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The map label for this gene is gpsA

Identifier: 167621987

GI number: 167621987

Start: 54808

End: 55827

Strand: Direct

Name: gpsA

Synonym: Shal_0046

Alternate gene names: 167621987

Gene position: 54808-55827 (Clockwise)

Preceding gene: 167621986

Following gene: 167621988

Centisome position: 1.05

GC content: 49.22

Gene sequence:

>1020_bases
ATGAAAAACACTGCCGACATTACGGTACTGGGGGCGGGCTCTTACGGGACCGCCCTTGCCATTTCTTTAGCGAGTAATGG
CCACAGAACCATGCTTTGGGGACACGAACCCGAGCACATAGAAAACCTGAAAAACGACAAGTCTAACGAAGCGTTTTTAC
CGGGTATTCCACTTCCTGACCTGCTGATCCCTGAAGCTGATTTAGCGACGGCTCTAGCTGCATCTAATAATGTACTAGTG
GTCGTACCTAGCCATGTATTTGGTTTGGTACTGAGCCAAGCCAAACCGCTTCTGCGTAAAGATTCGCGTATTGTTTGGGC
TACTAAAGGCCTAGAGCCTGAGACTGGCCGTTTAATACAAGATGTTGCCCGCGAAGTGTTAGGCGATGAGTATCCATTAG
CTGTGTTATCGGGACCGACTTTTGCAAAAGAACTTGCTGCAGGCATGCCGACTGCGATTTCGATTGCGGGTACCGATCCT
CAATTCACTAAAGATTTAGTTGAATTGCTGCACAGCCCTAAGCGTTTGCGTGTCTACGCCAATGATGACTTTATTGGTCT
GCAATTGGGCGGCGCAGTTAAAAACGTTATTGCTATTGGCGCGGGTCTTTCTGATGGTATCGGTTTTGGCGCTAATGCTA
GAACGGCTCTTATCACCCGCGGCCTAGTTGAGTTGACTCGACTCGGTGAGGCTATGGGGGCACAAGCCTCTACCTTTATG
GGAATGGCCGGACTCGGTGATTTGGTACTAACGTGTACCGATAACCAGTCTCGTAATCGTCGCTTCGGTTTAGCATTGGG
CAAAGGCTCAGATGTTGAAGCGGCTCAAGAAGAGATTGGCCAAGTGGTTGAAGGTTATCGCAACACTAAAGAGGTTTACA
CGCTAGCTAAGCGTTTAGGCGTCGAGATGCCGATTACCGAGCAGGTTTACCAAGTTCTGTATAAGGGTAAGTCTCCAGTA
GATGCTGCTAAAGAGCTGCTCAGTCGTGAGCAGAAGTCTGAGACATCGTCGGCAGAATAG

Upstream 100 bases:

>100_bases
CTAGCACCAGTTAACTTTGACGCACTATTTGCTCAGTATGTTCAACAGCGTCAAGCTGCAGCAGCTGATGCACCAGCAGA
AGAAGCTAACGCTTAATCGC

Downstream 100 bases:

>100_bases
TGTTTTAGCTATTAGACTGAACAACTTATAGAGTTGATTAAAACCGAAGCCTAGCTTCGGTTTTTTGTTTTTCAGCGTCA
GCTCTCATTGGGATTAGCAC

Product: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

Number of amino acids: Translated: 339; Mature: 339

Protein sequence:

>339_residues
MKNTADITVLGAGSYGTALAISLASNGHRTMLWGHEPEHIENLKNDKSNEAFLPGIPLPDLLIPEADLATALAASNNVLV
VVPSHVFGLVLSQAKPLLRKDSRIVWATKGLEPETGRLIQDVAREVLGDEYPLAVLSGPTFAKELAAGMPTAISIAGTDP
QFTKDLVELLHSPKRLRVYANDDFIGLQLGGAVKNVIAIGAGLSDGIGFGANARTALITRGLVELTRLGEAMGAQASTFM
GMAGLGDLVLTCTDNQSRNRRFGLALGKGSDVEAAQEEIGQVVEGYRNTKEVYTLAKRLGVEMPITEQVYQVLYKGKSPV
DAAKELLSREQKSETSSAE

Sequences:

>Translated_339_residues
MKNTADITVLGAGSYGTALAISLASNGHRTMLWGHEPEHIENLKNDKSNEAFLPGIPLPDLLIPEADLATALAASNNVLV
VVPSHVFGLVLSQAKPLLRKDSRIVWATKGLEPETGRLIQDVAREVLGDEYPLAVLSGPTFAKELAAGMPTAISIAGTDP
QFTKDLVELLHSPKRLRVYANDDFIGLQLGGAVKNVIAIGAGLSDGIGFGANARTALITRGLVELTRLGEAMGAQASTFM
GMAGLGDLVLTCTDNQSRNRRFGLALGKGSDVEAAQEEIGQVVEGYRNTKEVYTLAKRLGVEMPITEQVYQVLYKGKSPV
DAAKELLSREQKSETSSAE
>Mature_339_residues
MKNTADITVLGAGSYGTALAISLASNGHRTMLWGHEPEHIENLKNDKSNEAFLPGIPLPDLLIPEADLATALAASNNVLV
VVPSHVFGLVLSQAKPLLRKDSRIVWATKGLEPETGRLIQDVAREVLGDEYPLAVLSGPTFAKELAAGMPTAISIAGTDP
QFTKDLVELLHSPKRLRVYANDDFIGLQLGGAVKNVIAIGAGLSDGIGFGANARTALITRGLVELTRLGEAMGAQASTFM
GMAGLGDLVLTCTDNQSRNRRFGLALGKGSDVEAAQEEIGQVVEGYRNTKEVYTLAKRLGVEMPITEQVYQVLYKGKSPV
DAAKELLSREQKSETSSAE

Specific function: De novo phospholipid biosynthesis; glycerol-3 phosphate formation. [C]

COG id: COG0240

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI33695088, Length=336, Percent_Identity=28.5714285714286, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI24307999, Length=347, Percent_Identity=28.2420749279539, Blast_Score=131, Evalue=7e-31,
Organism=Escherichia coli, GI1790037, Length=336, Percent_Identity=72.9166666666667, Blast_Score=507, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI32564399, Length=330, Percent_Identity=27.2727272727273, Blast_Score=110, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI32564403, Length=339, Percent_Identity=26.8436578171091, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI193210136, Length=339, Percent_Identity=26.8436578171091, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17507425, Length=336, Percent_Identity=24.4047619047619, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI193210134, Length=212, Percent_Identity=29.2452830188679, Blast_Score=84, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320181, Length=340, Percent_Identity=28.5294117647059, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324513, Length=342, Percent_Identity=26.6081871345029, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI17136200, Length=358, Percent_Identity=26.536312849162, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17136204, Length=343, Percent_Identity=27.1137026239067, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI17136202, Length=343, Percent_Identity=27.1137026239067, Blast_Score=107, Evalue=9e-24,
Organism=Drosophila melanogaster, GI22026922, Length=349, Percent_Identity=23.2091690544413, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45551945, Length=263, Percent_Identity=29.277566539924, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281362270, Length=263, Percent_Identity=29.6577946768061, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24648969, Length=209, Percent_Identity=31.5789473684211, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GPDA_SHEHH (B0TLE9)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001672281.1
- ProteinModelPortal:   B0TLE9
- SMR:   B0TLE9
- GeneID:   5904349
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_0046
- HOGENOM:   HBG586392
- OMA:   NVAKGIE
- ProtClustDB:   PRK00094
- BioCyc:   SHAL458817:SHAL_0046-MONOMER
- HAMAP:   MF_00394
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR006168
- InterPro:   IPR006109
- InterPro:   IPR011128
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR11728
- PIRSF:   PIRSF000114
- PRINTS:   PR00077

Pfam domain/function: PF07479 NAD_Gly3P_dh_C; PF01210 NAD_Gly3P_dh_N; SSF48179 6DGDH_C_like

EC number: =1.1.1.94

Molecular weight: Translated: 36046; Mature: 36046

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00957 NAD_G3PDH

Important sites: ACT_SITE 194-194 BINDING 109-109 BINDING 109-109 BINDING 142-142 BINDING 258-258 BINDING 284-284

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTADITVLGAGSYGTALAISLASNGHRTMLWGHEPEHIENLKNDKSNEAFLPGIPLPD
CCCCCEEEEEECCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHCCCCCCEEECCCCCCC
LLIPEADLATALAASNNVLVVVPSHVFGLVLSQAKPLLRKDSRIVWATKGLEPETGRLIQ
CCCCCHHHHHHHHCCCCEEEEECHHHHHHHHHHCCHHHHCCCEEEEEECCCCCCHHHHHH
DVAREVLGDEYPLAVLSGPTFAKELAAGMPTAISIAGTDPQFTKDLVELLHSPKRLRVYA
HHHHHHCCCCCCEEEECCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEEE
NDDFIGLQLGGAVKNVIAIGAGLSDGIGFGANARTALITRGLVELTRLGEAMGAQASTFM
CCCEEEEEECHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
GMAGLGDLVLTCTDNQSRNRRFGLALGKGSDVEAAQEEIGQVVEGYRNTKEVYTLAKRLG
HHCCCCCEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
VEMPITEQVYQVLYKGKSPVDAAKELLSREQKSETSSAE
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKNTADITVLGAGSYGTALAISLASNGHRTMLWGHEPEHIENLKNDKSNEAFLPGIPLPD
CCCCCEEEEEECCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHCCCCCCEEECCCCCCC
LLIPEADLATALAASNNVLVVVPSHVFGLVLSQAKPLLRKDSRIVWATKGLEPETGRLIQ
CCCCCHHHHHHHHCCCCEEEEECHHHHHHHHHHCCHHHHCCCEEEEEECCCCCCHHHHHH
DVAREVLGDEYPLAVLSGPTFAKELAAGMPTAISIAGTDPQFTKDLVELLHSPKRLRVYA
HHHHHHCCCCCCEEEECCCHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCCCCEEEEEE
NDDFIGLQLGGAVKNVIAIGAGLSDGIGFGANARTALITRGLVELTRLGEAMGAQASTFM
CCCEEEEEECHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
GMAGLGDLVLTCTDNQSRNRRFGLALGKGSDVEAAQEEIGQVVEGYRNTKEVYTLAKRLG
HHCCCCCEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHC
VEMPITEQVYQVLYKGKSPVDAAKELLSREQKSETSSAE
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA