Click here to switch to the map view.

The map label for this gene is hutH [H]

Identifier: 167622315

GI number: 167622315

Start: 441080

End: 442642

Strand: Reverse

Name: hutH [H]

Synonym: Shal_0375

Alternate gene names: 167622315

Gene position: 442642-441080 (Counterclockwise)

Preceding gene: 167622316

Following gene: 167622314

Centisome position: 8.47

GC content: 52.46

Gene sequence:

>1563_bases
ATGACCCAACACAATACCTATAATCTTAGCCAGCAAACCGTTGAATTTGGCTATAACAGCCTATCGCTTGAAGATGTGGT
GGCTATCGCCAAAGGCGCGACAGCCAAGCTAAATCAGACTGGAGAGTATCGAGCCTATATCCAAAAAGGCGCCCAGTTTA
TCGATAGCTTACTTAAAGAAGAGGGCGTGGTTTACGGCGTTACCACAGGTTATGGCGACTCTTGCACTGTGACTGTTGGC
TTAGATTTAGTCCATGAGCTACCTCTGCACCTAACCCGTTTTCACGGCTGTGGCATGGGAGAAATTTTATCACCGATGCA
GGCCCGCGCCGTAATGGCATGCCGACTCAGCTCACTCGCCGTAGGTAAATCTGGCGTGAGTTACGAGCTACTCGCGCGTA
TCGAAACCCTACTCAACCTCAACATCACCCCAGTGATCCCTGAAGAGGGCTCGGTCGGTGCCAGCGGTGACTTAACGCCA
CTGTCTTACCTAGCAGCAGTATTGATCGGCGAGCGCGATGTCATCTATCAAGGTGAGCGATGCCCAACCGGCGACGTATA
TAAAGAACTTAATATCGTACCCCTTAAGCTACGTCCGAAAGAGGGCTTAGCACTGATGAACGGCACCGCAGTAATGACGG
CTCTGGCCTGCTTGGCTTTCGATCGCGCCCAATATATGGCGCGCCTTGCCAGCCGCATTACCGCCATGGCTTCATTAACC
CTCAAAGGTAACTCGAATCACTTCGATGAGATCCTATTTGCCGCCAAGCCACACCCGGGGCAAAACCAGATCGCAGCGTG
GATCCGTGAAGACCTCAATCATCATATCCATCCACGCAACTCAGACAGACTGCAGGACAGATATTCTATCCGCTGCGCCC
CCCATGTGATTGGTGTGCTGCAAGATGCACTACCGTTTATGCGCCAGTTTATTGAGACTGAGCTTAACAGCGCCAACGAT
AACCCGATTGTCGATGGTGAAGGCGAGCATATCTTGCACGGCGGCCACTTTTACGGTGGTCACATCGCCTTTGTCATGGA
CGCAATGAAAAATGCGGTAGCCAATATTGCCGATCTTATCGATCGTCAGATGGCGCTGGTGATGGATCAGAAGTTCAATA
ACGGCCTACCCGCTAACCTTTCCGGTGCTCAAGGCAAGCGTAAGGCGATTAACCACGGCTTTAAAGCGGTGCAGATTGGC
GTATCGGCTTGGACGGCTGAAGCCCTTAAGAACACTATGCCAGCGAGCGTGTTTTCGCGCTCTACCGAGTGTCACAACCA
AGATAAGGTAAGTATGGGTACCATCTCTGCACGCGACTGCATGCGCGTACTACAGCTAACCGAGCAAGTGGCCGCAGCGG
CGCTTCTAGCCATGTCGCAAGGCATTCGCCTGCGTATCGCACAGGAGGAGCTGGTGCCGAGTTCGATTACCCCATCGCTG
GGTAAAACCTTGGCCCAAGTCGAAGCAGACTTCGAACTATTGACCGAAGACAGACCGCTAGAGCAGACCCTACGCTCAAC
GGTGGATAAGATCCAAAATGGCTACTGGGAAGTGTGCAGCTAA

Upstream 100 bases:

>100_bases
TGCAATGGTTTAATTTTTATGATTTCTGGCGCAAGGATGAAGAGTTCCAACGTGCCGATGCGCAAAGCAGTGATTGCAGC
AGTAAAGGACAAGCAAGCAA

Downstream 100 bases:

>100_bases
TGAAGGGCATTCTACATACTGAACTGGAAGTAGAGATCCCTTTTCACGATGTCGATTCTATGGGCAATAACTGTTGGCAT
GACTTACCTGTGCCAAAAGT

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MTQHNTYNLSQQTVEFGYNSLSLEDVVAIAKGATAKLNQTGEYRAYIQKGAQFIDSLLKEEGVVYGVTTGYGDSCTVTVG
LDLVHELPLHLTRFHGCGMGEILSPMQARAVMACRLSSLAVGKSGVSYELLARIETLLNLNITPVIPEEGSVGASGDLTP
LSYLAAVLIGERDVIYQGERCPTGDVYKELNIVPLKLRPKEGLALMNGTAVMTALACLAFDRAQYMARLASRITAMASLT
LKGNSNHFDEILFAAKPHPGQNQIAAWIREDLNHHIHPRNSDRLQDRYSIRCAPHVIGVLQDALPFMRQFIETELNSAND
NPIVDGEGEHILHGGHFYGGHIAFVMDAMKNAVANIADLIDRQMALVMDQKFNNGLPANLSGAQGKRKAINHGFKAVQIG
VSAWTAEALKNTMPASVFSRSTECHNQDKVSMGTISARDCMRVLQLTEQVAAAALLAMSQGIRLRIAQEELVPSSITPSL
GKTLAQVEADFELLTEDRPLEQTLRSTVDKIQNGYWEVCS

Sequences:

>Translated_520_residues
MTQHNTYNLSQQTVEFGYNSLSLEDVVAIAKGATAKLNQTGEYRAYIQKGAQFIDSLLKEEGVVYGVTTGYGDSCTVTVG
LDLVHELPLHLTRFHGCGMGEILSPMQARAVMACRLSSLAVGKSGVSYELLARIETLLNLNITPVIPEEGSVGASGDLTP
LSYLAAVLIGERDVIYQGERCPTGDVYKELNIVPLKLRPKEGLALMNGTAVMTALACLAFDRAQYMARLASRITAMASLT
LKGNSNHFDEILFAAKPHPGQNQIAAWIREDLNHHIHPRNSDRLQDRYSIRCAPHVIGVLQDALPFMRQFIETELNSAND
NPIVDGEGEHILHGGHFYGGHIAFVMDAMKNAVANIADLIDRQMALVMDQKFNNGLPANLSGAQGKRKAINHGFKAVQIG
VSAWTAEALKNTMPASVFSRSTECHNQDKVSMGTISARDCMRVLQLTEQVAAAALLAMSQGIRLRIAQEELVPSSITPSL
GKTLAQVEADFELLTEDRPLEQTLRSTVDKIQNGYWEVCS
>Mature_519_residues
TQHNTYNLSQQTVEFGYNSLSLEDVVAIAKGATAKLNQTGEYRAYIQKGAQFIDSLLKEEGVVYGVTTGYGDSCTVTVGL
DLVHELPLHLTRFHGCGMGEILSPMQARAVMACRLSSLAVGKSGVSYELLARIETLLNLNITPVIPEEGSVGASGDLTPL
SYLAAVLIGERDVIYQGERCPTGDVYKELNIVPLKLRPKEGLALMNGTAVMTALACLAFDRAQYMARLASRITAMASLTL
KGNSNHFDEILFAAKPHPGQNQIAAWIREDLNHHIHPRNSDRLQDRYSIRCAPHVIGVLQDALPFMRQFIETELNSANDN
PIVDGEGEHILHGGHFYGGHIAFVMDAMKNAVANIADLIDRQMALVMDQKFNNGLPANLSGAQGKRKAINHGFKAVQIGV
SAWTAEALKNTMPASVFSRSTECHNQDKVSMGTISARDCMRVLQLTEQVAAAALLAMSQGIRLRIAQEELVPSSITPSLG
KTLAQVEADFELLTEDRPLEQTLRSTVDKIQNGYWEVCS

