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The map label for this gene is fkpA [H]

Identifier: 167622493

GI number: 167622493

Start: 666506

End: 667306

Strand: Direct

Name: fkpA [H]

Synonym: Shal_0553

Alternate gene names: 167622493

Gene position: 666506-667306 (Clockwise)

Preceding gene: 167622492

Following gene: 167622494

Centisome position: 12.75

GC content: 45.69

Gene sequence:

>801_bases
ATGAAAAAGCTTAAAAAAAGTGTCTTGGCCGTTGTGTCTTGTCTAACCCTATCAGTATCGGTGTCGTGTTTTGCGAATAG
CGACCTAACGACTGACGTTGAAAAGGAATCGTACAGTATAGGTGCGTCATTTGGTCACCATATCTCTAGTCAGGTATATG
GCCAAACTCAGCTCGGCGCTGAAGTTGATATGGGTCAAGTTGTAAATGGTTTACTCGATGCGTTACAAGACGAAACAAAA
ATGTCTAAAGAGGAAATCGTGACTTACCTAAACCAGCGCGCCGAAACGCTAAATGCGGCTAAGCAGGTCAAGTTAGATGC
ACTGACTGCTAAGAACTTAGCAGCTGGTGAAGCTTTCATGGCTGAAAATGCTAAAAACAGCGATGTTAAGCAGACCGAGT
CAGGCCTGCAATATGAAGTGATCACCATGGGTGAAGGTGCAATGCCGCAAGGCAATGATGTTGTCACTGTTCACTACAAG
GGTACCTTGATTGATGGCACTGAGTTTGACAGTACTTATGATCGTAACGAACCAAACCGTTTCTCTTTAGTTACCGTTAT
TGAAGGCTGGCAAGAAGCCCTTGCTTTAATGCCTCAAGGGTCAAAATTTAAGTTAGCTATTCCACCTGCACTTGCTTACG
GCGACCGTGTTGTTGGCATGATTCAGCCTCACTCAACTTTGGTATTCGAAGTTGAATTAGTCAAAGTTGAAGCGCCTGGT
GAAGGTGCTCACGGCATGGGTCTAAGTGGCATGGGTATGGGTGGCATGATGGGCGGCTCTATGGGCGCCAATCCACACTA
A

Upstream 100 bases:

>100_bases
CGTCAAATGCCAGATGGAATTTACGGCTGGCGTTTATCGAATCGAGTAACAGAAAAGCCATAACGGATTATGTTTATTTA
TTTTTAGTGAGATTGATTGT

Downstream 100 bases:

>100_bases
TAAATTTGATATTAATTATTGATATAGAGCCGAAATGAATACTGTACTTATTAGTATCTCAATTACCTTATTTTGTTCGT
TTGCATTTCTTTTTTGCCAT

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MKKLKKSVLAVVSCLTLSVSVSCFANSDLTTDVEKESYSIGASFGHHISSQVYGQTQLGAEVDMGQVVNGLLDALQDETK
MSKEEIVTYLNQRAETLNAAKQVKLDALTAKNLAAGEAFMAENAKNSDVKQTESGLQYEVITMGEGAMPQGNDVVTVHYK
GTLIDGTEFDSTYDRNEPNRFSLVTVIEGWQEALALMPQGSKFKLAIPPALAYGDRVVGMIQPHSTLVFEVELVKVEAPG
EGAHGMGLSGMGMGGMMGGSMGANPH

Sequences:

>Translated_266_residues
MKKLKKSVLAVVSCLTLSVSVSCFANSDLTTDVEKESYSIGASFGHHISSQVYGQTQLGAEVDMGQVVNGLLDALQDETK
MSKEEIVTYLNQRAETLNAAKQVKLDALTAKNLAAGEAFMAENAKNSDVKQTESGLQYEVITMGEGAMPQGNDVVTVHYK
GTLIDGTEFDSTYDRNEPNRFSLVTVIEGWQEALALMPQGSKFKLAIPPALAYGDRVVGMIQPHSTLVFEVELVKVEAPG
EGAHGMGLSGMGMGGMMGGSMGANPH
>Mature_266_residues
MKKLKKSVLAVVSCLTLSVSVSCFANSDLTTDVEKESYSIGASFGHHISSQVYGQTQLGAEVDMGQVVNGLLDALQDETK
MSKEEIVTYLNQRAETLNAAKQVKLDALTAKNLAAGEAFMAENAKNSDVKQTESGLQYEVITMGEGAMPQGNDVVTVHYK
GTLIDGTEFDSTYDRNEPNRFSLVTVIEGWQEALALMPQGSKFKLAIPPALAYGDRVVGMIQPHSTLVFEVELVKVEAPG
EGAHGMGLSGMGMGGMMGGSMGANPH

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=47.6635514018692, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=47.6635514018692, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI206725530, Length=88, Percent_Identity=52.2727272727273, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI17149844, Length=88, Percent_Identity=52.2727272727273, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI17149842, Length=88, Percent_Identity=52.2727272727273, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI4758380, Length=107, Percent_Identity=40.1869158878505, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI8923659, Length=92, Percent_Identity=42.3913043478261, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI224809329, Length=89, Percent_Identity=43.8202247191011, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI224809327, Length=89, Percent_Identity=43.8202247191011, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4758384, Length=89, Percent_Identity=43.8202247191011, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4503729, Length=92, Percent_Identity=43.4782608695652, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI224809331, Length=89, Percent_Identity=43.8202247191011, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI192448443, Length=95, Percent_Identity=40, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1789745, Length=218, Percent_Identity=41.2844036697248, Blast_Score=161, Evalue=4e-41,
Organism=Escherichia coli, GI87082390, Length=202, Percent_Identity=44.5544554455446, Blast_Score=145, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17540882, Length=92, Percent_Identity=46.7391304347826, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=39.622641509434, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324194, Length=108, Percent_Identity=43.5185185185185, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320727, Length=96, Percent_Identity=51.0416666666667, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=48.5981308411215, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281363946, Length=107, Percent_Identity=44.8598130841121, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17352457, Length=107, Percent_Identity=44.8598130841121, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21356629, Length=124, Percent_Identity=44.3548387096774, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24583150, Length=106, Percent_Identity=39.622641509434, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 28342; Mature: 28342

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLKKSVLAVVSCLTLSVSVSCFANSDLTTDVEKESYSIGASFGHHISSQVYGQTQLGA
CHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCEEECCHHHHHHHHHHCCCHHCCC
EVDMGQVVNGLLDALQDETKMSKEEIVTYLNQRAETLNAAKQVKLDALTAKNLAAGEAFM
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AENAKNSDVKQTESGLQYEVITMGEGAMPQGNDVVTVHYKGTLIDGTEFDSTYDRNEPNR
HCCCCCCCHHHHHCCCEEEEEEECCCCCCCCCCEEEEEEECEEECCCCCCCCCCCCCCCC
FSLVTVIEGWQEALALMPQGSKFKLAIPPALAYGDRVVGMIQPHSTLVFEVELVKVEAPG
EEEEHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCEEEEEECCCCEEEEEEEEEEEECCC
EGAHGMGLSGMGMGGMMGGSMGANPH
CCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKLKKSVLAVVSCLTLSVSVSCFANSDLTTDVEKESYSIGASFGHHISSQVYGQTQLGA
CHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCEEECCHHHHHHHHHHCCCHHCCC
EVDMGQVVNGLLDALQDETKMSKEEIVTYLNQRAETLNAAKQVKLDALTAKNLAAGEAFM
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AENAKNSDVKQTESGLQYEVITMGEGAMPQGNDVVTVHYKGTLIDGTEFDSTYDRNEPNR
HCCCCCCCHHHHHCCCEEEEEEECCCCCCCCCCEEEEEEECEEECCCCCCCCCCCCCCCC
FSLVTVIEGWQEALALMPQGSKFKLAIPPALAYGDRVVGMIQPHSTLVFEVELVKVEAPG
EEEEHHHHHHHHHHHHCCCCCEEEEECCCHHHCCCEEEEEECCCCEEEEEEEEEEEECCC
EGAHGMGLSGMGMGGMMGGSMGANPH
CCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]