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Identifier: 16751994

GI number: 16751994

Start: 885865

End: 887322

Strand: Direct

Name: Not Available

Synonym: CP0821

Alternate gene names: 16751994

Gene position: 885865-887322 (Clockwise)

Preceding gene: 16751993

Following gene: 16751995

Centisome position: 72.03

GC content: 43.48

Gene sequence:

>1458_bases
ATGACCTCAAGGACTAAATCCTCAAAAAATTTAGGGACCATAGCCCTTGCGGGTATGGTAGTCAGTTCCATAATTGGGGG
AGGGATTTTCAGCCTCCCCCAAAACATGGCAGCGACAGCAGGAGCTGGTGCCGTAATCCTATCTTGGATACTCACTGGCT
TCGGCATGTTCTTTATCGCAAATACGTTTAGGATCCTCTCTACAATACGTCCCGACCTTAAGGAAGGGATCTACATGTAC
AGTAGAGAAGGTTTCGGCCCCTACATAGGATTCACCATCGGCTGGGGATATTGGCTTTGTCAAATCTTCGGTAATGTGGG
ATATGCCGTAATTACTATGGATGCTCTAAACTACTTCTTCCCTCCCTACTTCCAAGGAGGAAATACCCTACCTGCTATTT
TAGGAGGCTCCATTCTTATCTGGGTGTTCAACTTCATAGTTCTGAAAGGAATCCGTCAAGCATCGATAATCAACGTCATC
GGAACTATATTTAAAATCATCCCTCTAATCATCTTCATTATCCTGACTGCGTTCTTCTTCAAGCTCGCTGTTTTCAAAAC
AGATTTTTGGGGACATGCCGTAACAAAAGCCCAACCGAGTTTAGGATCCGTAAGTTCACAACTTAAAGGGACTATGTTGG
TCACCCTATGGGCATTTATAGGAATCGAAGGTGCCGTGGTGATGTCTGGACGAGCAAAAAATCCTCTCTCTGTAGGGCAA
GCTACAGTCTTAGGATTTTTAGGTTGCCTAACAATCTACATCTTATTTTCTTTATTACCTTTTGGCTCGCTCTTCCAACA
TCAACTAGCGAACATCCCCAATCCCTCTACAGCTGGTGTCCTCGACATCCTCGTAGGGAAATGGGGAGAAGTGCTCATGA
ATGTCGGCCTGATTATTGCTGTTTTATCTAGCTGGTTATCCTGGACGATCATCGTTGCAGAAATCCCCTTCTCAGCAGCT
AAAAATGGCACCTTCCCTGAGATCTTCACTATAGAAAATAAAGAGAAATCTCCCAGCGTCTCCCTATACATTACGAGCTC
TGTGATGCAGCTCGCCATGCTCCTTGTTTACTTTTCTTCGAATGCTTGGAATACTATGCTCAGCATCACGGGGGTCATGG
TTCTCCCTGCGTATCTAGCGAGTGCTGCCTTTCTCTTTAAACTTAGCAAAAGCAAAACATATCCTAAAAAAGGGTCTATT
AAAGCCCCTTTGGCAATGATAACTGGTATCCTGGGAGTGGTTTACTCTCTATGGCTTATCTATGCAGGAGGTCTAAAATA
CCTCTTTATGGCCTTAGTTCTTTTAGCTCTTGGCATCCCCTTCTATATAGACGCAGGGAAAAAGAAGAAAAATGCTAAGA
CATTCTTTGCTAAAAAAGAAATTGTAGGAATGACTTTCATAGGCCTTCTTGCACTGACAGCGATCTTCCTATTCTCAACA
GGAAGAATCAAAATTTAA

Upstream 100 bases:

>100_bases
TACATCAACATCAAACAAAAATTCGGTTTTTGCTTAACTGCATTAGGATTCCTAAATTTCGAAAATGCTGAACCAGCTAA
GGTAAATTAAGGAGACTTTC

Downstream 100 bases:

