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Identifier: 16752351

GI number: 16752351

Start: 70180

End: 71400

Strand: Direct

Name: Not Available

Synonym: CP0057

Alternate gene names: 16752351

Gene position: 70180-71400 (Clockwise)

Preceding gene: 16752350

Following gene: 16752354

Centisome position: 5.71

GC content: 42.51

Gene sequence:

>1221_bases
GTGAAGAATTTAAAAGAAGATTTTCCGATTTTTGCTGCTAAAGCAAAAGAGAACGAGCCTTTTATTTATTTAGATTCAGC
TGCAACGACTCAGAAACCTCAACAGGTGATAGATGCCGTTGCTAACTTTTATACTTCTTCATATGCAACTGTAAATCGTG
CGATTTATAGTTCCTCTAGGAACGTCACGGAAGCATACGCAGCTGTTCGCGAAAAAGTGCGTAAGTGGGTATCCGCAGCC
TCTGATAGTGAAATCGTATTCACCCGTGGGACAACTGCAGGGTTAAATTTATTAGCCATTTCTGTTAATGACCTCTGGAT
CCCTAAGGGGGGTGTTGTTCTGGTTTCTGAGGCAGAACACCATGCGAATGTTTTATCTTGGGAGATTGCCTGTCGGCGGC
GAGGTTCTTTAGTAAAAAAGATCAGAGTTCATGATTCAGGGCTTATAGATCTTGATGATTTGGAAAAGCTTCTAAATGAA
GGTGCTCAATTTGTAAGCATTCCTCATGTGAGTAATGTTACGGGTTGTGTCCAACCTCTCCAACAAGTTGCTGAGCTTGT
CCACCGCTATGACGCTTACCTTGCTGTTGATGGTGCTCAGGGAGCTCCTCATCTTCCTATAGACGTTCAGCTTTGGGATG
TAGATTTCTATGTGTTTTCGTCACATAAGATTTATGGACCCACGGGCATAGGAGTCTTATATGGGAAAAAAGATCTATTA
GATCAGTTGCCTCCAGTAGAAGGAGGTGGTGATATGGTTGCTATCTACGATCATCAGAATCCTGAATATCTTCCTGCACC
TATGAAATTTGAAGCTGGGACTCCAAATATTGCTGGAGTTTTAGGCTTAGGGGCTGCTTTAGATTATCTCGATGGCTTGT
CAGCTAAGTTTATCTACGACAAAGAGATTGCCCTAACTACATATTTACATAAAGAGCTGCTTGAGATTCCAGGTGTAGAG
ATTCTCGGACCTTCTATAGAGGAACCCAGGGGAGCTCTTATAGGCATGACAATCGATGGAGCCCATCCTTTGGATCTAGG
TTTTTTATTAGATCTTAGAGGAATTGCTGTGCGGACGGGTCATCAATGTGCCCAACCTGCTATGGAGCGATGGAATGTGG
GTCATGTGTTGAGAGTGTCCTTAGGAATCTATAATGATGAGGATGATATCGATCAATTCATCCTTGTTTTGCAGGATTCT
TTAGATAAGATTCGTAGATGA

Upstream 100 bases:

>100_bases
GGGTTCCTAAAACAAGGATTAGTTTCCGATACGTTTTTGGGATCTTCTTTTCAGCTAAATCAAACCTCCTAGGTTTAGGA
TTTAGGGGGGGGGATGATCA

Downstream 100 bases:

>100_bases
CCCGTCTGCGATAGGATCTTCTATTTTTTTGGACGTGGTAAGGTTATCTTTTTGGAAGTTGTTTTTTGAGATACAGCTGT
TTACTTTTCTCTTTAATCCA

Product: aminotransferase, class V

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MKNLKEDFPIFAAKAKENEPFIYLDSAATTQKPQQVIDAVANFYTSSYATVNRAIYSSSRNVTEAYAAVREKVRKWVSAA
SDSEIVFTRGTTAGLNLLAISVNDLWIPKGGVVLVSEAEHHANVLSWEIACRRRGSLVKKIRVHDSGLIDLDDLEKLLNE
GAQFVSIPHVSNVTGCVQPLQQVAELVHRYDAYLAVDGAQGAPHLPIDVQLWDVDFYVFSSHKIYGPTGIGVLYGKKDLL
DQLPPVEGGGDMVAIYDHQNPEYLPAPMKFEAGTPNIAGVLGLGAALDYLDGLSAKFIYDKEIALTTYLHKELLEIPGVE
ILGPSIEEPRGALIGMTIDGAHPLDLGFLLDLRGIAVRTGHQCAQPAMERWNVGHVLRVSLGIYNDEDDIDQFILVLQDS
LDKIRR

Sequences:

>Translated_406_residues
MKNLKEDFPIFAAKAKENEPFIYLDSAATTQKPQQVIDAVANFYTSSYATVNRAIYSSSRNVTEAYAAVREKVRKWVSAA
SDSEIVFTRGTTAGLNLLAISVNDLWIPKGGVVLVSEAEHHANVLSWEIACRRRGSLVKKIRVHDSGLIDLDDLEKLLNE
GAQFVSIPHVSNVTGCVQPLQQVAELVHRYDAYLAVDGAQGAPHLPIDVQLWDVDFYVFSSHKIYGPTGIGVLYGKKDLL
DQLPPVEGGGDMVAIYDHQNPEYLPAPMKFEAGTPNIAGVLGLGAALDYLDGLSAKFIYDKEIALTTYLHKELLEIPGVE
ILGPSIEEPRGALIGMTIDGAHPLDLGFLLDLRGIAVRTGHQCAQPAMERWNVGHVLRVSLGIYNDEDDIDQFILVLQDS
LDKIRR
>Mature_406_residues
MKNLKEDFPIFAAKAKENEPFIYLDSAATTQKPQQVIDAVANFYTSSYATVNRAIYSSSRNVTEAYAAVREKVRKWVSAA
SDSEIVFTRGTTAGLNLLAISVNDLWIPKGGVVLVSEAEHHANVLSWEIACRRRGSLVKKIRVHDSGLIDLDDLEKLLNE
GAQFVSIPHVSNVTGCVQPLQQVAELVHRYDAYLAVDGAQGAPHLPIDVQLWDVDFYVFSSHKIYGPTGIGVLYGKKDLL
DQLPPVEGGGDMVAIYDHQNPEYLPAPMKFEAGTPNIAGVLGLGAALDYLDGLSAKFIYDKEIALTTYLHKELLEIPGVE
ILGPSIEEPRGALIGMTIDGAHPLDLGFLLDLRGIAVRTGHQCAQPAMERWNVGHVLRVSLGIYNDEDDIDQFILVLQDS
LDKIRR

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily

Homologues:

Organism=Homo sapiens, GI32307132, Length=385, Percent_Identity=24.9350649350649, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1787970, Length=396, Percent_Identity=42.4242424242424, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1789175, Length=381, Percent_Identity=38.5826771653543, Blast_Score=261, Evalue=5e-71,
Organism=Escherichia coli, GI48994898, Length=409, Percent_Identity=27.8728606356968, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25143064, Length=418, Percent_Identity=25.5980861244019, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI193211090, Length=380, Percent_Identity=26.0526315789474, Blast_Score=102, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6319831, Length=409, Percent_Identity=27.1393643031785, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI20129463, Length=395, Percent_Identity=28.6075949367089, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CSD_CHLPN (Q9Z7L5)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   F86576
- PIR:   G72047
- RefSeq:   NP_224885.1
- RefSeq:   NP_300745.1
- RefSeq:   NP_444609.1
- RefSeq:   NP_876988.1
- ProteinModelPortal:   Q9Z7L5
- SMR:   Q9Z7L5
- GeneID:   1467395
- GeneID:   895369
- GeneID:   919449
- GeneID:   963686
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0057
- KEGG:   cpn:CPn0689
- KEGG:   cpt:CpB0716
- TIGR:   CP_0057
- HOGENOM:   HBG635316
- OMA:   YDSTWKE
- PhylomeDB:   Q9Z7L5
- ProtClustDB:   CLSK871537
- BioCyc:   CPNE115711:CP_0057-MONOMER
- BioCyc:   CPNE115713:CPN0689-MONOMER
- BioCyc:   CPNE138677:CPJ0689-MONOMER
- BioCyc:   CPNE182082:CPB0716-MONOMER
- BRENDA:   2.8.1.7
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01979

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.8.1.7

Molecular weight: Translated: 44601; Mature: 44601

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: ACT_SITE 363-363

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLKEDFPIFAAKAKENEPFIYLDSAATTQKPQQVIDAVANFYTSSYATVNRAIYSSSR
CCCCCHHCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NVTEAYAAVREKVRKWVSAASDSEIVFTRGTTAGLNLLAISVNDLWIPKGGVVLVSEAEH
CHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEEECCEEECCCCEEEEECCCC
HANVLSWEIACRRRGSLVKKIRVHDSGLIDLDDLEKLLNEGAQFVSIPHVSNVTGCVQPL
CCHHEEHHHHHHHCCCHHHEEEECCCCCEEHHHHHHHHHCCCCEEECCCCCCHHHHHHHH
QQVAELVHRYDAYLAVDGAQGAPHLPIDVQLWDVDFYVFSSHKIYGPTGIGVLYGKKDLL
HHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEEEEEEEEECCEEECCCCCEEEECCHHHH
DQLPPVEGGGDMVAIYDHQNPEYLPAPMKFEAGTPNIAGVLGLGAALDYLDGLSAKFIYD
HHCCCCCCCCCEEEEEECCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEC
KEIALTTYLHKELLEIPGVEILGPSIEEPRGALIGMTIDGAHPLDLGFLLDLRGIAVRTG
CHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCEEEEEECCCCCCCHHHEEECCCEEEECC
HQCAQPAMERWNVGHVLRVSLGIYNDEDDIDQFILVLQDSLDKIRR
CHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNLKEDFPIFAAKAKENEPFIYLDSAATTQKPQQVIDAVANFYTSSYATVNRAIYSSSR
CCCCCHHCCEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NVTEAYAAVREKVRKWVSAASDSEIVFTRGTTAGLNLLAISVNDLWIPKGGVVLVSEAEH
CHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEEECCEEECCCCEEEEECCCC
HANVLSWEIACRRRGSLVKKIRVHDSGLIDLDDLEKLLNEGAQFVSIPHVSNVTGCVQPL
CCHHEEHHHHHHHCCCHHHEEEECCCCCEEHHHHHHHHHCCCCEEECCCCCCHHHHHHHH
QQVAELVHRYDAYLAVDGAQGAPHLPIDVQLWDVDFYVFSSHKIYGPTGIGVLYGKKDLL
HHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEEEEEEEEECCEEECCCCCEEEECCHHHH
DQLPPVEGGGDMVAIYDHQNPEYLPAPMKFEAGTPNIAGVLGLGAALDYLDGLSAKFIYD
HHCCCCCCCCCEEEEEECCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEC
KEIALTTYLHKELLEIPGVEILGPSIEEPRGALIGMTIDGAHPLDLGFLLDLRGIAVRTG
CHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCEEEEEECCCCCCCHHHEEECCCEEEECC
HQCAQPAMERWNVGHVLRVSLGIYNDEDDIDQFILVLQDSLDKIRR
CHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362