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The map label for this gene is clpP

Identifier: 167040915

GI number: 167040915

Start: 2314271

End: 2314858

Strand: Reverse

Name: clpP

Synonym: Teth514_2301

Alternate gene names: 167040915

Gene position: 2314858-2314271 (Counterclockwise)

Preceding gene: 167040916

Following gene: 167040914

Centisome position: 94.2

GC content: 39.29

Gene sequence:

>588_bases
ATGAGTCTTGTACCTATTGTTGTAGAGCAGACAAATAGAGGCGAACGTTCTTACGACATATTTTCACGTTTGCTAAAAGA
CAGGATTGTCTTTTTAGGAGAAGAAATAAATGATACTACGGCAAGTTTAGTTATTGCACAGCTTTTGTTCTTGGAAGCTG
AAGACCCTGATAAAGACATCTGGCTTTATATAAATAGTCCAGGAGGTTCAATAACAGCAGGTTTTGCCATTTATGATACT
ATGCAGTATATAAAACCAGATGTAGTGACTCTATGTGTCGGAATGGCGGCATCCATGGCTGCATTTTTACTGGCAGCAGG
CGCGAAAGGAAAAAGATTTGCACTTCCTAATAGCGAAATAATGATACATCAGCCTTTAGGGGGCATGCAGGGTCAAGCTA
CTGACATTAAGATTCATGCAGAAAGGATTTTAAAATTAAGAGATAAGTTGGATAAAATACTTGCAGAAAATACGGGGCAG
CCTATTGAAAAGATAAAGGCAGATACTGAGAGGGACTTTTTCATGGACGCGGAGGATGCAAAAGCGTATGGCATTATAGA
CGAGGTTCTCATCAGGAATAAAAGATGA

Upstream 100 bases:

>100_bases
AAAGCCAGATAAACAGCATAAAAGAGGATATAGCTTATTATAAGACGATTGACTTTATTTTCAGTAAGTGTAAAATAATA
AGTAAAGAGGAGTGATTATT

Downstream 100 bases:

>100_bases
TGCCCCAAAAGAGGTGAAATTATGGTCAAATATGATAATCAAAAACAACTAAAGTGTTCCTTTTGCGGAAAGACACAGGA
CCAGGTAAAGAGGCTAGTTG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MSLVPIVVEQTNRGERSYDIFSRLLKDRIVFLGEEINDTTASLVIAQLLFLEAEDPDKDIWLYINSPGGSITAGFAIYDT
MQYIKPDVVTLCVGMAASMAAFLLAAGAKGKRFALPNSEIMIHQPLGGMQGQATDIKIHAERILKLRDKLDKILAENTGQ
PIEKIKADTERDFFMDAEDAKAYGIIDEVLIRNKR

Sequences:

>Translated_195_residues
MSLVPIVVEQTNRGERSYDIFSRLLKDRIVFLGEEINDTTASLVIAQLLFLEAEDPDKDIWLYINSPGGSITAGFAIYDT
MQYIKPDVVTLCVGMAASMAAFLLAAGAKGKRFALPNSEIMIHQPLGGMQGQATDIKIHAERILKLRDKLDKILAENTGQ
PIEKIKADTERDFFMDAEDAKAYGIIDEVLIRNKR
>Mature_194_residues
SLVPIVVEQTNRGERSYDIFSRLLKDRIVFLGEEINDTTASLVIAQLLFLEAEDPDKDIWLYINSPGGSITAGFAIYDTM
QYIKPDVVTLCVGMAASMAAFLLAAGAKGKRFALPNSEIMIHQPLGGMQGQATDIKIHAERILKLRDKLDKILAENTGQP
IEKIKADTERDFFMDAEDAKAYGIIDEVLIRNKR

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=58.3333333333333, Blast_Score=233, Evalue=1e-61,
Organism=Escherichia coli, GI1786641, Length=190, Percent_Identity=64.7368421052632, Blast_Score=278, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17538017, Length=190, Percent_Identity=50.5263157894737, Blast_Score=202, Evalue=7e-53,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=59.4736842105263, Blast_Score=240, Evalue=5e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_THEP3 (B0KBA4)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001665628.1
- ProteinModelPortal:   B0KBA4
- SMR:   B0KBA4
- MEROPS:   S14.001
- GeneID:   5874689
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_1651
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- ProtClustDB:   PRK00277
- BioCyc:   TPSE340099:TETH39_1651-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21691; Mature: 21560

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 98-98 ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVPIVVEQTNRGERSYDIFSRLLKDRIVFLGEEINDTTASLVIAQLLFLEAEDPDKDI
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEE
WLYINSPGGSITAGFAIYDTMQYIKPDVVTLCVGMAASMAAFLLAAGAKGKRFALPNSEI
EEEEECCCCCEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCE
MIHQPLGGMQGQATDIKIHAERILKLRDKLDKILAENTGQPIEKIKADTERDFFMDAEDA
EEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCEECCCCC
KAYGIIDEVLIRNKR
HHHHHHHHHHHCCCC
>Mature Secondary Structure 
SLVPIVVEQTNRGERSYDIFSRLLKDRIVFLGEEINDTTASLVIAQLLFLEAEDPDKDI
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEE
WLYINSPGGSITAGFAIYDTMQYIKPDVVTLCVGMAASMAAFLLAAGAKGKRFALPNSEI
EEEEECCCCCEEEHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCE
MIHQPLGGMQGQATDIKIHAERILKLRDKLDKILAENTGQPIEKIKADTERDFFMDAEDA
EEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCEECCCCC
KAYGIIDEVLIRNKR
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA