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The map label for this gene is fkpA [H]

Identifier: 167622509

GI number: 167622509

Start: 685413

End: 686207

Strand: Direct

Name: fkpA [H]

Synonym: Shal_0569

Alternate gene names: 167622509

Gene position: 685413-686207 (Clockwise)

Preceding gene: 167622508

Following gene: 167622510

Centisome position: 13.11

GC content: 44.28

Gene sequence:

>795_bases
ATGATAATTATGAAAAAATTTACAAAAACCACCCTAGCTGTTGTGACTGGTTTTACTCTGTGTATGTCTGCCAACGCCAT
GGCGCAAACAGAGCTTACATCCGAAGTACAAAAAGAGTCTTACAGCATTGGCGCTTCATTAGGTAAGTACATCTCGGGTC
AAATTTATAACCAAACTGAACTTGGCGCAGAAGTGAATGTAGACCTTGTGATTGAAGGTGTGGTCGATGCGCTTAAAGAT
AACCCAAGGTTTTCAGACGAAGAGATTTTAACTTACCTCAATCAGCGTGCTGAGCAGTTAAACACAGCCAGAGAAGCGGC
TGAAGCTAAGTTAGCATTGGAGAGCTTAACTGCGGGTAACGAGTATCTTGCTGAAAACAAGAAAAAAGAGGGTGTTAAAG
AAACGGCATCTGGCTTGCAGTATGAAGTCATAAGCGAAGGTGAAGGTCGTAAACCTGATCCTCAAGATGTGGTTACTGTG
CATTACAAAGGCTCACTTATAGATGGGACTGAGTTTGATAGTACTTATGAGCGTAATGAACCAAACCGTTTTGCCTTGAT
GAGTGTTATTGAAGGCTGGCAAGAAGGGATCCCACTAATGAATGAGGGATCGACTTACAAATTATCTATTCCAGCAGCGC
TTGCCTATGGCGATAAGCAAGTTGGCATTATCCCGCCTGGTTCGGTTTTAGTGTTTGAAGTCGAACTGGTTAAAGTTGAA
GCGCCAGGCCAAAACTCTCATGGCATGGGCTTAAGTGGCATGGGCATGGGCGGCATGATGGGCGGCGGTCACTAA

Upstream 100 bases:

>100_bases
ATGGTATTTATGGATGGCGCCTCTCTAACCGAGTAACAGAAAGACCGTAACAGCTGGATGTTGGATACAAGAGTTAAACG
CAAATTGTTTATTTAAAGAG

Downstream 100 bases:

>100_bases
TAGTATGTACTCACTTAACTCATACCGTTGCTAGCGTACATGGCGCAGGTCACTTGAGTTAACTGAGCAGTTTAGATCTG
AATTGTAGTTTGTTTGTGTC

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MIIMKKFTKTTLAVVTGFTLCMSANAMAQTELTSEVQKESYSIGASLGKYISGQIYNQTELGAEVNVDLVIEGVVDALKD
NPRFSDEEILTYLNQRAEQLNTAREAAEAKLALESLTAGNEYLAENKKKEGVKETASGLQYEVISEGEGRKPDPQDVVTV
HYKGSLIDGTEFDSTYERNEPNRFALMSVIEGWQEGIPLMNEGSTYKLSIPAALAYGDKQVGIIPPGSVLVFEVELVKVE
APGQNSHGMGLSGMGMGGMMGGGH

Sequences:

>Translated_264_residues
MIIMKKFTKTTLAVVTGFTLCMSANAMAQTELTSEVQKESYSIGASLGKYISGQIYNQTELGAEVNVDLVIEGVVDALKD
NPRFSDEEILTYLNQRAEQLNTAREAAEAKLALESLTAGNEYLAENKKKEGVKETASGLQYEVISEGEGRKPDPQDVVTV
HYKGSLIDGTEFDSTYERNEPNRFALMSVIEGWQEGIPLMNEGSTYKLSIPAALAYGDKQVGIIPPGSVLVFEVELVKVE
APGQNSHGMGLSGMGMGGMMGGGH
>Mature_264_residues
MIIMKKFTKTTLAVVTGFTLCMSANAMAQTELTSEVQKESYSIGASLGKYISGQIYNQTELGAEVNVDLVIEGVVDALKD
NPRFSDEEILTYLNQRAEQLNTAREAAEAKLALESLTAGNEYLAENKKKEGVKETASGLQYEVISEGEGRKPDPQDVVTV
HYKGSLIDGTEFDSTYERNEPNRFALMSVIEGWQEGIPLMNEGSTYKLSIPAALAYGDKQVGIIPPGSVLVFEVELVKVE
APGQNSHGMGLSGMGMGGMMGGGH

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=47.6635514018692, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=47.6635514018692, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI206725530, Length=88, Percent_Identity=50, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI17149844, Length=88, Percent_Identity=50, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI17149842, Length=88, Percent_Identity=50, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=40.1869158878505, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI8923659, Length=103, Percent_Identity=39.8058252427184, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1789745, Length=221, Percent_Identity=40.2714932126697, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI87082390, Length=203, Percent_Identity=42.3645320197044, Blast_Score=136, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17540882, Length=92, Percent_Identity=44.5652173913043, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=38.6792452830189, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17561782, Length=103, Percent_Identity=38.8349514563107, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=92, Percent_Identity=51.0869565217391, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324194, Length=105, Percent_Identity=42.8571428571429, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=44.8598130841121, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21356629, Length=95, Percent_Identity=52.6315789473684, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI281363946, Length=110, Percent_Identity=42.7272727272727, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17352457, Length=110, Percent_Identity=42.7272727272727, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=38.4615384615385, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 28471; Mature: 28471

Theoretical pI: Translated: 4.38; Mature: 4.38

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIMKKFTKTTLAVVTGFTLCMSANAMAQTELTSEVQKESYSIGASLGKYISGQIYNQTE
CEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHH
LGAEVNVDLVIEGVVDALKDNPRFSDEEILTYLNQRAEQLNTAREAAEAKLALESLTAGN
CCCCCCHHEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EYLAENKKKEGVKETASGLQYEVISEGEGRKPDPQDVVTVHYKGSLIDGTEFDSTYERNE
HHHHHCHHHCCHHHHHCCCEEEEECCCCCCCCCCCCEEEEEEECCEECCCCCCCCCCCCC
PNRFALMSVIEGWQEGIPLMNEGSTYKLSIPAALAYGDKQVGIIPPGSVLVFEVELVKVE
CCHHHHHHHHHHHHHCCCCCCCCCEEEEECCEEEEECCCEEEEECCCCEEEEEEEEEEEE
APGQNSHGMGLSGMGMGGMMGGGH
CCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MIIMKKFTKTTLAVVTGFTLCMSANAMAQTELTSEVQKESYSIGASLGKYISGQIYNQTE
CEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHH
LGAEVNVDLVIEGVVDALKDNPRFSDEEILTYLNQRAEQLNTAREAAEAKLALESLTAGN
CCCCCCHHEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EYLAENKKKEGVKETASGLQYEVISEGEGRKPDPQDVVTVHYKGSLIDGTEFDSTYERNE
HHHHHCHHHCCHHHHHCCCEEEEECCCCCCCCCCCCEEEEEEECCEECCCCCCCCCCCCC
PNRFALMSVIEGWQEGIPLMNEGSTYKLSIPAALAYGDKQVGIIPPGSVLVFEVELVKVE
CCHHHHHHHHHHHHHCCCCCCCCCEEEEECCEEEEECCCEEEEECCCCEEEEEEEEEEEE
APGQNSHGMGLSGMGMGGMMGGGH
CCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]