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=504, Percent_Identity=36.5079365079365, Blast_Score=295, Evalue=7e-80,
Organism=Caenorhabditis elegans, GI17567831, Length=509, Percent_Identity=37.1316306483301, Blast_Score=276, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 56719; Mature: 56587

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQHNTYNLSQQTVEFGYNSLSLEDVVAIAKGATAKLNQTGEYRAYIQKGAQFIDSLLKE
CCCCCCCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EGVVYGVTTGYGDSCTVTVGLDLVHELPLHLTRFHGCGMGEILSPMQARAVMACRLSSLA
CCEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
VGKSGVSYELLARIETLLNLNITPVIPEEGSVGASGDLTPLSYLAAVLIGERDVIYQGER
CCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCC
CPTGDVYKELNIVPLKLRPKEGLALMNGTAVMTALACLAFDRAQYMARLASRITAMASLT
CCCCHHHHCCCEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
LKGNSNHFDEILFAAKPHPGQNQIAAWIREDLNHHIHPRNSDRLQDRYSIRCAPHVIGVL
EECCCCCHHHHHEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEEHHHHHHHH
QDALPFMRQFIETELNSANDNPIVDGEGEHILHGGHFYGGHIAFVMDAMKNAVANIADLI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEECCHHHHHHHHHHHHHHHHHHHH
DRQMALVMDQKFNNGLPANLSGAQGKRKAINHGFKAVQIGVSAWTAEALKNTMPASVFSR
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCEEEEEHHHHHHHHHHHHCCCHHHHHC
STECHNQDKVSMGTISARDCMRVLQLTEQVAAAALLAMSQGIRLRIAQEELVPSSITPSL
CHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCCCHH
GKTLAQVEADFELLTEDRPLEQTLRSTVDKIQNGYWEVCS
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TQHNTYNLSQQTVEFGYNSLSLEDVVAIAKGATAKLNQTGEYRAYIQKGAQFIDSLLKE
CCCCCCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
EGVVYGVTTGYGDSCTVTVGLDLVHELPLHLTRFHGCGMGEILSPMQARAVMACRLSSLA
CCEEEEEECCCCCCEEEEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
VGKSGVSYELLARIETLLNLNITPVIPEEGSVGASGDLTPLSYLAAVLIGERDVIYQGER
CCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCEEECCCC
CPTGDVYKELNIVPLKLRPKEGLALMNGTAVMTALACLAFDRAQYMARLASRITAMASLT
CCCCHHHHCCCEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
LKGNSNHFDEILFAAKPHPGQNQIAAWIREDLNHHIHPRNSDRLQDRYSIRCAPHVIGVL
EECCCCCHHHHHEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHEEEHHHHHHHH
QDALPFMRQFIETELNSANDNPIVDGEGEHILHGGHFYGGHIAFVMDAMKNAVANIADLI
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCEECCHHHHHHHHHHHHHHHHHHHH
DRQMALVMDQKFNNGLPANLSGAQGKRKAINHGFKAVQIGVSAWTAEALKNTMPASVFSR
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCEEEEEHHHHHHHHHHHHCCCHHHHHC
STECHNQDKVSMGTISARDCMRVLQLTEQVAAAALLAMSQGIRLRIAQEELVPSSITPSL
CHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCCCCHH
GKTLAQVEADFELLTEDRPLEQTLRSTVDKIQNGYWEVCS
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA