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The map label for this gene is mntH [H]

Identifier: 167040870

GI number: 167040870

Start: 2254408

End: 2255691

Strand: Reverse

Name: mntH [H]

Synonym: Teth514_2251

Alternate gene names: 167040870

Gene position: 2255691-2254408 (Counterclockwise)

Preceding gene: 167040871

Following gene: 167040869

Centisome position: 91.8

GC content: 34.89

Gene sequence:

>1284_bases
ATGTTTAAAGGCATAAAGAATTTGTTTAAAGGCATAAAGAATTTGTTTAAAGGCAGACATCGTCCGAAGTTTATGGCTTT
AGACTTTATTAAATACATAGGACCAGGGTTACTAGTTACTGTTGGTTTTATTGACCCGGGGAATTGGGCTTCTAATGTTG
CTGCAGGGTCATCATATGGTTACAAGCTTTTATGGATGGTAACTTTATCTACTGTTATGCTTATTATACTCCAACACAAT
GCTGCACATCTCGGCATAGTTACAGGTTATTGCATGTCTGAAGCTGCAAGTAAATTTTTGCAACCTTCTGTGTCCAAATT
TGTGCTTATTTCAGCAGTTTTAGCTTCTATACTTACGGCGATGGCGGAAATTTTAGGAGCTGCAATAGCTCTTCAAATGC
TTTTTAAAATTCCTATAAAGATAGGAAGTTTGATTACTGTTGTTTTTGTGTCATGGATGCTTTATACAAATTCCTACAAA
AAGTTGGAAAAATGGATTATAGGTTTTGTATCACTTATCGGCATTTCTTTTATATTTGAGCTTTCATTAGTTGATGTAAA
GTGGACAGAAGCAGTTGTAAGCTGGGTGAAACCAGAATTTCCGCCTGGTTCAATGCCTATAATCATGAGTGTGCTTGGTG
CTGTTGTTATGCCCCACAATTTGTTTTTACATTCAGAGATAATCCAGAGCAGGCAGTGGAATTTAGAAGATGAAGAAATA
ATTGTAAAGCAGCTTAATTATGAGTATTTTGATACTATTTTTTCCATGGTAATAGGTTGGGCGATAAACAGTGCGATGAT
TATTGTTGCTGCATCAGCCTTTTTTGCTAATCACATAAGTGTTACAGAATTAGACCAGGCACAGCAGATGTTAAAACCTC
TTTTGGGAAATGCGTCAGCAGTTGTTTTTGCTTTAGCTCTTCTTTTTGCAGGAATTTCTTCATCTATAACAGCAGGAATG
GCAGGTGGAAGTATTTTTGCAGGGATATATAAAGAGCCTTATGATATAAATGATATTCACACAAGAGTTGGAGTGGGAAT
TACATATATTTTTGCAGTACTCCTAATATTCTTTGTAAAAAGCCCCTTTCAAGGATTAGTTTATTCGCAGATGTTTTTAA
GTGTACAGCTTCCCATTACAATTTTTTTGCTCATTTATTTGACTTCTTCAAAGAAGATAATGGGAAAGTTTGCAAATACA
TTGCTTTATAAGATATTGTTGTGGACTACAGGAATTATAGTGACAATTTTAAATGTTATGCTTCTTATAAGTTTTGTGGT
GTGA

Upstream 100 bases:

>100_bases
GCTAAAAAATTACTAAAGAGGGATTACAATACTTATTGTACGCCTGACACCTCTTGCAGTTTAAAAGGTGAAGATTAAAA
TTTTAAAAAGAGGTGAACAT

Downstream 100 bases:

>100_bases
TTGATATGAATGCTATAAAATGGTAGAATATATGTAAAGAATTTTTGTGTGGTGATAAAGATGACTATTTCAGATGAAGA
AAAAAGGAAAATAAGAGAAA

Product: natural resistance-associated macrophage protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MFKGIKNLFKGIKNLFKGRHRPKFMALDFIKYIGPGLLVTVGFIDPGNWASNVAAGSSYGYKLLWMVTLSTVMLIILQHN
AAHLGIVTGYCMSEAASKFLQPSVSKFVLISAVLASILTAMAEILGAAIALQMLFKIPIKIGSLITVVFVSWMLYTNSYK
KLEKWIIGFVSLIGISFIFELSLVDVKWTEAVVSWVKPEFPPGSMPIIMSVLGAVVMPHNLFLHSEIIQSRQWNLEDEEI
IVKQLNYEYFDTIFSMVIGWAINSAMIIVAASAFFANHISVTELDQAQQMLKPLLGNASAVVFALALLFAGISSSITAGM
AGGSIFAGIYKEPYDINDIHTRVGVGITYIFAVLLIFFVKSPFQGLVYSQMFLSVQLPITIFLLIYLTSSKKIMGKFANT
LLYKILLWTTGIIVTILNVMLLISFVV

Sequences:

>Translated_427_residues
MFKGIKNLFKGIKNLFKGRHRPKFMALDFIKYIGPGLLVTVGFIDPGNWASNVAAGSSYGYKLLWMVTLSTVMLIILQHN
AAHLGIVTGYCMSEAASKFLQPSVSKFVLISAVLASILTAMAEILGAAIALQMLFKIPIKIGSLITVVFVSWMLYTNSYK
KLEKWIIGFVSLIGISFIFELSLVDVKWTEAVVSWVKPEFPPGSMPIIMSVLGAVVMPHNLFLHSEIIQSRQWNLEDEEI
IVKQLNYEYFDTIFSMVIGWAINSAMIIVAASAFFANHISVTELDQAQQMLKPLLGNASAVVFALALLFAGISSSITAGM
AGGSIFAGIYKEPYDINDIHTRVGVGITYIFAVLLIFFVKSPFQGLVYSQMFLSVQLPITIFLLIYLTSSKKIMGKFANT
LLYKILLWTTGIIVTILNVMLLISFVV
>Mature_427_residues
MFKGIKNLFKGIKNLFKGRHRPKFMALDFIKYIGPGLLVTVGFIDPGNWASNVAAGSSYGYKLLWMVTLSTVMLIILQHN
AAHLGIVTGYCMSEAASKFLQPSVSKFVLISAVLASILTAMAEILGAAIALQMLFKIPIKIGSLITVVFVSWMLYTNSYK
KLEKWIIGFVSLIGISFIFELSLVDVKWTEAVVSWVKPEFPPGSMPIIMSVLGAVVMPHNLFLHSEIIQSRQWNLEDEEI
IVKQLNYEYFDTIFSMVIGWAINSAMIIVAASAFFANHISVTELDQAQQMLKPLLGNASAVVFALALLFAGISSSITAGM
AGGSIFAGIYKEPYDINDIHTRVGVGITYIFAVLLIFFVKSPFQGLVYSQMFLSVQLPITIFLLIYLTSSKKIMGKFANT
LLYKILLWTTGIIVTILNVMLLISFVV

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=431, Percent_Identity=26.2180974477958, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI295293175, Length=434, Percent_Identity=26.9585253456221, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI295293173, Length=434, Percent_Identity=26.9585253456221, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI10835169, Length=434, Percent_Identity=26.9585253456221, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI295293171, Length=431, Percent_Identity=26.4501160092807, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI295293169, Length=431, Percent_Identity=26.4501160092807, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI295293178, Length=434, Percent_Identity=26.9585253456221, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI295293167, Length=434, Percent_Identity=26.9585253456221, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI1788736, Length=401, Percent_Identity=31.6708229426434, Blast_Score=172, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI17569473, Length=376, Percent_Identity=29.5212765957447, Blast_Score=131, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI193210616, Length=434, Percent_Identity=27.1889400921659, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71993856, Length=207, Percent_Identity=34.2995169082126, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71999499, Length=328, Percent_Identity=26.219512195122, Blast_Score=104, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6323062, Length=399, Percent_Identity=32.3308270676692, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321841, Length=406, Percent_Identity=30.0492610837438, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6324450, Length=419, Percent_Identity=28.8782816229117, Blast_Score=136, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24648607, Length=438, Percent_Identity=26.027397260274, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI281362176, Length=438, Percent_Identity=26.027397260274, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24648609, Length=438, Percent_Identity=26.027397260274, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45553443, Length=412, Percent_Identity=25.7281553398058, Blast_Score=112, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 47193; Mature: 47193

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHC
>Mature Secondary Structure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HHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]