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The map label for this gene is coaBC [H]

Identifier: 167622368

GI number: 167622368

Start: 503197

End: 504390

Strand: Reverse

Name: coaBC [H]

Synonym: Shal_0428

Alternate gene names: 167622368

Gene position: 504390-503197 (Counterclockwise)

Preceding gene: 167622374

Following gene: 167622367

Centisome position: 9.65

GC content: 50.59

Gene sequence:

>1194_bases
ATGGGTCTCAATAACAAAAAAGTGCTACTGGGTATTGGCGGCGGCATTGCCGCATATAAATCAGCTGATCTGGTACGTAA
GTTAAAAGAACGCGGCGCCGATGTCCGAGTTGTTATGAGTCAAAGTGCGCAGGAATTTATTACCCCGCTAACTTTGCAAG
CGCTGTCCGGTTATCCGGTGGCAACCGATCTGCTTGATCCTACAGCCGAAGCCTCTATGGGGCATATCGAGTTGGCACGT
TGGGCAGACTTAGTCATTATAGCTCCTGCGACAGCAAATCTTATCGCGCGTATTAATGCGGGTATGGCCGATGAGTTGAT
CACAACCACCTGCTTAGCTACCGAAGCGCCTGTAGTGCTTTGTCCAGCCATGAACCAACAGATGTATCGCAATGGCGCGA
CTCAAGCCAACTTAAAGCAAGTGGCCGAGCGAGGCATTCACATCTGGGGGCCTGAATCTGGCTCTCAAGCTTGCGGAGAA
GTCGGTCCAGGCAGAATGCTTGAGCCGGTAGCAATTGCAGATAAAGCGGTTAATTTTTTTGGCCCTAAGCTACTGCAAGG
CATGTCACTACTGCTTACAGCAGGTCCGACTCGAGAAGCAATCGACCCGGTGCGTTACATCTCCAACCACAGCTCAGGCA
AGATGGGCTTTGCACTGGCTAAAGCCGCCGCAGAGATGGGCGCCGAGGTGACGCTAGTTGCAGGTCCCGTCAATCTAGCG
ACCCCTAACGGCGTGACTCGCATCAATGTTGAGTCGGCTCAAGAGATGCTGGACGCGGTGATGCCGCAGGTTGAGAAGCA
CCAAATATTTATCGGCTGCGCCGCCGTTGCCGATTACCGCATCGCAGACGTGGCTGAGAGTAAAATAAAGAAATCGGCTG
AACAGATGCAACTTGCGCTAGTGCGAAATCCTGATATCTTAGCCAGCGTTGCCAGCCATGCTAACCGACCTTTTACCGTC
GGATTTGCAGCTGAAACCAACGATGTAGAGCAATATGCACGCGGAAAACTGACGCGTAAGAAGCTCGATATGATTGCCGC
TAATGACGTATCAAATAGCGCCATTGGCTTTAACAGTGACTCCAATGCACTCAGCGTATTTTGGAGTGATGGTAGCACCG
ATTTACCCGCTGTGAATAAAGACACTTTAGCCAAGCAATTGCTTACTCTAATAGCGAACAAAATAAAAAACTGA

Upstream 100 bases:

>100_bases
AAGTTGTTCATCACCATTTTATGGTTTGTGATATCTTAGGCCCAACCTCTGCAGCGTGATAAAATGTTTATCGCCGAAGT
GATGACGAAAAGAGTTAAGT

Downstream 100 bases:

>100_bases
TGAAAACACCAATCGAATTAAAGATTTTAGACTCACGCATCGGCACTGAATTTCCACTCCCAGCTTACGCAACACCAGGC
AGTGCAGGAATGGATCTTCG

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MGLNNKKVLLGIGGGIAAYKSADLVRKLKERGADVRVVMSQSAQEFITPLTLQALSGYPVATDLLDPTAEASMGHIELAR
WADLVIIAPATANLIARINAGMADELITTTCLATEAPVVLCPAMNQQMYRNGATQANLKQVAERGIHIWGPESGSQACGE
VGPGRMLEPVAIADKAVNFFGPKLLQGMSLLLTAGPTREAIDPVRYISNHSSGKMGFALAKAAAEMGAEVTLVAGPVNLA
TPNGVTRINVESAQEMLDAVMPQVEKHQIFIGCAAVADYRIADVAESKIKKSAEQMQLALVRNPDILASVASHANRPFTV
GFAAETNDVEQYARGKLTRKKLDMIAANDVSNSAIGFNSDSNALSVFWSDGSTDLPAVNKDTLAKQLLTLIANKIKN

Sequences:

