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The map label for this gene is atpA [H]

Identifier: 167040975

GI number: 167040975

Start: 2407603

End: 2409375

Strand: Reverse

Name: atpA [H]

Synonym: Teth514_2364

Alternate gene names: 167040975

Gene position: 2409375-2407603 (Counterclockwise)

Preceding gene: 167040976

Following gene: 167040974

Centisome position: 98.05

GC content: 49.8

Gene sequence:

>1773_bases
ATGAGCCAGGGTATAATAACCAAAGTTTCCGGCCCCCTTGTGGTAGCTGAGGGACTTCCTGAAGCCAAGATGTTCGACGT
GGTAAAGGTGGGTAATCAGGGTCTTATAGGTGAAATCATTGAAATACGCGGAGAGAGGGTATCAATTCAGGTATACGAAG
AAACTTCTGGACTGGGCCCTGGGGACCCTGTGGTGTCCACAGGGGAACCCCTCAGCGTCGAACTGGGACCGGGAATGCTG
GAAGGCATTTTTGACGGAATCCAGAGACCTCTTGACGTTATAGAAAAAAAAGTCGGCAGCTTTATAACAAGAGGCATAGA
TGTGCCTTCTCTGAACCGCGAGAAAAAGTGGAAATTTACGCCTAAAGTTAAGTCTGGCGACAAGGTCAGTGGTGGCGATA
TTATCGGCACAGTGCAGGAGACAGTTATAGTTGAACATCGCATAATGGTTCCTCCTGCTATTTCAGGTATTGTCGAAGAC
ATCAGGGAAGGAGAATATACAGTAACCGAGCCTATTGCCAGAATAAAAACCGATTCTGGACAGATAGTGGAAATCACGAT
GATGCAGAAATGGCCGGTTCGAAAGGCTAGGCCATACAAAGAGAAGCTGCCCCCCGAAATTCCGATGCCCACTGGACAAA
GGGTCATTGACACCCTTTTTCCGGTTACTAAGGGAGGTACGGCGTGCATACCTGGACCTTTTGGTAGCGGCAAAACTGTG
GTTCAGCACCAGCTAGCCAAGTGGGCCGATGCTGAAATAGTGGTATATATCGGCTGCGGTGAGCGGGGCAACGAGATGAC
CGACGTACTCCTTGAATTCCCAGAACTTAAGGACCCCAAAACAGAGGAACCTCTCATGAAACGAACAGTGCTTATTGCCA
ACACTTCTAACATGCCTGTGGCAGCGCGCGAAGCGTCTATATACACTGGCATAACCATCGCCGAATACTTCAGGGACATG
GGCTACAGCGTGGCTTTGATGGCAGACTCAACGTCCCGCTGGGCCGAGGCATTGCGTGAAATGTCCGGAAGGCTTGAAGA
AATGCCGGGGGAAGAAGGTTATCCAGCATACCTTGCAAGGAGGCTTGCGGAGTTTTATGAGAGAGCTGGCAGAGTCATAT
GCCTGGGCAGTGACAATCGGGAGGGAGCTTTGACGGTAGTAGGTGCTGTATCCCCACCAGGGGGCGACCTGTCAGAGCCG
GTTACTCAAGCAACCCTTCGCGTGGTGAAGGTGTTCTGGGCACTGGATTCGGAGCTGGCCTATGCGCGCCATTTCCCGGC
TATTAACTGGTTGACGAGCTATTCGTTGTATTCCGATGTTGTGGAAGACTACATGAACAAAAACGTGAGCAGTGACTGGG
GAGAGCTGCGCAGTGAGGCTATGAGGCTACTACAGGAAGAGGCAAGCCTCCAGGAAATCGTAAGATTAGTGGGTATCGAC
GTTCTTTCCACCAGAGATCGCCTAGTGCTAGAAGTTGCCAGATCCATCAGGGAAGATTTCTTACACCAGAACGCTTTTCA
CGAGGTGGACACATACTCGTCAATGGAAAAGCAGTACAGAATGCTTAAGCTTATAATGATATTCTACCAAGAAGCGCAGA
AAGCTCTTGAAAAAGGTGTCCCGTTTTCGGAAATAGAGAAGCACCCAGTACGCGAGAAAATTGCCCGTGCTAAATATGTT
GAAGAGTCGAAGTTGACTGTTTTCGACGAAATAGAGAAGGAGATAAAAAAGGCTATGCAAGGCCTCATCGAGGGAGGTGC
AGCCGATGCTTAG

