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The map label for this gene is cpx [H]

Identifier: 167622598

GI number: 167622598

Start: 805530

End: 806936

Strand: Direct

Name: cpx [H]

Synonym: Shal_0658

Alternate gene names: 167622598

Gene position: 805530-806936 (Clockwise)

Preceding gene: 167622597

Following gene: 167622599

Centisome position: 15.41

GC content: 49.82

Gene sequence:

>1407_bases
ATGAAACTGTTATATCAAGTTGAAGATAAACCACCCATGGGCGTCAGTATTATTTTGGCGTTGCAACATATGCTCGCAGC
TATGGGAGCTATCGTTGCGGTTCCCCTCGTTGTCGGTTCAGCCATAGGGCTACCCGTTAATGAAATGGTCATTCTAGTCA
ATGCCGCCCTTATGGTGTCAGGTGTTGTCACCATGATCCAGTGTAAAGGCTTAGGGCCCGTAGGCATTCGTCTTCCCGTC
GTGATGGGCACCAGCTTTACCTTTGTGGCGATATCGATTTCCATCGGTCTGGAGTCCGGCGTTTCGGCCATTTTTGGTTC
GGCGCTTATCGGCTCCTTAGTGATGATTATCGGCAGTCGTTTTATGCCTCAAATTCGCAAATTATTCCCTCCAGTTGTAT
CGGGCACCGTCGTGCTGCTTATTGGTTTAACTATCTTACCTGTGGCAGTGGACTGGTTTGCTGGTGGCTTTGTCGGTGAG
GAAACCTATGGTCATCATAGTAATCTAGCCTTGGGTTTCTTGGTTCTGGTGGTGGTTATTGCTCTGTCGCAATGGGGGAA
GGGCATTGTTTCCGCTGCCGCTATCGTTATCGGCATGTTCGTCGGTTACCTCGTGTCCATTATGCTAGGCATAGTCGATT
TTACCCCTGTTTTTGCCGCTGAAAACTTTGCGTTACCGACATTATTACCCTTTGGAATTAGTTTTACCATCAGTGGAATA
ATCGGCATGTCGATCGCCTATCTGGTCACGATTATGGAGTCTACAGGAGACTTTCTGGCCCTCAGTGACGCCACTCATAC
CAAGCTAACGGGTAAAAAGCTCTCCAGAGGCATCCTCTGTGATGGCGTGGGTAGCGCCTTAGCATCTGCCGTTGGCACCA
CACCGTTTTCATCATTTAGTCAAAACGTCGGCATCGTCTCAATCACTGGGGTTGCCAGTCGTCATGTGGTGGCATTAACC
GGCCTTATCATGGTGTTTGCAGGTCTATTTCCTAAGGTTGGCGCCTTAGTGGTGACGATTCCATCTCCCGTACTTGGCGG
CGCGGGACTGGTGATGTTCGCCATGATCATCTCATCAGGCATCGGAATTCTAGCCCGCATCAATTTCACTAAACGCAACA
TGCTGATCATCGCCGTAGGTGTTGCTGTTGGTATGAGCGTCACCATGCGCCCGGAAATTCTGGCTTATTTCCCCGATTAC
ATCAGAGTCATTTTTAGCTCAGGCATTACCGCTGGCTCCTTGGTCGCCTTGTTATTAAACCTCGTGCTCAGAGTGAGCCG
ATCCGATGAAGCGCAGTGCGCCGAAGAGAAGCGCGAGTCATTGAGAGAGCAGATAAAAGAGTGTGAATCATGCAACACCG
CACTCGCAGACCAAGAGGCTGCACGTGTAAAAGTGACTCGTGTTTAG

Upstream 100 bases:

>100_bases
GACATTTACCTAAAGCGTCGAGTACTGATTGTTACTGAGTCTCTATTGAGCTTGTTTTAGGCACCATACTCGCCGTTTAG
AGCCGAGAAAAGGATTTGAG

Downstream 100 bases:

