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The map label for this gene is algC [H]

Identifier: 167040858

GI number: 167040858

Start: 2240174

End: 2241541

Strand: Reverse

Name: algC [H]

Synonym: Teth514_2238

Alternate gene names: 167040858

Gene position: 2241541-2240174 (Counterclockwise)

Preceding gene: 167040859

Following gene: 167040857

Centisome position: 91.22

GC content: 36.11

Gene sequence:

>1368_bases
ATGAAGTTGAATGAAAATATGTTTAGGATGTATGATATTAGAGGCGTATGGGAAGATGATTTGACTGTTGAAAGTGCTGA
GCTTATAGGGAAGGCCTTTGGTACATATGTGAGACAAAAAGGAATTAAGGATGTGCTGGTAGGCAGAGATAATAGATTAT
CATCAAGACCTATACGAGATGCTTTGATTAAAGGACTTACTTCTACAGGCTGTGATGTATTAGATGTAGGGGTTTTGACG
ACTCCAGCTTTTTACTATTCTAATGTCCTGTACAATTATCAAGCAGGGATGATGATTACTGCAAGCCACAATCCGCCACA
ATTTAATGGTTTCAAAGTTATGGTAGGACCTTCTACAATTTATGGCGATGAACTTAAAAAACTTTACTATATAGCAGAAA
AAGGCGAATTTGAAGAAGGTACAGGAAATGTGAAGTATGCTTATCCAATTAATTCGTATATTAATATGATAAAAGAAAAG
GTTAAATTAGGCGACAGAAAGCTTAAAGTTGTTGTCGATTGTGGGAATGGCACAGGTTCATATTTTTATCCTGATGTGAT
ATACAATTTAGGTTGTGAAGTATATCCTCTCTATTGTGAATCTGATCCTACATTTCCAAACCATTTTCCAGATCCAGTAA
AAGAAGAAAATTTAAAAGATTTAATTGAAGAAGTAAAGAGGGTAAACGCAGATTTGGGTATAGCTTTTGACGGTGACGGT
GATAGAATCGGCGTCGTAGATGATAAAGGCAATGTAATTTGGGGAGATATGTTGATGATTCTTTATTGGAGAGAAATAAT
GAAAAAACATCCCGGCGCTGATGCCATTGTAGAAGTGAAATGTTCTCAGGCATTAGTAGAAGAAATTGAGAGATTGGGAG
GCAAACCTATCTTCTTCAAAACAGGGCATTCCCTCATAAAAGCAAAAATGAAAGAATTAGGTGCTGTGTTTACAGGAGAA
ATGTCTGGTCATATGTTTTTTGCAGATGAGTACTATGGGTTTGATGATGCGGCATACGCTGCTGCAAGGCTTTTACGAAT
ACTTTCTAATACAGATAAATCTTTGTCTGAGCTTTTAGCTGATGTTCCTAAATATCCTGCAACACCTGAAATAAGGTTAG
AATGTGACGATGAGAAAAAATTTGATGTGGTAAAAGGTGTAACTGAATACTTTAAAGAAAAAGGATACAACATTATAGAT
GTTGATGGTGCAAGAGTGTTGTTTGATGGAGGATGGGGACTGGTTAGAGCTTCTAACACAGGACCAGAGCTTATTGTGAG
ATGTGAGGCAAAGACAGAAGAAAAACTTGAAGCGATTAAAAAAGAGCTTTCAGAAGCTTTAGCTAAATTTAGCGTAGAGT
TTAAATAA

Upstream 100 bases:

>100_bases
CATAAAGTCAAGAAACAATTTTGTGAAGATTGTGTATTGAGGATTTTCAGTATTATCTATATAATTAAATTGTATGGCAT
AAAAAAGGAGGTTGAGACAA

Downstream 100 bases:

>100_bases
GCTGTAAAACTTGCATGGGAGGAAAAAACAGTGAAAATAAGAAAGGCGATAATTCCGGCTGCAGGCCTTGGTACGAGGTT
TTTGCCTGCTACCAAGGCTC

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MKLNENMFRMYDIRGVWEDDLTVESAELIGKAFGTYVRQKGIKDVLVGRDNRLSSRPIRDALIKGLTSTGCDVLDVGVLT
TPAFYYSNVLYNYQAGMMITASHNPPQFNGFKVMVGPSTIYGDELKKLYYIAEKGEFEEGTGNVKYAYPINSYINMIKEK
VKLGDRKLKVVVDCGNGTGSYFYPDVIYNLGCEVYPLYCESDPTFPNHFPDPVKEENLKDLIEEVKRVNADLGIAFDGDG
DRIGVVDDKGNVIWGDMLMILYWREIMKKHPGADAIVEVKCSQALVEEIERLGGKPIFFKTGHSLIKAKMKELGAVFTGE
MSGHMFFADEYYGFDDAAYAAARLLRILSNTDKSLSELLADVPKYPATPEIRLECDDEKKFDVVKGVTEYFKEKGYNIID
VDGARVLFDGGWGLVRASNTGPELIVRCEAKTEEKLEAIKKELSEALAKFSVEFK

Sequences:

>Translated_455_residues
MKLNENMFRMYDIRGVWEDDLTVESAELIGKAFGTYVRQKGIKDVLVGRDNRLSSRPIRDALIKGLTSTGCDVLDVGVLT
TPAFYYSNVLYNYQAGMMITASHNPPQFNGFKVMVGPSTIYGDELKKLYYIAEKGEFEEGTGNVKYAYPINSYINMIKEK
VKLGDRKLKVVVDCGNGTGSYFYPDVIYNLGCEVYPLYCESDPTFPNHFPDPVKEENLKDLIEEVKRVNADLGIAFDGDG
DRIGVVDDKGNVIWGDMLMILYWREIMKKHPGADAIVEVKCSQALVEEIERLGGKPIFFKTGHSLIKAKMKELGAVFTGE
MSGHMFFADEYYGFDDAAYAAARLLRILSNTDKSLSELLADVPKYPATPEIRLECDDEKKFDVVKGVTEYFKEKGYNIID
VDGARVLFDGGWGLVRASNTGPELIVRCEAKTEEKLEAIKKELSEALAKFSVEFK
>Mature_455_residues
MKLNENMFRMYDIRGVWEDDLTVESAELIGKAFGTYVRQKGIKDVLVGRDNRLSSRPIRDALIKGLTSTGCDVLDVGVLT
TPAFYYSNVLYNYQAGMMITASHNPPQFNGFKVMVGPSTIYGDELKKLYYIAEKGEFEEGTGNVKYAYPINSYINMIKEK
VKLGDRKLKVVVDCGNGTGSYFYPDVIYNLGCEVYPLYCESDPTFPNHFPDPVKEENLKDLIEEVKRVNADLGIAFDGDG
DRIGVVDDKGNVIWGDMLMILYWREIMKKHPGADAIVEVKCSQALVEEIERLGGKPIFFKTGHSLIKAKMKELGAVFTGE
MSGHMFFADEYYGFDDAAYAAARLLRILSNTDKSLSELLADVPKYPATPEIRLECDDEKKFDVVKGVTEYFKEKGYNIID
VDGARVLFDGGWGLVRASNTGPELIVRCEAKTEEKLEAIKKELSEALAKFSVEFK

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=442, Percent_Identity=31.2217194570136, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1789566, Length=459, Percent_Identity=28.322440087146, Blast_Score=126, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 51081; Mature: 51081

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNENMFRMYDIRGVWEDDLTVESAELIGKAFGTYVRQKGIKDVLVGRDNRLSSRPIRD
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHH
ALIKGLTSTGCDVLDVGVLTTPAFYYSNVLYNYQAGMMITASHNPPQFNGFKVMVGPSTI
HHHHHHCCCCCCEEECCHHHCCHHHHHHHHEEECCCEEEEECCCCCCCCCEEEEECCCCC
YGDELKKLYYIAEKGEFEEGTGNVKYAYPINSYINMIKEKVKLGDRKLKVVVDCGNGTGS
CHHHHHHEEEEECCCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCCC
YFYPDVIYNLGCEVYPLYCESDPTFPNHFPDPVKEENLKDLIEEVKRVNADLGIAFDGDG
EECHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCC
DRIGVVDDKGNVIWGDMLMILYWREIMKKHPGADAIVEVKCSQALVEEIERLGGKPIFFK
CEEEEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCEEEEE
TGHSLIKAKMKELGAVFTGEMSGHMFFADEYYGFDDAAYAAARLLRILSNTDKSLSELLA
CCHHHHHHHHHHHCCEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
DVPKYPATPEIRLECDDEKKFDVVKGVTEYFKEKGYNIIDVDGARVLFDGGWGLVRASNT
HCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCEEEEECCC
GPELIVRCEAKTEEKLEAIKKELSEALAKFSVEFK
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKLNENMFRMYDIRGVWEDDLTVESAELIGKAFGTYVRQKGIKDVLVGRDNRLSSRPIRD
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCHHH
ALIKGLTSTGCDVLDVGVLTTPAFYYSNVLYNYQAGMMITASHNPPQFNGFKVMVGPSTI
HHHHHHCCCCCCEEECCHHHCCHHHHHHHHEEECCCEEEEECCCCCCCCCEEEEECCCCC
YGDELKKLYYIAEKGEFEEGTGNVKYAYPINSYINMIKEKVKLGDRKLKVVVDCGNGTGS
CHHHHHHEEEEECCCCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCCC
YFYPDVIYNLGCEVYPLYCESDPTFPNHFPDPVKEENLKDLIEEVKRVNADLGIAFDGDG
EECHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCC
DRIGVVDDKGNVIWGDMLMILYWREIMKKHPGADAIVEVKCSQALVEEIERLGGKPIFFK
CEEEEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHCCCCEEEEE
TGHSLIKAKMKELGAVFTGEMSGHMFFADEYYGFDDAAYAAARLLRILSNTDKSLSELLA
CCHHHHHHHHHHHCCEEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHH
DVPKYPATPEIRLECDDEKKFDVVKGVTEYFKEKGYNIIDVDGARVLFDGGWGLVRASNT
HCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCEEEEECCC
GPELIVRCEAKTEEKLEAIKKELSEALAKFSVEFK
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1903398; 10984043; 7515870; 10481091; 8050998; 11716469; 11839312 [H]