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The map label for this gene is metC [H]

Identifier: 167040491

GI number: 167040491

Start: 1876070

End: 1877251

Strand: Direct

Name: metC [H]

Synonym: Teth514_1860

Alternate gene names: 167040491

Gene position: 1876070-1877251 (Clockwise)

Preceding gene: 167040488

Following gene: 167040504

Centisome position: 76.35

GC content: 35.96

Gene sequence:

>1182_bases
ATGGATTTAAGTTTTAAAACAAAAGTAGTACATACTGGAAACTACATAGATAAAGAAATTCCTCCAATGCCAAAAACTCT
TCCTATCTATCAAACTTCTGTTTTCACTTTTGATACGTTGGAAGAAGTTTACGATTATCTTGGTGGTAATCCTTCAAGGT
ATATGTACACAAGACTTGGAAACCCTAATCAAACTGCAGTGGAAGAATTAATTGCCAGTTTAGAAGGCGCGGAAGCAGGA
CAGGCTTGTTCATCCGGAATGGCGGCAATTTTTTCAGCTTTGTTGGCAGAAGTAAATTCAGGAGACCACATAATCGCCGC
AAAAGATATATACGGTGGTACAAACAGTCTTTTTAATGCAGAATTTAAAAGACTTAATATTGATGTAACTTTAGTGGATT
TCTCCGATTTAGAAGCTGTTGAAAAAGCTATAAAACCAAACACTAAAGTGATATACATGGAAATCATGACAAATCCTCTA
ATAAGAGTTTTTGATGTAGTAGAAGTTGCAAATATCGCAAAAAAGCACAATATAAAATTGATTGTTGACAATACTTTTAC
AACACCTTATTTGATAAAACCAATTGAATTAGGAGCTTATGCTGTAATACACAGCGCAACAAAATACATTAACGGCCACA
GCGATGTCATCGCCGGACTTATAGCAGGCAATAAAGAATTTATCTCTCGCACAAAAAGAATTACGCAAAACTTCGGCGGT
TCAATGAGCCCCTTTGACGCATGGCTGACTTTAAGAGGAGCAAAAACTCTATTCTTAAGAATGAGAGAACACTGTAAAAA
CGCAATGGAATTGGCTAAATTCTTAGAAAGCCATCCAAAAGTCAAAAAAGTGTATTATCCCGGACTTTCTTCTCACCCTG
ACTACAGTGTTTCAAAGAAGTTGTTTAAAGATGAGTTTGGAGGTATGTTAAGTTTTGAAATAGAAGGTGGAGAACCTGAA
GTAGATAAGTTTATGCAAGAGCTGAAACTGGTGAAATTTGCTCCTTCACTGGCAGGAGTACAAACCATGATAACTCATCC
AAAATCCACTTCCCATAGGTCTCTCAGCAAGGAAGAATTAAACGCGTTAGGAATTTCAGAAGGACTTATAAGAGTTTCTG
TTGGAATAGAGGAGATAGAAGATATTATAAAAGACTTTAAACAAGCTCTTGACAAGATATAA

Upstream 100 bases:

>100_bases
AATAGTTTACCTCAAAATATAATTCAAGTGAAGCGTTGTTGACTTTTAATTTTGCACATATTATCATTAATTTAAAGTAC
AAATTGTGGGAGTTGATAAA

Downstream 100 bases:

>100_bases
GAAAAAAAGTTTAGGGCTTTCCCTAAACTTTTTTTATATTTCATCTAGCACCTTTAATACCTCTTCAACGTGTCCATCTA
CTTTTACCCTTCTAAATATT

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MDLSFKTKVVHTGNYIDKEIPPMPKTLPIYQTSVFTFDTLEEVYDYLGGNPSRYMYTRLGNPNQTAVEELIASLEGAEAG
QACSSGMAAIFSALLAEVNSGDHIIAAKDIYGGTNSLFNAEFKRLNIDVTLVDFSDLEAVEKAIKPNTKVIYMEIMTNPL
IRVFDVVEVANIAKKHNIKLIVDNTFTTPYLIKPIELGAYAVIHSATKYINGHSDVIAGLIAGNKEFISRTKRITQNFGG
SMSPFDAWLTLRGAKTLFLRMREHCKNAMELAKFLESHPKVKKVYYPGLSSHPDYSVSKKLFKDEFGGMLSFEIEGGEPE
VDKFMQELKLVKFAPSLAGVQTMITHPKSTSHRSLSKEELNALGISEGLIRVSVGIEEIEDIIKDFKQALDKI

Sequences:

>Translated_393_residues
MDLSFKTKVVHTGNYIDKEIPPMPKTLPIYQTSVFTFDTLEEVYDYLGGNPSRYMYTRLGNPNQTAVEELIASLEGAEAG
QACSSGMAAIFSALLAEVNSGDHIIAAKDIYGGTNSLFNAEFKRLNIDVTLVDFSDLEAVEKAIKPNTKVIYMEIMTNPL
IRVFDVVEVANIAKKHNIKLIVDNTFTTPYLIKPIELGAYAVIHSATKYINGHSDVIAGLIAGNKEFISRTKRITQNFGG
SMSPFDAWLTLRGAKTLFLRMREHCKNAMELAKFLESHPKVKKVYYPGLSSHPDYSVSKKLFKDEFGGMLSFEIEGGEPE
VDKFMQELKLVKFAPSLAGVQTMITHPKSTSHRSLSKEELNALGISEGLIRVSVGIEEIEDIIKDFKQALDKI
>Mature_393_residues
MDLSFKTKVVHTGNYIDKEIPPMPKTLPIYQTSVFTFDTLEEVYDYLGGNPSRYMYTRLGNPNQTAVEELIASLEGAEAG
QACSSGMAAIFSALLAEVNSGDHIIAAKDIYGGTNSLFNAEFKRLNIDVTLVDFSDLEAVEKAIKPNTKVIYMEIMTNPL
IRVFDVVEVANIAKKHNIKLIVDNTFTTPYLIKPIELGAYAVIHSATKYINGHSDVIAGLIAGNKEFISRTKRITQNFGG
SMSPFDAWLTLRGAKTLFLRMREHCKNAMELAKFLESHPKVKKVYYPGLSSHPDYSVSKKLFKDEFGGMLSFEIEGGEPE
VDKFMQELKLVKFAPSLAGVQTMITHPKSTSHRSLSKEELNALGISEGLIRVSVGIEEIEDIIKDFKQALDKI

Specific function: The enzymatic degradation of amino acids in cheese is believed to generate aroma compounds and therefore to be essential for flavor development. Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine but is also able to catalyze an alpha

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=392, Percent_Identity=39.030612244898, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI299473759, Length=344, Percent_Identity=38.6627906976744, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI25453487, Length=391, Percent_Identity=34.2710997442455, Blast_Score=201, Evalue=1e-51,
Organism=Escherichia coli, GI1790375, Length=363, Percent_Identity=36.6391184573003, Blast_Score=251, Evalue=4e-68,
Organism=Escherichia coli, GI1789383, Length=370, Percent_Identity=23.5135135135135, Blast_Score=131, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI71980708, Length=376, Percent_Identity=41.2234042553192, Blast_Score=281, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17560056, Length=395, Percent_Identity=41.0126582278481, Blast_Score=277, Evalue=9e-75,
Organism=Caenorhabditis elegans, GI17538055, Length=391, Percent_Identity=40.153452685422, Blast_Score=263, Evalue=1e-70,
Organism=Saccharomyces cerevisiae, GI6319307, Length=399, Percent_Identity=38.0952380952381, Blast_Score=266, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6323333, Length=438, Percent_Identity=34.2465753424658, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6321254, Length=412, Percent_Identity=32.7669902912621, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6321170, Length=314, Percent_Identity=28.6624203821656, Blast_Score=139, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6321904, Length=379, Percent_Identity=26.9129287598945, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6323557, Length=279, Percent_Identity=26.8817204301075, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922554, Length=394, Percent_Identity=39.8477157360406, Blast_Score=276, Evalue=2e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43676; Mature: 43676

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSFKTKVVHTGNYIDKEIPPMPKTLPIYQTSVFTFDTLEEVYDYLGGNPSRYMYTRLG
CCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHCCCCCCEEEEECC
NPNQTAVEELIASLEGAEAGQACSSGMAAIFSALLAEVNSGDHIIAAKDIYGGTNSLFNA
CCCHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHCC
EFKRLNIDVTLVDFSDLEAVEKAIKPNTKVIYMEIMTNPLIRVFDVVEVANIAKKHNIKL
HHEEEEEEEEEEECHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCEEE
IVDNTFTTPYLIKPIELGAYAVIHSATKYINGHSDVIAGLIAGNKEFISRTKRITQNFGG
EEECCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCC
SMSPFDAWLTLRGAKTLFLRMREHCKNAMELAKFLESHPKVKKVYYPGLSSHPDYSVSKK
CCCCHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHH
LFKDEFGGMLSFEIEGGEPEVDKFMQELKLVKFAPSLAGVQTMITHPKSTSHRSLSKEEL
HHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHH
NALGISEGLIRVSVGIEEIEDIIKDFKQALDKI
HHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDLSFKTKVVHTGNYIDKEIPPMPKTLPIYQTSVFTFDTLEEVYDYLGGNPSRYMYTRLG
CCCCCEEEEEECCCCCCCCCCCCCCCCCEEEEEEEEHHHHHHHHHHHCCCCCCEEEEECC
NPNQTAVEELIASLEGAEAGQACSSGMAAIFSALLAEVNSGDHIIAAKDIYGGTNSLFNA
CCCHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHCC
EFKRLNIDVTLVDFSDLEAVEKAIKPNTKVIYMEIMTNPLIRVFDVVEVANIAKKHNIKL
HHEEEEEEEEEEECHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCEEE
IVDNTFTTPYLIKPIELGAYAVIHSATKYINGHSDVIAGLIAGNKEFISRTKRITQNFGG
EEECCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCC
SMSPFDAWLTLRGAKTLFLRMREHCKNAMELAKFLESHPKVKKVYYPGLSSHPDYSVSKK
CCCCHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHH
LFKDEFGGMLSFEIEGGEPEVDKFMQELKLVKFAPSLAGVQTMITHPKSTSHRSLSKEEL
HHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCHHHH
NALGISEGLIRVSVGIEEIEDIIKDFKQALDKI
HHCCCCCCEEEEECCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]