>Translated_397_residues
MGLNNKKVLLGIGGGIAAYKSADLVRKLKERGADVRVVMSQSAQEFITPLTLQALSGYPVATDLLDPTAEASMGHIELAR
WADLVIIAPATANLIARINAGMADELITTTCLATEAPVVLCPAMNQQMYRNGATQANLKQVAERGIHIWGPESGSQACGE
VGPGRMLEPVAIADKAVNFFGPKLLQGMSLLLTAGPTREAIDPVRYISNHSSGKMGFALAKAAAEMGAEVTLVAGPVNLA
TPNGVTRINVESAQEMLDAVMPQVEKHQIFIGCAAVADYRIADVAESKIKKSAEQMQLALVRNPDILASVASHANRPFTV
GFAAETNDVEQYARGKLTRKKLDMIAANDVSNSAIGFNSDSNALSVFWSDGSTDLPAVNKDTLAKQLLTLIANKIKN
>Mature_396_residues
GLNNKKVLLGIGGGIAAYKSADLVRKLKERGADVRVVMSQSAQEFITPLTLQALSGYPVATDLLDPTAEASMGHIELARW
ADLVIIAPATANLIARINAGMADELITTTCLATEAPVVLCPAMNQQMYRNGATQANLKQVAERGIHIWGPESGSQACGEV
GPGRMLEPVAIADKAVNFFGPKLLQGMSLLLTAGPTREAIDPVRYISNHSSGKMGFALAKAAAEMGAEVTLVAGPVNLAT
PNGVTRINVESAQEMLDAVMPQVEKHQIFIGCAAVADYRIADVAESKIKKSAEQMQLALVRNPDILASVASHANRPFTVG
FAAETNDVEQYARGKLTRKKLDMIAANDVSNSAIGFNSDSNALSVFWSDGSTDLPAVNKDTLAKQLLTLIANKIKN

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=176, Percent_Identity=32.9545454545455, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI87082301, Length=399, Percent_Identity=61.4035087719298, Blast_Score=483, Evalue=1e-137,
Organism=Drosophila melanogaster, GI24657262, Length=187, Percent_Identity=26.2032085561497, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42048; Mature: 41917

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLNNKKVLLGIGGGIAAYKSADLVRKLKERGADVRVVMSQSAQEFITPLTLQALSGYPV
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEHHCHHHHHHHHHHHHHCCCCC
ATDLLDPTAEASMGHIELARWADLVIIAPATANLIARINAGMADELITTTCLATEAPVVL
CHHHCCCCHHCCCCCEEHCCCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCCEEE
CPAMNQQMYRNGATQANLKQVAERGIHIWGPESGSQACGEVGPGRMLEPVAIADKAVNFF
ECCCCHHHHHCCCCHHHHHHHHHCCCEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHHC
GPKLLQGMSLLLTAGPTREAIDPVRYISNHSSGKMGFALAKAAAEMGAEVTLVAGPVNLA
CHHHHHCHHEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCEEC
TPNGVTRINVESAQEMLDAVMPQVEKHQIFIGCAAVADYRIADVAESKIKKSAEQMQLAL
CCCCEEEEEHHHHHHHHHHHCCCHHHCEEEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHH
VRNPDILASVASHANRPFTVGFAAETNDVEQYARGKLTRKKLDMIAANDVSNSAIGFNSD
CCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCHHHHHHHHHHEECCCCCCCCCCCCC
SNALSVFWSDGSTDLPAVNKDTLAKQLLTLIANKIKN
CCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GLNNKKVLLGIGGGIAAYKSADLVRKLKERGADVRVVMSQSAQEFITPLTLQALSGYPV
CCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEHHCHHHHHHHHHHHHHCCCCC
ATDLLDPTAEASMGHIELARWADLVIIAPATANLIARINAGMADELITTTCLATEAPVVL
CHHHCCCCHHCCCCCEEHCCCCCEEEECCCHHHHHHHHCCCCHHHHHHHHHHHCCCCEEE
CPAMNQQMYRNGATQANLKQVAERGIHIWGPESGSQACGEVGPGRMLEPVAIADKAVNFF
ECCCCHHHHHCCCCHHHHHHHHHCCCEEECCCCCCHHHCCCCCCCCCCHHHHHHHHHHHC
GPKLLQGMSLLLTAGPTREAIDPVRYISNHSSGKMGFALAKAAAEMGAEVTLVAGPVNLA
CHHHHHCHHEEEECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCEEC
TPNGVTRINVESAQEMLDAVMPQVEKHQIFIGCAAVADYRIADVAESKIKKSAEQMQLAL
CCCCEEEEEHHHHHHHHHHHCCCHHHCEEEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHH
VRNPDILASVASHANRPFTVGFAAETNDVEQYARGKLTRKKLDMIAANDVSNSAIGFNSD
CCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCHHHHHHHHHHEECCCCCCCCCCCCC
SNALSVFWSDGSTDLPAVNKDTLAKQLLTLIANKIKN
CCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]