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Identifier: 16752306

GI number: 16752306

Start: 15917

End: 16585

Strand: Direct

Name: Not Available

Synonym: CP0011

Alternate gene names: 16752306

Gene position: 15917-16585 (Clockwise)

Preceding gene: 16752305

Following gene: 16752308

Centisome position: 1.29

GC content: 35.72

Gene sequence:

>669_bases
ATGTTGATGATGCTTATGATGATTATTGGAATTACAGGAGGTTCTGGAGCTGGGAAAACCACCCTAACCCAAAACATTAA
AGAAATTTTCGGTGAGGATGTGAGTGTTATCTGCCAAGATAATTATTACAAAGATAGATCTCATTATACTCCTGAAGAAC
GTGCCAATTTAATTTGGGATCATCCGGACGCCTTTGATAATGACTTATTAATTTCAGACATAAAACGTCTAAAAAATAAT
GAGATTGTCCAAGCCCCAGTTTTTGATTTTGTTTTAGGTAATCGATCTAAAACGGAGATAGAAACGATCTATCCATCTAA
AGTTATTCTTGTTGAAGGTATTCTGGTCTTTGAAAATCAAGAACTTAGAGATCTTATGGATATTAGGATCTTTGTAGACA
CCGATGCTGATGAAAGGATACTACGCCGTATGGTTCGAGATGTTCAAGAACAAGGAGATAGCGTGGACTGCATCATGTCT
CGTTATCTTTCTATGGTAAAGCCTATGCATGAGAAATTTATAGAGCCGACTCGGAAATATGCTGATATCATTGTACATGG
AAATTACCGACAAAACGTAGTAACAAATATTTTGTCACAGAAAATTAAAAATCATTTAGAGAATGCCCTGGAAAGCGATG
AGACGTATTATATGGTCAACTCTAAGTAA

Upstream 100 bases:

>100_bases
CGAAGCTTTTTCTTTTGTCTCCTTTTAAATCAATAAATTCTCAAAGGACCCGCATTTTGTTGTGTGCTGATTACAAGAGA
AGTACTAAGGAGAAAAATTT

Downstream 100 bases:

>100_bases
TTTTTTTTTAAGAGACATGTGTTCTGGTTTCTTCACTTTTCTAAGTTTTACAACTCCCAGATGAAGAAACCAGAATAGGT
ATTAAATCAAACAACAACTT

Product: uridine kinase

Products: NA

Alternate protein names: Cytidine monophosphokinase; Uridine monophosphokinase

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MLMMLMMIIGITGGSGAGKTTLTQNIKEIFGEDVSVICQDNYYKDRSHYTPEERANLIWDHPDAFDNDLLISDIKRLKNN
EIVQAPVFDFVLGNRSKTEIETIYPSKVILVEGILVFENQELRDLMDIRIFVDTDADERILRRMVRDVQEQGDSVDCIMS
RYLSMVKPMHEKFIEPTRKYADIIVHGNYRQNVVTNILSQKIKNHLENALESDETYYMVNSK

Sequences:

>Translated_222_residues
MLMMLMMIIGITGGSGAGKTTLTQNIKEIFGEDVSVICQDNYYKDRSHYTPEERANLIWDHPDAFDNDLLISDIKRLKNN
EIVQAPVFDFVLGNRSKTEIETIYPSKVILVEGILVFENQELRDLMDIRIFVDTDADERILRRMVRDVQEQGDSVDCIMS
RYLSMVKPMHEKFIEPTRKYADIIVHGNYRQNVVTNILSQKIKNHLENALESDETYYMVNSK
>Mature_222_residues
MLMMLMMIIGITGGSGAGKTTLTQNIKEIFGEDVSVICQDNYYKDRSHYTPEERANLIWDHPDAFDNDLLISDIKRLKNN
EIVQAPVFDFVLGNRSKTEIETIYPSKVILVEGILVFENQELRDLMDIRIFVDTDADERILRRMVRDVQEQGDSVDCIMS
RYLSMVKPMHEKFIEPTRKYADIIVHGNYRQNVVTNILSQKIKNHLENALESDETYYMVNSK

Specific function: Pyrimidine salvage pathway. [C]

COG id: COG0572

COG function: function code F; Uridine kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uridine kinase family

Homologues:

Organism=Homo sapiens, GI18699734, Length=228, Percent_Identity=37.719298245614, Blast_Score=170, Evalue=8e-43,
Organism=Homo sapiens, GI13899253, Length=211, Percent_Identity=38.8625592417062, Blast_Score=157, Evalue=7e-39,
Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=38.6138613861386, Blast_Score=151, Evalue=4e-37,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=38.6138613861386, Blast_Score=151, Evalue=4e-37,
Organism=Homo sapiens, GI209863022, Length=150, Percent_Identity=40, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI87082034, Length=206, Percent_Identity=42.2330097087379, Blast_Score=163, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17539892, Length=206, Percent_Identity=37.8640776699029, Blast_Score=143, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17539894, Length=206, Percent_Identity=37.8640776699029, Blast_Score=143, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI71981181, Length=215, Percent_Identity=26.9767441860465, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324339, Length=184, Percent_Identity=34.2391304347826, Blast_Score=99, Evalue=4e-22,
Organism=Drosophila melanogaster, GI221458995, Length=215, Percent_Identity=34.4186046511628, Blast_Score=150, Evalue=8e-37,
Organism=Drosophila melanogaster, GI24649624, Length=209, Percent_Identity=33.9712918660287, Blast_Score=144, Evalue=4e-35,
Organism=Drosophila melanogaster, GI28573516, Length=209, Percent_Identity=38.2775119617225, Blast_Score=140, Evalue=7e-34,
Organism=Drosophila melanogaster, GI28573514, Length=209, Percent_Identity=38.2775119617225, Blast_Score=140, Evalue=7e-34,
Organism=Drosophila melanogaster, GI28573512, Length=209, Percent_Identity=38.2775119617225, Blast_Score=140, Evalue=7e-34,
Organism=Drosophila melanogaster, GI45550449, Length=209, Percent_Identity=38.2775119617225, Blast_Score=140, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): URK_CHLPN (Q9Z7H0)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   D86582
- PIR:   E72041
- RefSeq:   NP_224931.1
- RefSeq:   NP_300791.1
- RefSeq:   NP_444563.1
- RefSeq:   NP_877035.1
- ProteinModelPortal:   Q9Z7H0
- GeneID:   1467442
- GeneID:   894758
- GeneID:   919506
- GeneID:   963633
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0011
- KEGG:   cpj:CPj0735
- KEGG:   cpn:CPn0735
- KEGG:   cpt:CpB0763
- TIGR:   CP_0011
- HOGENOM:   HBG527126
- OMA:   NQFVEPT
- PhylomeDB:   Q9Z7H0
- ProtClustDB:   PRK05480
- BioCyc:   CPNE115711:CP_0011-MONOMER
- BioCyc:   CPNE115713:CPN0735-MONOMER
- BioCyc:   CPNE138677:CPJ0735-MONOMER
- BioCyc:   CPNE182082:CPB0763-MONOMER
- BRENDA:   2.7.1.48
- GO:   GO:0005737
- HAMAP:   MF_00551
- InterPro:   IPR006083
- InterPro:   IPR000764
- PANTHER:   PTHR10285:SF6
- PRINTS:   PR00988
- TIGRFAMs:   TIGR00235

Pfam domain/function: PF00485 PRK

EC number: =2.7.1.48

Molecular weight: Translated: 25759; Mature: 25759

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMMLMMIIGITGGSGAGKTTLTQNIKEIFGEDVSVICQDNYYKDRSHYTPEERANLIWD
CHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHCCEEEC
HPDAFDNDLLISDIKRLKNNEIVQAPVFDFVLGNRSKTEIETIYPSKVILVEGILVFENQ
CCCCCCCCHHHHHHHHHCCCCEEECHHHHHHHCCCCCCCEEEECCCEEEEEECEEEECCH
ELRDLMDIRIFVDTDADERILRRMVRDVQEQGDSVDCIMSRYLSMVKPMHEKFIEPTRKY
HHHHHHHEEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ADIIVHGNYRQNVVTNILSQKIKNHLENALESDETYYMVNSK
HEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC
>Mature Secondary Structure
MLMMLMMIIGITGGSGAGKTTLTQNIKEIFGEDVSVICQDNYYKDRSHYTPEERANLIWD
CHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHCCEEEC
HPDAFDNDLLISDIKRLKNNEIVQAPVFDFVLGNRSKTEIETIYPSKVILVEGILVFENQ
CCCCCCCCHHHHHHHHHCCCCEEECHHHHHHHCCCCCCCEEEECCCEEEEEECEEEECCH
ELRDLMDIRIFVDTDADERILRRMVRDVQEQGDSVDCIMSRYLSMVKPMHEKFIEPTRKY
HHHHHHHEEEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ADIIVHGNYRQNVVTNILSQKIKNHLENALESDETYYMVNSK
HEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362