>100_bases
TTAAACTTTCATCCTTCCCCACGGCTTATGCCGTGGGGGTCTCCCTAATTCTCTTCTCTATAGTAAAAAATTCACCCTTA
AGAATCAGGTTTTCATCTTC

Product: amino acid permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MTSRTKSSKNLGTIALAGMVVSSIIGGGIFSLPQNMAATAGAGAVILSWILTGFGMFFIANTFRILSTIRPDLKEGIYMY
SREGFGPYIGFTIGWGYWLCQIFGNVGYAVITMDALNYFFPPYFQGGNTLPAILGGSILIWVFNFIVLKGIRQASIINVI
GTIFKIIPLIIFIILTAFFFKLAVFKTDFWGHAVTKAQPSLGSVSSQLKGTMLVTLWAFIGIEGAVVMSGRAKNPLSVGQ
ATVLGFLGCLTIYILFSLLPFGSLFQHQLANIPNPSTAGVLDILVGKWGEVLMNVGLIIAVLSSWLSWTIIVAEIPFSAA
KNGTFPEIFTIENKEKSPSVSLYITSSVMQLAMLLVYFSSNAWNTMLSITGVMVLPAYLASAAFLFKLSKSKTYPKKGSI
KAPLAMITGILGVVYSLWLIYAGGLKYLFMALVLLALGIPFYIDAGKKKKNAKTFFAKKEIVGMTFIGLLALTAIFLFST
GRIKI

Sequences:

>Translated_485_residues
MTSRTKSSKNLGTIALAGMVVSSIIGGGIFSLPQNMAATAGAGAVILSWILTGFGMFFIANTFRILSTIRPDLKEGIYMY
SREGFGPYIGFTIGWGYWLCQIFGNVGYAVITMDALNYFFPPYFQGGNTLPAILGGSILIWVFNFIVLKGIRQASIINVI
GTIFKIIPLIIFIILTAFFFKLAVFKTDFWGHAVTKAQPSLGSVSSQLKGTMLVTLWAFIGIEGAVVMSGRAKNPLSVGQ
ATVLGFLGCLTIYILFSLLPFGSLFQHQLANIPNPSTAGVLDILVGKWGEVLMNVGLIIAVLSSWLSWTIIVAEIPFSAA
KNGTFPEIFTIENKEKSPSVSLYITSSVMQLAMLLVYFSSNAWNTMLSITGVMVLPAYLASAAFLFKLSKSKTYPKKGSI
KAPLAMITGILGVVYSLWLIYAGGLKYLFMALVLLALGIPFYIDAGKKKKNAKTFFAKKEIVGMTFIGLLALTAIFLFST
GRIKI
>Mature_484_residues
TSRTKSSKNLGTIALAGMVVSSIIGGGIFSLPQNMAATAGAGAVILSWILTGFGMFFIANTFRILSTIRPDLKEGIYMYS
REGFGPYIGFTIGWGYWLCQIFGNVGYAVITMDALNYFFPPYFQGGNTLPAILGGSILIWVFNFIVLKGIRQASIINVIG
TIFKIIPLIIFIILTAFFFKLAVFKTDFWGHAVTKAQPSLGSVSSQLKGTMLVTLWAFIGIEGAVVMSGRAKNPLSVGQA
TVLGFLGCLTIYILFSLLPFGSLFQHQLANIPNPSTAGVLDILVGKWGEVLMNVGLIIAVLSSWLSWTIIVAEIPFSAAK
NGTFPEIFTIENKEKSPSVSLYITSSVMQLAMLLVYFSSNAWNTMLSITGVMVLPAYLASAAFLFKLSKSKTYPKKGSIK
APLAMITGILGVVYSLWLIYAGGLKYLFMALVLLALGIPFYIDAGKKKKNAKTFFAKKEIVGMTFIGLLALTAIFLFSTG
RIKI

Specific function: Catalyzes the exchange of L-arginine for agmatine. The arginine uptake by the bacterium in the macrophage may be a virulence factor against the host innate immune response

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily

Homologues:

