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The map label for this gene is fabF [H]

Identifier: 167622309

GI number: 167622309

Start: 433902

End: 435200

Strand: Reverse

Name: fabF [H]

Synonym: Shal_0369

Alternate gene names: 167622309

Gene position: 435200-433902 (Counterclockwise)

Preceding gene: 167622310

Following gene: 167622308

Centisome position: 8.33

GC content: 49.65

Gene sequence:

>1299_bases
GTGAACTCAACAACACAAATCGCGATAACCCATCTAGGTTTATGCTGCCCTCTAGGTCAGTCACCGCAAGCTGTGCTCGA
CAATCTAGTCCAAGCCAGTATCGCAGGCATGCAGTGGCGTGACGATCTGCTATTTGAACACCCTGTACTAGTTGGCCAAG
TCGATGTAGAGCTGCCTGTGATCCCATCAGCCTTAAAGCGGTTTGATACCCGTAATAACCAGCTTACTCTGTTGATTGCT
CGGCAGATAGAGCAAGCCGTTGAGCAAGCTAAGGCACGCTACGGATGTGAACGAATCGGTATTATTATCGGTACCAGTAC
CTCAGGCATTGCCACCGGCGAAGCTGCGCTTAGTGAGCATGAAACTCATGGCGAGTTTCCAAAAGAGTATGATTATGCCA
AGCAAGAACTTGGGGATACGAGCCAGTTTTTGCAAGCCTACTTTGAGTTAACAGGCCCTTGCTATACCGTATCGACAGCT
TGCTCCTCTAGCGCCAAGGTCTTTGCCAGCGCCAAGCGCCTTATCGATGCCGAGATCTGCGATATGGTGATTGTCGGTGG
TATCGATACCCTGTGTAAGCTCACCCTTAACGGCTTTTACTCGCTCGAATCCATATCTAGCGGCCATTGCCAACCCTTTA
GCGCTAATCGTGATGGTATCAATATCGGCGAAGGTGGCGCCCTCTTTCTTTTAGAGAAAGTTACACTAGAGAAGCTTGCT
CCTGAAAAAACAGCGAAAGATGGTGAGGAGAAAGTGATAATTCTCAGTGGCATTGGCGAGTCTAGCGATGCCCACCATAT
CTCAGCACCGCATCCAGAAGGCAGAGGCGCAGTCAATGCGATGCAAGCCGCCCTTACCATGGCAAATCTTAAGCCTGAGC
AGATCGATTACCTCAACCTGCATGGCACTGCGACACCTAAAAATGACGCCATGGAGAGCCGCGCTGTACATCAAGTCTTT
AGCAATAACTTGCCTGCCGCGAGTTCAACCAAACCACTCACGGGCCATACTTTAGGCGCTGCGGGTGCGATAGAAGCAGC
GTTTTGCTATCTACTGCTCAGTGATTACAATACTCACCAGCAATTGCCACCGCAGGTGTGGGATGGGAAGCAAGATCCTA
ATGACCCAAGCCTGCCGCTAGTCGCAAAAGGGCAACAGGCCAGTATTAATCACGTAATGAGTAACTCTTTTGCCTTTGGT
GGCAGTAATGCTAGCCTGATCTTGAGCCGTAACAGCTCAAGTCGCGAAGCGCTAAAAAATATAGACAATGACTCAACAGA
GACAAACCAAGATGCTTGA

Upstream 100 bases:

>100_bases
AGTTTAGACAAGTGGCAAGCTCATGTTAGCCTAAGTATTGATGCTGCAAACTTTAAGCTGGCCATCAGCCCGTTATAAAC
CTGATTTAGTGGAAATTTAA

Downstream 100 bases:

>100_bases
TGTAACTCCGTGTGATGCAAACAAGTGTGATGTGACTAAGTTCGATGTCACTAGGCTTGCCGAGCAAGAGGTGGAAAAGT
TTATTCCCCATCGCCAGCCG

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MNSTTQIAITHLGLCCPLGQSPQAVLDNLVQASIAGMQWRDDLLFEHPVLVGQVDVELPVIPSALKRFDTRNNQLTLLIA
RQIEQAVEQAKARYGCERIGIIIGTSTSGIATGEAALSEHETHGEFPKEYDYAKQELGDTSQFLQAYFELTGPCYTVSTA
CSSSAKVFASAKRLIDAEICDMVIVGGIDTLCKLTLNGFYSLESISSGHCQPFSANRDGINIGEGGALFLLEKVTLEKLA
PEKTAKDGEEKVIILSGIGESSDAHHISAPHPEGRGAVNAMQAALTMANLKPEQIDYLNLHGTATPKNDAMESRAVHQVF
SNNLPAASSTKPLTGHTLGAAGAIEAAFCYLLLSDYNTHQQLPPQVWDGKQDPNDPSLPLVAKGQQASINHVMSNSFAFG
GSNASLILSRNSSSREALKNIDNDSTETNQDA

Sequences:

>Translated_432_residues
MNSTTQIAITHLGLCCPLGQSPQAVLDNLVQASIAGMQWRDDLLFEHPVLVGQVDVELPVIPSALKRFDTRNNQLTLLIA
RQIEQAVEQAKARYGCERIGIIIGTSTSGIATGEAALSEHETHGEFPKEYDYAKQELGDTSQFLQAYFELTGPCYTVSTA
CSSSAKVFASAKRLIDAEICDMVIVGGIDTLCKLTLNGFYSLESISSGHCQPFSANRDGINIGEGGALFLLEKVTLEKLA
PEKTAKDGEEKVIILSGIGESSDAHHISAPHPEGRGAVNAMQAALTMANLKPEQIDYLNLHGTATPKNDAMESRAVHQVF
SNNLPAASSTKPLTGHTLGAAGAIEAAFCYLLLSDYNTHQQLPPQVWDGKQDPNDPSLPLVAKGQQASINHVMSNSFAFG
GSNASLILSRNSSSREALKNIDNDSTETNQDA
>Mature_432_residues
MNSTTQIAITHLGLCCPLGQSPQAVLDNLVQASIAGMQWRDDLLFEHPVLVGQVDVELPVIPSALKRFDTRNNQLTLLIA
RQIEQAVEQAKARYGCERIGIIIGTSTSGIATGEAALSEHETHGEFPKEYDYAKQELGDTSQFLQAYFELTGPCYTVSTA
CSSSAKVFASAKRLIDAEICDMVIVGGIDTLCKLTLNGFYSLESISSGHCQPFSANRDGINIGEGGALFLLEKVTLEKLA
PEKTAKDGEEKVIILSGIGESSDAHHISAPHPEGRGAVNAMQAALTMANLKPEQIDYLNLHGTATPKNDAMESRAVHQVF
SNNLPAASSTKPLTGHTLGAAGAIEAAFCYLLLSDYNTHQQLPPQVWDGKQDPNDPSLPLVAKGQQASINHVMSNSFAFG
GSNASLILSRNSSSREALKNIDNDSTETNQDA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=280, Percent_Identity=37.8571428571429, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI223972627, Length=159, Percent_Identity=42.7672955974843, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI41872631, Length=329, Percent_Identity=28.8753799392097, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1788663, Length=422, Percent_Identity=28.9099526066351, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1787337, Length=277, Percent_Identity=33.5740072202166, Blast_Score=129, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71983541, Length=422, Percent_Identity=27.4881516587678, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71983535, Length=272, Percent_Identity=31.25, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI212642053, Length=281, Percent_Identity=28.8256227758007, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17550940, Length=297, Percent_Identity=24.9158249158249, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320904, Length=279, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24644341, Length=274, Percent_Identity=34.3065693430657, Blast_Score=140, Evalue=2e-33,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 46236; Mature: 46236

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSTTQIAITHLGLCCPLGQSPQAVLDNLVQASIAGMQWRDDLLFEHPVLVGQVDVELPV
CCCCCEEEEEHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEEEEEECCC
IPSALKRFDTRNNQLTLLIARQIEQAVEQAKARYGCERIGIIIGTSTSGIATGEAALSEH
CHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHC
ETHGEFPKEYDYAKQELGDTSQFLQAYFELTGPCYTVSTACSSSAKVFASAKRLIDAEIC
CCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEHHHHCCHHHHHHHHHHHHHHHHH
DMVIVGGIDTLCKLTLNGFYSLESISSGHCQPFSANRDGINIGEGGALFLLEKVTLEKLA
CEEEECCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCEECCCCEEEEEHHHHHHHHC
PEKTAKDGEEKVIILSGIGESSDAHHISAPHPEGRGAVNAMQAALTMANLKPEQIDYLNL
CHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEE
HGTATPKNDAMESRAVHQVFSNNLPAASSTKPLTGHTLGAAGAIEAAFCYLLLSDYNTHQ
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
QLPPQVWDGKQDPNDPSLPLVAKGQQASINHVMSNSFAFGGSNASLILSRNSSSREALKN
CCCCHHCCCCCCCCCCCCCEEECCCCHHHHHHHHCCEEECCCCCEEEEECCCCHHHHHHH
IDNDSTETNQDA
CCCCCCCCCCCC
>Mature Secondary Structure
MNSTTQIAITHLGLCCPLGQSPQAVLDNLVQASIAGMQWRDDLLFEHPVLVGQVDVELPV
CCCCCEEEEEHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHCCCEEEEEEEEECCC
IPSALKRFDTRNNQLTLLIARQIEQAVEQAKARYGCERIGIIIGTSTSGIATGEAALSEH
CHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHHC
ETHGEFPKEYDYAKQELGDTSQFLQAYFELTGPCYTVSTACSSSAKVFASAKRLIDAEIC
CCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEHHHHCCHHHHHHHHHHHHHHHHH
DMVIVGGIDTLCKLTLNGFYSLESISSGHCQPFSANRDGINIGEGGALFLLEKVTLEKLA
CEEEECCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCEECCCCEEEEEHHHHHHHHC
PEKTAKDGEEKVIILSGIGESSDAHHISAPHPEGRGAVNAMQAALTMANLKPEQIDYLNL
CHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEE
HGTATPKNDAMESRAVHQVFSNNLPAASSTKPLTGHTLGAAGAIEAAFCYLLLSDYNTHQ
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
QLPPQVWDGKQDPNDPSLPLVAKGQQASINHVMSNSFAFGGSNASLILSRNSSSREALKN
CCCCHHCCCCCCCCCCCCCEEECCCCHHHHHHHHCCEEECCCCCEEEEECCCCHHHHHHH
IDNDSTETNQDA
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]