Click here to switch to the map view.

The map label for this gene is iadA [H]

Identifier: 167040799

GI number: 167040799

Start: 2174761

End: 2175936

Strand: Direct

Name: iadA [H]

Synonym: Teth514_2176

Alternate gene names: 167040799

Gene position: 2174761-2175936 (Clockwise)

Preceding gene: 167040797

Following gene: 167040803

Centisome position: 88.5

GC content: 35.88

Gene sequence:

>1176_bases
ATGTTTTTACTTTTAAAAGGGGGAGAAGTTTACTCTCCTCAGCCTTTAGGTAGAAAAGATATTTTAATCTGCAATGGAAA
AATAATAAGAATTGCTGATGAAATAAAACCTATGAAGGAATTTGGAAATGTAGAAATTGTAGATTTACAAGGTTTTATCA
TAGTTCCAGGTTTCATTGACCAACACGTCCACATCGCAGGAGGCGGTGGAGAAGGAGGACCAGCCACAAGGACACCTGAA
ATAACTCTATCTGATATCACAAAAGGCGGAATAACTACAGTTGTAGGCCTCTTGGGAGCAGATGGAATAACGAGAGGCAT
GGCTTCTCTTCTTGCAAAAGCAAGAGCTTTAGAGCAAGAAGGCATAACTACCTACATTTATACAGGAGCTTATGAACTTC
CTACACGCACTTTAACAGGAAGTGTAAGATCAGACTTAGTTTTAATCGACAAAGTAATAGGTACTGGAGAAATCGCCATT
TCAGATCACAGGTCTGCACAACCAACTATTGAAGACTTGACAAAACTTGCTGCAGAAGCAAGAGTTGGAGGTCTTTTAGG
GGGTAAACCCGGAATAGTTCACCTTCATGTTGGAGATGGAATAAGAGGATTGTCCCCGTTATTTGAAATAGTGGAAAACA
CTGAAATACCTATTACGCAATTTGTTCCTACTCATATAAACAGAATAGGACATTTATTTGAACAAGGATTAAAATTTATA
GAAATGGGTGGCGTAATTGACCTTACTTCTGATATAAAGCCGGACGCCCACACAAAAACTGCTTTAACACCAAAAGAAGC
AATTAAAAAAATCGTAGAAAACAAATTACCTATAGAAAAAGTCACTATGAGCTCTGATAGCAATGGTAGCATTCCTGTAT
TTGATGAAAATAAGCGATTGGTAAAGGTTATGGTGGGAAGTGCACAAACTCTATACCGCGATTTAAGAGAAGTTATAGTG
GAAGGGATACTGCCAATAGAACAAGCAATTAAAATAATAACAGAAAATGTAGCAAAAGTATTGAATTTATATCCAAACAA
GGGGTGTATCAAGGAAAAATCAGACGGAGATATAGTAGTATTAGATAGCAATTTAAATATTCATTCTGTTATTGCAAAAG
GAGTATTCATGATAAAAGATAAAAAAATAGTAAAAAAAAGCATGTTTGAAGAATAA

Upstream 100 bases:

>100_bases
ATTATACCATTATCATGACAAAAATTCTTTTTAATTTTAAAATATATTATAATGGATATGGAAGAAAAAATATTATAAAG
AAACCAAATGAGGTGAGATC

Downstream 100 bases:

>100_bases
AAGAGGCGGTCTCACGCCTCTTATTCTTTATATTCTTGTAATATCATTTCAGCTATTATTTCCATTGGAATTGACAAATC
CATGCTCATCTTTCTCATAA

Product: isoaspartyl dipeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MFLLLKGGEVYSPQPLGRKDILICNGKIIRIADEIKPMKEFGNVEIVDLQGFIIVPGFIDQHVHIAGGGGEGGPATRTPE
ITLSDITKGGITTVVGLLGADGITRGMASLLAKARALEQEGITTYIYTGAYELPTRTLTGSVRSDLVLIDKVIGTGEIAI
SDHRSAQPTIEDLTKLAAEARVGGLLGGKPGIVHLHVGDGIRGLSPLFEIVENTEIPITQFVPTHINRIGHLFEQGLKFI
EMGGVIDLTSDIKPDAHTKTALTPKEAIKKIVENKLPIEKVTMSSDSNGSIPVFDENKRLVKVMVGSAQTLYRDLREVIV
EGILPIEQAIKIITENVAKVLNLYPNKGCIKEKSDGDIVVLDSNLNIHSVIAKGVFMIKDKKIVKKSMFEE

Sequences:

>Translated_391_residues
MFLLLKGGEVYSPQPLGRKDILICNGKIIRIADEIKPMKEFGNVEIVDLQGFIIVPGFIDQHVHIAGGGGEGGPATRTPE
ITLSDITKGGITTVVGLLGADGITRGMASLLAKARALEQEGITTYIYTGAYELPTRTLTGSVRSDLVLIDKVIGTGEIAI
SDHRSAQPTIEDLTKLAAEARVGGLLGGKPGIVHLHVGDGIRGLSPLFEIVENTEIPITQFVPTHINRIGHLFEQGLKFI
EMGGVIDLTSDIKPDAHTKTALTPKEAIKKIVENKLPIEKVTMSSDSNGSIPVFDENKRLVKVMVGSAQTLYRDLREVIV
EGILPIEQAIKIITENVAKVLNLYPNKGCIKEKSDGDIVVLDSNLNIHSVIAKGVFMIKDKKIVKKSMFEE
>Mature_391_residues
MFLLLKGGEVYSPQPLGRKDILICNGKIIRIADEIKPMKEFGNVEIVDLQGFIIVPGFIDQHVHIAGGGGEGGPATRTPE
ITLSDITKGGITTVVGLLGADGITRGMASLLAKARALEQEGITTYIYTGAYELPTRTLTGSVRSDLVLIDKVIGTGEIAI
SDHRSAQPTIEDLTKLAAEARVGGLLGGKPGIVHLHVGDGIRGLSPLFEIVENTEIPITQFVPTHINRIGHLFEQGLKFI
EMGGVIDLTSDIKPDAHTKTALTPKEAIKKIVENKLPIEKVTMSSDSNGSIPVFDENKRLVKVMVGSAQTLYRDLREVIV
EGILPIEQAIKIITENVAKVLNLYPNKGCIKEKSDGDIVVLDSNLNIHSVIAKGVFMIKDKKIVKKSMFEE

Specific function: Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation. The best substrate for the enzyme reported thus far is iso-Asp-Leu [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M38 family [H]

Homologues:

Organism=Escherichia coli, GI1790784, Length=389, Percent_Identity=47.0437017994859, Blast_Score=356, Evalue=2e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059
- InterPro:   IPR010229 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.4.19.- [C]

Molecular weight: Translated: 42233; Mature: 42233

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLLLKGGEVYSPQPLGRKDILICNGKIIRIADEIKPMKEFGNVEIVDLQGFIIVPGFID
CEEEEECCCCCCCCCCCCCCEEEECCEEEEEHHHHHHHHHHCCEEEEEECCEEEECCCCC
QHVHIAGGGGEGGPATRTPEITLSDITKGGITTVVGLLGADGITRGMASLLAKARALEQE
CEEEEECCCCCCCCCCCCCCEEHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
GITTYIYTGAYELPTRTLTGSVRSDLVLIDKVIGTGEIAISDHRSAQPTIEDLTKLAAEA
CCEEEEEECEEECCCHHCCCCHHCCEEEEEHHHCCCEEEECCCCCCCCCHHHHHHHHHHH
RVGGLLGGKPGIVHLHVGDGIRGLSPLFEIVENTEIPITQFVPTHINRIGHLFEQGLKFI
HHCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EMGGVIDLTSDIKPDAHTKTALTPKEAIKKIVENKLPIEKVTMSSDSNGSIPVFDENKRL
HCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEECCCCEE
VKVMVGSAQTLYRDLREVIVEGILPIEQAIKIITENVAKVLNLYPNKGCIKEKSDGDIVV
EEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEE
LDSNLNIHSVIAKGVFMIKDKKIVKKSMFEE
ECCCCCHHHHHHCCEEEEECHHHHHHHHCCC
>Mature Secondary Structure
MFLLLKGGEVYSPQPLGRKDILICNGKIIRIADEIKPMKEFGNVEIVDLQGFIIVPGFID
CEEEEECCCCCCCCCCCCCCEEEECCEEEEEHHHHHHHHHHCCEEEEEECCEEEECCCCC
QHVHIAGGGGEGGPATRTPEITLSDITKGGITTVVGLLGADGITRGMASLLAKARALEQE
CEEEEECCCCCCCCCCCCCCEEHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
GITTYIYTGAYELPTRTLTGSVRSDLVLIDKVIGTGEIAISDHRSAQPTIEDLTKLAAEA
CCEEEEEECEEECCCHHCCCCHHCCEEEEEHHHCCCEEEECCCCCCCCCHHHHHHHHHHH
RVGGLLGGKPGIVHLHVGDGIRGLSPLFEIVENTEIPITQFVPTHINRIGHLFEQGLKFI
HHCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EMGGVIDLTSDIKPDAHTKTALTPKEAIKKIVENKLPIEKVTMSSDSNGSIPVFDENKRL
HCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEECCCCEE
VKVMVGSAQTLYRDLREVIVEGILPIEQAIKIITENVAKVLNLYPNKGCIKEKSDGDIVV
EEEECCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEE
LDSNLNIHSVIAKGVFMIKDKKIVKKSMFEE
ECCCCCHHHHHHCCEEEEECHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7876157; 7610040; 9278503 [H]