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The map label for this gene is aprX [H]

Identifier: 167040815

GI number: 167040815

Start: 2191002

End: 2192732

Strand: Direct

Name: aprX [H]

Synonym: Teth514_2192

Alternate gene names: 167040815

Gene position: 2191002-2192732 (Clockwise)

Preceding gene: 167040809

Following gene: 167040828

Centisome position: 89.16

GC content: 38.99

Gene sequence:

>1731_bases
ATGAAGAGCCGACAAACATTAAAAGCTTTACTGGCCTTTGTGTTAATTGTAGCTTTAATGTCGCTAAGTGGAGTATTAGT
CCAAGCCCAGCCCAACCTAACAAACTTTCCTATTAACTCATCAACAAAAAATTACTTGCCTCAAATTCAAAAAGTTTTGA
TGCAAGACTCTAATAAAAATAAACTTTTTGACAACTTAGAAGCAAAAATTGCTGGTAAGCCAGACAGTGAAAAATTTCCA
GTTATAATAATTTTCAACAAAAACATAGATGATAACGAACTATTAAATATTTCTAAATCCATTGGAAAGTTTAATATAAA
GCATAAATACAAAATTATTCCAGGAATTGCTGCTACCTTAACTAAAGGACAAATAAACGCTTGGTCAAAATTGGATATAG
TAAAGCAAATTGAGTATGACGAGCCTGTATATGCCACATTAGACACTGCAACAAAATGGTTTGGGGTTACAAAAGCGAGA
AGTGATTTTGGTGTAACTGGTGATAGAGACGGTAATGCTTCTTCTTATTCCAAGAATGATATAGTAATAGCAGTTATTGA
TACCGGTATTGATGGCTCCCATGTTGACCTCGCTGGTGGCAAAGTAATAGGATGGCAAGATTTTGTAAACGGCAAATCTA
CCCCCTACGATGATAATGGACACGGAACTCATGTAGCAAGTATTGCGGCAGGTACTGGGACAGGGAACAACCTTTATAAA
GGTGTTGCTCCTGGTGCTGCTTTAGTAGGGATAAAAGTATTAGATTCAAATGGAAGCGGAACTATGAGCACTGTAACCGC
AGGAATTGACTGGGCTGTTCAAAACAAAGACGTATACGGAATCAAAGTTATAAATTTAAGCCTCGGAACTTCCACAAGTT
CTGATGGAACTGACTCTACCTCACTGGCAGTAAACGGAGCCGTAGATAGCGGAATTGTAGTAGTAGTTGCAGCTGGAAAT
TCAGGTCCTGCGAGATACACCATAGGATCACCTGGTGCAGCAGAAAAAGCCATAACCGTTGCAGCAATGGCGGATGTAGG
GGAACTTGGCTTTAACCTTGCAAGCTTCTCCAGCCGTGGTCCCACAGCTGACGGAAGGATAAAACCTGACATTGCAGCAC
CCGGATATAATATAACTGCCGCAAAAGCAAATTCTATAAATGGTTATGTGACATACAGTGGTACAAGCATGGCTACACCT
TTTGTAGCAGGTACAGTAGCCCTTATGCTCAGTGCAAATATAAACCTTGCACCACTTGATGTAAAAAATATAATAATGAC
TACTGCAAAAAGTTGGGGTCCTCCAAGCAAAAACATTGACTATGGTGTAGGAAGATTGGATGCATATGAAGCAATTAAAA
CAGCTGGAAATTTCACAGGAACTAATATATCTGTGCCAAACCACTATTATGCTAAAGAGTCACTTCCTGGGTCTCGTTAC
AGTGACATTTGGACATTTAATGTGACAGACACATCATATCCTATTGCAATAACTTTCATAATACCTGATTGGGCAAACTA
TAACCCTGATTTCGATATATACCTCTATGACCCAACTGGTACTCTTGTCAAAAGTTCAACTGGAACACAAAGGCAGGAGA
CAATAACATACATTCCAACACAAACGGGAACCTATTATATCAAAGTATATTCCTTCCGAGGCAGTGGAAATTATTACTTT
GATTTAAGTGTAGGAGGCGGGTCACTCACCCTTTCAAGTAACGACATATAA

Upstream 100 bases:

>100_bases
AAGGAGATGATGAATAGAAGAAAGAAACAGTTTCACTTAGCGACTAGAAGGGCTGACTTAAATTTTAAAAAATATTAAAT
TTTTAAGGAGGTAAGAAAAA

Downstream 100 bases:

>100_bases
AAAAATTAAAGAAGTATGGTGCCAATGGCTCCATACTTCTTTAATTTTTGAGACTTTCTACTTTATTTTCTCCTTTTTCA
AGTAAAATTTTTTTGTCAAA

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MKSRQTLKALLAFVLIVALMSLSGVLVQAQPNLTNFPINSSTKNYLPQIQKVLMQDSNKNKLFDNLEAKIAGKPDSEKFP
VIIIFNKNIDDNELLNISKSIGKFNIKHKYKIIPGIAATLTKGQINAWSKLDIVKQIEYDEPVYATLDTATKWFGVTKAR
SDFGVTGDRDGNASSYSKNDIVIAVIDTGIDGSHVDLAGGKVIGWQDFVNGKSTPYDDNGHGTHVASIAAGTGTGNNLYK
GVAPGAALVGIKVLDSNGSGTMSTVTAGIDWAVQNKDVYGIKVINLSLGTSTSSDGTDSTSLAVNGAVDSGIVVVVAAGN
SGPARYTIGSPGAAEKAITVAAMADVGELGFNLASFSSRGPTADGRIKPDIAAPGYNITAAKANSINGYVTYSGTSMATP
FVAGTVALMLSANINLAPLDVKNIIMTTAKSWGPPSKNIDYGVGRLDAYEAIKTAGNFTGTNISVPNHYYAKESLPGSRY
SDIWTFNVTDTSYPIAITFIIPDWANYNPDFDIYLYDPTGTLVKSSTGTQRQETITYIPTQTGTYYIKVYSFRGSGNYYF
DLSVGGGSLTLSSNDI

Sequences:

>Translated_576_residues
MKSRQTLKALLAFVLIVALMSLSGVLVQAQPNLTNFPINSSTKNYLPQIQKVLMQDSNKNKLFDNLEAKIAGKPDSEKFP
VIIIFNKNIDDNELLNISKSIGKFNIKHKYKIIPGIAATLTKGQINAWSKLDIVKQIEYDEPVYATLDTATKWFGVTKAR
SDFGVTGDRDGNASSYSKNDIVIAVIDTGIDGSHVDLAGGKVIGWQDFVNGKSTPYDDNGHGTHVASIAAGTGTGNNLYK
GVAPGAALVGIKVLDSNGSGTMSTVTAGIDWAVQNKDVYGIKVINLSLGTSTSSDGTDSTSLAVNGAVDSGIVVVVAAGN
SGPARYTIGSPGAAEKAITVAAMADVGELGFNLASFSSRGPTADGRIKPDIAAPGYNITAAKANSINGYVTYSGTSMATP
FVAGTVALMLSANINLAPLDVKNIIMTTAKSWGPPSKNIDYGVGRLDAYEAIKTAGNFTGTNISVPNHYYAKESLPGSRY
SDIWTFNVTDTSYPIAITFIIPDWANYNPDFDIYLYDPTGTLVKSSTGTQRQETITYIPTQTGTYYIKVYSFRGSGNYYF
DLSVGGGSLTLSSNDI
>Mature_576_residues
MKSRQTLKALLAFVLIVALMSLSGVLVQAQPNLTNFPINSSTKNYLPQIQKVLMQDSNKNKLFDNLEAKIAGKPDSEKFP
VIIIFNKNIDDNELLNISKSIGKFNIKHKYKIIPGIAATLTKGQINAWSKLDIVKQIEYDEPVYATLDTATKWFGVTKAR
SDFGVTGDRDGNASSYSKNDIVIAVIDTGIDGSHVDLAGGKVIGWQDFVNGKSTPYDDNGHGTHVASIAAGTGTGNNLYK
GVAPGAALVGIKVLDSNGSGTMSTVTAGIDWAVQNKDVYGIKVINLSLGTSTSSDGTDSTSLAVNGAVDSGIVVVVAAGN
SGPARYTIGSPGAAEKAITVAAMADVGELGFNLASFSSRGPTADGRIKPDIAAPGYNITAAKANSINGYVTYSGTSMATP
FVAGTVALMLSANINLAPLDVKNIIMTTAKSWGPPSKNIDYGVGRLDAYEAIKTAGNFTGTNISVPNHYYAKESLPGSRY
SDIWTFNVTDTSYPIAITFIIPDWANYNPDFDIYLYDPTGTLVKSSTGTQRQETITYIPTQTGTYYIKVYSFRGSGNYYF
DLSVGGGSLTLSSNDI

Specific function: Displays serine protease activity. Seems to have a broad substrate specificity [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Cytoplasm (Probable). Note=Is leaked to the culture medium during the late stationary phase owing to cell lysis [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI186972143, Length=226, Percent_Identity=34.070796460177, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI4506775, Length=294, Percent_Identity=28.5714285714286, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI31317307, Length=366, Percent_Identity=26.2295081967213, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17533391, Length=277, Percent_Identity=28.158844765343, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324576, Length=236, Percent_Identity=38.135593220339, Blast_Score=117, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6320775, Length=240, Percent_Identity=38.75, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319893, Length=286, Percent_Identity=34.2657342657343, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17137360, Length=246, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24653270, Length=246, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI45550681, Length=350, Percent_Identity=26, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 61062; Mature: 61062

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSRQTLKALLAFVLIVALMSLSGVLVQAQPNLTNFPINSSTKNYLPQIQKVLMQDSNKN
CCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
KLFDNLEAKIAGKPDSEKFPVIIIFNKNIDDNELLNISKSIGKFNIKHKYKIIPGIAATL
HHHHCCEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEEEEEEECCCCEEEE
TKGQINAWSKLDIVKQIEYDEPVYATLDTATKWFGVTKARSDFGVTGDRDGNASSYSKND
ECCCCCCCHHHHHHHHCCCCCCEEEEECCCHHHEEEEECCCCCCCCCCCCCCCCCCCCCC
IVIAVIDTGIDGSHVDLAGGKVIGWQDFVNGKSTPYDDNGHGTHVASIAAGTGTGNNLYK
EEEEEEECCCCCCEEEECCCEEECHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCC
GVAPGAALVGIKVLDSNGSGTMSTVTAGIDWAVQNKDVYGIKVINLSLGTSTSSDGTDST
CCCCCCEEEEEEEEECCCCCCEEEEEECEEEEEECCCEEEEEEEEEEECCCCCCCCCCCC
SLAVNGAVDSGIVVVVAAGNSGPARYTIGSPGAAEKAITVAAMADVGELGFNLASFSSRG
EEEEECCCCCCEEEEEECCCCCCEEEEECCCCCCCCEEEEEEEHHHHHHCCEEECCCCCC
PTADGRIKPDIAAPGYNITAAKANSINGYVTYSGTSMATPFVAGTVALMLSANINLAPLD
CCCCCEECCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCHHHHEEEEEEECCCCEEECC
VKNIIMTTAKSWGPPSKNIDYGVGRLDAYEAIKTAGNFTGTNISVPNHYYAKESLPGSRY
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCEEECCCCCCCCC
SDIWTFNVTDTSYPIAITFIIPDWANYNPDFDIYLYDPTGTLVKSSTGTQRQETITYIPT
CEEEEEEECCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCEEECCCCCCCCEEEEEEEC
QTGTYYIKVYSFRGSGNYYFDLSVGGGSLTLSSNDI
CCCEEEEEEEEEECCCCEEEEEEECCCEEEECCCCC
>Mature Secondary Structure
MKSRQTLKALLAFVLIVALMSLSGVLVQAQPNLTNFPINSSTKNYLPQIQKVLMQDSNKN
CCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
KLFDNLEAKIAGKPDSEKFPVIIIFNKNIDDNELLNISKSIGKFNIKHKYKIIPGIAATL
HHHHCCEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCEEEEEEEEECCCCEEEE
TKGQINAWSKLDIVKQIEYDEPVYATLDTATKWFGVTKARSDFGVTGDRDGNASSYSKND
ECCCCCCCHHHHHHHHCCCCCCEEEEECCCHHHEEEEECCCCCCCCCCCCCCCCCCCCCC
IVIAVIDTGIDGSHVDLAGGKVIGWQDFVNGKSTPYDDNGHGTHVASIAAGTGTGNNLYK
EEEEEEECCCCCCEEEECCCEEECHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCC
GVAPGAALVGIKVLDSNGSGTMSTVTAGIDWAVQNKDVYGIKVINLSLGTSTSSDGTDST
CCCCCCEEEEEEEEECCCCCCEEEEEECEEEEEECCCEEEEEEEEEEECCCCCCCCCCCC
SLAVNGAVDSGIVVVVAAGNSGPARYTIGSPGAAEKAITVAAMADVGELGFNLASFSSRG
EEEEECCCCCCEEEEEECCCCCCEEEEECCCCCCCCEEEEEEEHHHHHHCCEEECCCCCC
PTADGRIKPDIAAPGYNITAAKANSINGYVTYSGTSMATPFVAGTVALMLSANINLAPLD
CCCCCEECCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCHHHHEEEEEEECCCCEEECC
VKNIIMTTAKSWGPPSKNIDYGVGRLDAYEAIKTAGNFTGTNISVPNHYYAKESLPGSRY
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCEEECCCCCCCCC
SDIWTFNVTDTSYPIAITFIIPDWANYNPDFDIYLYDPTGTLVKSSTGTQRQETITYIPT
CEEEEEEECCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCEEECCCCCCCCEEEEEEEC
QTGTYYIKVYSFRGSGNYYFDLSVGGGSLTLSSNDI
CCCEEEEEEEEEECCCCEEEEEEECCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]