002; Mature: 56871

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQTQDENKLIAERRAKLEHIRTNCPANGHPNNFDRKHKAADIQAEFGHNTKEELEGMG
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCHHHCCCCCHHHHHCCC
IERSIAGRVMAKRGPFLVIQDVSGRIQAYAGKDVQKDLKEKFQGLDIGDIIGVTGQLHLS
CHHHHHHHHHHCCCCEEEEECCCCCEEECCCCHHHHHHHHHHCCCCHHHHHCCCEEEEEC
GKGDLYVNMEEYQLLTKALRPLPEKFHGLTDQETRYRQRYVDLIVNEQSREAFIMRSKVV
CCCCEEECHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
SAIRNFMVKKEFMEVETPMMHSIPGGASARPFATHHNALDIAMYLRIAPELYLKRLVVGG
HHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FERVFEINRNFRNEGLSPRHNPEFTMMEFYMAYADFNDLMDLTEEMLSSIATELCGSPQL
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PYGEHTVDFGGPYARLSMLDAIKKYNPDNATIQSMTYEEVKDVEFMRDLAKSLGMTVEKF
CCCCCEECCCCHHHHHHHHHHHHHCCCCCCEEHHCCHHHHHHHHHHHHHHHHHCCHHHHH
WTCGQLLEEIFGETAETQLMQPTFITGYPADISPLARRNDDNHFITDRFEFFIGGREVAN
HHHHHHHHHHHCCCHHHHHCCCEEECCCCCCCCHHHHCCCCCCEEHHHHHHEECCHHHHH
GFSELNDAEDQDRRFKAQVDAKDAGDDEAMFYDADYITALEHGLPPTAGQGIGIDRLVML
HHHHHCCCCCHHHHHHHEECCCCCCCCCEEEECCHHHHHHHHCCCCCCCCCCCHHHHHHH
FTNTHTIRDVILFPAMRPQAN
HHCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TEQTQDENKLIAERRAKLEHIRTNCPANGHPNNFDRKHKAADIQAEFGHNTKEELEGMG
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCHHHCCCCCHHHHHCCC
IERSIAGRVMAKRGPFLVIQDVSGRIQAYAGKDVQKDLKEKFQGLDIGDIIGVTGQLHLS
CHHHHHHHHHHCCCCEEEEECCCCCEEECCCCHHHHHHHHHHCCCCHHHHHCCCEEEEEC
GKGDLYVNMEEYQLLTKALRPLPEKFHGLTDQETRYRQRYVDLIVNEQSREAFIMRSKVV
CCCCEEECHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
SAIRNFMVKKEFMEVETPMMHSIPGGASARPFATHHNALDIAMYLRIAPELYLKRLVVGG
HHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FERVFEINRNFRNEGLSPRHNPEFTMMEFYMAYADFNDLMDLTEEMLSSIATELCGSPQL
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PYGEHTVDFGGPYARLSMLDAIKKYNPDNATIQSMTYEEVKDVEFMRDLAKSLGMTVEKF
CCCCCEECCCCHHHHHHHHHHHHHCCCCCCEEHHCCHHHHHHHHHHHHHHHHHCCHHHHH
WTCGQLLEEIFGETAETQLMQPTFITGYPADISPLARRNDDNHFITDRFEFFIGGREVAN
HHHHHHHHHHHCCCHHHHHCCCEEECCCCCCCCHHHHCCCCCCEEHHHHHHEECCHHHHH
GFSELNDAEDQDRRFKAQVDAKDAGDDEAMFYDADYITALEHGLPPTAGQGIGIDRLVML
HHHHHCCCCCHHHHHHHEECCCCCCCCCEEEECCHHHHHHHHCCCCCCCCCCCHHHHHHH
FTNTHTIRDVILFPAMRPQAN
HHCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA