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The map label for this gene is pepB [H]

Identifier: 167622696

GI number: 167622696

Start: 936167

End: 937444

Strand: Direct

Name: pepB [H]

Synonym: Shal_0756

Alternate gene names: 167622696

Gene position: 936167-937444 (Clockwise)

Preceding gene: 167622687

Following gene: 167622697

Centisome position: 17.91

GC content: 51.25

Gene sequence:

>1278_bases
ATGACAGATTTAATGAAAGTCACCCTGACTCACGAAGCCGCTGCCGCCCATTGGGGGAAAGCCGATGTGACTTTTCAAGG
GGATGTCGCTTCTATTCATTTAATAGAGGGAGACGTCCTGCTGCATGTACAGCAGGCGGCGCGTAAGTTAGAGCTTCAAG
GGGTGACTAAGGTTGCCCTTACTGGTGAGTTATGGAGCTTAGATCTGCAATGGGCATTTGCCCAAGGGTTTGCCACCGCA
CTGACCACTCCTGTTATTCACTGGACGGGTGATGACGCTACTCAGGCCTTGCTAACCAGCCGCCTGGAAAGTGCCACTTT
TGCGCGCCATCTCATTAATGAAACTCCTGAAAACTTATCGCCAGTGGCACTAGCGACTCAAGCGGCAAAGTGGCTAAGCG
CTATCGGTGGTGACAAGGTTAGCTACCGGATTATTGAAGGCGAAGCGCTATTAGAGAAAAAGTGGATTGGTATTCATGCG
GTTGGGCGTGGCAGTGAGCGTCCACCGGCATTGCTAGAGCTAGATTTTAATCCGTTAGGCTCTGATGCCGCAGTCTCCGT
TGCCCTTGTTGGTAAAGGGATCACCTTTGACTCAGGCGGTTATAGCATTAAAGGCTCAGAAGGTATGCTGGGCATGAAGT
GCGACATGGGTGGCGCTGCAACCGTGACGGCGGCGCTAGGTCTTGCGATGAAGTCTGGTCTCAATAAACGTGTAAAGCTG
TTTTTATGCTGCGCAGAAAACTTGATTAGTGGCCACGCTTACAAGCTCGGAGATATTCTTAAATATAAAAATGGTGTCAC
TGTAGAAGTGGTTAACACCGATGCCGAAGGTCGTCTAGTGTTAGCCGATGGTTTACAAGCGGCATCTGAAACCGGGGCAC
CGTTGATCATCGACGCCGCGACACTTACAGGCGCCGCGGTTATGGCGGTAGGCACTAACTATAATGCGATTTTCTCACCA
AAGGCTGAAGTGCTAGCATTGGCACAGCAAAAAGCATTGGCTGTGGGGGAACGTGTATGGCCACTGCCGCTAGACCCTTG
GCATAAAGATAATTGCCCAAGTGCATACGCTGATACCGCAAATAGTCGTCCCATGAAAGGCGGCGGAGCGGGCGGTGCAT
CAAATGCTGCTGGTTTCTTATGGCGCTTCGTTGCACCAGAAGCCAACTGGTTGCATATCGATTTAGCTTCGGCGTTTTCA
GATACGGGGGATGCCTTATGGTCAGCGGGTGCGACGACCCACGGCGTATTAACCATTGCAGGCCTATTAGAAGACTAA

Upstream 100 bases:

>100_bases
ATCCAGTAGACTGCTTGCACTAAAAATAGGCTAATTGACGATAACTCAAGCAACATAGCTGCAGTTATCGGAACATAGAT
TGATATAATAAGGACCTAGA

Downstream 100 bases:

>100_bases
TCGCTACGGCATGAGTCACTGTAAACCCTGCATTTTGTAGGGTTTTTATTTACAGACGCCATCGATGGACGCTCGAGTAG
CCCGAGCAAACAGCCTTTGC

Product: aminopeptidase B

Products: NA

Alternate protein names: Aminopeptidase B [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MTDLMKVTLTHEAAAAHWGKADVTFQGDVASIHLIEGDVLLHVQQAARKLELQGVTKVALTGELWSLDLQWAFAQGFATA
LTTPVIHWTGDDATQALLTSRLESATFARHLINETPENLSPVALATQAAKWLSAIGGDKVSYRIIEGEALLEKKWIGIHA
VGRGSERPPALLELDFNPLGSDAAVSVALVGKGITFDSGGYSIKGSEGMLGMKCDMGGAATVTAALGLAMKSGLNKRVKL
FLCCAENLISGHAYKLGDILKYKNGVTVEVVNTDAEGRLVLADGLQAASETGAPLIIDAATLTGAAVMAVGTNYNAIFSP
KAEVLALAQQKALAVGERVWPLPLDPWHKDNCPSAYADTANSRPMKGGGAGGASNAAGFLWRFVAPEANWLHIDLASAFS
DTGDALWSAGATTHGVLTIAGLLED

Sequences:

>Translated_425_residues
MTDLMKVTLTHEAAAAHWGKADVTFQGDVASIHLIEGDVLLHVQQAARKLELQGVTKVALTGELWSLDLQWAFAQGFATA
LTTPVIHWTGDDATQALLTSRLESATFARHLINETPENLSPVALATQAAKWLSAIGGDKVSYRIIEGEALLEKKWIGIHA
VGRGSERPPALLELDFNPLGSDAAVSVALVGKGITFDSGGYSIKGSEGMLGMKCDMGGAATVTAALGLAMKSGLNKRVKL
FLCCAENLISGHAYKLGDILKYKNGVTVEVVNTDAEGRLVLADGLQAASETGAPLIIDAATLTGAAVMAVGTNYNAIFSP
KAEVLALAQQKALAVGERVWPLPLDPWHKDNCPSAYADTANSRPMKGGGAGGASNAAGFLWRFVAPEANWLHIDLASAFS
DTGDALWSAGATTHGVLTIAGLLED
>Mature_424_residues
TDLMKVTLTHEAAAAHWGKADVTFQGDVASIHLIEGDVLLHVQQAARKLELQGVTKVALTGELWSLDLQWAFAQGFATAL
TTPVIHWTGDDATQALLTSRLESATFARHLINETPENLSPVALATQAAKWLSAIGGDKVSYRIIEGEALLEKKWIGIHAV
GRGSERPPALLELDFNPLGSDAAVSVALVGKGITFDSGGYSIKGSEGMLGMKCDMGGAATVTAALGLAMKSGLNKRVKLF
LCCAENLISGHAYKLGDILKYKNGVTVEVVNTDAEGRLVLADGLQAASETGAPLIIDAATLTGAAVMAVGTNYNAIFSPK
AEVLALAQQKALAVGERVWPLPLDPWHKDNCPSAYADTANSRPMKGGGAGGASNAAGFLWRFVAPEANWLHIDLASAFSD
TGDALWSAGATTHGVLTIAGLLED

Specific function: Probably plays an important role in intracellular peptide degradation [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=311, Percent_Identity=36.0128617363344, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI47155554, Length=262, Percent_Identity=41.2213740458015, Blast_Score=149, Evalue=7e-36,
Organism=Escherichia coli, GI87082123, Length=429, Percent_Identity=50.3496503496504, Blast_Score=372, Evalue=1e-104,
Organism=Escherichia coli, GI1790710, Length=314, Percent_Identity=39.8089171974522, Blast_Score=168, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17556903, Length=395, Percent_Identity=33.4177215189873, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17565172, Length=243, Percent_Identity=27.9835390946502, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI221379063, Length=265, Percent_Identity=38.8679245283019, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI221379062, Length=265, Percent_Identity=38.8679245283019, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI21357381, Length=265, Percent_Identity=38.8679245283019, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24661038, Length=301, Percent_Identity=31.8936877076412, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21355725, Length=298, Percent_Identity=31.8791946308725, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24662227, Length=297, Percent_Identity=28.2828282828283, Blast_Score=101, Evalue=8e-22,
Organism=Drosophila melanogaster, GI20129969, Length=361, Percent_Identity=26.0387811634349, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI161077148, Length=367, Percent_Identity=28.8828337874659, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI20130057, Length=367, Percent_Identity=28.8828337874659, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21355645, Length=330, Percent_Identity=25.4545454545455, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24662223, Length=330, Percent_Identity=25.4545454545455, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI20129963, Length=368, Percent_Identity=27.7173913043478, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19922386, Length=368, Percent_Identity=26.9021739130435, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646701, Length=286, Percent_Identity=27.6223776223776, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646703, Length=286, Percent_Identity=27.6223776223776, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21358201, Length=286, Percent_Identity=27.6223776223776, Blast_Score=82, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008330
- InterPro:   IPR011356
- InterPro:   IPR000819 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.23 [H]

Molecular weight: Translated: 44489; Mature: 44358

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLMKVTLTHEAAAAHWGKADVTFQGDVASIHLIEGDVLLHVQQAARKLELQGVTKVAL
CCCCEEEEEECHHHHHCCCCCCEEEECCCEEEEEECCCEEEEEHHHHHHHHHCCCEEEEE
TGELWSLDLQWAFAQGFATALTTPVIHWTGDDATQALLTSRLESATFARHLINETPENLS
ECCEEEEEEEEHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PVALATQAAKWLSAIGGDKVSYRIIEGEALLEKKWIGIHAVGRGSERPPALLELDFNPLG
CHHHHHHHHHHHHHHCCCCEEEEEECCCCEEHEECEEEEEECCCCCCCCEEEEEECCCCC
SDAAVSVALVGKGITFDSGGYSIKGSEGMLGMKCDMGGAATVTAALGLAMKSGLNKRVKL
CCCEEEEEEEECCEEECCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEE
FLCCAENLISGHAYKLGDILKYKNGVTVEVVNTDAEGRLVLADGLQAASETGAPLIIDAA
EEEEHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCCCEEEEECCCHHHHCCCCCEEEEEH
TLTGAAVMAVGTNYNAIFSPKAEVLALAQQKALAVGERVWPLPLDPWHKDNCPSAYADTA
HHCCEEEEEECCCCCEEECCHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCHHHCCC
NSRPMKGGGAGGASNAAGFLWRFVAPEANWLHIDLASAFSDTGDALWSAGATTHGVLTIA
CCCCCCCCCCCCCCCCHHEEEEEECCCCCEEEEEEHHHCCCCCHHHHCCCCCCCCEEEEE
GLLED
EECCC
>Mature Secondary Structure 
TDLMKVTLTHEAAAAHWGKADVTFQGDVASIHLIEGDVLLHVQQAARKLELQGVTKVAL
CCCEEEEEECHHHHHCCCCCCEEEECCCEEEEEECCCEEEEEHHHHHHHHHCCCEEEEE
TGELWSLDLQWAFAQGFATALTTPVIHWTGDDATQALLTSRLESATFARHLINETPENLS
ECCEEEEEEEEHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PVALATQAAKWLSAIGGDKVSYRIIEGEALLEKKWIGIHAVGRGSERPPALLELDFNPLG
CHHHHHHHHHHHHHHCCCCEEEEEECCCCEEHEECEEEEEECCCCCCCCEEEEEECCCCC
SDAAVSVALVGKGITFDSGGYSIKGSEGMLGMKCDMGGAATVTAALGLAMKSGLNKRVKL
CCCEEEEEEEECCEEECCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEE
FLCCAENLISGHAYKLGDILKYKNGVTVEVVNTDAEGRLVLADGLQAASETGAPLIIDAA
EEEEHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCCCEEEEECCCHHHHCCCCCEEEEEH
TLTGAAVMAVGTNYNAIFSPKAEVLALAQQKALAVGERVWPLPLDPWHKDNCPSAYADTA
HHCCEEEEEECCCCCEEECCHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCCCCHHHCCC
NSRPMKGGGAGGASNAAGFLWRFVAPEANWLHIDLASAFSDTGDALWSAGATTHGVLTIA
CCCCCCCCCCCCCCCCHHEEEEEECCCCCEEEEEEHHHCCCCCHHHHCCCCCCCCEEEEE
GLLED
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA