Definition Chlamydophila pneumoniae AR39, complete genome.
Accession NC_002179
Length 1,229,853

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The map label for this gene is glyA

Identifier: 16752521

GI number: 16752521

Start: 237854

End: 239347

Strand: Direct

Name: glyA

Synonym: CP0232

Alternate gene names: 16752521

Gene position: 237854-239347 (Clockwise)

Preceding gene: 16752516

Following gene: 16752522

Centisome position: 19.34

GC content: 42.17

Gene sequence:

>1494_bases
GTGGTTTCGTTGTTGCATAAGTTTTTAGAAAATGCTTCGGGGAAAAAGGGACAAAGTTTAGCTTCGACAGCGTATTTAGC
AGCTCTTGACCATCTCTTAAATGCGTTTCCTTCCATTGGGGAGAGAATCATTGATGAGTTGAAGAGCCAGCGTTCCCATT
TAAAGATGATTGCTTCTGAAAACTATTCTTCACTTTCAGTGCAGTTGGCTATGGGGAACTTGCTCACAGATAAGTATTGT
GAAGGAAGTCCCTTTAAGCGTTTCTATTCCTGTTGTGAAAATGTAGATGCTATTGAGTGGGAGTGTGTAGAGACAGCGAA
AGAACTTTTTGCTGCGGATTGCGCTTGTGTTCAGCCTCATTCTGGGGCTGATGCTAATTTACTGGCAGTAATGGCCATTC
TCACGCACAAAGTCCAAGGCCCAGCTGTCAGTAAGTTAGGTTATAAAACTGTAAACGAATTAACAGAAGAAGAATACACT
CTACTTAAGGCTGAAATGTCTTCTTGTGTTTGCTTAGGACCTTCATTAAATTCTGGAGGCCATTTGACCCATGGGAACGT
ACGTTTAAATGTGATGTCTAAGCTTATGCGTTGCTTCCCCTATGATGTCAATCCGGATACGGAGTGTTTTGATTATGCAG
AGATCTCCCGGTTAGCTAAGGAGTATAAACCTAAGGTACTGATCGCAGGATATTCTTCCTATTCTCGAAGATTAAACTTT
GCAGTTTTAAAACAGATTGCAGAGGATTGTGGATCTGTCTTGTGGGTAGATATGGCGCATTTTGCAGGCCTAGTTGCTGG
GGGAGTGTTTGTTGATGAAGAAAATCCTATTCCTTATGCAGATATAGTGACAACAACAACGCATAAGACATTACGCGGTC
CTCGCGGGGGATTAGTTTTGGCAACTCGAGAGTATGAAAGCACTCTCAATAAGGCGTGTCCTTTGATGATGGGAGGTCCT
CTACCTCACGTGATAGCTGCTAAAACAGTGGCTTTGAAGGAAGCTCTCTCTGTGGATTTCAAGAAATACGCTCATCAGGT
TGTAAATAATGCTCGTCGATTAGCAGAGAGATTTTTAAGTCATGGGCTACGTCTTTTGACGGGAGGAACAGACAACCACA
TGATGGTGATTGATTTAGGTTCTTTGGGCATTTCTGGAAAAATTGCTGAAGATATCTTGAGTTCCGTAGGAATTGCTGTG
AATCGGAATTCATTACCTTCAGATGCTATTGGTAAGTGGGACACTTCAGGTATACGTTTAGGAACCCCTGCACTAACGAC
TTTGGGTATGGGTATCGATGAAATGGAAGAAGTTGCAGATATTATTGTGAAAGTATTGCGAAATATTCGTTTAAGTTGCC
ATGTTGAAGGGAGTTCTAAGAAAAATAAAGGGGAACTTCCTGAAGCCATAGCGCAGGAAGCTAGAGATCGTGTTCGCAAC
TTGTTGCTGCGTTTCCCGCTCTACCCTGAAATTGATTTAGAAGCTTTAGTTTAG

Upstream 100 bases:

>100_bases
GTTCTCTCTATTAAGGCTTCGTCTTTAGAAGTCCTTGCTAAAAGTTTTTGAGAAATTTAAGAAATTCGCAATAGTGGAAA
TATTTACAAAGGTGGTTGCG

Downstream 100 bases:

>100_bases
TTAGGAGAGACATTATTTTATGGCAGACGGGGAAGTTCATAAATTACGTGATATTATAGAAAAAGAGTTATTGGAAGCGC
GCAGAGTATTTTTCTCAGAG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 497; Mature: 497

Protein sequence:

>497_residues
MVSLLHKFLENASGKKGQSLASTAYLAALDHLLNAFPSIGERIIDELKSQRSHLKMIASENYSSLSVQLAMGNLLTDKYC
EGSPFKRFYSCCENVDAIEWECVETAKELFAADCACVQPHSGADANLLAVMAILTHKVQGPAVSKLGYKTVNELTEEEYT
LLKAEMSSCVCLGPSLNSGGHLTHGNVRLNVMSKLMRCFPYDVNPDTECFDYAEISRLAKEYKPKVLIAGYSSYSRRLNF
AVLKQIAEDCGSVLWVDMAHFAGLVAGGVFVDEENPIPYADIVTTTTHKTLRGPRGGLVLATREYESTLNKACPLMMGGP
LPHVIAAKTVALKEALSVDFKKYAHQVVNNARRLAERFLSHGLRLLTGGTDNHMMVIDLGSLGISGKIAEDILSSVGIAV
NRNSLPSDAIGKWDTSGIRLGTPALTTLGMGIDEMEEVADIIVKVLRNIRLSCHVEGSSKKNKGELPEAIAQEARDRVRN
LLLRFPLYPEIDLEALV

Sequences:

>Translated_497_residues
MVSLLHKFLENASGKKGQSLASTAYLAALDHLLNAFPSIGERIIDELKSQRSHLKMIASENYSSLSVQLAMGNLLTDKYC
EGSPFKRFYSCCENVDAIEWECVETAKELFAADCACVQPHSGADANLLAVMAILTHKVQGPAVSKLGYKTVNELTEEEYT
LLKAEMSSCVCLGPSLNSGGHLTHGNVRLNVMSKLMRCFPYDVNPDTECFDYAEISRLAKEYKPKVLIAGYSSYSRRLNF
AVLKQIAEDCGSVLWVDMAHFAGLVAGGVFVDEENPIPYADIVTTTTHKTLRGPRGGLVLATREYESTLNKACPLMMGGP
LPHVIAAKTVALKEALSVDFKKYAHQVVNNARRLAERFLSHGLRLLTGGTDNHMMVIDLGSLGISGKIAEDILSSVGIAV
NRNSLPSDAIGKWDTSGIRLGTPALTTLGMGIDEMEEVADIIVKVLRNIRLSCHVEGSSKKNKGELPEAIAQEARDRVRN
LLLRFPLYPEIDLEALV
>Mature_497_residues
MVSLLHKFLENASGKKGQSLASTAYLAALDHLLNAFPSIGERIIDELKSQRSHLKMIASENYSSLSVQLAMGNLLTDKYC
EGSPFKRFYSCCENVDAIEWECVETAKELFAADCACVQPHSGADANLLAVMAILTHKVQGPAVSKLGYKTVNELTEEEYT
LLKAEMSSCVCLGPSLNSGGHLTHGNVRLNVMSKLMRCFPYDVNPDTECFDYAEISRLAKEYKPKVLIAGYSSYSRRLNF
AVLKQIAEDCGSVLWVDMAHFAGLVAGGVFVDEENPIPYADIVTTTTHKTLRGPRGGLVLATREYESTLNKACPLMMGGP
LPHVIAAKTVALKEALSVDFKKYAHQVVNNARRLAERFLSHGLRLLTGGTDNHMMVIDLGSLGISGKIAEDILSSVGIAV
NRNSLPSDAIGKWDTSGIRLGTPALTTLGMGIDEMEEVADIIVKVLRNIRLSCHVEGSSKKNKGELPEAIAQEARDRVRN
LLLRFPLYPEIDLEALV

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI261862352, Length=437, Percent_Identity=35.9267734553776, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI261862350, Length=437, Percent_Identity=35.9267734553776, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI261862348, Length=437, Percent_Identity=35.9267734553776, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI19923315, Length=437, Percent_Identity=35.9267734553776, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI22547186, Length=476, Percent_Identity=35.7142857142857, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI261862346, Length=437, Percent_Identity=35.0114416475973, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI22547189, Length=460, Percent_Identity=34.5652173913044, Blast_Score=229, Evalue=6e-60,
Organism=Escherichia coli, GI1788902, Length=443, Percent_Identity=41.9864559819413, Blast_Score=310, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI25144732, Length=437, Percent_Identity=37.7574370709382, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI25144729, Length=437, Percent_Identity=37.7574370709382, Blast_Score=280, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6323087, Length=440, Percent_Identity=36.1363636363636, Blast_Score=269, Evalue=9e-73,
Organism=Saccharomyces cerevisiae, GI6319739, Length=441, Percent_Identity=36.5079365079365, Blast_Score=268, Evalue=2e-72,
Organism=Drosophila melanogaster, GI221329721, Length=481, Percent_Identity=37.006237006237, Blast_Score=285, Evalue=4e-77,
Organism=Drosophila melanogaster, GI24640005, Length=481, Percent_Identity=37.006237006237, Blast_Score=285, Evalue=4e-77,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_CHLPN (Q9Z831)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   E86555
- PIR:   G81598
- PIR:   H72067
- RefSeq:   NP_224717.1
- RefSeq:   NP_300576.1
- RefSeq:   NP_444783.1
- RefSeq:   NP_876814.1
- ProteinModelPortal:   Q9Z831
- SMR:   Q9Z831
- GeneID:   1467221
- GeneID:   895462
- GeneID:   919273
- GeneID:   963819
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0232
- KEGG:   cpn:CPn0521
- KEGG:   cpt:CpB0542
- TIGR:   CP_0232
- HOGENOM:   HBG301263
- OMA:   DYLIDMD
- ProtClustDB:   PRK13580
- BioCyc:   CPNE115711:CP_0232-MONOMER
- BioCyc:   CPNE115713:CPN0521-MONOMER
- BioCyc:   CPNE138677:CPJ0521-MONOMER
- BioCyc:   CPNE182082:CPB0542-MONOMER
- BRENDA:   2.1.2.1
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 54263; Mature: 54263

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MVSLLHKFLENASGKKGQSLASTAYLAALDHLLNAFPSIGERIIDELKSQRSHLKMIASE
CHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NYSSLSVQLAMGNLLTDKYCEGSPFKRFYSCCENVDAIEWECVETAKELFAADCACVQPH
CCCCEEEEEEHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEECCC
SGADANLLAVMAILTHKVQGPAVSKLGYKTVNELTEEEYTLLKAEMSSCVCLGPSLNSGG
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCC
HLTHGNVRLNVMSKLMRCFPYDVNPDTECFDYAEISRLAKEYKPKVLIAGYSSYSRRLNF
CEEECCEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHH
AVLKQIAEDCGSVLWVDMAHFAGLVAGGVFVDEENPIPYADIVTTTTHKTLRGPRGGLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHEECCCHHHHCCCCCCEEE
ATREYESTLNKACPLMMGGPLPHVIAAKTVALKEALSVDFKKYAHQVVNNARRLAERFLS
EEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HGLRLLTGGTDNHMMVIDLGSLGISGKIAEDILSSVGIAVNRNSLPSDAIGKWDTSGIRL
CCCEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCEEE
GTPALTTLGMGIDEMEEVADIIVKVLRNIRLSCHVEGSSKKNKGELPEAIAQEARDRVRN
CCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
LLLRFPLYPEIDLEALV
HHHHCCCCCCCCHHHCC
>Mature Secondary Structure
MVSLLHKFLENASGKKGQSLASTAYLAALDHLLNAFPSIGERIIDELKSQRSHLKMIASE
CHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NYSSLSVQLAMGNLLTDKYCEGSPFKRFYSCCENVDAIEWECVETAKELFAADCACVQPH
CCCCEEEEEEHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCEECCC
SGADANLLAVMAILTHKVQGPAVSKLGYKTVNELTEEEYTLLKAEMSSCVCLGPSLNSGG
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCC
HLTHGNVRLNVMSKLMRCFPYDVNPDTECFDYAEISRLAKEYKPKVLIAGYSSYSRRLNF
CEEECCEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHH
AVLKQIAEDCGSVLWVDMAHFAGLVAGGVFVDEENPIPYADIVTTTTHKTLRGPRGGLVL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHEECCCHHHHCCCCCCEEE
ATREYESTLNKACPLMMGGPLPHVIAAKTVALKEALSVDFKKYAHQVVNNARRLAERFLS
EEHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HGLRLLTGGTDNHMMVIDLGSLGISGKIAEDILSSVGIAVNRNSLPSDAIGKWDTSGIRL
CCCEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCEEE
GTPALTTLGMGIDEMEEVADIIVKVLRNIRLSCHVEGSSKKNKGELPEAIAQEARDRVRN
CCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
LLLRFPLYPEIDLEALV
HHHHCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362