Organism=Escherichia coli, GI1787890, Length=472, Percent_Identity=40.6779661016949, Blast_Score=363, Evalue=1e-101,
Organism=Escherichia coli, GI2367353, Length=454, Percent_Identity=26.431718061674, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790575, Length=365, Percent_Identity=26.8493150684932, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786908, Length=446, Percent_Identity=25.1121076233184, Blast_Score=92, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AAXC_CHLPN (Q9Z6M8)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   A72006
- PIR:   D86619
- RefSeq:   NP_225225.1
- RefSeq:   NP_301086.1
- RefSeq:   NP_445360.1
- RefSeq:   NP_877343.1
- GeneID:   1467750
- GeneID:   894716
- GeneID:   919805
- GeneID:   962779
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0821
- KEGG:   cpj:CPj1031
- KEGG:   cpn:CPn1031
- KEGG:   cpt:CpB1071
- TIGR:   CP_0821
- HOGENOM:   HBG586921
- OMA:   HANSPSI
- PhylomeDB:   Q9Z6M8
- ProtClustDB:   CLSK871339
- BioCyc:   CPNE115713:CPN1031-MONOMER
- GO:   GO:0009405
- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004754
- PANTHER:   PTHR11785
- PIRSF:   PIRSF006060
- TIGRFAMs:   TIGR00905

Pfam domain/function: PF00324 AA_permease

EC number: NA

Molecular weight: Translated: 52549; Mature: 52417

Theoretical pI: Translated: 10.40; Mature: 10.40

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc83ad48)-; HASH(0xd29aab8)-; HASH(0xd6dcafc)-; HASH(0xd94aff4)-; HASH(0xd6e41a4)-; HASH(0xb6f624c)-; HASH(0xbf223e8)-; HASH(0xd6ded54)-; HASH(0xcc09100)-; HASH(0xc8c8c1c)-; HASH(0xd2eed20)-; HASH(0x95f9350)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRTKSSKNLGTIALAGMVVSSIIGGGIFSLPQNMAATAGAGAVILSWILTGFGMFFIA
CCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHH
NTFRILSTIRPDLKEGIYMYSREGFGPYIGFTIGWGYWLCQIFGNVGYAVITMDALNYFF
HHHHHHHHHCHHHHHCCEEEECCCCCCEEHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHC
PPYFQGGNTLPAILGGSILIWVFNFIVLKGIRQASIINVIGTIFKIIPLIIFIILTAFFF
CCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLAVFKTDFWGHAVTKAQPSLGSVSSQLKGTMLVTLWAFIGIEGAVVMSGRAKNPLSVGQ
HHHHHHCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHH
ATVLGFLGCLTIYILFSLLPFGSLFQHQLANIPNPSTAGVLDILVGKWGEVLMNVGLIIA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHH
VLSSWLSWTIIVAEIPFSAAKNGTFPEIFTIENKEKSPSVSLYITSSVMQLAMLLVYFSS
HHHHHHHEEEEEEECCCHHCCCCCCCEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHCC
NAWNTMLSITGVMVLPAYLASAAFLFKLSKSKTYPKKGSIKAPLAMITGILGVVYSLWLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
YAGGLKYLFMALVLLALGIPFYIDAGKKKKNAKTFFAKKEIVGMTFIGLLALTAIFLFST
HHCCHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GRIKI
CCCCH
>Mature Secondary Structure 
TSRTKSSKNLGTIALAGMVVSSIIGGGIFSLPQNMAATAGAGAVILSWILTGFGMFFIA
CCCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHH
NTFRILSTIRPDLKEGIYMYSREGFGPYIGFTIGWGYWLCQIFGNVGYAVITMDALNYFF
HHHHHHHHHCHHHHHCCEEEECCCCCCEEHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHC
PPYFQGGNTLPAILGGSILIWVFNFIVLKGIRQASIINVIGTIFKIIPLIIFIILTAFFF
CCCCCCCCCCHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLAVFKTDFWGHAVTKAQPSLGSVSSQLKGTMLVTLWAFIGIEGAVVMSGRAKNPLSVGQ
HHHHHHCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHH
ATVLGFLGCLTIYILFSLLPFGSLFQHQLANIPNPSTAGVLDILVGKWGEVLMNVGLIIA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHH
VLSSWLSWTIIVAEIPFSAAKNGTFPEIFTIENKEKSPSVSLYITSSVMQLAMLLVYFSS
HHHHHHHEEEEEEECCCHHCCCCCCCEEEEECCCCCCCCEEEEEHHHHHHHHHHHHHHCC
NAWNTMLSITGVMVLPAYLASAAFLFKLSKSKTYPKKGSIKAPLAMITGILGVVYSLWLI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
YAGGLKYLFMALVLLALGIPFYIDAGKKKKNAKTFFAKKEIVGMTFIGLLALTAIFLFST
HHCCHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GRIKI
CCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362