>100_bases
TTTCAGATTGAACCCATAGTGATAACAAACGCTAAATCAATATGAGTGATTTTAAATCGCTCATAGCTCAATAAGTAAAA
ATGAAAAAGTAACACCTGTC

Product: uracil-xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MKLLYQVEDKPPMGVSIILALQHMLAAMGAIVAVPLVVGSAIGLPVNEMVILVNAALMVSGVVTMIQCKGLGPVGIRLPV
VMGTSFTFVAISISIGLESGVSAIFGSALIGSLVMIIGSRFMPQIRKLFPPVVSGTVVLLIGLTILPVAVDWFAGGFVGE
ETYGHHSNLALGFLVLVVVIALSQWGKGIVSAAAIVIGMFVGYLVSIMLGIVDFTPVFAAENFALPTLLPFGISFTISGI
IGMSIAYLVTIMESTGDFLALSDATHTKLTGKKLSRGILCDGVGSALASAVGTTPFSSFSQNVGIVSITGVASRHVVALT
GLIMVFAGLFPKVGALVVTIPSPVLGGAGLVMFAMIISSGIGILARINFTKRNMLIIAVGVAVGMSVTMRPEILAYFPDY
IRVIFSSGITAGSLVALLLNLVLRVSRSDEAQCAEEKRESLREQIKECESCNTALADQEAARVKVTRV

Sequences:

>Translated_468_residues
MKLLYQVEDKPPMGVSIILALQHMLAAMGAIVAVPLVVGSAIGLPVNEMVILVNAALMVSGVVTMIQCKGLGPVGIRLPV
VMGTSFTFVAISISIGLESGVSAIFGSALIGSLVMIIGSRFMPQIRKLFPPVVSGTVVLLIGLTILPVAVDWFAGGFVGE
ETYGHHSNLALGFLVLVVVIALSQWGKGIVSAAAIVIGMFVGYLVSIMLGIVDFTPVFAAENFALPTLLPFGISFTISGI
IGMSIAYLVTIMESTGDFLALSDATHTKLTGKKLSRGILCDGVGSALASAVGTTPFSSFSQNVGIVSITGVASRHVVALT
GLIMVFAGLFPKVGALVVTIPSPVLGGAGLVMFAMIISSGIGILARINFTKRNMLIIAVGVAVGMSVTMRPEILAYFPDY
IRVIFSSGITAGSLVALLLNLVLRVSRSDEAQCAEEKRESLREQIKECESCNTALADQEAARVKVTRV
>Mature_468_residues
MKLLYQVEDKPPMGVSIILALQHMLAAMGAIVAVPLVVGSAIGLPVNEMVILVNAALMVSGVVTMIQCKGLGPVGIRLPV
VMGTSFTFVAISISIGLESGVSAIFGSALIGSLVMIIGSRFMPQIRKLFPPVVSGTVVLLIGLTILPVAVDWFAGGFVGE
ETYGHHSNLALGFLVLVVVIALSQWGKGIVSAAAIVIGMFVGYLVSIMLGIVDFTPVFAAENFALPTLLPFGISFTISGI
IGMSIAYLVTIMESTGDFLALSDATHTKLTGKKLSRGILCDGVGSALASAVGTTPFSSFSQNVGIVSITGVASRHVVALT
GLIMVFAGLFPKVGALVVTIPSPVLGGAGLVMFAMIISSGIGILARINFTKRNMLIIAVGVAVGMSVTMRPEILAYFPDY
IRVIFSSGITAGSLVALLLNLVLRVSRSDEAQCAEEKRESLREQIKECESCNTALADQEAARVKVTRV

Specific function: Unknown

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=465, Percent_Identity=24.5161290322581, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI44680143, Length=469, Percent_Identity=24.3070362473348, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI44680148, Length=453, Percent_Identity=24.5033112582781, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI40316845, Length=453, Percent_Identity=24.5033112582781, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI87082181, Length=469, Percent_Identity=34.5415778251599, Blast_Score=265, Evalue=6e-72,
Organism=Escherichia coli, GI1790087, Length=443, Percent_Identity=35.2144469525959, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI87082178, Length=437, Percent_Identity=34.7826086956522, Blast_Score=241, Evalue=6e-65,
Organism=Escherichia coli, GI1788843, Length=391, Percent_Identity=28.1329923273657, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87081818, Length=402, Percent_Identity=26.6169154228856, Blast_Score=105, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17541904, Length=451, Percent_Identity=23.059866962306, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17542262, Length=445, Percent_Identity=22.6966292134831, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17558856, Length=185, Percent_Identity=28.1081081081081, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71993493, Length=431, Percent_Identity=23.6658932714617, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21356175, Length=446, Percent_Identity=26.9058295964126, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 48771; Mature: 48771

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLYQVEDKPPMGVSIILALQHMLAAMGAIVAVPLVVGSAIGLPVNEMVILVNAALMVS
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GVVTMIQCKGLGPVGIRLPVVMGTSFTFVAISISIGLESGVSAIFGSALIGSLVMIIGSR
HHHHHHHCCCCCCCCEEEEEEECCCEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
FMPQIRKLFPPVVSGTVVLLIGLTILPVAVDWFAGGFVGEETYGHHSNLALGFLVLVVVI
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
ALSQWGKGIVSAAAIVIGMFVGYLVSIMLGIVDFTPVFAAENFALPTLLPFGISFTISGI
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHCCHHHHHHHH
IGMSIAYLVTIMESTGDFLALSDATHTKLTGKKLSRGILCDGVGSALASAVGTTPFSSFS
HHHHHHHHHHHHHCCCCEEEECCCCCHHCCHHHHHCCCEECHHHHHHHHHHCCCCCHHHH
QNVGIVSITGVASRHVVALTGLIMVFAGLFPKVGALVVTIPSPVLGGAGLVMFAMIISSG
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHHHHCC
IGILARINFTKRNMLIIAVGVAVGMSVTMRPEILAYFPDYIRVIFSSGITAGSLVALLLN
CCEEEEEEECCCCEEEEEEEHHHCCCEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LVLRVSRSDEAQCAEEKRESLREQIKECESCNTALADQEAARVKVTRV
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCEEEECC
>Mature Secondary Structure
MKLLYQVEDKPPMGVSIILALQHMLAAMGAIVAVPLVVGSAIGLPVNEMVILVNAALMVS
CCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
GVVTMIQCKGLGPVGIRLPVVMGTSFTFVAISISIGLESGVSAIFGSALIGSLVMIIGSR
HHHHHHHCCCCCCCCEEEEEEECCCEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHH
FMPQIRKLFPPVVSGTVVLLIGLTILPVAVDWFAGGFVGEETYGHHSNLALGFLVLVVVI
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
ALSQWGKGIVSAAAIVIGMFVGYLVSIMLGIVDFTPVFAAENFALPTLLPFGISFTISGI
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHCCHHHHHHHH
IGMSIAYLVTIMESTGDFLALSDATHTKLTGKKLSRGILCDGVGSALASAVGTTPFSSFS
HHHHHHHHHHHHHCCCCEEEECCCCCHHCCHHHHHCCCEECHHHHHHHHHHCCCCCHHHH
QNVGIVSITGVASRHVVALTGLIMVFAGLFPKVGALVVTIPSPVLGGAGLVMFAMIISSG
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHHHHCC
IGILARINFTKRNMLIIAVGVAVGMSVTMRPEILAYFPDYIRVIFSSGITAGSLVALLLN
CCEEEEEEECCCCEEEEEEEHHHCCCEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LVLRVSRSDEAQCAEEKRESLREQIKECESCNTALADQEAARVKVTRV
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11792842; 8162194 [H]