Upstream 100 bases:

>100_bases
CCAGCAACCGAGGTACTCTGGGAATCGGTATAAATGACGTGAGAAAATCTGTGGAAAAAGCTATTGGAGCAGATATCATT
TTTGAAAGAGAGGGAAGGGA

Downstream 100 bases:

>100_bases
AGAATATAAAACCGTTAGAGAAATTGTCGGCCCGTTAATGCTGGTTGAAAAAGTGGAAGGTGTCAAATACAATGAGCTGG
TGGAAATTGAGACCGGCTCG

Product: ATP synthase subunit A

Products: NA

Alternate protein names: V-ATPase subunit A [H]

Number of amino acids: Translated: 590; Mature: 589

Protein sequence:

>590_residues
MSQGIITKVSGPLVVAEGLPEAKMFDVVKVGNQGLIGEIIEIRGERVSIQVYEETSGLGPGDPVVSTGEPLSVELGPGML
EGIFDGIQRPLDVIEKKVGSFITRGIDVPSLNREKKWKFTPKVKSGDKVSGGDIIGTVQETVIVEHRIMVPPAISGIVED
IREGEYTVTEPIARIKTDSGQIVEITMMQKWPVRKARPYKEKLPPEIPMPTGQRVIDTLFPVTKGGTACIPGPFGSGKTV
VQHQLAKWADAEIVVYIGCGERGNEMTDVLLEFPELKDPKTEEPLMKRTVLIANTSNMPVAAREASIYTGITIAEYFRDM
GYSVALMADSTSRWAEALREMSGRLEEMPGEEGYPAYLARRLAEFYERAGRVICLGSDNREGALTVVGAVSPPGGDLSEP
VTQATLRVVKVFWALDSELAYARHFPAINWLTSYSLYSDVVEDYMNKNVSSDWGELRSEAMRLLQEEASLQEIVRLVGID
VLSTRDRLVLEVARSIREDFLHQNAFHEVDTYSSMEKQYRMLKLIMIFYQEAQKALEKGVPFSEIEKHPVREKIARAKYV
EESKLTVFDEIEKEIKKAMQGLIEGGAADA

Sequences:

>Translated_590_residues
MSQGIITKVSGPLVVAEGLPEAKMFDVVKVGNQGLIGEIIEIRGERVSIQVYEETSGLGPGDPVVSTGEPLSVELGPGML
EGIFDGIQRPLDVIEKKVGSFITRGIDVPSLNREKKWKFTPKVKSGDKVSGGDIIGTVQETVIVEHRIMVPPAISGIVED
IREGEYTVTEPIARIKTDSGQIVEITMMQKWPVRKARPYKEKLPPEIPMPTGQRVIDTLFPVTKGGTACIPGPFGSGKTV
VQHQLAKWADAEIVVYIGCGERGNEMTDVLLEFPELKDPKTEEPLMKRTVLIANTSNMPVAAREASIYTGITIAEYFRDM
GYSVALMADSTSRWAEALREMSGRLEEMPGEEGYPAYLARRLAEFYERAGRVICLGSDNREGALTVVGAVSPPGGDLSEP
VTQATLRVVKVFWALDSELAYARHFPAINWLTSYSLYSDVVEDYMNKNVSSDWGELRSEAMRLLQEEASLQEIVRLVGID
VLSTRDRLVLEVARSIREDFLHQNAFHEVDTYSSMEKQYRMLKLIMIFYQEAQKALEKGVPFSEIEKHPVREKIARAKYV
EESKLTVFDEIEKEIKKAMQGLIEGGAADA
>Mature_589_residues
SQGIITKVSGPLVVAEGLPEAKMFDVVKVGNQGLIGEIIEIRGERVSIQVYEETSGLGPGDPVVSTGEPLSVELGPGMLE
GIFDGIQRPLDVIEKKVGSFITRGIDVPSLNREKKWKFTPKVKSGDKVSGGDIIGTVQETVIVEHRIMVPPAISGIVEDI
REGEYTVTEPIARIKTDSGQIVEITMMQKWPVRKARPYKEKLPPEIPMPTGQRVIDTLFPVTKGGTACIPGPFGSGKTVV
QHQLAKWADAEIVVYIGCGERGNEMTDVLLEFPELKDPKTEEPLMKRTVLIANTSNMPVAAREASIYTGITIAEYFRDMG
YSVALMADSTSRWAEALREMSGRLEEMPGEEGYPAYLARRLAEFYERAGRVICLGSDNREGALTVVGAVSPPGGDLSEPV
TQATLRVVKVFWALDSELAYARHFPAINWLTSYSLYSDVVEDYMNKNVSSDWGELRSEAMRLLQEEASLQEIVRLVGIDV
LSTRDRLVLEVARSIREDFLHQNAFHEVDTYSSMEKQYRMLKLIMIFYQEAQKALEKGVPFSEIEKHPVREKIARAKYVE
ESKLTVFDEIEKEIKKAMQGLIEGGAADA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit [H]

COG id: COG1155

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI19913424, Length=541, Percent_Identity=53.4195933456562, Blast_Score=590, Evalue=1e-168,
Organism=Homo sapiens, GI32189394, Length=363, Percent_Identity=29.4765840220386, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI19913426, Length=258, Percent_Identity=27.1317829457364, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI19913428, Length=243, Percent_Identity=25.9259259259259, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI50345984, Length=256, Percent_Identity=26.171875, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI4757810, Length=256, Percent_Identity=26.171875, Blast_Score=83, Evalue=8e-16,
Organism=Escherichia coli, GI1790170, Length=386, Percent_Identity=29.7927461139896, Blast_Score=122, Evalue=9e-29,
Organism=Escherichia coli, GI1788251, Length=329, Percent_Identity=25.531914893617, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1790172, Length=263, Percent_Identity=25.4752851711027, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17565854, Length=542, Percent_Identity=52.9520295202952, Blast_Score=587, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI25144756, Length=320, Percent_Identity=30.3125, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17510931, Length=372, Percent_Identity=26.6129032258064, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17570191, Length=360, Percent_Identity=24.7222222222222, Blast_Score=99, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71988080, Length=257, Percent_Identity=26.4591439688716, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71988063, Length=257, Percent_Identity=26.4591439688716, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71988074, Length=257, Percent_Identity=26.4591439688716, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320016, Length=318, Percent_Identity=50, Blast_Score=327, Evalue=2e-90,
Organism=Saccharomyces cerevisiae, GI6322581, Length=331, Percent_Identity=31.1178247734139, Blast_Score=116, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6319603, Length=346, Percent_Identity=25.4335260115607, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6319370, Length=235, Percent_Identity=27.6595744680851, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583988, Length=599, Percent_Identity=49.9165275459099, Blast_Score=593, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24583986, Length=599, Percent_Identity=49.9165275459099, Blast_Score=593, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24583984, Length=599, Percent_Identity=49.9165275459099, Blast_Score=593, Evalue=1e-170,
Organism=Drosophila melanogaster, GI24583992, Length=563, Percent_Identity=52.0426287744227, Blast_Score=584, Evalue=1e-167,
Organism=Drosophila melanogaster, GI20129479, Length=537, Percent_Identity=52.8864059590317, Blast_Score=579, Evalue=1e-165,
Organism=Drosophila melanogaster, GI28574560, Length=306, Percent_Identity=34.640522875817, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI24638766, Length=303, Percent_Identity=31.3531353135314, Blast_Score=116, Evalue=6e-26,
Organism=Drosophila melanogaster, GI281361666, Length=243, Percent_Identity=25.9259259259259, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24646341, Length=243, Percent_Identity=25.9259259259259, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17136796, Length=243, Percent_Identity=25.9259259259259, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24658560, Length=257, Percent_Identity=26.4591439688716, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: 10836 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005726
- InterPro:   IPR003593
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022878 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 65433; Mature: 65302

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQGIITKVSGPLVVAEGLPEAKMFDVVKVGNQGLIGEIIEIRGERVSIQVYEETSGLGP
CCCCCEEECCCCEEEECCCCCHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEEECCCCCCC
GDPVVSTGEPLSVELGPGMLEGIFDGIQRPLDVIEKKVGSFITRGIDVPSLNREKKWKFT
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEC
PKVKSGDKVSGGDIIGTVQETVIVEHRIMVPPAISGIVEDIREGEYTVTEPIARIKTDSG
CCCCCCCCCCCCCEEHHHHHHHHHHHEEECCHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
QIVEITMMQKWPVRKARPYKEKLPPEIPMPTGQRVIDTLFPVTKGGTACIPGPFGSGKTV
CEEEEEEECCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCHHH
VQHQLAKWADAEIVVYIGCGERGNEMTDVLLEFPELKDPKTEEPLMKRTVLIANTSNMPV
HHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHCEEEEEECCCCCC
AAREASIYTGITIAEYFRDMGYSVALMADSTSRWAEALREMSGRLEEMPGEEGYPAYLAR
EECCCHHHCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
RLAEFYERAGRVICLGSDNREGALTVVGAVSPPGGDLSEPVTQATLRVVKVFWALDSELA
HHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YARHFPAINWLTSYSLYSDVVEDYMNKNVSSDWGELRSEAMRLLQEEASLQEIVRLVGID
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
VLSTRDRLVLEVARSIREDFLHQNAFHEVDTYSSMEKQYRMLKLIMIFYQEAQKALEKGV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PFSEIEKHPVREKIARAKYVEESKLTVFDEIEKEIKKAMQGLIEGGAADA
CHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SQGIITKVSGPLVVAEGLPEAKMFDVVKVGNQGLIGEIIEIRGERVSIQVYEETSGLGP
CCCCEEECCCCEEEECCCCCHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEEECCCCCCC
GDPVVSTGEPLSVELGPGMLEGIFDGIQRPLDVIEKKVGSFITRGIDVPSLNREKKWKFT
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEC
PKVKSGDKVSGGDIIGTVQETVIVEHRIMVPPAISGIVEDIREGEYTVTEPIARIKTDSG
CCCCCCCCCCCCCEEHHHHHHHHHHHEEECCHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
QIVEITMMQKWPVRKARPYKEKLPPEIPMPTGQRVIDTLFPVTKGGTACIPGPFGSGKTV
CEEEEEEECCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCCHHH
VQHQLAKWADAEIVVYIGCGERGNEMTDVLLEFPELKDPKTEEPLMKRTVLIANTSNMPV
HHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCHHHHCEEEEEECCCCCC
AAREASIYTGITIAEYFRDMGYSVALMADSTSRWAEALREMSGRLEEMPGEEGYPAYLAR
EECCCHHHCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
RLAEFYERAGRVICLGSDNREGALTVVGAVSPPGGDLSEPVTQATLRVVKVFWALDSELA
HHHHHHHHCCCEEEEECCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
YARHFPAINWLTSYSLYSDVVEDYMNKNVSSDWGELRSEAMRLLQEEASLQEIVRLVGID
HHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
VLSTRDRLVLEVARSIREDFLHQNAFHEVDTYSSMEKQYRMLKLIMIFYQEAQKALEKGV
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PFSEIEKHPVREKIARAKYVEESKLTVFDEIEKEIKKAMQGLIEGGAADA
CHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA