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The map label for this gene is dapA

Identifier: 167040807

GI number: 167040807

Start: 2184020

End: 2184913

Strand: Direct

Name: dapA

Synonym: Teth514_2184

Alternate gene names: 167040807

Gene position: 2184020-2184913 (Clockwise)

Preceding gene: 167040806

Following gene: 167040808

Centisome position: 88.88

GC content: 38.48

Gene sequence:

>894_bases
ATGCCTGTTTTTAAAGGATCGGGTGTTGCTATTGTTACCCCATTTAATGAAGAGGGCGTAAATTTTGAAAAACTTGGCGA
GCTTATTGAATGGCATATCAAAGAAGGAACTGATGCTATCATCATATGTGGTACCACTGGTGAAGCCTCTACAATGACAC
AAGAAGAACAACAGCAAGCAATTAAATTTACAGTCGAAAAAGTGGCTGGAAGAATACCAGTAATTGCAGGGACCGGTTCT
AACAACACAGCCCATGCTGTTGAAATGAGTGAATATGCTCAATCTGCAGGTGCTGATGCTCTTTTAGTTATAACACCCTA
TTACAACAAAACAACACAAAAGGGATTAGTGGCTCATTTTACTGAAATAGCAAGACACGTAGACATACCTATTATTATTT
ATAATGTCCCCAGCAGGACATCTCTCAATATGTTGCCAGAAACTTATCTCGAATTGAGCAAACACGTAGATAATGTAGTA
GGTGTAAAAGAAGCCAGTGGTGACATCGTACAGGTAGCCGAAATTGCCCGCATCATGGGTAAATCCTTTGAAATATACTC
AGGAAATGACGACCAAGTAATACCAATAATGTCTTTAGGTGGCCTTGGGGTAATATCCGTCACGGCAAATATAATCCCGG
CAAAAATACATGAAATGACAACCGCTTATTTAAATGGAGATATTGAAAAGGCAAGAGACATGCAGTTAGAACTTAATCCT
CTAAATAAAGCCCTCTTTATAGAAACAAACCCTATTCCTGTAAAAACTGCTATGAACTTAATGGGATTCAACGTAGGACC
CCTACGCCTCCCACTTGTTGAAATGAGCGATAAAAACTTAGAATATCTGAAATCTGTTCTTTCAAAATACGGTTTATTGA
AGGAGGCAAATTAA

Upstream 100 bases:

>100_bases
AACATGTGGATTGTAGCCGACAACATAAGAAAAGGGGCGGCAACAAATGCCGTTCAAATAGCAGAACTTTTAATTAAAAA
TATGTGAAAGGAGAATAATT

Downstream 100 bases:

>100_bases
TGATTAGAATAATAATTCACGGCTGTAACGGAAAAATGGGAAAAGTCGTAGCAAAGTTAGCAGCAGAAAGTCCCGATTTT
AAAATAGTGGCAGGAGTAGA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MPVFKGSGVAIVTPFNEEGVNFEKLGELIEWHIKEGTDAIIICGTTGEASTMTQEEQQQAIKFTVEKVAGRIPVIAGTGS
NNTAHAVEMSEYAQSAGADALLVITPYYNKTTQKGLVAHFTEIARHVDIPIIIYNVPSRTSLNMLPETYLELSKHVDNVV
GVKEASGDIVQVAEIARIMGKSFEIYSGNDDQVIPIMSLGGLGVISVTANIIPAKIHEMTTAYLNGDIEKARDMQLELNP
LNKALFIETNPIPVKTAMNLMGFNVGPLRLPLVEMSDKNLEYLKSVLSKYGLLKEAN

Sequences:

>Translated_297_residues
MPVFKGSGVAIVTPFNEEGVNFEKLGELIEWHIKEGTDAIIICGTTGEASTMTQEEQQQAIKFTVEKVAGRIPVIAGTGS
NNTAHAVEMSEYAQSAGADALLVITPYYNKTTQKGLVAHFTEIARHVDIPIIIYNVPSRTSLNMLPETYLELSKHVDNVV
GVKEASGDIVQVAEIARIMGKSFEIYSGNDDQVIPIMSLGGLGVISVTANIIPAKIHEMTTAYLNGDIEKARDMQLELNP
LNKALFIETNPIPVKTAMNLMGFNVGPLRLPLVEMSDKNLEYLKSVLSKYGLLKEAN
>Mature_296_residues
PVFKGSGVAIVTPFNEEGVNFEKLGELIEWHIKEGTDAIIICGTTGEASTMTQEEQQQAIKFTVEKVAGRIPVIAGTGSN
NTAHAVEMSEYAQSAGADALLVITPYYNKTTQKGLVAHFTEIARHVDIPIIIYNVPSRTSLNMLPETYLELSKHVDNVVG
VKEASGDIVQVAEIARIMGKSFEIYSGNDDQVIPIMSLGGLGVISVTANIIPAKIHEMTTAYLNGDIEKARDMQLELNPL
NKALFIETNPIPVKTAMNLMGFNVGPLRLPLVEMSDKNLEYLKSVLSKYGLLKEAN

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=290, Percent_Identity=27.5862068965517, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI13540533, Length=307, Percent_Identity=26.0586319218241, Blast_Score=92, Evalue=6e-19,
Organism=Escherichia coli, GI1788823, Length=293, Percent_Identity=43.0034129692833, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI87082415, Length=299, Percent_Identity=30.1003344481605, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1786463, Length=234, Percent_Identity=31.1965811965812, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1789620, Length=287, Percent_Identity=27.5261324041812, Blast_Score=111, Evalue=4e-26,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_THEP3 (B0KAL7)

Other databases:

- EMBL:   CP000924
- RefSeq:   YP_001665487.1
- ProteinModelPortal:   B0KAL7
- SMR:   B0KAL7
- GeneID:   5874862
- GenomeReviews:   CP000924_GR
- KEGG:   tpd:Teth39_1502
- HOGENOM:   HBG358848
- OMA:   QKGLIEH
- ProtClustDB:   PRK03170
- BioCyc:   TPSE340099:TETH39_1502-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 32319; Mature: 32187

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 163-163 BINDING 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVFKGSGVAIVTPFNEEGVNFEKLGELIEWHIKEGTDAIIICGTTGEASTMTQEEQQQA
CCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHCCHHHHHHH
IKFTVEKVAGRIPVIAGTGSNNTAHAVEMSEYAQSAGADALLVITPYYNKTTQKGLVAHF
HHHHHHHHCCCCCEEEECCCCCCEEEEEHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHH
TEIARHVDIPIIIYNVPSRTSLNMLPETYLELSKHVDNVVGVKEASGDIVQVAEIARIMG
HHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHC
KSFEIYSGNDDQVIPIMSLGGLGVISVTANIIPAKIHEMTTAYLNGDIEKARDMQLELNP
CCEEEEECCCCCEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEC
LNKALFIETNPIPVKTAMNLMGFNVGPLRLPLVEMSDKNLEYLKSVLSKYGLLKEAN
CCEEEEEECCCCCHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PVFKGSGVAIVTPFNEEGVNFEKLGELIEWHIKEGTDAIIICGTTGEASTMTQEEQQQA
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHCCHHHHHHH
IKFTVEKVAGRIPVIAGTGSNNTAHAVEMSEYAQSAGADALLVITPYYNKTTQKGLVAHF
HHHHHHHHCCCCCEEEECCCCCCEEEEEHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHH
TEIARHVDIPIIIYNVPSRTSLNMLPETYLELSKHVDNVVGVKEASGDIVQVAEIARIMG
HHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHC
KSFEIYSGNDDQVIPIMSLGGLGVISVTANIIPAKIHEMTTAYLNGDIEKARDMQLELNP
CCEEEEECCCCCEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEC
LNKALFIETNPIPVKTAMNLMGFNVGPLRLPLVEMSDKNLEYLKSVLSKYGLLKEAN
CCEEEEEECCCCCHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA